IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PEG3 Ensembl ENSG00000198300 Chromosome 19 Start 61977742 End 62043887
Description Zinc finger imprinted 2 [Source:UniProtKB/Swiss-Prot;Acc:Q9NZV7]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8826
     Entrez Gene : 5178
     UCSC : uc010etr.2
     GeneCards : 8826
     RefSeq : NM_001146184
     CCDS : CCDS12948.1
     Uniprot : Q9GZU2
     Interpro : Q9GZU2
     OMIM : 601483
     GeneTests : PEG3
     CGAP : PEG3
     PMID : 9149948

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39701_at  -0.83  5.27e-4  1.79e-3  -0.74  9.47e-3  2.21e-2
 HG_U133A  209242_at  -0.91  3.32e-26  4.00e-25  -0.22  1.87e-4  2.12e-4
 HG_U133A  209243_s_at  -1.09  4.09e-9  1.34e-8  6.52  1.50e-111  1.41e-110
 HG_U133_Plus2  209242_at  -1.30  3.26e-19  7.09e-18  -1.50  4.32e-29  1.77e-27
 HG_U133_Plus2  209243_s_at  -1.42  1.21e-11  1.08e-10  -2.16  5.11e-17  5.05e-16
 HG_U133_Plus2  230068_s_at  -0.68  7.11e-5  2.32e-4  -1.15  1.38e-8  5.10e-8
 Stanford  13313  0.60  7.10e-2  1.97e-1  0.26  5.80e-1  7.73e-1
 Stanford  13679  1.19  1.24e-2  7.41e-2  0.61  2.70e-1  5.10e-1
 Agilent_HS_21.6K  16298  0.09  2.69e-2  9.40e-2  0.06  4.38e-2  1.12e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209242_at  0.05  8.39e-1  9.87e-1  0.09  5.61e-1  1.00e+0
 HG_U133A  209243_s_at  0.30  6.55e-1  9.61e-1  0.53  1.98e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39701_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209242_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209243_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209242_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209243_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230068_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13313    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13679    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16298    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
peg3 cancer The imprinted status of PEG3 throughout life coupled with its neural expression and putative roles in regulating cell growth suggests that PEG3 may be a susceptibility locus for cancer as well as neurobehavioral deficits. 11161803 Human
peg3 glioma Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. 11260267 Human
peg3 tumour Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. 11260267 Human
peg3 glioma A significant decrease in PEG3 expression was more commonly observed in glioma cell lines as compared with that in primary cultures of astrocytes. 11260267 Human
peg3 glioma Transfection of PEG3 cDNA in a glioma cell line resulted in a loss of tumorigenicity in nude mice. 11260267 Human
peg3 glioma Introduction of PEG3 cDNA into the glioma cells suggests that human PEG3 protein functions as a tumour suppressor. 11260267 Human
peg3 tumour Introduction of PEG3 cDNA into the glioma cells suggests that human PEG3 protein functions as a tumour suppressor. 11260267 Human
peg3 tumour Human PEG3 is located on 19q13.4 and is one of the candidates for tumour suppressor genes that are predicted to be sited in gliomas. 11260267 Human
peg3 glioma Epigenetic silencing of PEG3 gene expression in human glioma cell lines. 11398192 Human
peg3 glioma Because PEG3 expression is downregulated in some gliomas and glioma cell lines, despite high-level expression in normal brain tissues, we investigated whether the loss of PEG3 expression is related to epigenetic modifications involving DNA methylation. 11398192 Human
peg3 glioma We found monoallelic expression of PEG3 in all normal brain tissues examined and five of nine glioma cell lines that had both unmethylated and methylated alleles; the remaining four glioma cell lines exhibited gain of imprinting with hypermethylated allel 11398192 Human
peg3 glioma In addition, treatment of glioma cell lines with the DNA demethylating agent 5-aza-2'-deoxycytidine reversed the silencing of PEG3 biallelically. 11398192 Human
peg3 glioma In this article, we report that the epigenetic silencing of PEG3 expression in glioma cell lines depends on aberrant DNA methylation of an exonic CpG island, suggesting that PEG3 contributes to glioma carcinogenesis in certain cases. 11398192 Human
peg3 hydatidiform moles We analyzed the PEG3 gene for mutations in women with familial recurrent hydatidiform moles and to determine its imprinting status in humans. 11677152 Human
