il-11 |
tumourbearing |
We examined the kinetics of IL-6, IL-11, oncostatinM (OSM) and leukaemia inhibitory factor (LIF) induction in the splenocytes of tumour-bearing mice. |
11884029 |
Human |
il-11 |
inflammatory bowel disease |
A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). |
14701802 |
Human |
interleukin-11 |
inflammatory bowel disease |
A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). |
14701802 |
Human |
il-11 |
human breast carcinoma |
METHODS: Slides containing sections of 3 pelleted human breast carcinoma cell lines (DAKO HercepTest) and expressing HER-2/neu protein-receptor scored at 3+ (SKBR-3), 1+ (MDA-175), and 0 (MDA-231), respectively, were reacted in immunohistochemical procedu |
11848612 |
Human |
interleukin-11 |
lewis lung carcinoma |
Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells. |
11862431 |
Human |
interleukin-11 |
leukemia |
An interim analysis of an ongoing placebo controlled study of recombinant interleukin-11 to assess its efficacy in reducing sepsis in leukemia patients through prevention of chemotherapy induced gut epithelial cell apoptosis, has demonstrated a difference |
12009573 |
Human |
interleukin 11 |
inflammatory bowel disease |
Biologic therapies that have been proven ineffective for inflammatory bowel disease include: interleukin 10; interleukin 11; anti-sense intercellular adhesion molecule-1; and the tumor necrosis factor receptor fusion protein etanercept. |
12016425 |
Human |
interleukin 11 |
myelodysplastic syndrome |
Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside. |
12036860 |
Human |
interleukin 11 |
acute myeloid leukemia |
Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside. |
12036860 |
Human |
il-11 |
myelodysplastic syndrome |
Thus, there is little evidence to suggest that GO with or without IL-11 should be used instead of IA in older patients with newly diagnosed AML or myelodysplastic syndrome. |
12036860 |
Human |
il-11 |
leukaemia |
The aim of this study was to analyse the capacity of myocytes and fibroblasts isolated from human atrium to secrete IL-6, leukaemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), IL-11, oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and the solu |
12126642 |
Human |
interleukin-11 |
breast cancer |
Recombinant human interleukin-11 (Neumega, rhIL-11) reduces thrombocytopenia in breast cancer patients receiving tandem autologous circulating progenitor cell transportation. |
12141272 |
Human |
il-11 |
myeloma |
Several studies have reported that IL-10 affects myeloma cells by stimulating secondary signals for cell proliferation through oncostatin M (OSM) and IL-11. |
12148907 |
Human |
il-11 |
leukaemia |
Interleukin (IL)-6, leukaemia inhibitory factor (LIF) and IL-11 belong to the same family of cytokines whose receptors utilize gp130 as the signalling molecule. |
12200462 |
Human |
interleukin-11 |
leukaemia |
Members of the interleukin-6 family of cytokines include leukaemia inhibitory factor (LIF), interleukin-6, interleukin-11, cardiotrophin, ciliary neurotropic growth factor, oncostatin M and the recently discovered cardiotropin-like cytokine (NNT-1). |
12385838 |
Human |
il-11 |
breast cancer |
Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor. |
14999770 |
Human |
il-11 |
breast cancer |
Breast cancer cell lines produced primarily PTHrP, with lesser amounts of IL-6, IL-11 and TNF-alpha. |
14999770 |
Human |
il-11 |
breast cancer |
We conclude that breast cancer cells induce OCL formation by stimulating osteoblastic production of IL-11. |
14999770 |
Human |
interleukin-11 |
breast cancer |
Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats. |
12498296 |
Rat |
il-11 |
tumor |
IL-11 did not affect tumor apoptosis or proliferation. |
12498296 |
Human |
il-11 |
polycythaemia vera |
Abnormal production of interleukin (IL)-11 and IL-8 in polycythaemia vera. |
12543083 |
Human |
il-11 |
polycythemia vera |
We studied the production of interleukin (IL)-11 and IL-8, two cytokines known to affect erythropoiesis, in polycythemia vera (PV). |
12543083 |
Human |
interleukin-11 |
inflammatory bowel disease |
Recombinant human interleukin-11 (rhIL-11) reduces the clinical signs and histological lesions of inflammatory bowel disease (IBD) in transgenic rats expressing the human major histocompatability complex (MHC) class I allele, HLA-B27. |
12629504 |
Rat |
interleukin-11 |
human osteogenic sarcoma |
Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. |
11172736 |
Human |
interleukin-11 |
pituitary adenomas |
Effects of the gp130 cytokines ciliary neurotropic factor (CNTF) and interleukin-11 on pituitary cells: CNTF receptors on human pituitary adenomas and stimulation of prolactin and GH secretion in normal rat anterior pituitary aggregate cultures. |
11375124 |
Human |
il-11 |
tumors |
We studied the expression of the specific receptor subunits for CNTF in mammotropic, non-functioning and somatotropic tumors and the action of CNTF and IL-11 in the regulation of hormone secretion in these and normal pituitary cells. |
11375124 |
Human |
il-11 |
tumors |
We found that both IL-11 and CNTF exerted a similar stimulatory effect on GH mRNA expression in somatotropic monolayer cell cultures from acromegalic tumors, but these cytokines had no significant influence on GH secretion. |
11375124 |
Human |
il-11 |
breast tumors |
We investigated the expression of IL-6 and IL-11 in 99 invasive primary breast tumors by immunohistochemistry and in situ hybridization, respectively. |
11410329 |
Human |
il-11 |
tumor |
15/89 (17%) of the tumor samples expressed IL-11 mRNA. |
11410329 |
Human |
il-11 |
tumor |
A positive IL-11 mRNA status was associated with a low tumor grade (P=0.05). |
11410329 |
Human |
il-11 |
bone metastases |
Tumors expressing IL-11 mRNA had a statistically significant (P=0.002) higher rate of bone metastases occurrence (12/15, 80%) than IL-11 negative tumors (27/74, 37%). |
11410329 |
Human |
il-11 |
tumors |
Tumors expressing IL-11 mRNA had a statistically significant (P=0.002) higher rate of bone metastases occurrence (12/15, 80%) than IL-11 negative tumors (27/74, 37%). |
11410329 |
Human |
il-11 |
negative tumors |
Tumors expressing IL-11 mRNA had a statistically significant (P=0.002) higher rate of bone metastases occurrence (12/15, 80%) than IL-11 negative tumors (27/74, 37%). |
11410329 |
Human |
il-11 |
breast tumors |
Our findings demonstrate for the first time IL-11 gene expression in some primary invasive breast tumors and suggest the potential of this cytokine as possible biological predictive factor for the development of bone metastases. |
11410329 |
Human |
il-11 |
bone metastases |
Our findings demonstrate for the first time IL-11 gene expression in some primary invasive breast tumors and suggest the potential of this cytokine as possible biological predictive factor for the development of bone metastases. |
11410329 |
Human |
interleukin 11 |
leukaemia |
We examined the effects of cytokines such as leukaemia inhibitory factor (LIF), interleukin 6 (IL-6), oncostatin M and interleukin 11 on the secretion of these hormones by the cells. |
11448119 |
Human |
interleukin 11 |
leukaemia |
METHOD: Enzyme-linked immunosorbent assay (ELISA) or bioassays were used to assess the concentrations of leukaemia inhibitory factor (LIF), tumour necrosis factor, interleukin 11, gamma interferon, progesterone and oestradiol in follicular fluids from pre |
11574494 |
Human |
il-11 |
plasmacytoma |
IL-11 was discovered as a soluble factor in fibroblast supernatants that stimulated the proliferation of "IL-6-dependent" plasmacytoma cells. |
11590369 |
Human |
il-11 |
cancer |
RT-PCR and ELISA demonstrated that the major factors responsible for LPL inhibition and lipolysis were not IL-1beta, IL-6, IL-11, TNF-alpha, TGF-beta1 or LIF in all the cancer cell lines except for MMG-1 cells. |
11848498 |
Human |
il-11 |
leukaemia |
We examined the kinetics of IL-6, IL-11, oncostatinM (OSM) and leukaemia inhibitory factor (LIF) induction in the splenocytes of tumour-bearing mice. |
11884029 |
Human |
il-11 |
lung carcinoma |
Using a lung carcinoma line, which grows in C57BL/6J mice, we observed that when the tumour grew and cachexia was observed, the splenocytes produced IL-6, IL-11, and OSM, but not LIF. |
11884029 |
Human |
il-11 |
tumour |
Using a lung carcinoma line, which grows in C57BL/6J mice, we observed that when the tumour grew and cachexia was observed, the splenocytes produced IL-6, IL-11, and OSM, but not LIF. |
11884029 |
Human |
il-11 |
metastases |
Cytokine expression was observed within 1 week (day 3 for IL-6 and IL-11, and day 1 for OSM) of administration of tumour cells, and was observed in splenocytes without tumour metastases to the spleen. |
11884029 |
Human |
il-11 |
tumour |
Cytokine expression was observed within 1 week (day 3 for IL-6 and IL-11, and day 1 for OSM) of administration of tumour cells, and was observed in splenocytes without tumour metastases to the spleen. |
11884029 |
Human |
il-11 |
tumour |
Exogenous administration of IL-11 resulted in the accelerated onset of cachexia, compared to control protein treatment, but without an effect on the tumour burden. |
11884029 |
Human |
il-11 |
leukaemia |
Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M. |
10632674 |
Human |
il-11 |
leukaemia |
We investigated both in vitro and ex vivo the role of mature osteoblasts (OB) and bone marrow stromal cells (BMSC) in RA and OA by analysing the expression of the following IL-6-type cytokines: IL-11, leukaemia inhibitory factor (LIF), oncostatin M (OSM) |
10632674 |
Human |
il-11 |
plasmacytoma |
IL-11, a cytokine initially identified as a plasmacytoma growth factor, belongs to this family. |
10737606 |
Human |
il-11 |
leukaemia |
An increase in the CD14+CD1a- population with reduction in CD14-CD1a+ DCs was observed with the addition of IL-6 to cultures, whereas IL-11, leukaemia inhibitory factor, oncostatin M or macrophage colony-stimulating factor did not affect the differentiati |
10848814 |
Human |
il-11 |
leukaemia |
Leukaemia inhibitory factor belongs to a group of cytokines that includes ciliary neurotrophic factor, interleukin (IL)-6, IL-11, cardiotrophin-1 and oncostatin M. |
10874517 |
Human |
il-11 |
leukaemia |
Following earlier findings that OM-85 BV induces the synthesis of IL-6, a study was undertaken to investigate its possible effect on other gp130 binding cytokines including IL-11, IL-12, leukaemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary n |
10899245 |
Human |
interleukin 11 |
inflammatory bowel disease |
Human recombinant interleukin 11 (rhIL-11) is a cytokine that suppresses the clinical signs of colitis in animal models of inflammatory bowel disease (IBD) and may be an effective therapeutic agent in the treatment of IBD. |
10950118 |
Human |
il-11 |
chondrosarcoma |
RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. |
10990217 |
Human |
interleukin-11 |
leukaemia |
Expression of interleukin-11 during the human menstrual cycle: coincidence with stromal cell decidualization and relationship to leukaemia inhibitory factor and prolactin. |
11006319 |
Human |
il-11 |
leukaemia |
This study examined the localization and expression of IL-11 in human endometrium throughout the menstrual cycle and of prolactin and leukaemia inhibitory factor (LIF) in secretory phase endometrium. |
11006319 |
Human |
il-11 |
multiple myeloma |
Relationship between circulating interleukin-10 (IL-10) with interleukin-6 (IL-6) type cytokines (IL-6, interleukin-11 (IL-11), oncostatin M (OSM)) and soluble interleukin-6 (IL-6) receptor (sIL-6R) in patients with multiple myeloma. |
11022130 |
Human |
interleukin-11 |
multiple myeloma |
Relationship between circulating interleukin-10 (IL-10) with interleukin-6 (IL-6) type cytokines (IL-6, interleukin-11 (IL-11), oncostatin M (OSM)) and soluble interleukin-6 (IL-6) receptor (sIL-6R) in patients with multiple myeloma. |
11022130 |
Human |
interleukin 11 |
leukaemia |
This family includes interleukin 6, interleukin 11, oncostatin M, leukaemia inhibitory factor, ciliary neurotrophic factor and cardiotrophin-1. |
11023660 |
Human |
interleukin-11 |
myeloma |
Finally, using a sensitive HGF bioassay (interleukin-11 production from the osteosarcoma cell line Saos-2) and intact syndecan-1 isolated from the U-266 myeloma cell line, we found that the presence of high concentrations of syndecan-1 (more than 3 microg |
11049995 |
Human |
il-11 |
pituitary adenoma |
Eighteen pituitary adenoma biopsies removed in transsphenoidal surgery (six corticotrophic adenomas, four nonfunctioning adenomas, four somatotrophinomas, four prolactinomas) and six normal anterior pituitaries were examined for the expression of IL-6 rec |
11095488 |
Human |
il-11 |
adenomas |
Eighteen pituitary adenoma biopsies removed in transsphenoidal surgery (six corticotrophic adenomas, four nonfunctioning adenomas, four somatotrophinomas, four prolactinomas) and six normal anterior pituitaries were examined for the expression of IL-6 rec |
11095488 |
Human |
il-11 |
nonfunctioning adenomas |
Eighteen pituitary adenoma biopsies removed in transsphenoidal surgery (six corticotrophic adenomas, four nonfunctioning adenomas, four somatotrophinomas, four prolactinomas) and six normal anterior pituitaries were examined for the expression of IL-6 rec |
11095488 |
Human |
il-11 |
adenoma |
The expression of all other cytokines (LIF, IL-11, CNTF) and receptors (IL-6-R, LIF-R, IL-11-R, OSM-R, CNTF-R) was found in different patterns in the adenoma subtypes and normal pituitaries. |
11095488 |
Human |
il-11 |
breast carcinoma |
The role of cytokines and extracellular matrices produced by lymphocytes, histiocytes and fibroblasts on migration and invasion of breast carcinoma cells has not been fully investigated METHODS: We investigated the effect of hepatocyte growth factor (HGF) |
11029802 |
Human |
il-11 |
human breast carcinoma |
