IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KLK11 Ensembl ENSG00000167757 Chromosome 19 Start 56217301 End 56223102
Description Kallikrein-11 Precursor (hK11)(EC 3.4.21.-)(Hippostasin)(Trypsin-like protease)(Serine protease 20) [Contains Kallikrein-11 inactive chain 1;Kallikrein-11 inactive chain 2] [Source:UniProtKB/Swiss-Prot;Acc:Q9UBX7]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6359
     Entrez Gene : 11012
     UCSC : uc002pvd.1
     GeneCards : 6359
     RefSeq : NM_001136032
     CCDS : CCDS12818.1
     Uniprot : Q9UBX7
     Interpro : Q9UBX7
     OMIM : 604434
     GeneTests : KLK11
     CGAP : KLK11
     PMID : 9765601

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40035_at  -1.27  2.46e-3  6.96e-3  -1.14  4.17e-3  1.07e-2
 HG_U133A  205470_s_at  -1.13  8.88e-7  2.30e-6  -2.52  3.61e-71  1.20e-70
 HG_U133_Plus2  205470_s_at  -1.06  3.98e-4  1.12e-3  -1.23  2.29e-5  5.59e-5
 Agilent_HS_21.6K  18507  -0.13  6.16e-2  1.68e-1  -0.05  5.73e-1  7.09e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205470_s_at  1.12  5.14e-2  7.08e-1  0.11  8.22e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40035_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205470_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205470_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18507    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
klk11 prostate cancer Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines. 11550212 Human
hippostasin prostate cancer Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines. 11550212 Human
prss20 prostate cancer Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines. 11550212 Human
hippostasin prostate cancer METHODS: We analyzed the expression and localization of hippostasin in normal prostate tissue, BPH tissue, and prostate cancer cell lines. 11550212 Human
hippostasin prostate cancer All tested prostate cancer cell lines, including PSA-negative cell lines, expressed hippostasin. 11550212 Human
hippostasin prostate cancer Interestingly, all the prostate cancer cell lines expressed only brain-type but not prostate-type hippostasin, while normal prostate and BPH expressed both types of hippostasin CONCLUSIONS: Our results suggest the possibility that hippostasin may be a use 11550212 Human
tlsp breast carcinoma TLSP expression appears to be regulated by steroid hormones in the breast carcinoma cell line BT-474. 10662548 Human
kallikrein 11 ovarian carcinoma Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. 11782391 Human
kallikrein 11 prostate cancer The usefulness of serum human kallikrein 11 for discriminating between prostate cancer and benign prostatic hyperplasia. 14559849 Human
kallikrein 11 benign prostatic hyperplasia The usefulness of serum human kallikrein 11 for discriminating between prostate cancer and benign prostatic hyperplasia. 14559849 Human
hippostasin prostate cancer We previously reported alternative expression of hippostasin in prostate cancer cell lines. 12539228 Human
klk11 ovarian cancer We found that seven KLK genes (KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, and KLK14) are up-regulated in ovarian cancer. 12727843 Human
klk11 ovarian cancer Probing 2 normal and 10 ovarian cancer serial analysis of gene expression libraries with gene-specific tags for each KLK indicated that whereas no expression was detected in any normal libraries (with the exception of KLK10 and KLK11), these KLKs were fou 12727843 Human
klk11 prostate cancer METHODS: We compared the expression of hippostasin/KLK11 isoforms in 76 matched pairs of human normal and prostate cancer tissues by quantitative reverse transcriptase-polymerase chain reaction. 12736044 Human
hippostasin prostate cancer METHODS: We compared the expression of hippostasin/KLK11 isoforms in 76 matched pairs of human normal and prostate cancer tissues by quantitative reverse transcriptase-polymerase chain reaction. 12736044 Human
klk11 cancer RESULTS: The expression of both isoforms of KLK11 was 25% to 45% higher in cancer tissues compared with their normal counterparts. 12736044 Human
klk11 tumor Regarding prostate-type KLK11, we identified a significant association between lower expression and higher tumor stage, Gleason score, and tumor grade. 12736044 Human
klk11 prostate cancer CONCLUSIONS: : The expression of the prostate-type isoform of KLK11 is increased in prostate cancer. 12736044 Human
kallikrein 11 ovarian carcinoma Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. 12845660 Human
kallikrein 11 ovarian cancer Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients. 15329323 Human
kallikrein 11 prostate cancer Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer. 15893744 Human
