IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTPRH Ensembl ENSG00000080031 Chromosome 19 Start 60384428 End 60412654
Description Receptor-type tyrosine-protein phosphatase H Precursor (EC 3.1.3.48)(Transmembrane-type protein-tyrosine phosphatase type H)(Stomach cancer-associated protein tyrosine phosphatase 1)(SAP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9HD43]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9672
     Entrez Gene : 5794
     UCSC : uc002qjq.2
     GeneCards : 9672
     RefSeq : NM_001161440
     CCDS : CCDS33110.1
     Uniprot : Q9HD43
     Interpro : Q9HD43
     OMIM : 602510
     GeneTests : PTPRH
     CGAP : PTPRH
     PMID : 8294459

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1811_at  0.81  9.89e-5  4.04e-4  0.56  1.69e-2  3.64e-2
 HG_U133A  208300_at  0.24  1.01e-2  1.57e-2  -2.77  1.61e-94  9.42e-94
 HG_U133_Plus2  208300_at  1.89  3.07e-19  6.71e-18  1.26  9.60e-9  3.63e-8
 Agilent_HS_21.6K  15273  0.05  5.27e-1  6.96e-1  -0.01  8.61e-1  9.16e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208300_at  -0.34  1.59e-1  8.13e-1  -0.17  3.61e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1811_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208300_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208300_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15273    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
sap-1 breast cancer Interestingly, our studies reveal that although both Elk-1 and SAP-1 are highly homologous members of a subfamily of ETS domain proteins called ternary complex factors, it is only Elk-1 but not SAP-1 that can augment the growth suppressive function of BRC 11313879 Human
sap-1 cancer SAP-1 (stomach cancer-associated protein-tyrosine phosphatase-1) is a transmembrane-type protein-tyrosine phosphatase that is abundant in the brain and certain cancer cell lines. 11278335 Human
sap-1 human colorectal cancers Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers. 9070877 Human
sap-1 pancreatic cancer SAP-1 is a human transmembrane-type protein tyrosine phosphatase that is abundant in colon and pancreatic cancer cell lines. 9070877 Human
sap-1 human colorectal cancer The expression of SAP-1 in surgically excised human colorectal cancer specimens has now been investigated by immunohistochemical staining and in situ hybridization. 9070877 Human
sap-1 adenomas Normal colon tissue or adenomas with mild dysplasia showed no detectable expression of SAP-1. 9070877 Human
sap-1 adenocarcinomas In contrast, 2 of 17 adenomas with moderate or severe dysplasia and 19 of 48 (40%) adenocarcinomas expressed SAP-1, SAP-1 was localized predominantly to the apical surface of colonic cells in adenoma tissue showing moderate dysplasia, but it was also obse 9070877 Human
sap-1 adenoma In contrast, 2 of 17 adenomas with moderate or severe dysplasia and 19 of 48 (40%) adenocarcinomas expressed SAP-1, SAP-1 was localized predominantly to the apical surface of colonic cells in adenoma tissue showing moderate dysplasia, but it was also obse 9070877 Human
sap-1 adenomas In contrast, 2 of 17 adenomas with moderate or severe dysplasia and 19 of 48 (40%) adenocarcinomas expressed SAP-1, SAP-1 was localized predominantly to the apical surface of colonic cells in adenoma tissue showing moderate dysplasia, but it was also obse 9070877 Human
sap-1 adenocarcinoma In contrast, 2 of 17 adenomas with moderate or severe dysplasia and 19 of 48 (40%) adenocarcinomas expressed SAP-1, SAP-1 was localized predominantly to the apical surface of colonic cells in adenoma tissue showing moderate dysplasia, but it was also obse 9070877 Human
sap-1 colorectal cancers In situ hybridization with a SAP-1 antisense RNA probe detected SAP-1 mRNA in 6 of 9 colorectal cancers, but not in the surrounding mesenchymal tissue or normal mucosa. 9070877 Human
sap-1 human colorectal cancers These results suggest that SAP-1 is frequently overexpressed in human colorectal cancers and that such overexpression may occur relatively late in the adenoma-carcinoma sequence. 9070877 Human
sap-1 human hepatoma Two cDNA clones encoding prepro-sphingolipid activator protein 1 (SAP-1) were isolated from a lambda gt11 human hepatoma expression library using polyclonal antibodies. 2825202 Human
sap-1 human hepatoma A cDNA coding for SAP-1 was isolated from a lambda gt11 human hepatoma expression library using polyclonal antibodies raised against human SAP-1. 2868718 Human
sap-1 metachromatic leukodystrophy Extracts of the cells were subjected to SDS-PAGE and immunoblotting with antisphingolipid activator protein-1 (SAP-1) rabbit antiserum, and no cross-reacting material was detected confirming the diagnosis of metachromatic leukodystrophy caused by SAP-1 de 2764035 Human
sap-1 cancer In contrast, among cancer cell lines tested, SAP-1 was highly expressed in pancreatic and colorectal cancer cells. 8294459 Human
sap-1 colorectal cancer In contrast, among cancer cell lines tested, SAP-1 was highly expressed in pancreatic and colorectal cancer cells. 8294459 Human
sap-1 metachromatic leukodystrophy Recently, patients have been identified who have a variant form of metachromatic leukodystrophy which is characterized by mutations in the gene coding for SAP-1, which is also called "prosaposin." All of the mutations characterized in these pati 1350885 Human
sap-1 murine leukemia We now report the insertion of the full-length prosaposin cDNA into the Moloney murine leukemia virus-derived retroviral vector, pLJ, and the infection of cultured skin fibroblasts from a newly diagnosed and molecularly characterized patient with SAP-1 de 1350885 Human
sap-1 metachromatic leukodystrophy While most patients with metachromatic leukodystrophy have defects in arylsulfatase A, some patients have defects in SAP-1. 2302219 Human
sap-1 metachromatic leukodystrophy While most patients with metachromatic leukodystrophy have mutations in the gene for arylsulfatase A, some patients have deficient SAP-1, as determined by immunological techniques. 1689485 Human
sap-1 human hepatocellular carcinoma Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma. 12879010 Human
ptprh polyp Eight candidate genes mapping to the breakpoint region--U2AF2, EPN1, NALP4, NALP11, NALP5, ZNF444, PTPRH, and KIAA1811--were screened for mutations in germ-line and polyp DNA from the case and from 15 PJS cases that did not harbor germ-line STK11 mutation 15287029 Human
sap-1 hcc Furthermore, expression of recombinant SAP-1 in two highly motile human HCC cell lines resulted in a change in morphology and a marked reduction in both migratory activity and growth rate. 12879010 Human
sap-1 hcc In conclusion, these results indicate that SAP-1 expression is downregulated during the dedifferentiation of human HCC, and that this downregulation may play a causal role in disease progression. 12879010 Human
sapi cm We measured the right portal venous peak velocity (PVPV; cm/s), right hepatic arterial peak systolic velocity (cm/s), hepatic arterial pulsatility index, and the splenic arterial pulsatility index (SAPI). 12324756 Human

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