The role of cytokines and extracellular matrices produced by lymphocytes, histiocytes and fibroblasts on migration and invasion of breast carcinoma cells has not been fully investigated METHODS: We investigated the effect of hepatocyte growth factor (HGF) |
11029802 |
Human |
il-11 |
myeloma |
Recent investigations of the cytokine network surrounding myeloma cells have disclosed the importance of gp130-related cytokines including interleukin (IL)-6 for myeloma cell survival and proliferation, identification of IL-10 as a growth factor for myelo |
11122145 |
Human |
il-11 |
leukaemia |
However, supplement of anti-IL-10 mAb caused upregulation of certain genes such as IL-11, leukaemia inhibitory factor receptor (LIFR) and syndecan-1 in IL-10R-expressing cell lines. |
11122145 |
Human |
il-11 |
bone metastasis |
No correlation was observed between the formation of bone metastasis and the expression of other metastasis-related cytokines (IL-1, IL-6, IL-8, IL-10, IL-11, TNF-alpha, VEGF, M-CSF). |
11417746 |
Human |
interleukin-11 |
human myeloid leukemia |
Thrombopoietin, interleukin-11, and early-acting megakaryocyte growth factors in human myeloid leukemia cells. |
11426619 |
Human |
oprelvekin |
cancer |
Until pharmacoeconomics studies determine the most cost-effective strategy for use of oprelvekin, it is likely to be used primarily in patients receiving dose-intensive chemotherapy to maintain the high-dose regimen that may provide a survival advantage f |
10533354 |
Human |
il-11 |
myeloma |
In coculture experiments, both the myeloma cell line JJN-3 and primary myeloma cells from 3 patients induced IL-11 secretion from osteoblasts, whereas no induction was observed with the non-HGF producing myeloma cell line OH-2. |
10572104 |
Human |
il-11 |
myeloma |
Enhanced IL-11 induction was observed with physical contact between osteoblasts and myeloma cells as compared with experiments in which contact was prohibited by tissue inserts. |
10572104 |
Human |
il-11 |
myeloma |
Anti-HGF serum strongly reduced the myeloma cell-induced IL-11 secretion. |
10572104 |
Human |
il-11 |
myeloma |
Furthermore, HGF emerges as a possible factor involved in myeloma bone disease by its ability to induce IL-11. |
10572104 |
Human |
il-11 |
leukaemia |
Using OA synovial fibroblasts, we investigated the effects of interleukin 8 (IL-8), leukaemia inhibitory factor (LIF) and IL-11 on the level of TNF-alpha-induced PGE(2), and their impact on the TNF-alpha-induced cellular signalling cascades including the |
10623427 |
Human |
il-11 |
leukaemia |
Many cytokines have been demonstrated to be expressed at the maternal-fetal interface although, currently, in mice only two (IL-11 and leukaemia inhibitory factor) appear to be absolutely essential for successful pregnancy outcome. |
10690798 |
Human |
il-11 |
nonfunctioning pituitary adenomas |
Using RT-PCR, IL-11 and IL-11R gene expression were also detected in normal human pituitaries, as well as in corticotropic and nonfunctioning pituitary adenomas. |
10098488 |
Human |
interleukin-11 |
solid tumors |
Recombinant human interleukin-11 is unlikely to stimulate the growth of the most common solid tumors. |
10194552 |
Human |
il-11 |
cancer |
Since RNA for the receptor and signal transducer for IL-11 is detected in many cell types including some cancer cells, it was theoretically possible that rhIL-11 could affect the growth of tumor cells. |
10194552 |
Human |
il-11 |
tumor |
Since RNA for the receptor and signal transducer for IL-11 is detected in many cell types including some cancer cells, it was theoretically possible that rhIL-11 could affect the growth of tumor cells. |
10194552 |
Human |
il-11 |
myelomas |
In this report, a DNA fragment encoding human IL-11 was transduced into fusion partners (mouse myelomas Ag8.653 and SP2/0, and human lymphoblastoid cell line HF2) mediated by lipofection. |
10331181 |
Human |
il-11 |
leukaemia |
We investigated the serum concentration of interleukin-6 (IL-6) and four IL-6 family cytokines - oncostatin M (OSM), leukaemia inhibitory factor (LIF), interleukin-11 (IL-11) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) |
10233412 |
Human |
interleukin-11 |
leukaemia |
We investigated the serum concentration of interleukin-6 (IL-6) and four IL-6 family cytokines - oncostatin M (OSM), leukaemia inhibitory factor (LIF), interleukin-11 (IL-11) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) |
10233412 |
Human |
il-11 |
other carcinomas |
Therefore, we have investigated immunoreactive concentrations of IL-4, IL-6, IL-11, IL-15, IL-17, IL-18, and tumor necrosis factor-alpha (TNF-alpha) in pleural effusions and peripheral blood from patients with tuberculosis, bronchial carcinoma and other c |
15072171 |
Human |
il-11 |
bronchial carcinoma |
Therefore, we have investigated immunoreactive concentrations of IL-4, IL-6, IL-11, IL-15, IL-17, IL-18, and tumor necrosis factor-alpha (TNF-alpha) in pleural effusions and peripheral blood from patients with tuberculosis, bronchial carcinoma and other c |
15072171 |
Human |
il-11 |
acute myelogenous leukemia |
Interleukin-11 (IL-11) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL-11 receptor alpha chain and signal transducing gp130. |
10400417 |
Human |
interleukin-11 |
acute myelogenous leukemia |
Interleukin-11 (IL-11) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL-11 receptor alpha chain and signal transducing gp130. |
10400417 |
Human |
il-11 |
acute myelogenous leukemia (aml) |
We examined the effect of recombinant human interleukin (IL)-11 alone or in combination with various colony-stimulating factors (CSFs), including IL-3, granulocyte/macrophage (GM)-CSF, granulocyte (G)-CSF, stem cell factor (SCF), flt3 ligand (FL), and thr |
10400417 |
Human |
il-11 |
aplasia |
RESULTS: Although no correlation could be demonstrated between endogenous IL-11 or SCF levels, infection, and leukocyte counts, endogenous G-CSF levels were increased during both aplasia and infection. |
10421271 |
Human |
interleukin 11 |
acute myeloid leukemia |
Thrombopoietin and interleukin 11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells. |
10428502 |
Human |
il-11 |
cancer |
Because some of these growth factors, especially TPO and IL-11, are now being evaluated clinically to reduce chemotherapy-associated thrombocytopenia in cancer patients, we evaluated 25 acute myeloid leukemia (AML) samples to test whether TPO, IL-11, and |
10428502 |
Human |
il-11 |
cancer |
IL-11 is useful in elevating the platelet count in cancer patients with chemotherapy-induced thrombocytopenia and has a cytoprotective effect on the bowel mucosa in a variety of causes of gut damage and a trophic effect on the villi after massive bowel re |
10483899 |
Human |
interleukin-11 |
bone metastasis |
Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis. |
9488033 |
Human |
il-11 |
melanoma |
The production of IL-11 in BDECs was also promoted by conditioned medium of human melanoma A375M cells. |
9488033 |
Human |
il-11 |
bone metastasis |
Because A375M cells formed osteolytic bone metastasis in vivo, BDECs might be involved in pathological osteolysis by producing IL-11. |
9488033 |
Human |
il-11 |
leukaemia |
The effect of combinations of interleukin 1 (IL-1), 6 (IL-6), and 11 (IL-11), interferon gamma (INF-gamma), leukaemia inhibitory factor (LIF) and tumour necrosis factor alpha (TNF-alpha) on the expression of LPL in macrophages was studied using the murine |
9505144 |
Human |
il-11 |
cancer |
These cancer cells produced interleukin-11 (IL-11) by themselves and stimulated its production from osteoblasts. |
9572469 |
Human |
interleukin-11 |
cancer |
These cancer cells produced interleukin-11 (IL-11) by themselves and stimulated its production from osteoblasts. |
9572469 |
Human |
il-11 |
bone metastasis |
Therefore, IL-11 could play an important role in the promotion of osteolysis at the site of bone metastasis. |
9572469 |
Human |
il-11 |
cancer |
These results indicate that IL-11 promotes bone resorption through a PGE2 synthesis-dependent mechanism and that cyclooxygenases inhibitors could be interesting drugs to suppress IL-11-mediated osteolytic bone metastasis of cancer cells. |
9572469 |
Human |
il-11 |
bone metastasis |
These results indicate that IL-11 promotes bone resorption through a PGE2 synthesis-dependent mechanism and that cyclooxygenases inhibitors could be interesting drugs to suppress IL-11-mediated osteolytic bone metastasis of cancer cells. |
9572469 |
Human |
interleukin-11 |
breast cancer |
Production and regulation of interleukin-11 by breast cancer cells. |
9619855 |
Human |
il-11 |
breast cancer |
We have studied the production of interleukin-11 (Il-11) in 13 breast cancer cell (BCC) lines. |
9619855 |
Human |
interleukin-11 |
breast cancer |
We have studied the production of interleukin-11 (Il-11) in 13 breast cancer cell (BCC) lines. |
9619855 |
Human |
il-11 |
leukaemia |
The family of cytokines signalling through the common receptor subunit gp130 comprises interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1. |
9716487 |
Human |
il-11 |
leukaemia |
To substitute the autocrine activity by a single physiological component, 28 cytokines, growth factors and biomodulators were tested [interleukin 1alpha (IL-1alpha), IL-1beta, IL-2, IL-3, IL-4, IL-6, IL-10, IL-11, stem cell factor (SCF), platelet-derived |
9764576 |
Human |
il-11 |
leukaemia |
Leukaemia inhibitory factor (LIF), was named after its effect on haemopoietic cells, and belongs to a group of cytokines which includes CNTF, IL-6, CT-1, OM and IL-11. |
9851659 |
Human |
interleukin-11 |
inflammatory bowel disease |
Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. |
9881950 |
Rat |
il-11 |
renal angiomyolipoma |
In order to understand the ability of normal human kidney, benign renal angiomyolipoma and malignant renal cell carcinoma (RCC) cells to produce cytokines, we determined the IL-1-beta, IL-6, IL-10, IL-11, TNF-alpha and TGF-beta-1 concentration in the supe |
9891467 |
Human |
interleukin-11 |
breast cancer |
A randomized trial of recombinant human interleukin-11 following autologous bone marrow transplantation with peripheral blood progenitor cell support in patients with breast cancer. |
9923411 |
Human |
il-11 |
myeloma |
Two human myeloma cell lines secreted OSM and IL-6, but not IL-11 or leukaemia inhibitory factor (LIF), which suggests an important role for OSM and IL-6 in supporting growth of myeloma cells. |
9012701 |
Human |
il-11 |
leukaemia |
Two human myeloma cell lines secreted OSM and IL-6, but not IL-11 or leukaemia inhibitory factor (LIF), which suggests an important role for OSM and IL-6 in supporting growth of myeloma cells. |
9012701 |
Human |
il-11 |
renal-cell carcinomas |
Renal cell carcinomas produce IL-6, IL-10, IL-11, and TGF-beta 1 in primary cultures and modulate T lymphocyte blast transformation. |
9058315 |
Human |
il-11 |
tumors |
The results clearly show that immunomodulatory capacity is a common feature of RCC and that in vitro these tumors can produce interleukin-10 (IL-10) up to 20 ng/ml, IL-6 up to 35 micrograms/ml (> 250 kU/ml in the B9 system), IL-11 up to 15 micrograms/ml, |
9058315 |
Human |
interleukin-11 |
leukaemia |
Interleukin-6 and related cytokines, interleukin-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and cardiotrophin-1, are all pleiotrophic, from the haematopoietic to the nervous system, and exhibit overlapping biological activi |
9073325 |
Human |
interleukin-11 |
human erythroleukemia |
Interleukin-11 induces rapid PKC activation and cytosolic to particulate translocation of alpha and beta PKC isoforms in human erythroleukemia K562 cells. |
9125152 |
Human |
il-11 |
leukaemia |
The patterns of induction of sPLA2, HP and ACH were distinct for each of IL- 1, tumour necrosis factor (TNF) and IL-6, oncostatin M, IL-11 and leukaemia inhibitory factor. |
9097927 |
Human |
il-11 |
tumoral diseases |
A family of cytokines [IL-6, IL-11, oncostatin M (OM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF) and cardiotrophin-1] involved in various inflammatory or tumoral diseases share the same gp130 signal transducer chain. |
9112331 |
Human |
il-11 |
leukaemia |
A family of cytokines [IL-6, IL-11, oncostatin M (OM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF) and cardiotrophin-1] involved in various inflammatory or tumoral diseases share the same gp130 signal transducer chain. |
9112331 |
Human |
interleukin-11 |
tumor |
Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors. |
9139879 |
Human |
il-11 |
tumour |
The relation between the number of platelets in blood and the concentrations of immunoreactive thrombopoietin (TPO), interleukin 6 and interleukin 11 (IL-6, IL-11) was studied in the sera of 32 normal subjects, of 29 untreated tumour patients and of 6 tum |
9260581 |
Human |
interleukin 11 |
tumour |
The relation between the number of platelets in blood and the concentrations of immunoreactive thrombopoietin (TPO), interleukin 6 and interleukin 11 (IL-6, IL-11) was studied in the sera of 32 normal subjects, of 29 untreated tumour patients and of 6 tum |
9260581 |
Human |
il-11 |
tumor |
Using cDNA array, LSA tumor cells were found to express several cytokine genes including IL-2, IL-7, IL-11, IL-13, IL-16, lymphotoxin beta, and tumor necrosis factor beta. |
14597213 |
Human |
interleukin-11 |
breast cancer |
Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. |
9363868 |
Human |
il-11 |
agnogenic myeloid metaplasia |
Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia. |
9369414 |
Human |
interleukin-11 |
leukaemia |
It is clear that interleukin-3, interleukin-6, interleukin-11, stem cell factor, leukaemia inhibitory factor and oncostatin-M all influence the proliferation and maturation of megakaryocytes. |
10174279 |
Human |
il-11 |
human ovarian carcinomas |
Expression of macrophage colony-stimulating factor (M-CSF), interleukin-6, (IL-6), interleukin-1 beta (IL-1 beta), interleukin-11 (IL-11) and tumour necrosis factor-alpha (TNF-alpha) in p53-characterised human ovarian carcinomas. |
