IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FCAR Ensembl ENSG00000186431 Chromosome 19 Start 60077361 End 60093651
Description Immunoglobulin alpha Fc receptor Precursor (IgA Fc receptor)(CD89 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P24071]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3608
     Entrez Gene : 2204
     UCSC : uc002qhr.1
     GeneCards : 3608
     RefSeq : NM_002000
     CCDS : CCDS12907.1
     Uniprot : Q53X38
     Interpro : Q53X38
     OMIM : 147045
     GeneTests : FCAR
     CGAP : FCAR
     PMID : 1577457

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38868_at  -0.43  4.69e-3  1.22e-2  -0.39  8.88e-2  1.49e-1
 HG_U133A  207674_at  -0.34  3.75e-3  6.28e-3  0.15  1.70e-1  1.78e-1
 HG_U133A  211305_x_at  -0.10  4.52e-1  5.07e-1  -0.37  6.66e-2  7.06e-2
 HG_U133A  211306_s_at  -0.49  6.95e-5  1.47e-4  -0.35  1.13e-1  1.19e-1
 HG_U133A  211307_s_at  -0.11  4.45e-1  5.00e-1  -0.40  7.25e-2  7.68e-2
 HG_U133A  211816_x_at  -0.23  4.47e-2  6.27e-2  -1.21  4.81e-21  7.10e-21
 HG_U133_Plus2  207674_at  -0.59  6.87e-3  1.47e-2  -0.43  8.61e-2  1.17e-1
 HG_U133_Plus2  211305_x_at  0.31  6.82e-2  1.10e-1  0.63  4.03e-3  7.04e-3
 HG_U133_Plus2  211306_s_at  -0.16  3.29e-1  4.18e-1  -0.50  5.87e-3  9.96e-3
 HG_U133_Plus2  211307_s_at  -0.58  9.57e-4  2.49e-3  -0.47  3.26e-2  4.84e-2
 HG_U133_Plus2  211816_x_at  -0.18  3.55e-1  4.45e-1  -0.02  9.20e-1  9.36e-1
 Agilent_HS_21.6K  5301  0.02  3.07e-1  4.95e-1  0.02  4.49e-1  6.05e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207674_at  -0.65  1.31e-1  7.95e-1  0.39  2.20e-1  1.00e+0
 HG_U133A  211305_x_at  -0.04  9.28e-1  9.95e-1  0.50  6.42e-2  1.00e+0
 HG_U133A  211306_s_at  0.48  1.85e-1  8.23e-1  0.11  6.33e-1  1.00e+0
 HG_U133A  211307_s_at  -0.69  1.69e-1  8.15e-1  -0.25  2.88e-1  1.00e+0
 HG_U133A  211816_x_at  0.33  3.86e-1  8.96e-1  -0.31  3.04e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38868_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207674_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211305_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211306_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211307_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211816_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207674_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211305_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211306_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211307_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211816_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5301    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cd89 tumor Previous studies have demonstrated that, in addition to IgG Fc receptors, the human myeloid IgA receptor (Fc(alpha)RI, CD89) also effectively triggered tumor cell killing. 12393717 Human
cd89 tumor Enhancement of polymorphonuclear cell-mediated tumor cell killing on simultaneous engagement of fcgammaRI (CD64) and fcalphaRI (CD89). 11358825 Human
cd89 tumor The human Fc receptor for IgA (Fc alpha RI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis. 10397160 Mouse
cd89 tumor Bispecific molecules directed to the Fc receptor for IgA (Fc alpha RI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood. 9469424 Human
cd89 tumor We investigated the potential of IgA as antibody isotype for cell- or complement-mediated tumor cell lysis and assessed the potential of its myeloid Fc receptor, FcalphaRI (CD89), as trigger molecule for bispecific antibody (BsAb)-mediated immunotherapy. 9373259 Human
cd89 tumor In this study, we examined human and mouse neutrophil-mediated tumor cell lysis via targeting the IgA FcR, FcalphaRI (CD89), in more detail. 15843545 Human

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