peg3 hydatidiform moles Our data support that PEG3 is not mutated in women with familial recurrent hydatidiform moles, although mutations in the regulatory regions that might affect imprinting or transcriptional level of the gene could not be evaluated. 11677152 Human
paternally expressed gene-3 prostatic adenocarcinoma Androgens down-regulate the expression of the human homologue of paternally expressed gene-3 in the prostatic adenocarcinoma cell line LNCaP. mRNA differential display polymerase chain reaction analysis was used to screen systematically for novel androgen 10580840 Human
peg3 tumor No detectable levels of Peg3 mRNA were observed in two other androgen receptor-positive prostate tumor cell lines (MDA PCa-2a and -2b), and in the poorly differentiated and androgen receptor-negative prostate tumor lines PC-3 and DU-145. 10580840 Human
peg-3 myeloid leukemia PEG-3 shares significant nucleotide and amino acid sequence homology with the hamster growth arrest and DNA damage-inducible gene gadd34 and a homologous murine gene, MyD116, that is induced during induction of terminal differentiation by interleukin-6 in 9256446 Human
peg-3 cancer PEG-3, a nontransforming cancer progression gene, is a positive regulator of cancer aggressiveness and angiogenesis. 10611347 Human
peg-3 cancer Subtraction hybridization identified a genetic element, progression elevated gene-3 (PEG-3), whose expression directly correlates with cancer progression and acquisition of oncogenic potential by transformed rodent cells. 10611347 Human
peg-3 cancer We presently demonstrate that forced expression of PEG-3 in tumorigenic rodent cells, and in human cancer cells, increases their oncogenic potential in nude mice as reflected by a shorter tumor latency time and the production of larger tumors with increas 10611347 Mouse
peg-3 tumors We presently demonstrate that forced expression of PEG-3 in tumorigenic rodent cells, and in human cancer cells, increases their oncogenic potential in nude mice as reflected by a shorter tumor latency time and the production of larger tumors with increas 10611347 Mouse
peg-3 tumor We presently demonstrate that forced expression of PEG-3 in tumorigenic rodent cells, and in human cancer cells, increases their oncogenic potential in nude mice as reflected by a shorter tumor latency time and the production of larger tumors with increas 10611347 Mouse
peg-3 cancer Moreover, inhibiting endogenous PEG-3 expression in progressed rodent cancer cells by stable expression of an antisense expression vector extinguishes the progressed cancer phenotype. 10611347 Mouse
peg-3 cancer Cancer aggressiveness of PEG-3 expressing rodent cells correlates directly with increased RNA transcription, elevated mRNA levels, and augmented secretion of vascular endothelial growth factor (VEGF). 10611347 Mouse
peg-3 cancer Furthermore, transient ectopic expression of PEG-3 transcriptionally activates VEGF in transformed rodent and human cancer cells. 10611347 Mouse
peg-3 cancer Taken together these data demonstrate that PEG-3 is a positive regulator of cancer aggressiveness, a process regulated by augmented VEGF production. 10611347 Mouse
peg-3 cancer These studies also support an association between expression of a single nontransforming cancer progression-inducing gene, PEG-3, and the processes of cancer aggressiveness and angiogenesis. 10611347 Human
peg-3 developing cancer In these contexts, PEG-3 may represent an important target molecule for developing cancer therapeutics and inhibitors of angiogenesis. 10611347 Human
peg-3 cancer To define the mechanism by which expression of PEG-3 is enhanced as a function of cancer progression a 5'-flanking promoter region of approximately 2.0-kb, PEG-Prom, was isolated, cloned and characterized. 10918598 Human
peg-3 cancer Our findings document the importance of both AP1 and PEA3 transcription factors in mediating basal and elevated expression of PEG-3 in H5ts125-transformed rat embryo cells displaying an aggressive and progressed cancer phenotype. 10918598 Human
peg-3 cancer These cellular changes correlate with an induction in the expression of a cancer progression-promoting gene, progression elevated gene-3 (PEG-3). 11292838 Human
peg-3 human tumor Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells. 12115734 Human
peg-3 cancer Subtraction hybridization identified a novel rodent gene, progression elevated gene-3 (PEG-3) whose expression directly correlates with cancer aggressiveness and progression. 12115734 Human
peg-3 human tumor Moreover, ectopic expression of PEG-3 in rodent or human tumor cells produces an aggressive transformed phenotype. 12115734 Human
