IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HAS1 Ensembl ENSG00000105509 Chromosome 19 Start 56908177 End 56919049
Description Hyaluronan synthase 1 (EC 2.4.1.212)(Hyaluronate synthase 1)(Hyaluronic acid synthase 1)(HA synthase 1)(HuHAS1) [Source:UniProtKB/Swiss-Prot;Acc:Q92839]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4818
     Entrez Gene : 3036
     UCSC : uc002pxo.1
     GeneCards : 4818
     RefSeq : NM_001523
     CCDS : CCDS12838.1
     Uniprot : Q92839
     Interpro : Q92839
     OMIM : 601463
     GeneTests : HAS1
     CGAP : HAS1
     PMID : 9169154

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32424_at  -1.28  2.23e-8  2.11e-7  -1.41  1.24e-3  3.73e-3
 HG_U133A  207316_at  -0.81  7.09e-10  2.50e-9  -1.18  6.31e-16  8.65e-16
 HG_U133_Plus2  207316_at  -1.91  1.30e-15  1.88e-14  -1.86  5.63e-10  2.48e-9
 Agilent_HS_21.6K  18468  -0.20  4.90e-9  2.34e-7  -0.19  1.04e-6  1.61e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207316_at  0.14  7.20e-1  9.72e-1  0.71  3.94e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32424_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207316_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207316_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18468    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
has1 multiple myeloma Characterization of hyaluronan synthase expression and hyaluronan synthesis in bone marrow mesenchymal progenitor cells: predominant expression of HAS1 mRNA and up-regulated hyaluronan synthesis in bone marrow cells derived from multiple myeloma patients. 12239172 Human
has1 myeloma Of the 3 Has isoforms, Has1 mRNA was expressed predominantly in myeloma bmMPCs, with expression 7.6-fold greater than Has2. 12239172 Human
has1 myeloma Compared with normal bmMPCs, Has1 mRNA expression was 20-fold greater in myeloma bmMPCs. 12239172 Human
has1 myeloma Upon coculture of myeloma bmMPCs with plasma cells, Has1 transcript was strongly attenuated. 12239172 Human
has1 melanoma Next, in order to directly investigate the effects of hyaluronate on melanoma cell migration, we transfected cDNA encoding mouse hyaluronate synthase HAS1 or HAS2 into the re-cloned human melanoma cell line that produced a low amount of hyaluronate (WM793 10594733 Human
has1 cancer HA and its biosynthetic enzymes (HAS1, HAS2 and HAS3) are thought to participate in tumor growth and cancer progression. 14566823 Human
has1 tumor HA and its biosynthetic enzymes (HAS1, HAS2 and HAS3) are thought to participate in tumor growth and cancer progression. 14566823 Human
has1 subcutaneous tumors The introduction of the HAS1 and HAS2 genes promoted the growth of subcutaneous tumors in a manner dependent on the levels of hyaluronan synthesis. 14724275 Human
has1 metastasis Lung metastasis after i.v. injection of HAS1 transfectants was also recovered significantly. 10344764 Mouse
has1 multiple myeloma (mm) Additionally, in WM patients, we have detected novel variants of HAS1, one of which was also detected in multiple myeloma (MM) patients. 12720129 Human
has-1 hyperplasia These data demonstrate a role for CD-44 and HAS-1 transcription in vein graft intimal hyperplasia, which is further altered by cholesterol supplementation. 9514237 others
has-1 malignant mesothelioma RESULTS: We found that 9/10 malignant mesothelioma cell lines and one primary culture of malignant mesothelioma cells expressed HAS-1, while 10/10 malignant mesothelioma cell lines and one primary culture of malignant mesothelioma cells expressed HAS-2 an 15161000 Human
has1 tumor When the ratio of tumor to normal tissue in the HAS1 level was compared with that of the HA receptor transcript level, there was a positive correlation with that of the CD44 variant 6 level at Dukes' stage C. 15065603 Human
has1 human colon cancer Our current results therefore suggest that HAS1 plays a role in the malignant progression of human colon cancer cells. 15065603 Human
has1 malignancy Of three HAS isoforms (HAS1, HAS2, and HAS3), only HAS2 gene expression was increased in the v-Ha-ras transformed 3Y1 cells, which show less malignancy. 14724275 Human
has1 cancer Hyaluronan (HA) and its biosynthetic enzymes, HA synthases (HAS1, 2, and 3) are thought to participate in cancer progression. 15231668 Human
has1 ovarian cancer In the 33 ovarian cancer cases, 12 cases had positive expression of HAS1, 21 cases had positive expression of HAS2 and 11 cases had positive expression of HAS3. 15375493 Human
has1 ovarian cancer These results suggest that HAS1 expression in ovarian cancer may be associated with disease progression through angiogenesis and is an independent predictor of patient survival. 15375493 Human
has1 pulmonary adenocarcinoma Of 20 cases of pulmonary adenocarcinoma, 5 overexpressed HAS1 (25%), 16 of 20 HAS2 (80%), and 4 of 20 HAS3 (20%). 15731923 Human
has1 mesotheliomas The expression level of HAS1 was significantly higher in mesotheliomas than in pulmonary adenocarcinoma (P=0.0036). 15731923 Human
has1 pulmonary adenocarcinoma The expression level of HAS1 was significantly higher in mesotheliomas than in pulmonary adenocarcinoma (P=0.0036). 15731923 Human
has1 malignant mesothelioma Our data suggests that HAS1 might be a useful positive marker of malignant mesothelioma. 15731923 Human
has1 waldenstrom's macroglobulinemia Previously, in patients with Waldenstrom's macroglobulinemia (WM), we detected upregulation of HAS1 transcripts and identified aberrant splice variants of this gene. 15794859 Human
has1 endometrial cancer HAS1 expression and an increase in serum hyaluronan in endometrial cancer may be associated with disease progression through myometrial invasion and lymph-vascular space involvement. 15870928 Human
has1 multiple myeloma Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. 15731173 Human
has1 multiple myeloma (mm) In this study, we show that the hyaluronan synthase 1 (HAS1) gene undergoes aberrant intronic splicing in multiple myeloma (MM). 15731173 NA
has1 mgus In addition to HAS1 full length (HAS1(FL)), we identify 3 novel splice variants of HAS1, HAS1Va, HAS1Vb, and HAS1Vc, detected in patients with MM or monoclonal gammopathy of undetermined significance (MGUS). 15731173 Human
has1 monoclonal gammopathy of undetermined significance In addition to HAS1 full length (HAS1(FL)), we identify 3 novel splice variants of HAS1, HAS1Va, HAS1Vb, and HAS1Vc, detected in patients with MM or monoclonal gammopathy of undetermined significance (MGUS). 15731173 Human
has1 mgus This study highlights the potential importance of HAS1 and its alternative splicing in pathophysiology of MGUS and MM. 15731173 NA
hyaluronan synthase1 human colon cancer Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer. 15065603 Human
hyaluronan synthase 1 waldenstrom's macroglobulinemia Potential Impact of a Single Nucleotide Polymorphism in the Hyaluronan Synthase 1 Gene in Waldenstrom's Macroglobulinemia. 15794859 Human
hyaluronan synthase 1 multiple myeloma Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. 15731173 Human
hyaluronan synthase 1 multiple myeloma (mm) In this study, we show that the hyaluronan synthase 1 (HAS1) gene undergoes aberrant intronic splicing in multiple myeloma (MM). 15731173 NA

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