9470814 |
Human |
interleukin-11 |
human ovarian carcinomas |
Expression of macrophage colony-stimulating factor (M-CSF), interleukin-6, (IL-6), interleukin-1 beta (IL-1 beta), interleukin-11 (IL-11) and tumour necrosis factor-alpha (TNF-alpha) in p53-characterised human ovarian carcinomas. |
9470814 |
Human |
il-11 |
tumours |
In this study, 30 tumours of patients with a primary diagnosis of human ovarian carcinoma were characterised for p53 expression with immunohistochemistry and analysed for the expression of M-CSF, IL-6, IL-1 beta, IL-11 and TNF-alpha with Northern blotting |
9470814 |
Human |
il-11 |
human ovarian carcinoma |
In this study, 30 tumours of patients with a primary diagnosis of human ovarian carcinoma were characterised for p53 expression with immunohistochemistry and analysed for the expression of M-CSF, IL-6, IL-1 beta, IL-11 and TNF-alpha with Northern blotting |
9470814 |
Human |
il-11 |
tumours |
None of the tumours expressed IL-1 beta or IL-11. |
9470814 |
Human |
il-11 |
breast cancer |
The released factors then stimulate tumor cell signaling, which causes breast cancer cells to make increased amounts of osteolytic factors, such as parathyroid hormone-related protein (PTHrP), interleukin-11 (IL-11), and vascular endothelial growth factor |
14600590 |
Human |
interleukin-11 |
breast cancer |
The released factors then stimulate tumor cell signaling, which causes breast cancer cells to make increased amounts of osteolytic factors, such as parathyroid hormone-related protein (PTHrP), interleukin-11 (IL-11), and vascular endothelial growth factor |
14600590 |
Human |
il-11 |
tumor |
The released factors then stimulate tumor cell signaling, which causes breast cancer cells to make increased amounts of osteolytic factors, such as parathyroid hormone-related protein (PTHrP), interleukin-11 (IL-11), and vascular endothelial growth factor |
14600590 |
Human |
interleukin-11 |
tumor |
The released factors then stimulate tumor cell signaling, which causes breast cancer cells to make increased amounts of osteolytic factors, such as parathyroid hormone-related protein (PTHrP), interleukin-11 (IL-11), and vascular endothelial growth factor |
14600590 |
Human |
interleukin-11 |
cancer |
A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. |
8611684 |
Human |
il-11 |
cancer |
We conducted a multicenter, randomized, placebo-controlled trial of recombinant human IL-11 (rhIL-11) in 93 patients with cancer who had already been transfused platelets for severe thrombocytopenia resulting from chemotherapy. |
8611684 |
Human |
interleukin-11 |
breast cancer |
A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. |
8611685 |
Human |
interleukin-11 |
breast cancer |
We performed a phase I trial of recombinant human interleukin-11 (rhIL-11) in women with breast cancer. |
8611685 |
Human |
il-11 |
hepatoma |
Addition of COS cell-derived soluble mIL-11R to the hepatoma cell cultures prominently enhanced IL-11 regulation of transfected reporter gene constructs and expression of endogenous acute phase plasma protein genes. |
8683127 |
Human |
il-11 |
embryonal carcinoma |
Similarly, the complex of soluble mIL-11R and IL-11 was capable of mediating an IL-6-type signaling in cells that are naturally deficient in IL-11 response as shown by the activation of STAT1 and STAT3 in mouse embryonal carcinoma cells and human T cells. |
8683127 |
Mouse |
il-11 |
cancer |
Of these, IL-11 and PIXY 321 hold promise for clinical amelioration of thrombocytopenia in cancer patients. |
8707763 |
Human |
il-11 |
leukaemia |
No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. |
8757531 |
Human |
il-11 |
leukaemia |
Circulating levels of IL-11 and leukaemia inhibitory factor (LIF) do not significantly participate in the production of acute-phase proteins by the liver. |
8706331 |
Human |
il-11 |
carcinoma |
A uterine carcinoma cell line, Yumoto, produced a large amount of interleukin 6 (IL-6), and an oral cavity carcinoma cell line, OCC-1C, concomitantly produced LIF, IL-6, and IL-11. |
8765417 |
Human |
il-11 |
oral cavity carcinoma |
A uterine carcinoma cell line, Yumoto, produced a large amount of interleukin 6 (IL-6), and an oral cavity carcinoma cell line, OCC-1C, concomitantly produced LIF, IL-6, and IL-11. |
8765417 |
Human |
il-11 |
cancer |
These findings suggest that in four of eight animal models in which cancer cachexia syndrome developed, LIF, IL-6, or possibly IL-11 produced by cancer cells may be toxohormones, but in the remaining four cancer cell lines the mechanism responsible for ca |
8765417 |
Human |
interleukin 11 |
cancer |
Thrombopoietic activity of recombinant human interleukin 11 in cancer patients receiving chemotherapy. |
8765426 |
Human |
il-11 |
breast cancer |
In clinical phase I trials, subcutaneous IL-11 was well tolerated and induced a dose-related thrombopoietic effect in women with breast cancer. |
8765426 |
Human |
il-11 |
myeloma |
However, its clinical use in patients with hematological malignancies may be restricted because IL-11 has been reported to stimulate some leukemia and myeloma cells. |
8765427 |
Human |
il-11 |
hematological malignancies |
However, its clinical use in patients with hematological malignancies may be restricted because IL-11 has been reported to stimulate some leukemia and myeloma cells. |
8765427 |
Human |
interleukin-11 |
retinoblastoma |
Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation. |
8780393 |
Human |
il-11 |
myeloma |
Of these cytokines, those that have been shown to be paracrine growth factors for some myeloma cells include IL-6, IL-11, ciliary neurotrophic factor, leukemia inhibitory factor, and oncostatin M (OSM). |
8816418 |
Human |
il-11 |
leukaemia |
Oncostatin M (OSM) is structurally and functionally similar to leukaemia inhibitory factor (LIF), interleukin 6 (IL-6), interleukin 11 (IL-11) and ciliary neurotrophic factor (CNTF). |
8818547 |
Human |
interleukin 11 |
leukaemia |
Oncostatin M (OSM) is structurally and functionally similar to leukaemia inhibitory factor (LIF), interleukin 6 (IL-6), interleukin 11 (IL-11) and ciliary neurotrophic factor (CNTF). |
8818547 |
Human |
interleukin-11 |
murine mammary carcinoma |
Interaction of interleukin-11 with cytotoxic therapies in vitro against CEM cells and in vivo against EMT-6 murine mammary carcinoma. |
8824560 |
Mouse |
interleukin-11 |
cancer |
Recently, several non-specific cytokines with thrombopoietic activity have been evaluated in phase I clinical trials, including interleukin-1, interleukin-3 followed by GM-CSF, interleukin-6, and interleukin-11 in cancer patients, showing an encouraging t |
8877716 |
Human |
il-11 |
leukaemia |
Although exposure to LPS, interleukin 11 (IL-11), tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma) and IL-1, over the physiological range of concentrations, resulted in a decrease in the heparin-releasable LPL activity, LPL-mRNA leve |
8891433 |
Human |
interleukin 11 |
leukaemia |
Although exposure to LPS, interleukin 11 (IL-11), tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma) and IL-1, over the physiological range of concentrations, resulted in a decrease in the heparin-releasable LPL activity, LPL-mRNA leve |
8891433 |
Human |
il-11 |
myeloma |
We found that myeloma cells from XG-1 and XG-2 HMCL and from 5 of 6 patients' tumoral samples produced oncostatin M (OM) constitutively but failed to produce IL-6, IL-11 and leukemia-inhibitory factor (LIF). |
8916964 |
Human |
il-11 |
tumor |
We now report that the DA-3 cell line derived from this tumor, as well as the in vivo tumor itself, express IL-11. |
12527946 |
Human |
il-11 |
tumor |
The expression of IL-11 in the tumor is detectable at the transcriptional and translational levels, as evidenced by RT-PCR and Western blots. |
12527946 |
Human |
il-11 |
tumor |
Interestingly, elevated levels of IL-11 were found in the sera of tumor-bearers, when compared to normal animals and even higher levels of IL-11 were detected in the tumor cystic fluid. |
12527946 |
Mouse |
il-11 |
human hepatoma |
IL-11Ralpha was shown to confer IL-11 responsiveness to human hepatoma cells either by cDNA transfection or by adding a soluble form of the receptor (sIL11Ralpha) expressed in the baculovirus system to the culture medium. |
8940087 |
Human |
interleukin-11 |
chronic myeloid leukemia |
Synergistic effects of interleukin-11 with other growth factors on the expansion of hematopoietic progenitors from normal individuals and chronic myeloid leukemia patients resistant to treatment with cytosine arabinoside or eilatin. |
8947585 |
Human |
il-11 |
plasmacytoma |
These stimulatory effects were dose and time dependent, and the IL-11 that was produced was bioactive, as demonstrated by its ability to stimulate the proliferation of T10D plasmacytoma cells. |
7835281 |
Human |
interleukin 11 |
murine leukemia |
We examined the effects of recombinant human erythropoietin (rhEPO), recombinant murine interleukin 3 (rmIL-3), recombinant human interleukin 6 (rhIL-6), recombinant human interleukin 11 (rhIL-11), recombinant murine leukemia inhibitory factor (rmLIF) and |
7869746 |
Human |
il-11 |
myelofibrosis |
Because IL-3 as well as IL-11 are known as efficient growth factors for human megakaryocytes in vitro, our data provide insights into the regulatory mechanisms involved in megakaryopoiesis and the development of myelofibrosis. |
7869769 |
Human |
il-11 |
myeloma |
The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells. |
7647014 |
Human |
il-11 |
myeloma |
In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL-6 autocrine human myeloma cell lines, LP1, OPM2 and L363, have been treated with dexamethasone in the presence or absence of cytokines belongi |
7647014 |
Human |
il-11 |
melanoma |
Expression of leukemia inhibitory factor and interleukin-11 by human melanoma cell lines: LIF, IL-6, and IL-11 are not coregulated. |
7648448 |
Human |
interleukin-11 |
melanoma |
Expression of leukemia inhibitory factor and interleukin-11 by human melanoma cell lines: LIF, IL-6, and IL-11 are not coregulated. |
7648448 |
Human |
il-11 |
melanoma |
Because IL-6 belongs to the hematopoietic cytokine family, which includes leukemia inhibitory factor (LIF) and interleukin-11 (IL-11), we examined the possibility of coordinate expression of LIF, IL-6, and IL-11 in three human melanoma cell lines derived |
7648448 |
Human |
interleukin-11 |
melanoma |
Because IL-6 belongs to the hematopoietic cytokine family, which includes leukemia inhibitory factor (LIF) and interleukin-11 (IL-11), we examined the possibility of coordinate expression of LIF, IL-6, and IL-11 in three human melanoma cell lines derived |
7648448 |
Human |
il-11 |
melanomas |
Recombinant LIF and IL-11 protein had no effect on the proliferation of any of the seven lines, suggesting that they do not act as autocrine growth factors for these melanomas. |
7648448 |
Human |
il-11 |
melanoma |
Assay of IL-6, IL-11, and LIF protein in conditioned medium from early and advanced melanoma lines gave no evidence of coordinate expression of these cytokines. |
7648448 |
Human |
il-11 |
melanoma |
We conclude that LIF and IL-11 production by melanomas may have some paracrine or endocrine function in the course of melanoma progression. |
7648448 |
Human |
il-11 |
melanomas |
We conclude that LIF and IL-11 production by melanomas may have some paracrine or endocrine function in the course of melanoma progression. |
7648448 |
Human |
il-11 |
leukaemia |
Extensive mutagenesis of residues between Q153 and H165 of human IL-6, a region which is partly homologous in cytokines which also signal via gp130 (oncostatin M, ciliary neurotrophic factor, leukaemia inhibitory factor, IL-11), did result in the isolatio |
7578977 |
Human |
interleukin-11 |
glioblastoma |
Expression of interleukin-11 and its encoding mRNA by glioblastoma cells. |
7501271 |
Human |
il-11 |
glioblastoma |
Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore. |
7501271 |
Human |
il-11 |
breast cancer |
Interleukin-6 (IL-6) and interleukin-11 (IL-11) are frequently produced by breast cancer cells. |
12889600 |
Human |
interleukin-11 |
breast cancer |
Interleukin-6 (IL-6) and interleukin-11 (IL-11) are frequently produced by breast cancer cells. |
12889600 |
Human |
il-11 |
breast cancer |
Transforming growth factor-beta (TGF-beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) up-regulate IL-6 and IL-11 production in a cytokine-dependent fashion in breast cancer cells, but very little is known about their intrace |
12889600 |
Human |
il-11 |
breast cancer |
To study TGF-beta, TNF-alpha and IL-1beta regulation of IL-6 and IL-11 production in human MDA-MB-231 breast cancer cells, we established single cell clones stably expressing dominant negative (DN) forms of the mitogen-activated protein kinases p38 (p38/A |
12889600 |
Human |
il-11 |
leukaemia |
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the a |
12773095 |
Human |
il-11 |
nasal polyps |
IL-11 and IL-17 expression in nasal polyps: relationship to collagen deposition and suppression by intranasal fluticasone propionate. |
14520110 |
Human |
interleukin-11 |
myeloma |
Interleukin-10 induces interleukin-11 responsiveness in human myeloma cell lines. |
8549788 |
Human |
interleukin-11 |
leukaemia |
Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor. |
8597881 |
Human |
interleukin-11 |
leukaemia |
Ciliary neurotrophic factor (CNTF), leukaemia inhibitory factor (LIF), oncostatin M (OSM), interleukin-6 (IL-6), and interleukin-11 (IL-11) are structurally and functionally related cytokines. |
8742440 |
Human |
il-11 |
leukaemia |
Ciliary neurotrophic factor (CNTF), leukaemia inhibitory factor (LIF), oncostatin M (OSM), interleukin-6 (IL-6), and interleukin-11 (IL-11) are structurally and functionally related cytokines. |
8742440 |
Human |
interleukin-11 |
plasmacytoma |
We have recently found that the inhibitor of plasmacytoma cell growth, restrictin-P, is a stroma derived activin A and that it is an antagonist of interleukin-6 and interleukin-11. |
