IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LAIR1 Ensembl ENSG00000167613 Chromosome 19 Start 59557047 End 59573977
Description Leukocyte-associated immunoglobulin-like receptor 1 Precursor (LAIR-1)(hLAIR1)(CD305 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q6GTX8]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6477
     Entrez Gene : 3903
     UCSC : uc002qfk.1
     GeneCards : 6477
     RefSeq : NM_002287
     CCDS : CCDS12891.1
     Uniprot : Q6GTX8
     Interpro : Q6GTX8
     OMIM : 602992
     GeneTests : LAIR1
     CGAP : LAIR1
     PMID : 9285412

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37470_at  -0.06  4.34e-1  5.40e-1  -0.25  1.22e-2  2.75e-2
 HG_U133A  208071_s_at  -0.59  1.90e-4  3.81e-4  -0.18  1.35e-1  1.41e-1
 HG_U133A  210644_s_at  -0.69  8.81e-18  5.87e-17  -5.59  1.67e-113  1.65e-112
 HG_U133_Plus2  208071_s_at  -1.03  4.81e-7  2.29e-6  -2.17  5.89e-16  5.16e-15
 HG_U133_Plus2  210644_s_at  -0.67  1.72e-8  1.02e-7  -0.91  7.50e-13  4.62e-12
 Agilent_HS_21.6K  9641  -0.18  1.38e-5  2.28e-4  -0.23  2.63e-11  1.85e-9

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208071_s_at  0.61  3.66e-1  8.95e-1  -0.90  3.10e-2  1.00e+0
 HG_U133A  210644_s_at  0.61  4.88e-2  7.08e-1  -0.26  2.15e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37470_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208071_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210644_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208071_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210644_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9641    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
leukocyte-associated ig-like receptor-1 acute myeloid leukemia Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor-dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. 11745387 Human
lair-1 acute myeloid leukemia (aml) The leukocyte-associated Ig-like receptor-1 (LAIR-1), a surface leukocyte receptor containing two immune receptor tyrosine-based inhibitory motif (ITIM) is expressed on acute myeloid leukemia (AML) blasts isolated from peripheral blood or bone marrow of 1 11745387 Human
leukocyte-associated ig-like receptor-1 acute myeloid leukemia (aml) The leukocyte-associated Ig-like receptor-1 (LAIR-1), a surface leukocyte receptor containing two immune receptor tyrosine-based inhibitory motif (ITIM) is expressed on acute myeloid leukemia (AML) blasts isolated from peripheral blood or bone marrow of 1 11745387 Human
lair-1 leukemia Indeed, leukemia cells stimulated with GM-CSF were blocked in the G0/G1 phase of the cell cycle and underwent apoptosis within 4 days after the engagement of LAIR-1. 11745387 Human
leukocyte-associated ig-like receptor-1 human myeloid leukemias Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias. 11069054 Human
lair-1 solid tumors As blocking of NF-kappaB activation has been shown to rescue sensitivity to anti-cancer drugs in solid tumors, we suggest that LAIR-1 may represent a possible target for pharmacological approaches aimed to potentiate anti-leukemic therapy. 11069054 Human
lair-1 aml Remarkably, LAIR-1 was functional also in AML blasts which do not express CD33, mainly M4 and M5. 11745387 Human
lair-1 aml Altogether, these findings indicate that the engagement of LAIR-1 can down-regulate GM-CSF-mediated survival and proliferation of AML blasts, suggesting an additional therapeutic approach to the treatment of AML patients. 11745387 Human
lair-1 leukemia METHODS: Genes encoding LAIR-1 and LAIR-2 were cloned by RT-PCR from human peripheral blood mononuclear cells(PBMC) and two leukemia cell lines Jurkat and HL-60. 15151743 Human
lair-1 leukemia METHODS: Genes encoding LAIR-1 and LAIR-2 were cloned by RT-PCR from human peripheral blood mononuclear cells(PBMC) and two leukemia cell lines Jurkat and HL-60. 15151743 Human
lair-1 rat basophilic leukemia (rbl) In contrast, in rat basophilic leukemia (RBL) cells, both mutants of LAIR-1 are partially effective. 14565933 Rat
lair-1 melanoma RESULTS: Both LAIR-1 and LAIR-2 fusion proteins bound strongly with human amnion-derived epithelial cell line WISH, and moderately with human melanoma cell line C32, human embryo kidney epithelial cell line 293T, and human umbilical vein endothelial cell 16143055 Human

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