IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NKG7 Ensembl ENSG00000105374 Chromosome 19 Start 56566686 End 56567772
Description Protein NKG7 (Natural killer cell protein 7)(G-CSF-induced gene 1 protein)(Protein GIG-1) [Source:UniProtKB/Swiss-Prot;Acc:Q16617]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7830
     Entrez Gene : 4818
     UCSC : uc002pwj.2
     GeneCards : 7830
     RefSeq : NM_005601
     CCDS : CCDS12830.1
     Uniprot : Q16617
     Interpro : Q16617
     OMIM : 606008
     GeneTests : NKG7
     CGAP : NKG7
     PMID : 8458737

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37121_at  -1.11  7.02e-10  8.91e-9  -1.01  2.98e-8  2.51e-7
 HG_U133A  213915_at  -1.68  1.18e-11  4.88e-11  -0.26  9.99e-2  1.05e-1
 HG_U133_Plus2  213915_at  -1.27  3.62e-9  2.34e-8  -1.65  1.04e-8  3.90e-8
 Stanford  9101  -0.43  4.01e-1  5.97e-1  -0.97  3.67e-2  1.37e-1
 Agilent_HS_21.6K  15665  -0.18  1.63e-2  6.58e-2  -0.17  6.87e-3  2.64e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  213915_at  2.32  6.76e-3  6.53e-1  -0.06  8.92e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37121_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213915_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213915_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9101    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15665    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nkg7 mycosis fungoides RESULTS: We identified a set of Th1-specific genes [e.g., TBX21 (T-bet), NKG7, and SCYA5 (RANTES)] to be down-regulated in Sezary syndrome as well as in a proportion of mycosis fungoides samples. 16914566 Human
nkg7 sezary syndrome RESULTS: We identified a set of Th1-specific genes [e.g., TBX21 (T-bet), NKG7, and SCYA5 (RANTES)] to be down-regulated in Sezary syndrome as well as in a proportion of mycosis fungoides samples. 16914566 Human
nkg7 tumors Increased expression of MMP-1, CXCL5, FRA-1, and NKG7 was detected in a subset of tumors, and TLR4 and MHC I showed robust down-regulation in all tumors. 18434409 Human
gig-1 chronic myelogenous leukemia The granulocyte colony-stimulating factor (G-CSF)-induced gene, GIG-1, was originally cloned from G-CSF-stimulated bone marrow mononuclear cells obtained from a patient with chronic myelogenous leukemia (CML). 9886253 Human
gig-1 acute myelogenous leukemia Expression of GIG-1 mRNA was elevated by treatment with G-CSF in normal bone marrow mononuclear cells, as well as in some cases of blast cells obtained from patients with acute myelogenous leukemia (AML) and CML. 9886253 Human

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