8930019 |
Human |
interleukin-11 |
cancer |
Several clinical studies have demonstrated interleukin-11 to be well tolerated and suggest interleukin-11 is a promising cytokine to prevent both neutropenia and thrombocytopenia in patients with cancer who are receiving chemotherapy. |
9371993 |
Human |
interleukin-11 |
leukaemia |
In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. |
8127368 |
Human |
interleukin 11 |
myeloma |
Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130. |
8145045 |
Human |
il-11 |
multiple myeloma |
We analyzed the stimulatory effect of oncostatin M (OSM), leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and the inhibitory effect of anti-IL-6 antibody (Ab), anti-IL-6 receptor monoclonal antibody (mAb), and anti-gp130 mAb on the growth o |
8145046 |
Human |
il-11 |
plasmacytoma |
We analyzed the stimulatory effect of oncostatin M (OSM), leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and the inhibitory effect of anti-IL-6 antibody (Ab), anti-IL-6 receptor monoclonal antibody (mAb), and anti-gp130 mAb on the growth o |
8145046 |
Human |
interleukin-11 |
tumors |
These data suggest that interleukin-11 could allow significant dose intensification in the treatment of tumors which are nitrosourea sensitive. |
8069861 |
Human |
il-11 |
leukaemia |
The capacity to bind IL-11 with high affinity (Kd = 300-800 pM) appeared to require coexpression of both NR1 and gp130, the common subunit of the IL-6, leukaemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) receptors. |
7957045 |
Human |
interleukin 11 |
chronic myelogenous leukemia |
Interleukin 11 May improve thrombocytopenia associated with imatinib mesylate therapy in chronic Myelogenous leukemia. |
15120938 |
Human |
il-11 |
leukaemia |
In addition to specific ligand binding elements, receptor assembly for interleukin(IL)-6, oncostatin-M, leukaemia inhibitory factor, ciliary neurotrophic factor and IL-11 includes an additional unit, gp130. |
7734154 |
Human |
il-11 |
lymphocytic leukemia |
In contrast, three acute pre-B lymphocytic leukemia (pre-B-ALL) and two acute T lymphocytic leukemia (T-ALL) lines failed to respond to IL-11 alone or when combined with other cytokines. |
8453105 |
Human |
interleukin-11 |
hepatoma |
Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells. |
8503920 |
Human |
interleukin-11 |
hepatoma |
Effect of recombinant human interleukin-11 (rhIL-11) on the expression of transcripts encoding microsomal heme oxygenase (HO), the rate-limiting enzyme in heme catabolism, and haptoglobin (Hpt), a major acute-phase protein, were examined in human HepG2 he |
8503920 |
Human |
interleukin-11 |
leukaemia |
However, it is now clear that there is a complex interaction between the cytokines with interleukin-6 predominant, but also involving interleukin-1, tumour necrosis factor and a group of recently described cytokines including interleukin-11, leukaemia inh |
7685227 |
Human |
il-11 |
hepatoma |
The cytokines, IL-1 beta, TNF-alpha, IL-6, IL-11, leukemia inhibitory factor, and ciliary neurotrophic factor, stimulate the expression of specific sets of acute phase plasma proteins in the rat hepatoma H-35 cell line. |
7687632 |
Rat |
interleukin 11 |
cell hyperplasia |
Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras. |
8104229 |
Human |
interleukin 11 |
myeloid leukemia |
Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras. |
8104229 |
Human |
il-11 |
cancer |
IL-11 has demonstrated activity in preclinical models for the treatment of thrombocytopenia and, in some cases, neutropenia; studies are underway to confirm its usefulness in the clinic for treatment of myelosuppression associated with cancer chemotherapy |
8401258 |
Human |
il-11 |
hepatoma |
Several cytokines including IL-6, leukemia inhibitory factor, and IL-11 are capable of stimulating APP synthesis by hepatocytes and hepatoma cells. |
1371787 |
Human |
interleukin 11 |
multiple myeloma |
Lack of a role of interleukin 11 in the growth of multiple myeloma. |
1532843 |
Human |
il-11 |
murine plasmacytoma |
Since IL-6 is known to promote the growth of human myeloma, either in an autocrine or paracrine fashion, we examined the effect of IL-11 on the growth of a murine plasmacytoma cell line, human myeloma-derived cell lines, and freshly isolated human myeloma |
1532843 |
Mouse |
il-11 |
myeloma |
Since IL-6 is known to promote the growth of human myeloma, either in an autocrine or paracrine fashion, we examined the effect of IL-11 on the growth of a murine plasmacytoma cell line, human myeloma-derived cell lines, and freshly isolated human myeloma |
1532843 |
Human |
interleukin 11 |
murine plasmacytoma |
Interleukin 11 does increase DNA synthesis by the murine plasmacytoma line T10 in the presence of neutralizing antibody to IL-6. |
1532843 |
Mouse |
il-11 |
myeloma |
However, neither human myeloma cells nor derived cell lines express IL-11 mRNA; secrete IL-11; express IL-11 cell surface receptors; or augment either DNA synthesis or Ig secretion in response to exogenous IL-11. |
1532843 |
Human |
il-11 |
murine plasmacytoma |
These findings strongly suggest that IL-11 does support the growth of a murine plasmacytoma cell line but does not play a role in the growth of either freshly isolated human myeloma cells or derived cell lines. |
1532843 |
Mouse |
il-11 |
myeloma |
These findings strongly suggest that IL-11 does support the growth of a murine plasmacytoma cell line but does not play a role in the growth of either freshly isolated human myeloma cells or derived cell lines. |
1532843 |
Human |
interleukin-11 |
murine plasmacytoma |
Interleukin-11 (IL-11) is a recently described stromal-derived cytokine that supports the growth of an IL-6-dependent murine plasmacytoma line in the presence of antibody to IL-6 and appears to act in a manner similar to IL-6 on hematopoietic stem cells. |
1450406 |
Mouse |
il-11 |
murine plasmacytoma |
Interleukin-11 (IL-11) is a recently described stromal-derived cytokine that supports the growth of an IL-6-dependent murine plasmacytoma line in the presence of antibody to IL-6 and appears to act in a manner similar to IL-6 on hematopoietic stem cells. |
1450406 |
Mouse |
il-11 |
plasmacytoma |
It has been shown that IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, enhances antigen-specific antibody responses, synergizes with IL-3 in supporting megakaryocyte colony formation, acts synergistically with IL-3 in short |
1292471 |
Human |
interleukin-11 |
solid tumor |
Pharmacoeconomic analysis of oprelvekin (recombinant human interleukin-11) for secondary prophylaxis of thrombocytopenia in solid tumor patients receiving chemotherapy. |
12784347 |
Human |
il-11 |
plasmacytoma |
IL-11 was originally identified in a medium conditioned by the macaque bone marrow-derived stromal cell line PU-34 and cloned as a growth factor for the IL-6-dependent plasmacytoma cell line T1165. |
1307488 |
Human |
interleukin-11 |
hepatoma |
Treatment of rat hepatoma H-35 cells with purified human recombinant interleukin-11 (IL-11) resulted in the stimulated production of several major acute phase plasma proteins. |
1718962 |
Rat |
il-11 |
hepatoma |
Treatment of rat hepatoma H-35 cells with purified human recombinant interleukin-11 (IL-11) resulted in the stimulated production of several major acute phase plasma proteins. |
1718962 |
Rat |
il-11 |
human hepatoma |
Comparison of rat and human hepatoma cells indicated that the IL-11 response did not correlate with that of IL-6 or LIF, suggesting that the action of IL-11 was mediated by an IL-11-specific receptor system. |
1718962 |
Rat |
il-11 |
aml |
The growth enhancement of IL-11 among the AML patient samples was dose dependent and remarkably constant with half-efficient concentrations in the range of 0.3 to 0.4 ng/mL. |
8453105 |
Human |
il-11 |
aml |
Detailed analysis with several patient samples further revealed that SF and IL-11 both enhance IL-3-supported clonogenic growth of AML blasts and the combination of all three growth factors yields optimal growth. |
8453105 |
Human |
il-11 |
human osteosarcoma |
To test this hypothesis, we characterized the IL-11 production of unstimulated and stimulated SaOS-2 human osteosarcoma cells. |
7835281 |
Human |
il-11 |
metastatic tumors |
Because IL-6 belongs to the hematopoietic cytokine family, which includes leukemia inhibitory factor (LIF) and interleukin-11 (IL-11), we examined the possibility of coordinate expression of LIF, IL-6, and IL-11 in three human melanoma cell lines derived |
7648448 |
Human |
il-11 |
aml |
For this paper we have studied the constitutive expression of IL-11 mRNA in a panel of wellknown leukaemic cell lines and samples from AML patients at diagnosis. |
8547068 |
Human |
il-11 |
aml |
In eight additional AML cases the number of S-phase leukaemic cells induced by IL-11 was determined by the bromodeoxyuridine (BRDU) incorporation assay after 3d of liquid culture. |
8547068 |
Human |
il-11 |
aml |
When tested on primary AML samples, IL-11 alone showed little, if any, proliferative activity. |
8547068 |
Human |
il-11 |
aml |
The BRDU studies showed the significant increase of AML cells in S-phase when IL-11 was combined with SCF, whereas the two CSF had no activity on their own. |
8547068 |
Human |
il-11 |
aml |
Reverse transcriptase-polymerase chain reaction amplification (RT-PCR) demonstrated the constitutive expression of IL-11 mRNA in all the cell lines and 11/12 AML samples studied at diagnosis. |
8547068 |
Human |
il-11 |
metastatic tumor |
Our results indicate that metastatic tumor cells induce osteolysis by activating TGF-beta, which leads IL-11 production from osteoblasts to promote bone resorption. |
9139879 |
Human |
il-11 |
cancer |
[Cytokine in cancer chemotherapy--clinical trials of IL-3, IL-11 and thrombopoietin against thrombocytopenia] Clinical trials of IL-3, IL-11 and thrombopoietin (TPO) against chemotherapy-induced thrombocytopenia were reviewed. |
9474925 |
Human |
il-11 |
ibd |
Clinical trials of the newer entities IL-10, IL-11, tacrolimus, and anti-TNFalpha, have demonstrated variable efficacy in refractory IBD patients. |
10029372 |
Human |
il-11 |
ibd |
Other exciting new methods to treat IBD could be use of monoclonal antibodies to effector T cell molecules (such as CD4 or CD44v7) removal of such cytokine secreting cells (apheresis), antibodies to proinflammatory cytokines (such as TNF-alpha, IFN-alpha, |
10695414 |
Human |
il-11 |
myeloproliferative disorders |
Although these reports included patients with various malignancies, studies of IL-11 in patients with myeloproliferative disorders have not been presented. |
10720151 |
Human |
il-11 |
aml |
Given the potential for adversely affecting patients with these disorders, the affects of IL-11 or TPO in patients with AML must continue to be carefully studied. |
10720151 |
Human |
il-11 |
aml |
Conversely, effects of IL-11 on AML cells demonstrated that cell cycle changes (recruitment from G0 to S phase) were promoted only in a minority of samples (2/14) and there was little, if any, effect on CFU-L growth (mean colony number=17.5 +/- 9.5) or Ap |
11426619 |
Human |
il-11 |
crohn's disease |
Preliminary results have shown that antisense oligonucleotides (anti-ICAM), anti-cytokine antibodies (anti-TNF) or recombinant human cytokines (IL-10 or IL-11) are effective in some patients with Crohn's disease refractory to steroids. |
10210767 |
Human |
il-11 |
pel |
PEL cell lines did not respond proliferatively to IL-6, IL-10, IL-11, LIF, MIP-1alpha, or OSM. |
10214873 |
Human |
il-11 |
aml |
Combination of both TPO and IL-11 is rarely synergistic in stimulating AML clonogenic growth. |
10428502 |
Human |
il-11 |
human osteosarcoma |
Epinephrine increased gene- and protein-expression of interleukin-6 (IL-6) and interleukin-11 (IL-11), which are capable of stimulating the development of osteoclasts from their hematopoietic precursors, in human osteoblast (SaM-1) and human osteosarcoma |
11172736 |
Human |
il-11 |
crohn's disease |
Other novel agents, including anti-alpha4 integrin antibodies, interleukin (IL)-10 and IL-11, and the immunomodulators tacrolimus and mycophenolate mofetil have been evaluated as treatment in patients with severely active or fistulizing Crohn's disea |
11380043 |
Human |
il-11 |
necrosis |
In experiment 1, IL-11 significantly reduced proteinuria (13.2 +/- 3.3 versus 63.2 +/- 4.3 mg/24 h), fibrinoid necrosis (0.58 +/- 0.08 versus 1.52 +/- 0.06 quadrants/glomerular cross section [gcs]), macrophage infiltration (ED1-positive cells, 24.4 +/- 1. |
11675407 |
Human |
il-11 |
necrosis |
In experiment 2, a lower dose of IL-11 significantly reduced proteinuria and fibrinoid necrosis. |
11675407 |
Human |
il-11 |
necrosis |
In this model of necrotizing glomerulonephritis, high-dose IL-11 treatment markedly reduced both proteinuria and fibrinoid necrosis. |
11675407 |
Human |
il-11 |
ibd |
Among other antiinflammatory peptides and proteins, monoclonal antibodies directed against TNFalpha and adhesion molecule alpha4beta7 integrin, recombinant anti-inflammatory cytokines IL-10 and IL-11, as well as colony-stimulating factors and peptide grow |
11890353 |
Human |
il-11 |
aml |
Thus, there is little evidence to suggest that GO with or without IL-11 should be used instead of IA in older patients with newly diagnosed AML or myelodysplastic syndrome. |
12036860 |
Human |
il-11 |
necrosis |
These data indicate that following IR injury, IL-11 improves enterocyte survival by reducing necrosis and apoptosis. |
12505051 |
Human |
il-11 |
crohn's disease |
The clinical utility of IL-11 is being investigated in Crohn's disease. |
12760902 |
Human |
il-11 |
ibd |
A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). |
14701802 |
Human |
il-11 |
ibd |
Despite the fact that the clinical usefulness of the anti-inflammatory effects of this cytokine is presently investigated in patients with IBD, there are no data available regarding the target cells of IL-11 action and the mechanisms of tissue protection |
