IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PPP2R1A Ensembl ENSG00000105568 Chromosome 19 Start 57385046 End 57422499
Description Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform)(PP2A, subunit A, R1-alpha isoform)(Medium tumor antigen-associated 61 kDa protein) [Source:UniProtKB/Swiss-Prot;Acc:P30153]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 9302
     Entrez Gene : 5518
     UCSC : uc002pyp.2
     GeneCards : 9302
     RefSeq : NM_014225
     CCDS : CCDS12849.1
     Uniprot : P30153
     Interpro : P30153
     OMIM : 605983
     GeneTests : PPP2R1A
     CGAP : PPP2R1A

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40867_at  -0.10  1.40e-1  2.18e-1  -0.19  3.71e-2  7.13e-2
 HG_U95  922_at  0.02  8.01e-1  8.58e-1  0.11  1.70e-1  2.55e-1
 HG_U133A  200695_at  0.16  4.62e-3  7.62e-3  0.51  7.14e-14  9.49e-14
 HG_U133_Plus2  200695_at  0.54  3.45e-8  1.96e-7  1.13  2.15e-15  1.76e-14
 Stanford  9830  0.70  2.12e-3  2.37e-2  0.50  1.01e-1  2.74e-1
 Agilent_HS_21.6K  1796  -0.13  1.51e-5  2.47e-4  -0.11  6.56e-4  3.84e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200695_at  -0.11  5.55e-1  9.41e-1  0.09  4.25e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40867_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 922_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200695_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200695_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9830    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1796    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ppp2r1a lung carcinomas The PPP2R1A gene, encoding the alpha isoform of the heterotrimeric serine/threonine protein phosphatase 2A (PP2A), is located within the FWT2 candidate region and is altered in breast and lung carcinomas. 11360189 Human
ppp2r1a tumor These findings suggested that both PPP2R1A and PPP2R1B may be tumor suppressor genes. 11360189 Human
ppp2r1a tumors Since PPP2R1A was therefore a compelling candidate for the FWT2 gene, we analysed the coding region of PPP2R1A in DNA and RNA samples from affected members of four Wilms tumor families and 30 sporadic tumors and identified no mutations in PPP2R1A in any o 11360189 Human
ppp2r1a familial wilms tumor We conclude that PPP2R1A is not the 19q familial Wilms tumor gene and that mutation of PPP2R1A is not a common event in the etiology of sporadic Wilms tumor. 11360189 Human
ppp2r1a neoplasms Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. 10713707 Human
ppp2r1a melanomas Here, we report the detection of mutations in breast, lung carcinomas and melanomas in the genes of both alpha (PPP2R1A) and beta isoforms. 10713707 Human
ppp2r1a lung carcinomas Here, we report the detection of mutations in breast, lung carcinomas and melanomas in the genes of both alpha (PPP2R1A) and beta isoforms. 10713707 Human
ppp2r1a breast carcinomas Mutations affecting PPP2R1B were found in four breast carcinomas, while mutations in PPP2R1A were found in carcinomas of the breast and of the lung and in one melanoma. 10713707 Human
ppp2r1a melanoma Mutations affecting PPP2R1B were found in four breast carcinomas, while mutations in PPP2R1A were found in carcinomas of the breast and of the lung and in one melanoma. 10713707 Human
ppp2r1a carcinomas Mutations affecting PPP2R1B were found in four breast carcinomas, while mutations in PPP2R1A were found in carcinomas of the breast and of the lung and in one melanoma. 10713707 Human
ppp2r1a carcinomas of the breast Mutations affecting PPP2R1B were found in four breast carcinomas, while mutations in PPP2R1A were found in carcinomas of the breast and of the lung and in one melanoma. 10713707 Human
ppp2r1a wilms tumor Absence of PPP2R1A mutations in Wilms tumor. 11360189 Human
ppp2r1a wilms tumor Since PPP2R1A was therefore a compelling candidate for the FWT2 gene, we analysed the coding region of PPP2R1A in DNA and RNA samples from affected members of four Wilms tumor families and 30 sporadic tumors and identified no mutations in PPP2R1A in any o 11360189 Human
ppp2r1a wilms tumor We conclude that PPP2R1A is not the 19q familial Wilms tumor gene and that mutation of PPP2R1A is not a common event in the etiology of sporadic Wilms tumor. 11360189 Human

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