IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NCR1 Ensembl ENSG00000189430 Chromosome 19 Start 60109338 End 60116251
Description Natural cytotoxicity triggering receptor 1 Precursor (Natural killer cell p46-related protein)(hNKp46)(NK-p46)(NKp46)(NK cell-activating receptor)(Lymphocyte antigen 94 homolog)(CD335 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O76036]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6731
     Entrez Gene : 9437
     UCSC : uc002qib.2
     GeneCards : 6731
     RefSeq : NR_027043
     CCDS : CCDS12911.1
     Uniprot : O76036
     Interpro : O76036
     OMIM : 604530
     GeneTests : NCR1
     CGAP : NCR1
     PMID : 9730896

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34039_at  -0.82  3.35e-5  1.54e-4  -0.46  1.29e-1  2.03e-1
 HG_U95  34040_s_at  0.15  4.08e-1  5.15e-1  0.18  4.65e-1  5.68e-1
 HG_U133A  207860_at  -0.58  2.30e-6  5.70e-6  0.35  4.42e-5  5.07e-5
 HG_U133A  217088_s_at  -0.55  4.11e-6  9.96e-6  3.94  4.02e-99  2.65e-98
 HG_U133A  217095_x_at  -0.59  1.58e-7  4.42e-7  -1.72  2.63e-18  3.73e-18
 HG_U133_Plus2  207860_at  -0.65  3.66e-4  1.04e-3  -0.81  1.95e-4  4.18e-4
 HG_U133_Plus2  217088_s_at  -0.44  1.96e-2  3.71e-2  0.01  9.74e-1  9.80e-1
 HG_U133_Plus2  217095_x_at  0.29  1.10e-1  1.66e-1  0.67  3.66e-4  7.53e-4
 Agilent_HS_21.6K  1859  0.03  7.57e-1  8.59e-1  -0.03  7.82e-1  8.63e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207860_at  -0.13  8.03e-1  9.83e-1  0.50  9.01e-2  1.00e+0
 HG_U133A  217088_s_at  -0.03  9.22e-1  9.95e-1  -0.26  2.97e-1  1.00e+0
 HG_U133A  217095_x_at  0.19  5.73e-1  9.47e-1  0.01  9.75e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34039_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 34040_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207860_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217088_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217095_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207860_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217088_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217095_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1859    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
nkp46 tumor Four lysis receptors for human NK cells were recently identified, including the NKp30, NKp44, NKp46 and CD16, all of which are capable of mediating direct killing of virus-infected and tumor cells. 11606250 Human
nkp46 tumor The destruction of viral-infected and tumor cells is mediated in part via the lysis receptor of natural killer (NK) cells, NKp46. 14504081 Human
nkp46 tumors NKp30 cooperates with NKp46 and/or NKp44 in the induction of NK-mediated cytotoxicity against the majority of target cells, whereas it represents the major triggering receptor in the killing of certain tumors. 10562324 Human
nkp46 tumor In this study, we further analyzed the role of NKp46 in natural cytotoxicity against different tumor target cells. 9730896 Human
nkp46 tumor We provide direct evidence that NKp46 represents a major activating receptor involved in the recognition and lysis of both human and murine tumor cells. 9730896 Human
nkp46 human tumor Although NKp46 may cooperate with other activating receptors (including the recently identified NKp44 molecule) in the induction of NK-mediated lysis of human tumor cells, it may represent the only human NK receptor involved in recognition of murine targe 9730896 Human
nkp46 tumour NKp46 is a major NK cell-specific triggering receptor involved in the recognition and lysis of human and murine tumour and virally infected cells. 14646088 Human
nkp46 neuroblastoma We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, involves NKp46 and NKp30 (natural cytotoxicity receptors). 15604290 Human
nkp46 mouse tumor Moreover, preincubation of the effector cells with WEN23 F(ab')2 fragments reduced killing of target cells, confirming the activating function of NKp46 and indicating that the mouse tumor target cells express a ligand for rat NKp46. 15356098 Human
nkp46 human tumor Lysis of FcR- mouse and human tumor target cells was reduced after incubation of effector cells with WEN23, suggesting that rat NKp46 recognizes a ligand that is conserved between primates and rodents. 15356098 Human
nkp46 chronic myelogenous leukaemia NKp46 and NKp30 are the major receptors involved in the NK-mediated killing of K562, a human chronic myelogenous leukaemia cell line. 15654827 Human
nkp46 tumor We provide evidence that tumor cells can induce apoptosis of NK cells by engaging the natural cytotoxicity receptors (NCR) NKp30, NKp44, and NKp46. 15728472 Human
nkp46 tumor Recognition of tumor cells by the NCRs NKp30 and NKp46 involves heparan sulfate epitopes expressed on the tumor cell membrane. 15759080 Human

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