14701802 |
Human |
il-11 |
myeloma |
Consistently, RANKL did not have a direct effect on myeloma cell survival, but RANKL treatment induced a significant increase of interleukin (IL)-6 and IL-11 secretion by both BMSC and endothelial cells. |
15377473 |
Human |
il-11 |
myeloma |
Moreover, in a co-culture system we found that myeloma cells up-regulated both IL-6 and IL-11 secretion by BMSC and endothelial cells through cell-to-cell contact. |
15377473 |
Human |
il-11 |
necrosis |
Hyperoxic acute lung injury (HALI) is characterized by a cell death response with features of apoptosis and necrosis that is inhibited by IL-11 and other interventions. |
15841185 |
Human |
il-11 |
myelodysplastic syndrome |
An adaptive randomized phase III study of the addition of IL-11 to idarubicin and cytarabine (IA) induction in 100 patients >/=50 years of age with AML or high-risk myelodysplastic syndrome (MDS) was conducted. |
15863204 |
Human |
il-11 |
aml |
An adaptive randomized phase III study of the addition of IL-11 to idarubicin and cytarabine (IA) induction in 100 patients >/=50 years of age with AML or high-risk myelodysplastic syndrome (MDS) was conducted. |
15863204 |
Human |
il-11 |
aml |
There was no significant impact on CR rates, TTF, survival, or toxicity of adding an IL-11 regimen to IA induction in patients >/=50 years of age with AML. |
15863204 |
Human |
il-11 |
inflammatory bowel disease |
Interleukin-11 (IL-11) is a pleiotropic cytokine that exhibits anti-inflammatory and mucosal protective effects in a variety of animal models of acute and chronic inflammation, such as mucositis, inflammatory bowel disease and autoimmune joint disease. |
15992047 |
Human |
il-11 |
cancer |
Elevated levels of IL-6 and IL-11 are associated with multiple myeloma, rheumatoid arthritis, hypercalcemia, cancer cachexia, and Castleman's disease. |
16086584 |
Human |
il-11 |
multiple myeloma |
Elevated levels of IL-6 and IL-11 are associated with multiple myeloma, rheumatoid arthritis, hypercalcemia, cancer cachexia, and Castleman's disease. |
16086584 |
Human |
il-11 |
castleman's disease |
Elevated levels of IL-6 and IL-11 are associated with multiple myeloma, rheumatoid arthritis, hypercalcemia, cancer cachexia, and Castleman's disease. |
16086584 |
Human |
il-11 |
prostate cancer |
To clarify whether serum levels of interleukin-11 (IL-11) could be a useful marker in patients with prostate cancer, serum IL-11 was determined in 73 and 23 men with prostate cancer and benign prostate hyperplasia (BPH), respectively, before treatment. |
16132763 |
Human |
il-11 |
prostate cancer |
There were no statistical differences of IL-11 levels between patients with prostate cancer and BPH. |
16132763 |
Human |
il-11 |
bph |
There were no statistical differences of IL-11 levels between patients with prostate cancer and BPH. |
16132763 |
Human |
il-11 |
hormone-resistant prostate cancer |
Patients with hormone-resistant prostate cancer had a significantly higher level of IL-11 than those with untreated cancer. |
16132763 |
Human |
il-11 |
cancer |
Patients with hormone-resistant prostate cancer had a significantly higher level of IL-11 than those with untreated cancer. |
16132763 |
Human |
il-11 |
prostate cancer |
Serum IL-11 levels may be a potential tumor marker for prostate cancer progression. |
16132763 |
Human |
il-11 |
tumor |
Serum IL-11 levels may be a potential tumor marker for prostate cancer progression. |
16132763 |
Human |
il-11 |
tumor |
Methods: To evaluate the role of IL-6 and IL-11 as ligands regulating tumor growth and submucosal invasion, we compared tumor characteristics of gp130(757F/F) mice with gp130(757F/F) mice lacking IL-6 or mature T and B cells. |
16143138 |
Human |
il-11 |
tumors |
Results: As a result of the gp130(757F/F) mutation, expression of IL-6 and IL-11 was greatly up-regulated concomitant with activation of STAT3 and development of tumors. |
16143138 |
Human |
il-11 |
tumor |
While IL-6 did not regulate tumor growth or tumor vascularization, gp130(757F/F)/IL-6(-/-) mice showed approximately 10-20-fold more submucosal tumor invasion, reduced mononuclear inflammatory cell infiltrate, and greater IL-11 and matrix metalloproteinas |
16143138 |
Mouse |
il-11 |
lower gingival squamous cell carcinoma |
Our results suggest that various cancer-derived cytokines, such as PTHrP, TNF-alpha, IL-6 and IL-11, play an important role in the mechanism of bone invasion associated with lower gingival squamous cell carcinoma. |
15982855 |
Human |
il11 |
ibd |
The IL11 gene is therefore a good candidate involved in genetic predisposition to IBD. |
12486609 |
Human |
il11 |
ibd |
To evaluate the role of the IL11 gene in IBD, two polymorphisms, including a dinucleotide repeat in the promoter region, have been genotyped in 222 patients with CD, 152 patients with ulcerative colitis (UC) and 400 healthy controls. |
12486609 |
Human |
interleukin-11 |
human osteosarcoma |
Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. |
7835281 |
Human |
interleukin-11 |
metastatic tumors |
Because IL-6 belongs to the hematopoietic cytokine family, which includes leukemia inhibitory factor (LIF) and interleukin-11 (IL-11), we examined the possibility of coordinate expression of LIF, IL-6, and IL-11 in three human melanoma cell lines derived |
7648448 |
Human |
interleukin-11 |
necrosis |
Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis. |
9124575 |
Mouse |
interleukin-11 |
human osteosarcoma |
Epinephrine increased gene- and protein-expression of interleukin-6 (IL-6) and interleukin-11 (IL-11), which are capable of stimulating the development of osteoclasts from their hematopoietic precursors, in human osteoblast (SaM-1) and human osteosarcoma |
11172736 |
Human |
interleukin-11 |
ibd |
A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). |
14701802 |
Human |
interleukin-11 |
acute megakaryocytic leukemia |
Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. |
15307108 |
Human |
interleukin-11 |
myeloma |
The RANK/RANK ligand system is involved in interleukin-6 and interleukin-11 up-regulation by human myeloma cells in the bone marrow microenvironment. |
15377473 |
Human |
interleukin-11 |
myeloma |
EXPERIMENTAL DESIGN: Four biological sequels of HGF related to multiple myeloma were studied: (1) proliferation of myeloma cells, (2) secretion of interleukin-11 from osteogenic cells, (3) migration of myeloma cells, and (4) adhesion of myeloma cells to f |
15475459 |
Human |
interleukin-11 |
multiple myeloma |
EXPERIMENTAL DESIGN: Four biological sequels of HGF related to multiple myeloma were studied: (1) proliferation of myeloma cells, (2) secretion of interleukin-11 from osteogenic cells, (3) migration of myeloma cells, and (4) adhesion of myeloma cells to f |
15475459 |
Human |
interleukin-11 |
myeloma |
Interleukin-11, a cytokine with multiple biological activities, has been shown to stimulate the proliferation and to support the long-term growth of human myeloma cell lines. |
15512823 |
Human |
interleukin-11 |
acute myeloid leukemia |
Adaptive randomized study of idarubicin and cytarabine alone or with interleukin-11 as induction therapy in patients aged 50 or above with acute myeloid leukemia or high-risk myelodysplastic syndromes. |
15863204 |
Human |
interleukin-11 |
myelodysplastic syndromes |
Adaptive randomized study of idarubicin and cytarabine alone or with interleukin-11 as induction therapy in patients aged 50 or above with acute myeloid leukemia or high-risk myelodysplastic syndromes. |
15863204 |
Human |
interleukin-11 |
inflammatory bowel disease |
Interleukin-11 (IL-11) is a pleiotropic cytokine that exhibits anti-inflammatory and mucosal protective effects in a variety of animal models of acute and chronic inflammation, such as mucositis, inflammatory bowel disease and autoimmune joint disease. |
15992047 |
Human |
interleukin-11 |
prostate cancer |
Serum interleukin-11 in patients with benign prostatic hyperplasia and prostate cancer. |
16132763 |
Human |
interleukin-11 |
benign prostatic hyperplasia |
Serum interleukin-11 in patients with benign prostatic hyperplasia and prostate cancer. |
16132763 |
Human |
interleukin-11 |
prostate cancer |
To clarify whether serum levels of interleukin-11 (IL-11) could be a useful marker in patients with prostate cancer, serum IL-11 was determined in 73 and 23 men with prostate cancer and benign prostate hyperplasia (BPH), respectively, before treatment. |
16132763 |
Human |
oprelvekin |
follicular lymphoma |
METHODS: A 38-year-old man with a history of relapsed non-Hodgkins follicular lymphoma complained of bilateral loss of vision following oprelvekin therapy for thrombocytopenia. |
15734010 |
Human |
interleukin 11 |
ibd |
Information from these and other preclinical animal models, such as those involving interleukin 11, has led to human trials testing novel therapies for IBD and other diseases in which inflammation of the gut mucosa is an important component. |
11694562 |
Human |
il-11 |
leukaemia |
The same applies to IL-1, TNF, IL-11, the leukaemia inhibitory factor (LIF) or the transforming growth factor beta (TGF beta). |
8341924 |
Human |
il-11 |
acute myeloblastic leukemia (aml) |
Analysis of a panel of samples from different patients with acute myeloblastic leukemia (AML) and myeloid leukemic cell lines indicated that IL-11 alone was ineffective in supporting myeloid leukemic cell growth but frequently enhanced growth supported by |
8453105 |
Human |
il-11 |
plasmacytoma |
It has been shown that IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, enhances antigen-specific antibody responses, synergizes with IL-3 in supporting megakaryocyte colony formation, acts synergistically with IL-3 in short |
1292471 |
Human |
il-11 |
plasmacytoma |
IL-11 was originally identified in a medium conditioned by the macaque bone marrow-derived stromal cell line PU-34 and cloned as a growth factor for the IL-6-dependent plasmacytoma cell line T1165. |
1307488 |
Human |
il-11 |
plasmacytoma |
Preliminary biological characterization indicates that in addition to stimulating plasmacytoma proliferation, IL-11 stimulates the T-cell-dependent development of immunoglobulin-producing B cells and synergizes with IL-3 in supporting murine megakaryocyte |
2145578 |
Mouse |
il-11 |
metastases |
To determine if the reduced bone metastases observed in mice bearing 1205Lu-Smad7 clones was due to reduced expression of TGF-beta target genes known to enhance metastases to bone from breast cancer cells, we analyzed gene expression of osteolytic factors |
17332363 |
Human |
il-11 |
bone metastases |
To determine if the reduced bone metastases observed in mice bearing 1205Lu-Smad7 clones was due to reduced expression of TGF-beta target genes known to enhance metastases to bone from breast cancer cells, we analyzed gene expression of osteolytic factors |
17332363 |
Human |
il-11 |
breast cancer |
To determine if the reduced bone metastases observed in mice bearing 1205Lu-Smad7 clones was due to reduced expression of TGF-beta target genes known to enhance metastases to bone from breast cancer cells, we analyzed gene expression of osteolytic factors |
17332363 |
Human |
il-11 |
bone metastases |
In addition, 1205Lu-Smad7 bone metastases expressed significantly lower levels of IL-11, connective tissue growth factor, and PTHrP. |
17332363 |
Human |
il-11 |
human gastric carcinoma |
Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. |
17332920 |
Human |
il-11 |
tumor |
Previous investigations have shown that interleukin-11 (IL-11) and the IL-11 receptor (IL-11R) have been correlated with the regulation of tumor progression, cellular growth and differentiation in several malignant tumors. |
17332920 |
Human |
il-11 |
malignant tumors |
Previous investigations have shown that interleukin-11 (IL-11) and the IL-11 receptor (IL-11R) have been correlated with the regulation of tumor progression, cellular growth and differentiation in several malignant tumors. |
17332920 |
Human |
il-11 |
human gastric carcinoma |
The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric carcinoma. |
17332920 |
Human |
il-11 |
gastric adenocarcinomas |
IL-11 and IL-11Ralpha were studied in 73 cases of surgically resected human gastric adenocarcinomas by immunohistochemistry. |
17332920 |
Human |
il-11 |
adenocarcinoma |
Among the 73 cases of adenocarcinoma, 53 (72.6%) and 47 cases (64.4%) showed positive staining in carcinoma cells for the IL-11 and IL-11Ralpha proteins, respectively. |
17332920 |
Human |
il-11 |
carcinoma |
Among the 73 cases of adenocarcinoma, 53 (72.6%) and 47 cases (64.4%) showed positive staining in carcinoma cells for the IL-11 and IL-11Ralpha proteins, respectively. |
17332920 |
Human |
il-11 |
gastric carcinoma |
All of the four gastric carcinoma cell lines expressed both IL-11 and IL-11Ralpha proteins in western blot analysis. |
17332920 |
Human |
il-11 |
sch |
Recombinant human IL-11 (rhIL-11) promoted the migration of SCH cells by the activation of the phosphatidylinositol-3 kinase pathway. |
17332920 |
Human |
il-11 |
human gastric carcinomas |
These findings suggest that the IL-11/IL-11R pathway plays an important role in the progression and the differentiation of human gastric carcinomas. |
17332920 |
Human |
il-11 |
two acute t lymphocytic leukemia (t-all) |
In contrast, three acute pre-B lymphocytic leukemia (pre-B-ALL) and two acute T lymphocytic leukemia (T-ALL) lines failed to respond to IL-11 alone or when combined with other cytokines. |
8453105 |
Human |
interleukin-11 |
leukaemia |
It is now clear that there is a complex interaction between the cytokines with interleukin-6 predominant, but also involving interleukin-1, tumor necrosis factor and a group of recently described cytokines including as well interleukin-11, leukaemia inhib |
8539481 |
Human |
interleukin-11 |
plasmacytoma |
