nkp46 |
tumor |
Four lysis receptors for human NK cells were recently identified, including the NKp30, NKp44, NKp46 and CD16, all of which are capable of mediating direct killing of virus-infected and tumor cells. |
11606250 |
Human |
nkp46 |
tumor |
The destruction of viral-infected and tumor cells is mediated in part via the lysis receptor of natural killer (NK) cells, NKp46. |
14504081 |
Human |
nkp46 |
tumors |
NKp30 cooperates with NKp46 and/or NKp44 in the induction of NK-mediated cytotoxicity against the majority of target cells, whereas it represents the major triggering receptor in the killing of certain tumors. |
10562324 |
Human |
nkp46 |
tumor |
In this study, we further analyzed the role of NKp46 in natural cytotoxicity against different tumor target cells. |
9730896 |
Human |
nkp46 |
tumor |
We provide direct evidence that NKp46 represents a major activating receptor involved in the recognition and lysis of both human and murine tumor cells. |
9730896 |
Human |
nkp46 |
human tumor |
Although NKp46 may cooperate with other activating receptors (including the recently identified NKp44 molecule) in the induction of NK-mediated lysis of human tumor cells, it may represent the only human NK receptor involved in recognition of murine targe |
9730896 |
Human |
nkp46 |
tumour |
NKp46 is a major NK cell-specific triggering receptor involved in the recognition and lysis of human and murine tumour and virally infected cells. |
14646088 |
Human |
nkp46 |
neuroblastoma |
We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, involves NKp46 and NKp30 (natural cytotoxicity receptors). |
15604290 |
Human |
nkp46 |
mouse tumor |
Moreover, preincubation of the effector cells with WEN23 F(ab')2 fragments reduced killing of target cells, confirming the activating function of NKp46 and indicating that the mouse tumor target cells express a ligand for rat NKp46. |
15356098 |
Human |
nkp46 |
human tumor |
Lysis of FcR- mouse and human tumor target cells was reduced after incubation of effector cells with WEN23, suggesting that rat NKp46 recognizes a ligand that is conserved between primates and rodents. |
15356098 |
Human |
nkp46 |
chronic myelogenous leukaemia |
NKp46 and NKp30 are the major receptors involved in the NK-mediated killing of K562, a human chronic myelogenous leukaemia cell line. |
15654827 |
Human |
nkp46 |
tumor |
We provide evidence that tumor cells can induce apoptosis of NK cells by engaging the natural cytotoxicity receptors (NCR) NKp30, NKp44, and NKp46. |
15728472 |
Human |
nkp46 |
tumor |
Recognition of tumor cells by the NCRs NKp30 and NKp46 involves heparan sulfate epitopes expressed on the tumor cell membrane. |
15759080 |
Human |