IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KLK13 Ensembl ENSG00000167759 Chromosome 19 Start 56251275 End 56260179
Description Kallikrein-13 Precursor (EC 3.4.21.-)(Kallikrein-like protein 4)(KLK-L4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UKR3]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6361
     Entrez Gene : 26085
     UCSC : uc002pvn.2
     GeneCards : 6361
     RefSeq : NM_015596
     CCDS : CCDS12822.1
     Uniprot : Q9UKR3
     Interpro : Q9UKR3
     OMIM : 605505
     GeneTests : KLK13
     CGAP : KLK13
     PMID : 16800724

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36406_at  0.07  6.84e-1  7.65e-1  0.35  5.27e-2  9.57e-2
 HG_U95  36407_at  0.53  2.75e-4  1.01e-3  0.82  1.75e-6  1.04e-5
 HG_U133A  205783_at  -0.19  4.96e-2  6.90e-2  -1.11  1.88e-15  2.56e-15
 HG_U133A  216670_at  0.32  1.62e-4  3.28e-4  3.59  4.34e-101  3.03e-100
 HG_U133A  217315_s_at  -0.16  6.01e-2  8.23e-2  -0.72  3.94e-16  5.42e-16
 HG_U133_Plus2  205783_at  0.75  1.30e-4  4.02e-4  1.23  6.66e-9  2.57e-8
 HG_U133_Plus2  216670_at  0.28  8.78e-2  1.37e-1  0.78  8.47e-6  2.19e-5
 HG_U133_Plus2  217315_s_at  0.73  3.74e-5  1.29e-4  1.30  2.31e-12  1.35e-11
 Stanford  13183  -0.65  1.84e-1  3.69e-1  -0.07  8.94e-1  9.54e-1
 Agilent_HS_21.6K  10832  0.01  6.70e-1  8.02e-1  0.02  3.17e-1  4.75e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205783_at  0.20  3.75e-1  8.96e-1  -0.05  7.43e-1  1.00e+0
 HG_U133A  216670_at  0.17  5.50e-1  9.39e-1  0.27  1.94e-1  1.00e+0
 HG_U133A  217315_s_at  -0.29  2.31e-1  8.46e-1  -0.05  7.74e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36406_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36407_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205783_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216670_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217315_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205783_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216670_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217315_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13183    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10832    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
klk13 breast cancer Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer. 11986781 Human
klk13 breast carcinoma We studied the expression of KLK13 by quantitative reverse transcriptase-polymerase chain reaction in 173 patients with epithelial breast carcinoma. 11986781 Human
klk13 tumours Cox multivariate analysis indicated that KLK13 was an independent prognostic variable in the subgroups of patients with Grade I-II tumours and in patients who were oestrogen receptor and progesterone receptor positive, and node positive. 11986781 Human
klk13 breast cancer Taken together, these data suggest that higher KLK13 expression in these subgroups of breast cancer patients is associated with an approximately 55 to 80% reduction in the risk of relapse or death. 11986781 Human
klk13 breast carcinoma We conclude that KLK13 expression, as assessed by quantitative reverse transcriptase-polymerase chain reaction, is an independent favourable prognostic marker for breast carcinoma. 11986781 Human
klk13 testicular cancer Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer. 11848466 Human
klk-l4 testicular cancer Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer. 11848466 Human
klk-l4 testicular cancer In addition, differential expression of the KLK-L4 gene was found in various histological types of testicular cancer. 11848466 Human
klk-l4 testicular tumors Our results suggest that the KLK-L4 gene is expressed in normal and cancerous testicular tissue; however, its five variants are all expressed in normal tissue but not in testicular tumors. 11848466 Human
klk-l4 breast cancer Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. 10766816 Human
klk-l4 breast cancer Our preliminary results show that KLK-L4 is down-regulated, at the mRNA level, in breast cancer tissues and breast cancer cell lines. 10766816 Human
kallikrein 13 ovarian cancer Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker. 14966091 Human
klk13 breast cancer We have previously reported steroid hormone regulation of the KLK13 gene and its clinical value as a marker of favorable prognosis in breast cancer at the mRNA level. 14966091 Human
klk13 breast cancer Several lines of evidence suggest that members of the kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14). 12633763 Human
klk13 testicular germ-cell tumors In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated. 12752266 Human
klk13 testicular cancer In this paper, the expression of KLK5, KLK10, KLK13 and KLK14 in testicular cancer and their possible roles during testicular cancer development, as well as their clinical applications are briefly reviewed. 12752266 Human
klk13 testicular germ cell tumors In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated. 12752266 Human
klk13 ovarian cancer Human kallikrein gene 13 (KLK13) is a member of this family and codes for a trypsin-like, secreted serine protease (hK13) that is overexpressed in ovarian cancer patients. 15381110 Human

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