We have recently found that the inhibitor of plasmacytoma cell growth, restrictin-P, is a stroma derived activin A and that it is an antagonist of interleukin-6 and interleukin-11. |
8930019 |
Human |
interleukin-11 |
essential thrombocythemia (et) |
In an attempt to evaluate the role of TPO in the pathobiology of essential thrombocythemia (ET), we have examined levels of TPO and other cytokines with thrombopoietic activity (interleukin-6 and interleukin-11) in sera obtained from 25 patients with ET ( |
9858146 |
Human |
interleukin-11 |
multiple myeloma (mm) |
We investigated the serum concentration of interleukin-6 (IL-6) and four IL-6 family cytokines - oncostatin M (OSM), leukaemia inhibitory factor (LIF), interleukin-11 (IL-11) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) |
10233412 |
Human |
interleukin-11 |
osteosarcoma |
Finally, using a sensitive HGF bioassay (interleukin-11 production from the osteosarcoma cell line Saos-2) and intact syndecan-1 isolated from the U-266 myeloma cell line, we found that the presence of high concentrations of syndecan-1 (more than 3 microg |
11049995 |
Human |
interleukin-11 |
acute myeloid leukemia (aml) |
In this study we report our data on effects of early-acting megakaryocyte growth factors, particularly the c-mpl ligand also known as thrombopoietin (TPO) and interleukin-11 (IL-11), on cell proliferation and apoptosis (Apo) of primary acute myeloid leuke |
11426619 |
Human |
interleukin-11 |
crohn's disease |
In clinical trials other anti-TNF-alpha-effective substances (CDP 571, etanercept, thalidomide), interleukin-10, interleukin-11, ICAM-1-antisense-oligonucleotides and antibodies against alpha 4-integrin were evaluated for the treatment of Crohn's dis |
12078390 |
Human |
interleukin-11 |
cml |
We report on the use of interleukin-11 in three CML patients with grade > or =3, imatinib-induced thrombocytopenia. |
15120938 |
Human |
interleukin-11 |
acute myeloid leukemia (aml) |
A higher complete remission (CR) rate was observed in patients with acute myeloid leukemia (AML) who, on a prior randomized study of induction therapy, received gemtuzumab ozogamicin (GO) plus interleukin-11 (IL-11) rather than GO alone. |
15863204 |
Human |
interleukin-11 |
leukaemia |
Of known importance are members of the gp130 family such as interleukin-11 (IL-11) and leukaemia inhibitory factor (LIF), the transforming growth factor beta (TGFbeta) superfamily including the activins, the colony-stimulating factors (CSF), the IL-1 syst |
16006437 |
Human |
interleukin-11 |
inflammatory bowel diseases |
BACKGROUND: Interleukin-11 (IL-11) has been evaluated as an anti-inflammatory and mucosa-protective therapeutic agent in inflammatory bowel diseases (IBDs). |
16292518 |
Human |
il-11 |
plasmacytoma |
IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors. |
7532057 |
Human |
il-11 |
plasmacytoma |
IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors. |
7532057 |
Human |
il-11 |
multiple myeloma (mm) |
In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL-6 autocrine human myeloma cell lines, LP1, OPM2 and L363, have been treated with dexamethasone in the presence or absence of cytokines belongi |
7647014 |
Human |
il-11 |
plasmacytoma |
These stimulatory effects were dose and time dependent, and the IL-11 that was produced was bioactive, as demonstrated by its ability to stimulate the proliferation of T10D plasmacytoma cells. |
7835281 |
Human |
il-11 |
cml |
IL-11 in combination with IL-3 and GM-CSF markedly increased CFU-C colony growth pre- and post-ARA-C or Eilatin incubation from CML and normal individual bone marrow (BM) cells. |
8947585 |
Human |
il-11 |
cml |
A decrease in BCR/ABL fusion product was observed (by FISH analysis) after incubation of BM cells from CML patients in liquid culture for 7 days with 10(-9) M ARA-C or 10(-7) M Eilatin in the presence of IL-11 alone or in combination with other cytokines. |
8947585 |
Human |
il-11 |
cml |
These results indicate that following cytoreductive therapy IL-11 may enhance to a greater extent the growth of normal myeloid progenitors than the malignant clone and may, therefore, be of clinical importance for CML patients treated with chemotherapeuti |
8947585 |
Human |
il-11 |
renal cell carcinomas |
Renal cell carcinomas produce IL-6, IL-10, IL-11, and TGF-beta 1 in primary cultures and modulate T lymphocyte blast transformation. |
9058315 |
Human |
il-11 |
cml |
However, clonogenic assays using recombinant human CSFs demonstrated a remarkable proliferation of CML cells when stimulated by SCF, IL-11 and IL-3, used as single factors in the presence of erythropoietin (EPO) and was almost entirely due to erythroid pr |
9576192 |
Human |
il-11 |
tumors |
The production of the assayed cytokines IL-6, IL-10, IL-11, and TGF beta 1 was variable and there was no significant correlation to the immunomodulatory capacity of the tumors. |
9646428 |
Human |
il-11 |
tumor |
The IL-6-related cytokines [IL-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor, ciliary neurotrophic factor, and cardiotrophin] often modulate tumor phenotype and control the proliferation of many tumor cell lines. |
9815830 |
Human |
il-11 |
renal cell carcinoma (rcc) |
In order to understand the ability of normal human kidney, benign renal angiomyolipoma and malignant renal cell carcinoma (RCC) cells to produce cytokines, we determined the IL-1-beta, IL-6, IL-10, IL-11, TNF-alpha and TGF-beta-1 concentration in the supe |
9891467 |
Human |
il-11 |
acute promyelocytic leukaemia (apl) |
Endogenous serum thrombopoietin (TPO) and various cytokines including erythropoietin (EPO), interleukin (IL)-3, IL-6, IL-11, granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage-colony stimulating factor (GM-CSF) and stem cell factor (SCF |
10233408 |
Human |
il-11 |
multiple myeloma (mm) |
We investigated the serum concentration of interleukin-6 (IL-6) and four IL-6 family cytokines - oncostatin M (OSM), leukaemia inhibitory factor (LIF), interleukin-11 (IL-11) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) |
10233412 |
Human |
il-11 |
acute myeloid leukemia (aml) |
Because some of these growth factors, especially TPO and IL-11, are now being evaluated clinically to reduce chemotherapy-associated thrombocytopenia in cancer patients, we evaluated 25 acute myeloid leukemia (AML) samples to test whether TPO, IL-11, and |
10428502 |
Human |
il-11 |
osteosarcoma |
We now report that HGF induces IL-11 secretion from human osteoblast-like cells and from the osteosarcoma cell lines Saos-2 and HOS. |
10572104 |
Human |
il-11 |
ibd |
Based on recent advances in our understanding of the pathogenesis of IBD, several new therapeutic strategies are currently being tested in clinical practice, including recombinant anti-inflammatory cytokines (IFN-alpha, IL-10, IL-11) and inhibitors of cel |
10662999 |
Human |
il-11 |
multiple myeloma (mm) |
We investigated the serum concentration of the interleukin-10 (IL-10), along with cytokines of interleukin-6 (IL-6) family (IL-6, IL-11 and oncostatin M - OSM), as well as soluble receptor for IL-6 (sIL-6R), in 121 patients with multiple myeloma (MM) and |
11022130 |
Human |
il-11 |
acute myeloid leukemia (aml) |
In this study we report our data on effects of early-acting megakaryocyte growth factors, particularly the c-mpl ligand also known as thrombopoietin (TPO) and interleukin-11 (IL-11), on cell proliferation and apoptosis (Apo) of primary acute myeloid leuke |
11426619 |
Human |
il-11 |
plasmacytoma |
IL-11 was discovered as a soluble factor in fibroblast supernatants that stimulated the proliferation of "IL-6-dependent" plasmacytoma cells. |
11590369 |
Human |
il-11 |
b-chronic lymphocytic leukemia (b-cll) |
In the present study using reverse-transcriptase polymerase chain reaction (RT-PCR), FACS analysis and immunofluorescence we have shown the constitutive expression of IL-11 and IL-11R alpha in B-chronic lymphocytic leukemia (B-CLL). |
11699207 |
Human |
il-11 |
idiopathic pulmonary fibrosis (ipf) |
Because interleukin (IL)-6 and IL-11 may alter repair and remodeling processes, we hypothesized that they may play a role in idiopathic pulmonary fibrosis (IPF). |
12714376 |
Human |
il-11 |
acute leukemia |
Preclinical and clinical studies have demonstrated that IL-11 effectively accelerates the recovery of peripheral blood platelets of acute leukemia patients after chemotherapy. |
15498143 |
Human |
il-11 |
mds |
Nine patients (27%) responded to IL-11 (six MDS, three AA). |
15598951 |
Human |
il-11 |
acute myeloid leukemia (aml) |
A higher complete remission (CR) rate was observed in patients with acute myeloid leukemia (AML) who, on a prior randomized study of induction therapy, received gemtuzumab ozogamicin (GO) plus interleukin-11 (IL-11) rather than GO alone. |
15863204 |
Human |
il-11 |
mds |
An adaptive randomized phase III study of the addition of IL-11 to idarubicin and cytarabine (IA) induction in 100 patients >/=50 years of age with AML or high-risk myelodysplastic syndrome (MDS) was conducted. |
15863204 |
Human |
il-11 |
leukaemia |
Of known importance are members of the gp130 family such as interleukin-11 (IL-11) and leukaemia inhibitory factor (LIF), the transforming growth factor beta (TGFbeta) superfamily including the activins, the colony-stimulating factors (CSF), the IL-1 syst |
16006437 |
Human |
il-11 |
inflammatory bowel diseases |
BACKGROUND: Interleukin-11 (IL-11) has been evaluated as an anti-inflammatory and mucosa-protective therapeutic agent in inflammatory bowel diseases (IBDs). |
16292518 |
Human |
il-11 |
colorectal carcinoma |
Because of reduced binding and signal transduction, it is unlikely that therapeutically administered IL-11 would contribute to colorectal carcinoma induction and growth. |
16292518 |
Human |
il-11 |
colorectal adenocarcinoma |
Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. |
16964382 |
Human |
il-11 |
human colorectal carcinoma |
Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. |
16964382 |
Human |
il-11 |
tumor |
Previous investigations have shown that interleukin (IL)-11/IL-11 receptor alpha-chain (IL-11Ralpha), a member of the PI3K, MAPK and JAK-STAT activating family of cytokines/receptors, correlates with the regulation of tumor progression. |
16964382 |
Human |
il-11 |
colorectal adenocarcinoma (crc) |
In this study, we established the IL-11/IL-11Ralpha expression profile in human colorectal adenocarcinoma (CRC) and clarified its signaling pathway and role in the invasion activity of CRC cell lines. |
16964382 |
Human |
il-11 |
colorectal adenoma |
To elucidate the role of IL-11/IL-11Ralpha, we examined 103 cases of CRC and 24 cases of colorectal adenoma by immunohistochemistry. |
16964382 |
Human |
interleukin 11 |
plasmacytoma |
The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11. |
7494003 |
Human |
interleukin 11 |
crohn's disease |
Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease. |
10381910 |
Human |
il-11 |
tumor-induced osteolysis |
Two features were studied: the proliferation of BCC and their production of the osteolytic cytokines interleukins-6 (IL-6) and -11 (IL-11) since BCC frequently metastasize to bone and induce tumor-induced osteolysis. |
10652584 |
Human |
il-11 |
primary ovarian carcinomas |
OBJECTIVES: The objectives of this study were to determine (1) the frequency of expression of the interleukin-11 receptor alpha subunit (IL-11Ralpha) and its signal transducing subunit, gp130, among primary ovarian carcinomas; (2) the frequency of express |
11161848 |
Human |
il-11 |
primary ovarian carcinomas |
METHODS: An immunohistochemical assay was used to determine the expression of IL-11Ralpha and the gp130 cofactor among primary ovarian carcinomas; the expression of IL-11 in ovarian malignancies was determined using reverse transcription polymerase chain |
11161848 |
Human |
il-11 |
acute lymphocyte leukemia |
IL-11 could be safely used in the HDMTX treatment of childhood acute lymphocyte leukemia. |
15730719 |
Human |
interleukin-11 |
benign prostate hyperplasia (bph) |
To clarify whether serum levels of interleukin-11 (IL-11) could be a useful marker in patients with prostate cancer, serum IL-11 was determined in 73 and 23 men with prostate cancer and benign prostate hyperplasia (BPH), respectively, before treatment. |
16132763 |
Human |
interleukin-11 |
breast cancer metastasis |
Interleukin-11 (IL-11), a potent mediator of osteoclastogenesis, is involved in breast cancer metastasis to bone. |
16457848 |
Human |
interleukin-11 |
colorectal adenocarcinoma |
Expression of Interleukin-11 and Interleukin-11 receptor alpha in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors. |
16482637 |
Human |
interleukin-11 |
tumor |
AIM: There is strong evidence that interleukin-11 (IL-11) is involved in the regulation of tumor progression, cellular growth and differentiation. |
16482637 |
Human |
interleukin-11 |
inflammatory bowel disease |
BACKGROUND: Interleukin-11 has shown benefit in animal inflammatory bowel disease models. |
16635225 |
Mouse |
il-11 |
tumor |
The results showed that MEP increased the mRNA levels of metabolic enzymes CYP1A1 and CYP1B1, proinflammatory cytokines interleukin (IL)-1alpha, IL-6, and IL-11, fibroblast growth factor (FGF)-6 and FGF-9, vascular endothelial growth factor (VEGF)-D, onco |
16002475 |
Human |
il-11 |
tumor |
Tumor tissues overexpressed IL-1beta, IL-6, IL-8, IL-10, IL-11, IL-12 p40, IL-18, IFN-gamma, TGF-beta1, TGF-beta2 and TGF-beta3 at the mRNA level and IL-1beta, IL-18, TGF-beta2 and TGF-beta3 also at the protein level. |
16094523 |
Human |
il-11 |
benign prostate hyperplasia (bph) |
To clarify whether serum levels of interleukin-11 (IL-11) could be a useful marker in patients with prostate cancer, serum IL-11 was determined in 73 and 23 men with prostate cancer and benign prostate hyperplasia (BPH), respectively, before treatment. |
16132763 |
Human |
il-11 |
bone metastases |
