IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FPR1 Ensembl ENSG00000171051 Chromosome 19 Start 56940839 End 56946962
Description fMet-Leu-Phe receptor (fMLP receptor)(N-formyl peptide receptor)(FPR)(N-formylpeptide chemoattractant receptor) [Source:UniProtKB/Swiss-Prot;Acc:P21462]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3826
     Entrez Gene : 2357
     UCSC : uc002pxq.2
     GeneCards : 3826
     RefSeq : NM_002029
     CCDS : CCDS12839.1
     Uniprot : P21462
     Interpro : P21462
     OMIM : 136537
     GeneTests : FPR1
     CGAP : FPR1
     PMID : 2161213

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36919_r_at  -0.13  5.57e-1  6.55e-1  -0.80  9.74e-3  2.26e-2
 HG_U133A  205118_at  -0.48  1.17e-3  2.10e-3  1.11  3.68e-10  4.62e-10
 HG_U133A  205119_s_at  -0.91  2.97e-21  2.56e-20  -4.15  4.98e-79  1.97e-78
 HG_U133_Plus2  205118_at  -1.82  2.07e-17  3.69e-16  -1.67  1.21e-12  7.31e-12
 HG_U133_Plus2  205119_s_at  -1.45  9.14e-18  1.71e-16  -2.24  2.10e-21  3.41e-20
 Stanford  4606  -1.32  1.67e-2  8.96e-2  -1.29  3.91e-2  1.44e-1
 Agilent_HS_21.6K  14844  -0.66  2.64e-9  1.33e-7  -0.70  1.23e-7  2.62e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205118_at  0.48  3.35e-1  8.87e-1  0.34  3.78e-1  1.00e+0
 HG_U133A  205119_s_at  0.25  4.43e-1  9.13e-1  -0.41  7.76e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36919_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205118_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205119_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205118_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205119_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4606    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14844    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
fpr astrocytoma Our study demonstrates for the first time that FPR and FPRL1 expressed by astrocytoma cell lines are functional, and suggests a molecular basis for the involvement of these receptors in host defense in the brain. 11063827 Human
fmlp rat basophilic leukemia In fact, CaG chemoattracts rat basophilic leukemia cells (RBL cells) expressing the high affinity human fMLP receptor FPR, but not parental RBL cells or cells transfected with other chemoattractant receptors. 15210802 Rat
fpr rat basophilic leukemia In fact, CaG chemoattracts rat basophilic leukemia cells (RBL cells) expressing the high affinity human fMLP receptor FPR, but not parental RBL cells or cells transfected with other chemoattractant receptors. 15210802 Human
fpr malignant glioma FPR-siRNA additionally abrogated the expression and function of FPR in a human malignant glioma cell line. 15258259 Human
fpr malignant human gliomas Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. 15928303 Human
fpr glioma We previously showed that selected human glioma cell lines also express functional FPR. 15928303 Human
fpr gliomas FPR protein expression was detected in specimens from 33 human primary gliomas by immunohistochemistry. 15928303 Human
fpr glioblastomas multiforme RESULTS: FPR was selectively expressed by the highly malignant human glioblastoma cell line U-87 and most primary grade IV glioblastomas multiforme and grade III anaplastic astrocytomas. 15928303 Human
fpr glioblastoma RESULTS: FPR was selectively expressed by the highly malignant human glioblastoma cell line U-87 and most primary grade IV glioblastomas multiforme and grade III anaplastic astrocytomas. 15928303 Human
fpr anaplastic astrocytomas RESULTS: FPR was selectively expressed by the highly malignant human glioblastoma cell line U-87 and most primary grade IV glioblastomas multiforme and grade III anaplastic astrocytomas. 15928303 Human
fpr mean tumor FPR siRNA substantially reduced the tumorigenicity of U-87 cells in nude mice (38 days after implantation, mean tumor volume from wild-type U-87 cells = 842 mm3, 95% confidence interval [CI] = 721 to 963 mm3; and from FPR-siRNA transfected U-87 cells = 22 15928303 Human
fpr glioblastoma Necrotic glioblastoma cells released a factor(s) that activated FPR in live U-87 cells. 15928303 Human
fpr glioblastoma CONCLUSIONS: FPR is expressed by highly malignant human glioma cells and appears to mediate motility, growth, and angiogenesis of human glioblastoma by interacting with host-derived agonists. 15928303 Human
fpr glioma CONCLUSIONS: FPR is expressed by highly malignant human glioma cells and appears to mediate motility, growth, and angiogenesis of human glioblastoma by interacting with host-derived agonists. 15928303 Human
fmlp cml Therapy with IFN-alpha resulted in significantly diminished values for oxygen species (NaF stimulation) and LTB4 (FMLP stimulation) generation, as well as FMLP receptor expression as compared to untreated CML. 8174673 Human
fmlp cml The results indicate that the fMLP pathway is suppressed in CML granulocytes whereas PAF and LTB4 pathways appear unaltered in these cells. 8756080 Human
fmlp cml Our results show that the number of fMLP receptors/cell is significantly lower in CML PMNL (P < 0.05) than in normal PMNL, while their affinity constants and dissociation constants were comparable. 8756080 Human
fmlp mds Flow cytometric analysis of MDS neutrophils disclosed that most MDS patients showed normal neutrophil cytoplasmic Ca2+ response to FMLP and rhIL-8. 8943888 Human
fmlp mds These data suggest that most MDS patients have low FMLP chemiluminescence which is not due to a defect in the FMLP receptor. 8943888 Human
fmlp mds It is proposed that defective FMLP chemiluminescence in MDS results from a putative defect in protein kinase C- and Ca(2+)-independent cell-signalling mechanisms. 8943888 Human
