IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TNNI3 Ensembl ENSG00000129991 Chromosome 19 Start 60354950 End 60360912
Description Troponin I, cardiac muscle (Cardiac troponin I) [Source:UniProtKB/Swiss-Prot;Acc:P19429]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11947
     Entrez Gene : 7137
     UCSC : uc010yft.1
     GeneCards : 11947
     RefSeq : NM_000363
     CCDS : CCDS42628.1
     Uniprot : P19429
     Interpro : P19429
     OMIM : 191044
     GeneTests : TNNI3
     CGAP : TNNI3
     PMID : 9605869

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36477_at  0.91  9.49e-3  2.24e-2  0.47  1.95e-1  2.85e-1
 HG_U133A  205742_at  0.12  3.02e-1  3.55e-1  2.82  1.28e-79  5.13e-79
 HG_U133_Plus2  205742_at  0.95  2.93e-7  1.44e-6  1.17  7.25e-11  3.53e-10
 Agilent_HS_21.6K  9331  0.15  5.70e-2  1.60e-1  0.11  1.31e-1  2.53e-1
 Agilent_HS_21.6K  18376  0.20  1.80e-1  3.49e-1  0.16  1.81e-1  3.20e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205742_at  -0.10  8.00e-1  9.82e-1  0.01  9.46e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36477_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205742_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205742_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9331    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18376    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ctni necrosis Importantly, elevations of cTnI in patients with myocarditis were significantly correlated with < or = 1 month duration of heart failure symptoms (P = .02), suggesting that the majority of myocyte necrosis occurs early, and thus the window for diagnosis a 8994432 Human
ctni hematologic malignancies We used a recently developed new-generation immunoassay with high analytical sensitivity to measure cTnI in patients diagnosed with hematologic malignancies, before chemotherapy and after an intermediate cumulative dose of anthracyclines. 9431482 Human
ctni necrosis CONCLUSION: A cTnI concentration less than 15 micrograms/L (mean + 2 standard deviations [SDs] of peak cTnI in group 3) within 24 to 48 hours after cardiac surgery is highly suggestive of the absence of perioperative myocardial necrosis. 9636910 Human
ctni necrosis Because of its higher cardiospecificity than CK-MB mass, and its prolonged release after myocardial necrosis, cTnI might be a useful tool in the diagnosis of PMI after cardiac surgery. 9636910 Human
ctni necrosis The volume of the necrosis may be estimated by the rise of several biochemical marker levels, classically creatinine kinase (CK) and CK-MB. cTnI is a newly available biochemical marker with a high cardiac specificity. 9842005 Human
ctni necrosis Therefore we suggest that monitoring of cTnI is the best way to detect and quantify the size of myocardial necrosis created by radiofrequency ablation. 9842005 Human
ctni necrosis INTERVENTIONS: Biochemical markers of myocardial necrosis (cardiac troponin I (cTnI), creatine kinase (CK), creatine kinase MB mass (CKMB) and myoglobin) were measured at 12 h (T1), 24 h (T2) and 48 h (T3) after enrollment. 10663277 Human
ctni malignant pleural mesothelioma (mpm) In five patients who were treated for malignant pleural mesothelioma (MPM) with pleuropneumonectomy and intraoperative photodynamic therapy (IPDT), impending myocardial damage was monitored using ECG, the classical biochemical markers (creatine kinase [CK 10732455 Human
ctni cancer METHODS: We measured, in 204 patients (45+/-10 years) affected by cancer resistant to conventional treatment, the cTnI plasma concentration after every single cycle of HDC. 10933366 NA
ctni necrosis (1) The mean values of cTnI in AMI patients who died, >60 years old and with anterolateral necrosis are constantly higher than in survivors, <60 years old and with inferoposterior necrosis, respectively. 11182185 Human
ctni necrosis (4) The persistent increase of cTnI in AMI patients with advanced Killip class suggests that the high cTnI values are not only a strong index of myocardial necrosis but also of ongoing myocyte injury and hemodynamic impairment predictive of poor outcome. 11182185 Human
ctni necrosis (5) The hypothesis can be reasonably advanced that the higher values of cTnI in unstable angina are due to focal areas of myocardial necrosis undetectable by the conventional serum markers or to a clinically silent AMI occurred in the week or so before in 11182185 Human
ctni cancer In this prospective study, children being treated on several Children's Cancer Group protocols underwent measurement of shortening fraction (SF), ejection fraction (EF), and serum cTnI levels prior to anthracycline therapy. 11405175 Human