Genetic depletion experiments further demonstrate that Smad4 contributes to the formation of osteolytic bone metastases and is essential for the induction of IL-11, a gene implicated in bone metastasis in this mouse model system. |
16172383 |
Human |
il-11 |
bone metastasis |
Genetic depletion experiments further demonstrate that Smad4 contributes to the formation of osteolytic bone metastases and is essential for the induction of IL-11, a gene implicated in bone metastasis in this mouse model system. |
16172383 |
Human |
il-11 |
osteosarcoma |
Human osteoblast-like cells from osteosarcoma cell line MG 63 were grown in wells in the presence of titanium (Ti), titanium alloy (Ti6A14V) and stainless steel implant materials incubated at 37 degrees C. Interleukin-1alpha (IL-1alpha), IL-6, IL-8, IL-11 |
16312193 |
Human |
il-11 |
human breast cancer |
COX-2 Induces IL-11 Production in Human Breast Cancer Cells. |
16457848 |
Human |
il-11 |
breast cancer metastasis |
Interleukin-11 (IL-11), a potent mediator of osteoclastogenesis, is involved in breast cancer metastasis to bone. |
16457848 |
Human |
il-11 |
breast cancers |
Since breast cancers that overexpress COX-2 are associated with a higher rate of metastasis to bone, we hypothesized that COX-2 expression in tumor cells would induce IL-11. |
16457848 |
Human |
il-11 |
metastasis |
Since breast cancers that overexpress COX-2 are associated with a higher rate of metastasis to bone, we hypothesized that COX-2 expression in tumor cells would induce IL-11. |
16457848 |
Human |
il-11 |
tumor |
Since breast cancers that overexpress COX-2 are associated with a higher rate of metastasis to bone, we hypothesized that COX-2 expression in tumor cells would induce IL-11. |
16457848 |
Human |
il-11 |
breast cancer |
We also used a nude mouse model to study COX-2 and IL-11 production from breast cancer cells that metastasized to bone. |
16457848 |
Mouse |
il-11 |
bone metastasis |
MDA-435S-COX2-BSC (cells isolated from bone metastasis) produced elevated levels of IL-11 and PGE2 (an important mediator of COX-2) as compared to the parental MDA-435S-COX2 cells. |
16457848 |
Human |
il-11 |
bone metastases |
CONCLUSION: COX-2-mediated production of IL-11 in breast cancer cells may be vital to the development of osteolytic bone metastases in patients with breast cancer, and a COX-2 inhibitor may be useful in inhibiting this process. |
16457848 |
Human |
il-11 |
breast cancer |
CONCLUSION: COX-2-mediated production of IL-11 in breast cancer cells may be vital to the development of osteolytic bone metastases in patients with breast cancer, and a COX-2 inhibitor may be useful in inhibiting this process. |
16457848 |
Human |
il-11 |
tumor |
AIM: There is strong evidence that interleukin-11 (IL-11) is involved in the regulation of tumor progression, cellular growth and differentiation. |
16482637 |
Human |
il-11 |
primary breast cancer |
We examined the expression of IL-11 and its receptor in primary breast cancer tissue samples and correlated their level of expression with the clinical outcome. |
16614887 |
Human |
il-11 |
tumors |
Tumors with a poor prognostic index and poor histological grade showed a higher level of IL-11. |
16614887 |
Human |
il-11 |
human breast cancer |
CONCLUSIONS: IL-11 can be a predictor of poor prognosis in human breast cancer. |
16614887 |
Human |
interleukin 11 |
acute myeloid leukemia (aml) |
Phase II trial of subcutaneous recombinant human interleukin 11 with subcutaneous recombinant human granulocyte-macrophage colony stimulating factor in patients with acute myeloid leukemia (AML) receiving high-dose cytarabine during induction: ECOG 3997. |
16413056 |
Human |
interleukin 11 |
metastasis |
Communication of MDA-MB-231 cells with the bone microenvironment, which is needed for optimal tumor cell growth and metastasis, may be affected in Smad4 knockdown cells as TGF-beta-induced expression of interleukin 11 was attenuated on Smad4 knockdown. |
16489022 |
Human |
interleukin 11 |
tumor |
Communication of MDA-MB-231 cells with the bone microenvironment, which is needed for optimal tumor cell growth and metastasis, may be affected in Smad4 knockdown cells as TGF-beta-induced expression of interleukin 11 was attenuated on Smad4 knockdown. |
16489022 |
Human |
interleukin 11 |
human breast cancer |
Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer. |
16614887 |
Human |
interleukin-11 |
mds |
Much can be expected from newer cytokines, such as thrombopoietin, stem cell factor, interleukin-11 or of the combination of different cytokines and growth factors, to alleviate MDS-symptoms and to possibly alter the course of the disease. |
8730556 |
Human |
oprelvekin |
solid tumors |
In placebo-controlled trials of patients with solid tumors receiving dose-intensive chemotherapy, 68% of oprelvekin recipients escaped transfusion altogether, compared with only 41% of those who received a placebo. |
10028521 |
Human |
il-11 |
neuroblastoma |
The neuroblastoma cell line SH-SY5Y did not express IL-11 mRNA in response to these agents. |
7501271 |
Human |
il-11 |
leukemia |
It is now recognized that the beta-subunit of the interleukin-6 (IL-6) receptor, also known as gp130, is a common signal transducer shared by other cytokines, including ciliary neurotrophic factor, leukemia inhibitor factor, oncostatin M, and IL-11. |
7615645 |
Human |
il-11 |
leukemia |
IL-11 transcripts also existed in other leukemia cell lines: HL-60, U937, and K562. |
8427997 |
Human |
il-11 |
leukemia |
The cytokines interleukin (IL)-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitor factor (LIF), oncostatin M (OSM) and probably the recently cloned cytokine cardiotrophin-1, signal, in combination with their specific receptors, through the c |
8566040 |
Human |
il-11 |
leukemia |
However, its clinical use in patients with hematological malignancies may be restricted because IL-11 has been reported to stimulate some leukemia and myeloma cells. |
8765427 |
Human |
il-11 |
solid tumors |
In Japan, phase II trials studying the thrombopoietic effect of IL-11 in patients with solid tumors postchemotherapy, in patients undergoing BMT, and in patients with aplastic or refractory anemia are now under way. |
8765427 |
Human |
il-11 |
rcc |
The results clearly show that immunomodulatory capacity is a common feature of RCC and that in vitro these tumors can produce interleukin-10 (IL-10) up to 20 ng/ml, IL-6 up to 35 micrograms/ml (> 250 kU/ml in the B9 system), IL-11 up to 15 micrograms/ml, |
9058315 |
Human |
il-11 |
breast cancer |
Since Il-11 and Il-6 are potent stimulators of osteoclast development and bone is a major source of TGF-beta1, our data suggest that Il-11, together with Il-6, contributes to the high bone destructive capacity of MDA-MB-231 cells and could play a role in |
9619855 |
Human |
interleukin-11 |
cancer |
Interleukin-11 (IL-11) promotes osteoclast formation and inhibits osteoblast activity and may, thus, be one factor involved in cancer-induced bone destruction. |
10572104 |
Human |
interleukin-11 |
osteosarcoma |
Finally, using a sensitive HGF bioassay (interleukin-11 production from the osteosarcoma cell line Saos-2) and intact syndecan-1 isolated from the U-266 myeloma cell line, we found that the presence of high concentrations of syndecan-1 (more than 3 microg |
11049995 |
Human |
interleukin-11 |
leukemia |
[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] OBJECTIVE: To explore the therapeutic effect of interleukin-11 (IL-11) on high-dose methotrexate (HDMTX) induced mucositis in Wistar's rats, the proli |
15730719 |
Rat |
interleukin-11 |
myelodysplastic syndromes |
Use of interleukin-11 to stimulate platelet production in myelodysplastic syndromes. |
17071464 |
Human |
interleukin-11 |
myelodysplastic syndrome |
Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome. |
17071475 |
Human |
oprelvekin |
solid tumor |
Pharmacoeconomic analysis of oprelvekin (recombinant human interleukin-11) for secondary prophylaxis of thrombocytopenia in solid tumor patients receiving chemotherapy. |
12784347 |
Human |
il-11 |
oncogene |
Endothelial cells have been shown to express interleukin-1 (IL-1), IL-5, IL-6, IL-8, IL-11, IL-15, several colony-stimulating factors (CSF), granulocyte-CSF (G-CSF), macrophage CSF (M-CSF) and granulocyte-macrophage CSF (GM-CSF), and the chemokines, monoc |
10090394 |
Human |
il-11 |
leukemia |
All control- and IL-11-treated allogeneic animals effectively rejected their leukemia, but IL-11 also reduced GVHD-related mortality. |
10430613 |
Mouse |
il-11 |
cancer |
Interleukin-11 (IL-11) promotes osteoclast formation and inhibits osteoblast activity and may, thus, be one factor involved in cancer-induced bone destruction. |
10572104 |
Human |
il-11 |
metastasis |
No correlation was observed between the formation of bone metastasis and the expression of other metastasis-related cytokines (IL-1, IL-6, IL-8, IL-10, IL-11, TNF-alpha, VEGF, M-CSF). |
11417746 |
Human |
il-11 |
solid tumors |
We have conducted a pilot study to mobilize PBSC in eight pediatric patients with relapsed solid tumors using ifosfamide, carboplatin, and etoposide (ICE) followed-up by IL-11 plus granulocyte colony-stimulating factor (G-CSF). |
11464987 |
Human |
il-11 |
tumor |
IL-11-induced reduction of C/EBP transcription factor binding may contribute to the IL-12 downregulation in tumor-bearing mice. |
12527946 |
Mouse |
il-11 |
tumor |
Using a murine IL-11 ELISA, we observed no differences in IL-11 production between normal and tumor-bearer's macrophages or T cells, with or without activation. |
12527946 |
Mouse |
il-11 |
tumorigenesis |
Our results suggest that tumor-derived IL-11 may play a role in the depressed IL-12 production by macrophages, leading to the impaired immune functions observed during mammary tumorigenesis. |
12527946 |
Human |
il-11 |
oncogene |
DESIGN: The effects of IL-13 and TNF-beta, on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8, growth-regulated oncogene alpha (GROalpha), monocyte chemoattractant protein-1 (MCP-1), regulated on activation, T-cell expressed and secr |
12620497 |
Human |
il-11 |
lymphoma |
[Human bone marrow mesenchymal stem cells express multiple hematopoietic growth factors] To study the biological role of human cultured bone marrow mesenchymal stem cell (BM-MSC) in hematopoiesis by investigation of its expression of multiple hematopoieti |
12744729 |
Human |
il-11 |
leukemia |
[Human bone marrow mesenchymal stem cells express multiple hematopoietic growth factors] To study the biological role of human cultured bone marrow mesenchymal stem cell (BM-MSC) in hematopoiesis by investigation of its expression of multiple hematopoieti |
12744729 |
Human |
il-11 |
cancer |
Blood concentrations of several cytokines (TNF-alpha, IL-1beta, IL-5, IL-6, IL-8, IL-11 and IL-12) in cancer-bearing patients with or without elevation of blood PTHrP were measured by ELISA. |
14503917 |
Human |
il-11 |
oncogene |
DESIGN: The effects of leptin on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8, growth-regulated oncogene (GRO)-alpha, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-3alpha by ESC and the endome |
14505754 |
Human |
il-11 |
neuroblastoma |
A beta(1-42) also induced cell death in rat neuroblastoma B104 cells, which was abolished by addition of IL-11. |
15333986 |
Rat |
il-11 |
leukemia |
Progress on research and clinical application of IL-11 in treatment of leukemia was reviewed in this paper. |
15498143 |
Human |
il-11 |
leukemia |
[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.] OBJECTIVE: To explore the therapeutic effect of interleukin-11 (IL-11) on high-dose methotrexate (HDMTX) induced mucositis in Wistar's rats, the proli |
15730719 |
Human |
il-11 |
leukemia |
In these rats, not only PTHrP but also several other human proinflammatory cytokines, such as IL-6, leukemia-inducing factor, IL-8, IL-5 and IL-11, were secreted to the bloodstream. |
15800941 |
Human |
il-11 |
cancer |
Our results suggest that various cancer-derived cytokines, such as PTHrP, TNF-alpha, IL-6 and IL-11, play an important role in the mechanism of bone invasion associated with lower gingival squamous cell carcinoma. |
15982855 |
Human |
il-11 |
oncogene |
The results showed that MEP increased the mRNA levels of metabolic enzymes CYP1A1 and CYP1B1, proinflammatory cytokines interleukin (IL)-1alpha, IL-6, and IL-11, fibroblast growth factor (FGF)-6 and FGF-9, vascular endothelial growth factor (VEGF)-D, onco |
16002475 |
Human |
il-11 |
adenocarcinoma |
RESULTS: Among 115 cases of adenocarcinoma, 100 cases (87.0%) showed positive staining in the cytoplasm of carcinoma cells for the IL-11, and 87 cases (75.6%) were positive for the IL-11Ra. |
16482637 |
Human |
il-11 |
carcinoma |
RESULTS: Among 115 cases of adenocarcinoma, 100 cases (87.0%) showed positive staining in the cytoplasm of carcinoma cells for the IL-11, and 87 cases (75.6%) were positive for the IL-11Ra. |
16482637 |
Human |
il-11 |
adenomas |
Six cases (54.5%) and four cases (36.4%) of 11 adenomas were positive for IL-11 and IL-11Ra, respectively. |
16482637 |
Human |
il-11 |
carcinoma |
In Western blot analysis, two human colorectal carcinoma cell lines and four tissues of surgically resected human carcinoma expressed both IL-11 and IL-11Ra proteins. |
16482637 |
Human |
il-11 |
human colorectal carcinoma |
In Western blot analysis, two human colorectal carcinoma cell lines and four tissues of surgically resected human carcinoma expressed both IL-11 and IL-11Ra proteins. |
16482637 |
Human |
il-11 |
colorectal adenocarcinoma |
CONCLUSION: IL-11 and IL-11Ra are highly expressed in human colorectal adenocarcinoma and the IL-11Ra expression is correlated with clinicopathological factors. |
16482637 |
Human |
il-11 |
tumour |
New signalling pathways of interleukin (IL)-1 family, IL-6, IL-11, IL-18, interferons (IFNs) and interferon regulatory factors 1 (IRF-1) and 2 (IRF-2) have been found within tumour microenvironments and in metastatic sites. |
16931107 |
Human |
il-11 |
breast cancer |
