IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LILRB1 Ensembl ENSG00000104972 Chromosome 19 Start 59820424 End 59840791
Description Leukocyte immunoglobulin-like receptor subfamily B member 1 Precursor (Leukocyte immunoglobulin-like receptor 1)(LIR-1)(Immunoglobulin-like transcript 2)(ILT-2)(Monocyte/macrophage immunoglobulin-like receptor 7)(MIR-7)(CD85 antigen-like family member J)(CD85j antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q8NHL6]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6605
     Entrez Gene : 10859
     UCSC : uc002qgm.2
     GeneCards : 6605
     RefSeq : NM_001081637
     CCDS : CCDS42614.1
     Uniprot : Q8NHL6
     Interpro : Q8NHL6
     OMIM : 604811
     GeneTests : LILRB1
     CGAP : LILRB1
     PMID : 9285411

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35927_r_at  0.31  1.29e-1  2.03e-1  0.03  9.30e-1  9.52e-1
 HG_U133A  207104_x_at  -0.20  2.78e-1  3.30e-1  0.71  6.41e-10  8.03e-10
 HG_U133A  211336_x_at  -0.27  5.57e-2  7.68e-2  -0.11  2.62e-1  2.71e-1
 HG_U133_Plus2  207104_x_at  -0.98  1.73e-6  7.51e-6  -2.07  3.66e-12  2.08e-11
 HG_U133_Plus2  211336_x_at  -0.73  1.91e-5  6.93e-5  -1.35  7.68e-9  2.94e-8
 HG_U133_Plus2  229937_x_at  -1.11  2.00e-13  2.24e-12  -1.71  3.68e-14  2.62e-13
 Agilent_HS_21.6K  11832  -0.23  7.61e-8  2.65e-6  -0.21  8.58e-6  9.89e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207104_x_at  0.64  2.75e-1  8.65e-1  -0.29  4.86e-1  1.00e+0
 HG_U133A  211336_x_at  0.89  6.33e-2  7.27e-1  -0.22  5.76e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35927_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207104_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211336_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207104_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211336_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229937_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11832    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ilt-2 human breast cancer A report in this issue of the journal demonstrates for the first time the expression of HLA-G and its KIR ligand, ILT-2 in human breast cancer. 11857486 Human
ilt2 human breast cancer Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer. 11857488 Human
ilt2 breast cancer The presence of ILT2 (Ig-like transcript 2) killing inhibitory receptors known to interact with HLA-G was also demonstrated in host immune cells that infiltrate breast cancer lesions. 11857488 Human
ilt2 sezary syndrome Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their CD3/TCR signaling. 12130517 Human
cd85j sezary syndrome Engagement of ILT2/CD85j in Sezary syndrome cells inhibits their CD3/TCR signaling. 12130517 Human
ilt2 t-cell lymphomas Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2. 14592815 Human
ilt2 cutaneous t-cell lymphomas We investigated the expression of human leukocyte antigen G (HLA-G) and interleukin 10 (IL-10) in conjunction with expression of HLA-G killer-cell inhibitory receptor ligand immunoglobulin-like transcript 2 (ILT2) in 3 CD56+CD4+ and 4 CD8+ cutaneous T-cel 14592815 Human
lir-1 cutaneous lymphomas Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p5 11337356 Human
lir-1 lymphomas Apart from LIR-1, the CD8+ lymphomas in our series express p70 and p140 from the inhibitory receptors and only one or two of the cytotoxic proteins. 11337356 Human
lir-1 lymphomas The CD56+ lymphomas, on the other hand, express only LIR-1 of the set of inhibitory receptors and the whole panel of cytotoxic antigens. 11337356 Human
ilt2 melanoma In this study we analyzed the expression of nine NK receptors (p58.1, p58.2, p70, p140, ILT2, NKRP1A, ZIN176, CD94 and CD94/NKG2A) in PBL from both healthy donors and melanoma patients. 10382762 Human

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