klk11 epithelial ovarian cancer Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer. 15102682 Human
klk11 epithelial ovarian tumors PURPOSE: The purpose of this study was to examine expression levels of the human tissue kallikrein 11 gene (KLK11) in epithelial ovarian tumors and to identify the relationship between KLK11 expression and patient survival. 15102682 Human
klk11 low malignant potential tumors EXPERIMENTAL DESIGN: KLK11 mRNA expression was examined by semiquantitative PCR in 64 epithelial ovarian tumors (7 adenomas, 6 low malignant potential tumors, and 51 adenocarcinomas) and in 10 normal ovaries. 15102682 Human
klk11 epithelial ovarian tumors EXPERIMENTAL DESIGN: KLK11 mRNA expression was examined by semiquantitative PCR in 64 epithelial ovarian tumors (7 adenomas, 6 low malignant potential tumors, and 51 adenocarcinomas) and in 10 normal ovaries. 15102682 Human
klk11 adenomas EXPERIMENTAL DESIGN: KLK11 mRNA expression was examined by semiquantitative PCR in 64 epithelial ovarian tumors (7 adenomas, 6 low malignant potential tumors, and 51 adenocarcinomas) and in 10 normal ovaries. 15102682 Human
klk11 adenocarcinomas EXPERIMENTAL DESIGN: KLK11 mRNA expression was examined by semiquantitative PCR in 64 epithelial ovarian tumors (7 adenomas, 6 low malignant potential tumors, and 51 adenocarcinomas) and in 10 normal ovaries. 15102682 Human
klk11 ovarian carcinoma RESULTS: KLK11 mRNA expression was detected in various human cancer tissues including breast, lung, colon, prostate, pancreas, and ovarian carcinoma. 15102682 Human
klk11 cancer RESULTS: KLK11 mRNA expression was detected in various human cancer tissues including breast, lung, colon, prostate, pancreas, and ovarian carcinoma. 15102682 Human
klk11 ovarian tumor The mean value of relative KLK11 expression ratio was significantly higher in ovarian tumor samples than in normal ovary samples (compared with normal samples: adenoma, P = 0.0006; low malignant potential tumor, P = 0.0049; and carcinoma, P < 0.0001). 15102682 Human
klk11 adenoma The mean value of relative KLK11 expression ratio was significantly higher in ovarian tumor samples than in normal ovary samples (compared with normal samples: adenoma, P = 0.0006; low malignant potential tumor, P = 0.0049; and carcinoma, P < 0.0001). 15102682 Human
klk11 carcinoma The mean value of relative KLK11 expression ratio was significantly higher in ovarian tumor samples than in normal ovary samples (compared with normal samples: adenoma, P = 0.0006; low malignant potential tumor, P = 0.0049; and carcinoma, P < 0.0001). 15102682 Human
klk11 low malignant potential tumor The mean value of relative KLK11 expression ratio was significantly higher in ovarian tumor samples than in normal ovary samples (compared with normal samples: adenoma, P = 0.0006; low malignant potential tumor, P = 0.0049; and carcinoma, P < 0.0001). 15102682 Human
klk11 ovarian cancer CONCLUSIONS: KLK11 expression may play an important role in ovarian cancer development and act as an independent prognostic marker in ovarian cancer patients. 15102682 Human
klk11 prostate cancer METHODS: In the present study, the expression of prostate type variant of KLK11 gene was analyzed by RT-PCR in 66 prostate cancer tissues. 15893744 Human
klk11 prostate cancer RESULTS: KLK11 was found to be highly expressed in 43/66 (65%) of prostate cancer samples. 15893744 Human
klk11 tumors CONCLUSIONS: We conclude that down-regulation of the KLK11 gene in advanced and more aggressive tumors may open the possibility of being used as a future biological marker distinguishing the tumor aggressiveness as well as a useful prognostic biomarker fo 15893744 Human
klk11 prostate cancer CONCLUSIONS: We conclude that down-regulation of the KLK11 gene in advanced and more aggressive tumors may open the possibility of being used as a future biological marker distinguishing the tumor aggressiveness as well as a useful prognostic biomarker fo 15893744 Human
klk11 tumor CONCLUSIONS: We conclude that down-regulation of the KLK11 gene in advanced and more aggressive tumors may open the possibility of being used as a future biological marker distinguishing the tumor aggressiveness as well as a useful prognostic biomarker fo 15893744 Human
hippostasin bph METHODS: We analyzed the expression and localization of hippostasin in normal prostate tissue, BPH tissue, and prostate cancer cell lines. 11550212 Human
hippostasin bph Interestingly, all the prostate cancer cell lines expressed only brain-type but not prostate-type hippostasin, while normal prostate and BPH expressed both types of hippostasin CONCLUSIONS: Our results suggest the possibility that hippostasin may be a use 11550212 Human

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