Some cytokines (IL-1, IL-6, IL-11, TGFbeta) stimulate while others (IL-12, IL-18, IFNs) inhibit breast cancer proliferation and/or invasion. |
16931107 |
Human |
il-11 |
leukaemia |
Interleukin 11 (IL-11) and leukaemia-inhibitory factor (LIF) are factors associated with implantation window in human eutopic endometrium. |
17000646 |
Human |
il-11 |
mds |
We report the results of a phase II trial to more accurately assess the clinical response and toxicity data for low-dose IL-11 (10 microg/kg/day) in patients with MDS. |
17071475 |
Human |
il-11 |
mds |
Our study provides additional clinical evidence that chronic administration of IL-11, at low doses, can raise platelet counts and reduce platelet transfusion requirements in a subset of patients with MDS. |
17071475 |
Human |
interleukin 11 |
solid tumors |
Recombinant human interleukin 11, a thrombopoietic cytokine, reduced the incidence of chemotherapy-induced thrombocytopenia in patients with solid tumors. |
16413056 |
Human |
interleukin 11 |
leukaemia |
Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis. |
17000646 |
Human |
interleukin 11 |
leukaemia |
Interleukin 11 (IL-11) and leukaemia-inhibitory factor (LIF) are factors associated with implantation window in human eutopic endometrium. |
17000646 |
Human |
il11 |
neoplasia |
The majority of the cooperative targets display increased expression in tumors derived from either Min (many intestinal neoplasia) or mouse mammary tumor virus (MMTV)-Wnt1 mice, two models of Wnt-induced tumors, with nine of these genes (Ankrd1, Ccnd1, Ct |
17210685 |
Human |
il11 |
tumors |
The majority of the cooperative targets display increased expression in tumors derived from either Min (many intestinal neoplasia) or mouse mammary tumor virus (MMTV)-Wnt1 mice, two models of Wnt-induced tumors, with nine of these genes (Ankrd1, Ccnd1, Ct |
17210685 |
Human |
il-11 |
leukemia |
BACKGROUND: The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor (LIF), IL-11, and oncostatin M. |
8529123 |
Human |
il-11 |
polyposis |
OBJECTIVES: To determine the role of interleukin (IL)-4, IL-4 receptor (R), IL-6, IL-8, IL-11, and transforming growth factor (TGF)-beta in chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRS/NP). |
15805881 |
Human |
il-11 |
tumor |
RESULTS: The intensity of staining for both IL-11 and the IL-11 receptor was distinctly high in tumor samples (P<.01). |
16614887 |
Human |
il-11 |
tumor |
The transcript level of IL-11 was significantly higher in node-positive tumor samples compared with node-negative samples (P=.02). |
16614887 |
Human |
il-11 |
resected gastric cancer |
IL-6, IL-11, and activated STAT3 and ERK1/2 were quantified in antral biopsies from gastritic stomach, metaplastic tissue, and resected gastric cancer tissues. |
17724739 |
Human |
il-11 |
gastric cancer |
Of known gastric ligands that drive STAT3 activation, IL-6 expression was increased after H. pylori infection and both IL-6 and IL-11 were strongly up-regulated in the gastric cancer biopsies. |
17724739 |
Human |
il-11 |
gastric cancer |
This suggests a mechanism by which IL-11 drives STAT3 activation and proliferation during gastric cancer progression. |
17724739 |
Human |
il-11 |
adenocarcinoma |
IL-11 expression is associated with adenocarcinoma development, but not gastritic lesions, and we identify a novel mechanism for IL-11 as a potent inducer of proliferation in the human gastric cancer setting. |
17724739 |
Human |
il-11 |
human gastric cancer |
IL-11 expression is associated with adenocarcinoma development, but not gastritic lesions, and we identify a novel mechanism for IL-11 as a potent inducer of proliferation in the human gastric cancer setting. |
17724739 |
Human |
il-11 |
ibd |
Recently, numerous new genes have been identified to be involved in the genetic susceptibility to IBD: NOD1/Caspase-activation recruitment domains 4 (CARD4), Chemokine ligand 20 (CCL20), IL-11, and IL-18 among others. |
17948929 |
Human |
il-11 |
leukaemia |
Immunohistology suggested expression of OSM, gp130, leukaemia inhibitory factor receptor (LIFr) and IL-11r in the hair follicle root sheaths and dermal papilla, while IL-11, IL-6r and OSMr were expressed in root sheaths alone. |
17979974 |
Human |
il-11 |
ibd |
In late, more severe IBD, serum levels of IL-11, IP-10, haptoglobin, matrix metalloproteinase-9, macrophage inflammatory protein (MIP)-1gamma, fibrinogen, immunoglobulin A, MIP-3 beta (beta), VCAM-1, apolipoprotein (Apo) A1, and IL-18 were elevated. |
18095317 |
Human |
il-11 |
leukaemia |
Cerebrospinal fluid (CSF) levels of interleukin (IL)-6, IL-11 and leukaemia inhibitory factor (LIF) were evaluated in 43 patients with Alzheimer's disease (AD) and 24 patients with frontotemporal lobar degeneration (FTLD) as compared with 30 agematch |
18204920 |
Human |
il-11 |
tumorigenesis |
What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis. |
18431518 |
Human |
il-11 |
oncogenic |
In this issue of the JCI, a study in mice by Ernst et al. provides new insight into the role of IL-11 and its glycoprotein 130 (gp130) receptor in inflammation-associated gastric epithelial cell oncogenic transformation, which they show is mediated by and |
18431518 |
Human |
il-11 |
tumorigenesis |
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. |
18431520 |
Mouse |
il-11 |
tumorigenesis |
Using the gp130(Y757F/Y757F) mouse model of gastric cancer, which carries a mutated gp130 cytokine receptor signaling subunit that cannot bind the negative regulator of cytokine signaling SOCS3 and is characterized by hyperactivation of the signaling mole |
18431520 |
Mouse |
il-11 |
gastric cancer |
Using the gp130(Y757F/Y757F) mouse model of gastric cancer, which carries a mutated gp130 cytokine receptor signaling subunit that cannot bind the negative regulator of cytokine signaling SOCS3 and is characterized by hyperactivation of the signaling mole |
18431520 |
Mouse |
il-11 |
gastric tumors |
Expression of IL-11 was increased in gastric tumors in gp130(Y757F/Y757F) mice, when compared with unaffected gastric tissue in wild-type mice, while gp130(Y757F/Y757F) mice lacking the IL-11 ligand-binding receptor subunit (IL-11Ralpha) showed normal gas |
18431520 |
Mouse |
il-11 |
gastric tumor |
Furthermore, reducing STAT3 activity in gp130(Y757F/Y757F) mice, either genetically or by therapeutic administration of STAT3 antisense oligonucleotides, normalized gastric IL-11 expression and alleviated gastric tumor burden. |
18431520 |
Mouse |
il-11 |
tumorigenesis |
Surprisingly, the genetic reduction of STAT1 expression also reduced gastric tumorigenesis in gp130(Y757F/Y757F) mice and coincided with reduced gastric inflammation and IL-11 expression. |
18431520 |
Mouse |
il-11 |
tumorigenesis |
Collectively, our data have identified IL-11 as a crucial cytokine promoting chronic gastric inflammation and associated tumorigenesis mediated by excessive activation of STAT3 and STAT1. |
18431520 |
Mouse |
il-11 |
myeloma |
MATERIALS AND METHODS: Interleukin (IL)-6, IL-11, IL-10, and tumor necrosis factor (TNF)-alpha production by CD166+ mesenchymal BMSCs and the CD38+/CD138+ RPMI8226 myeloma cell line cultivated in vitro in monocultures or co-cultivated under cell-to-cell c |
18512025 |
Human |
il-11 |
polyp |
GC suppress pro-fibrotic cytokines related to polyp growth, such as IL-11, the basic fibroblast growth factor (b-FGF), and the vascular endotelial growth factor (VEGF). |
18568209 |
Human |
il-11 |
solid tumors |
Interleukin 11 (IL-11) reduces the incidence and the severity of thrombocytopenia in solid tumors. |
18629842 |
Human |
il-11 |
cml |
METHODS: The authors investigated the efficacy and safety of low-dose IL-11 for improving thrombocytopenia associated with TKI therapy in 14 patients with CML. |
18629842 |
Human |
il-11 |
cml |
CONCLUSIONS: The current results indicated that IL-11 may correct thrombocytopenia associated with TKI therapy for patients with CML and that it has a favorable toxicity profile. |
18629842 |
Human |
il-11 |
two acute t lymphocytic leukemia |
In contrast, three acute pre-B lymphocytic leukemia (pre-B-ALL) and two acute T lymphocytic leukemia (T-ALL) lines failed to respond to IL-11 alone or when combined with other cytokines. |
8453105 |
Human |
il-11 |
immune thrombocytopenia purpura |
In patients with immune thrombocytopenia purpura (ITP), with decreased PLT survival, but intact bone marrow megakaryocytopoiesis, endogenous IL-11 levels were significantly increased (328.0 +/- 92.6 pg/mL, [PLT: 20,900 +/- 3,000/microL], P < .05, n = 25). |
8896400 |
Human |
il-11 |
multiple myeloma |
In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL-6 autocrine human myeloma cell lines, LP1, OPM2 and L363, have been treated with dexamethasone in the presence or absence of cytokines belongi |
7647014 |
Human |
il-11 |
acute myeloblastic leukemia |
Analysis of a panel of samples from different patients with acute myeloblastic leukemia (AML) and myeloid leukemic cell lines indicated that IL-11 alone was ineffective in supporting myeloid leukemic cell growth but frequently enhanced growth supported by |
8453105 |
Human |
il-11 |
renal cell carcinoma |
In order to understand the ability of normal human kidney, benign renal angiomyolipoma and malignant renal cell carcinoma (RCC) cells to produce cytokines, we determined the IL-1-beta, IL-6, IL-10, IL-11, TNF-alpha and TGF-beta-1 concentration in the supe |
9891467 |
Human |
il-11 |
acute promyelocytic leukaemia |
Endogenous serum thrombopoietin (TPO) and various cytokines including erythropoietin (EPO), interleukin (IL)-3, IL-6, IL-11, granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage-colony stimulating factor (GM-CSF) and stem cell factor (SCF |
10233408 |
Human |
il-11 |
multiple myeloma |
We investigated the serum concentration of interleukin-6 (IL-6) and four IL-6 family cytokines - oncostatin M (OSM), leukaemia inhibitory factor (LIF), interleukin-11 (IL-11) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) |
10233412 |
Human |
il-11 |
leukemia |
Cardiotrophin-1 (CT-1) is a recently discovered member of the gp130 cytokine family, which includes IL-6, IL-11, leukemia inhibitory factor, ciliary neurotrophic factor, and oncostatin M. |
10357926 |
Human |
il-11 |
acute myeloid leukemia |
Because some of these growth factors, especially TPO and IL-11, are now being evaluated clinically to reduce chemotherapy-associated thrombocytopenia in cancer patients, we evaluated 25 acute myeloid leukemia (AML) samples to test whether TPO, IL-11, and |
10428502 |
Human |
il-11 |
multiple myeloma |
We investigated the serum concentration of the interleukin-10 (IL-10), along with cytokines of interleukin-6 (IL-6) family (IL-6, IL-11 and oncostatin M - OSM), as well as soluble receptor for IL-6 (sIL-6R), in 121 patients with multiple myeloma (MM) and |
11022130 |
Human |
il-11 |
leukemia |
The assay displays no cross-reactivities with any of the IL-6 family of cytokines including IL-11, leukemia inhibitory factor, ciliary neurotrophic factor, and oncostatin M. |
11118285 |
Human |
il-11 |
acute myeloid leukemia |
In this study we report our data on effects of early-acting megakaryocyte growth factors, particularly the c-mpl ligand also known as thrombopoietin (TPO) and interleukin-11 (IL-11), on cell proliferation and apoptosis (Apo) of primary acute myeloid leuke |
11426619 |
Human |
il-11 |
b-chronic lymphocytic leukemia |
In the present study using reverse-transcriptase polymerase chain reaction (RT-PCR), FACS analysis and immunofluorescence we have shown the constitutive expression of IL-11 and IL-11R alpha in B-chronic lymphocytic leukemia (B-CLL). |
11699207 |
Human |
il-11 |
idiopathic pulmonary fibrosis |
Because interleukin (IL)-6 and IL-11 may alter repair and remodeling processes, we hypothesized that they may play a role in idiopathic pulmonary fibrosis (IPF). |
12714376 |
Human |
il-11 |
acute myeloid leukemia |
A higher complete remission (CR) rate was observed in patients with acute myeloid leukemia (AML) who, on a prior randomized study of induction therapy, received gemtuzumab ozogamicin (GO) plus interleukin-11 (IL-11) rather than GO alone. |
15863204 |
Human |
il-11 |
benign prostate hyperplasia |
To clarify whether serum levels of interleukin-11 (IL-11) could be a useful marker in patients with prostate cancer, serum IL-11 was determined in 73 and 23 men with prostate cancer and benign prostate hyperplasia (BPH), respectively, before treatment. |
16132763 |
Human |
il-11 |
leukemia |
Immunofluorescence microscopic analyses revealed that IL-11 treatment led to the cell elongation, as is the case with other cardiotrophic members of IL-6 family, such as leukemia inhibitory factor. |
17629706 |
Human |
il-11 |
leukemia |
Interleukin (IL-11) and leukemia inhibitory factor (LIF) are essential for murine implantation and signal via intracellular phosphorylation (p) of STAT3 in the endometrium. |
18047677 |
Human |
il-11 |
leukemia |
This family also includes IL-11, oncostatin-M, and leukemia inhibitory factor (LIF). |
18071945 |
Human |
il-11 |
leukemia |
Of the IL-6 family cytokines measured in lungs from infected C57BL/6 mice, IL-6, oncostatin M, leukemia inhibitory factor (LIF), and IL-11 were significantly elevated. |
18192501 |
Human |
il-11 |
leukemia |
A number of these genes, including cyclooxygenase (COX)-2, leukemia inhibitory factor, IL-6, IL-8, and IL-11 are regulated in the endometrium during implantation and early pregnancy. |
18339712 |
Human |
il-11 |
leukemia |
Constitutive mRNA expression of IL-6, IL-11, and leukemia inhibitory factor (LIF), but not of oncostatin M (OSM), was demonstrated, as was concentration-dependent stimulation of IL-6 and LIF mRNA and of protein by IL-1beta and TNF-alpha. |
18502965 |
Human |
il-11 |
leukemia |
Abbreviations: IL-1alpha (interleukin-1alpha); IL-1beta (interleukin-1beta); IL-6 (interleukin-6); IL-11 (interleukin-11); LIF (leukemia inhibitory factor); OSM (oncostatin M); alpha(1)-coll. |
18502965 |
Human |