ctni necrosis CONCLUSION: Over half of patients undergoing emergency operation and more than a quarter of those having elective aortic surgery suffered myocardial necrosis as determined by detectable cTnI levels. 11531867 Human
ctni consecutive breast cancer We performed a multiparametric cardiologic monitoring in 16 consecutive breast cancer patients undergoing HD-CTX by means of serial ECG registrations and cardiac enzymes (CPK, CPK-MB and cTnI) determinations plus echocardiography in order to clarify acute 11535996 Human
ctni necrosis In contrast with normothermia, moderate hypothermia was also associated with significantly lower cumulative cardiac lymphatic flow during and after CPB, significantly lower lymphatic cTnI concentrations after CPB, significantly lower percentages of myocar 11583906 Human
ctni necrosis Myoglobin, CK-MB, and Troponin I (cTnI) are cardiac muscle necrosis markers that are useful for detecting acute myocardial infarction (AMI). 11793431 Human
ctni malignancy BACKGROUND: Increased cardiac troponin I (cTnI) in patients treated with high-dose chemotherapy (HDCT) for aggressive malignancy has been proposed as an early marker of late HDCT-induced cardiac dysfunction. 12560347 Human
ctni pd METHODS AND RESULTS: We assessed cardiac troponin I (cTnI) release in the 24 hours following direct coronary stenting (DS) as compared to stenting with balloon predilatation (PD) in a total of 311 patients and 440 vessels/lesions (vessel to lesion ratio = 12612383 Human
ctni necrosis RESULTS: All antibodies detected cTnT or cTnI in normal myocardium and its loss from necrotic myocardium, in some cases as early as 30 min after coronary occlusion, before histologic evidence of necrosis was present. 12684160 Human
ctni necrosis Loss of cTnT and cTnI occurs very early following ischemic injury and may precede histologic evidence of necrosis, but does not occur in myocardium that is not necrotic. 12684160 Human
ctni necrosis Immunohistochemical staining of hearts for cTnT and cTnI can assist in the often difficult recognition of myocardial necrosis at autopsy, in patients suspected of dying from acute myocardial ischemia. 12684160 Human
ctni necrosis CONCLUSIONS: cTnI proved to be the most sensitive marker in detecting myocardial necrosis following PCI. 14659867 Human
ctni necrosis Cardiac troponin I (cTnI) is a marker of myocardial necrosis. 14977902 Human
ctni necrosis Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) are sensitive and specific markers for myocardial ischemia and necrosis. 15188818 Human
ctni necrosis However, this concept is largely derived from models of brief, sublethal ischemia essentially devoid of necrosis, and there is speculation that defects in cTnI may be model-dependent. 15249179 Human
ctni cancer By multivariate analysis, elevated cTnI levels, a high APACHE II score, and underlying cancer were the three most important independent predictors for a shorter survival. 15257080 Human
ctni necrosis CONCLUSIONS: Being sensitive, specific, and precise, the Liaison cTnI assay meets current requirements to aid in the diagnosis of myocardial necrosis. 15329312 Human
ctni cm Compared with the healthy population, median plasma cTnI was increased in dogs with CM (0.14 ng/mL; range, 0.03-1.88 ng/mL; P < .001; n = 26), in dogs with MVD (0.11 ng/mL; range, 0.01-9.53 ng/mL; P < .001; n = 37), and in dogs with SAS (0.08 ng/mL; range 15638266 others
ctni cm In dogs with CM and MVD, plasma cTnI was correlated with left ventricular and left atrial size. 15638266 others
ctni cm In dogs with CM, the median survival time of those with cTnI >0.20 ng/mL was significantly shorter than median survival time of those with cTnI <0.20 ng/mL (112 days versus 357 days; P = .006). 15638266 others
ctni malignancy The aim of our study was to investigate whether plasma levels of NT-pro-BNP and cardiac troponin I (cTnI) can be used as specific markers for doxorubicin-induced cardiotoxicity in children with malignancy. 16127512 Human
ctni malignancy Were measured plasma NT-pro-BNP and cTnI in 31 patients (14 boys and 17 girls) who received doxorubicin-containing chemotherapy for their malignancy at cumulative doses of 30-600 mg/m2, between October 2000 and December 2004. 16127512 Human
tnni3 cm The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5-10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus. 8903721 Human

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