IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PRKCG Ensembl ENSG00000126583 Chromosome 19 Start 59077279 End 59102713
Description Protein kinase C gamma type (PKC-gamma)(EC 2.7.11.13) [Source:UniProtKB/Swiss-Prot;Acc:P05129]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9402
     Entrez Gene : 5582
     UCSC : uc002qcq.1
     GeneCards : 9402
     RefSeq : NM_002739
     CCDS : CCDS12867.1
     Uniprot : P05129
     Interpro : P05129
     OMIM : 176980
     GeneTests : PRKCG
     CGAP : PRKCG
     PMID : 8432525

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
4 1.78 225 4 2.05 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16686 AD c.951G>C p.M317I Substitution - Missense Heterozygous 19:59093036-5909303618948947
16835 AD c.1027C>G p.P343A Substitution - Missense Heterozygous 19:59093112-5909311218948947
16905 AD c.1561T>A p.Y521N Substitution - Missense Heterozygous 19:59095801-5909580118948947
16951 AD c.327C>A p.S109R Substitution - Missense Heterozygous 19:59084745-5908474518948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  363_at  0.63  5.68e-5  2.47e-4  0.56  2.01e-2  4.21e-2
 HG_U133A  206270_at  -0.03  6.99e-1  7.40e-1  5.12  8.52e-115  8.75e-114
 HG_U133_Plus2  206270_at  -0.23  9.24e-2  1.43e-1  -0.58  3.80e-4  7.81e-4
 HG_U133_Plus2  236195_x_at  0.94  6.32e-8  3.45e-7  1.61  1.48e-15  1.23e-14
 Stanford  8327  -0.32  1.92e-1  3.81e-1  -0.33  3.10e-1  5.51e-1
 Agilent_HS_21.6K  15921  0.01  8.06e-1  8.90e-1  0.02  5.01e-1  6.49e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206270_at  -0.30  2.43e-1  8.50e-1  -0.03  8.46e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 363_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206270_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206270_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 236195_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8327    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15921    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pkc-gamma melanoma PKC-beta I and -beta II were expressed exclusively in normal melanocytes but not in melanoma cells, whereas PKC-gamma was not found in any of the cultures studied. 11894137 Human
pkcgamma gastric cancer (4) Fluorescence intensity presented adriamycin accumulation in SGC7901/VCR cells was increased from 1.14+/-0.36 to 2.71+/-0.94 when cells were co-incubated with anti-PKC-alpha but not with anti-PKC-beta I PKC-beta II and PKCgamma antibodies.CONCLUSION: P 12046066 Human
pkcgamma cultured human colon cancer In the present study, we found that treatment of the cultured human colon cancer cell line COLO-205 with a PKC agonist, 12-O-tetradecanoylphorbol-13-acetate (TPA), resulted in cell-cycle arrest at the G(0)/G(1) phase, decrease in cell number, PKCgamma iso 12203364 Human
pkc gamma c6 glioma Western blot analysis, using isoform-specific anti-PKC antibodies showed that under our culture conditions C6 glioma cells express the conventional isoforms PKC alpha, PKC gamma, as well as the novel isoforms PKC delta, PKC epsilon, and the atypical isofo 11299321 Rat
pkcgamma pancreatic tumor No PKCgamma activity was present in the pancreatic tumor cell line RINm5F. 11399908 Rat
pkcgamma tumor These results suggest that PKCgamma overexpression in immortalized mammary epithelial cells may generate, through an increase in ERK, signaling changes in the expression of genes associated with an epithelium-to-mesenchyme transition that may be sufficien 12939403 Human
pkc-gamma liver metastases Although PKC-gamma was detected in about 29.6% of primary CRC and liver metastases, it was absent from all corresponding normal tissue. 7861778 Human
pkc gamma glioma In order to address the question of whether protein kinase C (PKC) is involved in the growth regulation of human glioma cells, we introduced PKC cDNA expression vectors into a human glioma cell line, U-251 MG, and established sets of stable cell clones th 8198596 Human
pkc gamma c6 glioma All PkC subspecies including PkC gamma were detected in C6 glioma cells. 8084470 Rat
pkc-gamma tumor The aim of our study was to examine the potential usefulness of transducing the protein kinase C-gamma (PKC-gamma) cDNA gene into tumor-specific T cells as a technique for facilitating the generation of large numbers of functional Ag-specific T for tumor 7930583 Human
pkc-gamma tumor When levels of the four isoforms in the tumor cells were compared to levels in the normal cells, no increase was observed in PKC-alpha or PKC-gamma, but PKC-epsilon was elevated three to 30 times in six of the eight tumors, and PKC-zeta was elevated appro 7931620 Human
pkc-gamma tumors When levels of the four isoforms in the tumor cells were compared to levels in the normal cells, no increase was observed in PKC-alpha or PKC-gamma, but PKC-epsilon was elevated three to 30 times in six of the eight tumors, and PKC-zeta was elevated appro 7931620 Human
pkc gamma colon tumors PKC gamma was expressed at a very low level in two of the colon tumors but could not be detected in the remaining tumors or any of the normal mucosa samples. 7999261 Human
pkc gamma tumors PKC gamma was expressed at a very low level in two of the colon tumors but could not be detected in the remaining tumors or any of the normal mucosa samples. 7999261 Human
pkc gamma tumor Fifteen minutes following topical treatment with a tumor promoting dose of TPA (3.4 nmol), the activities of PKC beta and PKC gamma decreased in the epidermal cytosol to 30% and 50% of control values, respectively, while these activities were increased in 8001237 Human
pkc-gamma papillomas We were unable to detect PKC-gamma in mouse epidermis or papillomas. 1638676 Mouse
pkc gamma tumor In this report, we show that transient expression of the PKC gamma isoenzyme can trans-activate a murine VL30 enhancer element in a pattern similar to that of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate. 2007096 Human

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