fmlp mds The disturbed Rac and PI-3K activation observed in MDS neutrophils did not appear to reflect a general GM-CSF or fMLP receptor-signaling defect, as fMLP-triggered Ras activation could be primed by GM-CSF in MDS and healthy neutrophils. 15107457 Human
fpr glioma We recently found that formylpeptide receptor (FPR), a G-protein-coupled receptor that mediates chemotaxis of phagocytic leukocytes induced by bacterial peptide N-formyl-methionyl-leucyl-phenylalanine, is expressed by malignant human glioma cells and prom 16516855 Human
fpr tumor We recently found that formylpeptide receptor (FPR), a G-protein-coupled receptor that mediates chemotaxis of phagocytic leukocytes induced by bacterial peptide N-formyl-methionyl-leucyl-phenylalanine, is expressed by malignant human glioma cells and prom 16516855 Human
fpr glioma We found that FPR was expressed at the protein level by highly malignant human glioma cell lines U87 and BT325, and a rat glioma cell line C6. 16516855 Human
fpr rat glioma We found that FPR was expressed at the protein level by highly malignant human glioma cell lines U87 and BT325, and a rat glioma cell line C6. 16516855 Rat
fpr malignancy The expression level of FPR was correlated with the degree of the malignancy of tumor cells. 16516855 Human
fpr tumor The expression level of FPR was correlated with the degree of the malignancy of tumor cells. 16516855 Human
fpr glioma The poorly differentiated glioma cell line U87 expressed the highest level of FPR. 16516855 Human
fpr glioma In U87 glioma cells, the expression of FPR was attenuated at the protein level by Nordy treatment for 48 (P<0.05). 16516855 Human
fpr leukemia Cleaved forms of suPAR (c-suPAR) were released in vitro by PBMNCs and were also detected in the serum of G-CSF-treated donors. c-suPAR was able to chemoattract CD34+ KG1 leukemia cells and CD34+ HSCs, as documented by their in vitro migratory response to 15494432 Human
fmlp leukemia Cleaved forms of suPAR (c-suPAR) were released in vitro by PBMNCs and were also detected in the serum of G-CSF-treated donors. c-suPAR was able to chemoattract CD34+ KG1 leukemia cells and CD34+ HSCs, as documented by their in vitro migratory response to 15494432 Human
fpr tumorigenesis The G protein-coupled formylpeptide receptor (FPR), which mediates leukocyte migration in response to bacterial and host-derived chemotactic peptides, promotes the chemotaxis, survival, and tumorigenesis of highly malignant human glioblastoma cells. 17575160 Human
fpr glioblastoma The G protein-coupled formylpeptide receptor (FPR), which mediates leukocyte migration in response to bacterial and host-derived chemotactic peptides, promotes the chemotaxis, survival, and tumorigenesis of highly malignant human glioblastoma cells. 17575160 Human
fpr glioblastoma We found that N-formyl-methionyl-leucyl-phenylalanine, an FPR agonist peptide, rapidly induced EGFR phosphorylation at tyrosine residue (Tyr) 992, but not residues 846, 1068, or 1173, in glioblastoma cells, whereas all these residues were phosphorylated a 17575160 Human
fpr tumorigenesis Furthermore, depletion of both FPR and EGFR by short interference RNA abolished the tumorigenesis of the glioblastoma cells. 17575160 Human
fpr glioblastoma Glioblastoma cells bearing FPR siRNA exhibited reduced rate of tumorigenicity in nude mice and tumors formed by such tumor cells showed less active angiogenesis and lower level expression of both IL-8 and VEGF. 17611713 Human
fpr tumors Glioblastoma cells bearing FPR siRNA exhibited reduced rate of tumorigenicity in nude mice and tumors formed by such tumor cells showed less active angiogenesis and lower level expression of both IL-8 and VEGF. 17611713 Human
fpr tumor cell migration In addition, FPR aberrantly expressed on highly malignant human glioblastoma cells promotes tumor cell migration, proliferation and production of vascular endothelial growth factor in response to agonists released by necrotic tumor cells. 18045224 Human
fpr glioblastoma In addition, FPR aberrantly expressed on highly malignant human glioblastoma cells promotes tumor cell migration, proliferation and production of vascular endothelial growth factor in response to agonists released by necrotic tumor cells. 18045224 Human
fpr metastasis In the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which 18433988 Human
fpr glioblastoma In the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which 18433988 Human
fpr tumor In the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which 18433988 Human
fpr anaplastic astrocytoma In the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which 18433988 Human
fpr glioma Screening of human glioma cell lines revealed that FPR was expressed selectively in glioma cell lines with a more highly malignant phenotype. 18433988 Human
fpr glioblastoma FPR expressed in glioblastoma cell lines mediates cell chemotaxis, proliferation and production of an angiogenic factor, vascular endothelial growth factor (VEGF), in response to agonists released by necrotic tumor cells. 18433988 Human
fpr glioblastoma Furthermore, FPR in glioblastoma cells activates the receptor for epidermal growth factor (EGFR) by increasing the phosphorylation of a selected tyrosine residue in the intracellular tail of EGFR. 18433988 Human
fpr tumor Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression. 18433988 Human
fpr glioma Our results indicate that FPR expressed by human GSCs may play an important role in glioma angiogenesis. 18523971 Human
fpr tumor Glioblastoma cells bearing FPR siRNA exhibited reduced rate of tumorigenicity in nude mice and tumors formed by such tumor cells showed less active angiogenesis and lower level expression of both IL-8 and VEGF. 17611713 Human

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