peg-3 tumor We demonstrate that PEG-3 expression in rodent tumor cells correlates directly with genomic instability as characterized by alterations in chromosome composition and structure. 12115734 Human
peg-3 human tumor Additionally, elevated endogenous or ectopic expression of PEG-3 in rodent and human tumor cells, respectively, enhances gene amplification, as monitored by resistance to methothrexate (MTX) and amplification of the dihydrofolate reductase (dhfr) gene. 12115734 Human
peg-3 cancer The present studies document that stable, inducible, and transient expression of PEG-3 in cancer cells augments genomic instability. 12115734 Human
peg-3 cancer In these contexts, one mechanism by which PEG-3 influences cancer progression may be by preferentially facilitating the development of genomic changes in evolving cancer cells. 12115734 Human
peg-3 tumors Recently it was reported that a novel rat Gadd34-related gene, PEG-3, was upregulated in transformed cells, and that forced expression of this gene led to increased tumorigenic potential of cells implanted into nude mice and increased angiogenesis of thes 12813455 Human
peg-3 tumour necrosis Immunohistochemistry was performed to detect vascular endothelial growth factor (VEGF), c-myc, p53, paternally expressed gene-3 (PEG-3), transforming growth factor beta (TGFB), and tumour necrosis factor alpha (TNFA). 14753496 Human
peg-3 tumor Progression elevated gene-3 (PEG-3) induces pleiotropic effects on tumor progression: Modulation of genomic stability and invasion. 15389539 Human
peg-3 human tumor Previous reports document that ectopic expression of PEG-3 in rodent or human tumor cells produces an aggressive transformed/tumorigenic phenotype. 15389539 Human
peg-3 tumor Moreover, PEG-3 expression in rodent tumor cells correlates directly with genomic instability, as indicated by chromosomal alterations and gene amplification, and it promotes angiogenesis. 15389539 Human
peg-3 cancer The present studies were designed to further elucidate the functional significance and role of PEG-3 in cancer progression with a specific focus on genomic instability and cancer invasion. 15389539 Human
peg-3 cancer In vitro invasion of transformed rodent cells was augmented by PEG-3, which correlated with an increase in the transcription and activity of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), which play important roles in local invasion during cancer pr 15389539 Human
peg-3 tumor These findings demonstrate that PEG-3 plays a central role in augmenting tumor progression by modulating several critical parameters of the carcinogenic process, such as genomic stability and local tumor cell invasion. 15389539 Human
peg3 prostate tumor No detectable levels of Peg3 mRNA were observed in two other androgen receptor-positive prostate tumor cell lines (MDA PCa-2a and -2b), and in the poorly differentiated and androgen receptor-negative prostate tumor lines PC-3 and DU-145. 10580840 Human
peg3 gliomas Human PEG3 is located on 19q13.4 and is one of the candidates for tumour suppressor genes that are predicted to be sited in gliomas. 11260267 Human
peg3 gliomas Because PEG3 expression is downregulated in some gliomas and glioma cell lines, despite high-level expression in normal brain tissues, we investigated whether the loss of PEG3 expression is related to epigenetic modifications involving DNA methylation. 11398192 Human
peg3 glioma Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines. 15141944 Human
peg3 tumor The human paternally expressed gene 3 (PEG3) on chromosome 19q13.4 is one of the candidate tumor suppressor genes for glioma. 15141944 Human
peg3 glioma The human paternally expressed gene 3 (PEG3) on chromosome 19q13.4 is one of the candidate tumor suppressor genes for glioma. 15141944 Human
peg3 glioma We have previously reported that the epigenetic silencing of PEG3 expression in glioma cell lines is dependent on aberrant DNA methylation of an exonic CpG island. 15141944 Human
peg3 glioma The ITUP1 showed a similar expression profile with PEG3 in glioma cell lines. 15141944 Human
peg3 glioma This suggests that ITUP1 and PEG3 are coordinately regulated, and that downregulation of the both genes may be important in the development of glioma. 15141944 Human
peg3 oligodendrogliomas Parental 19q loss and PEG3 expression in oligodendrogliomas. 15172758 Human
paternally expressed gene 3 tumor The human paternally expressed gene 3 (PEG3) on chromosome 19q13.4 is one of the candidate tumor suppressor genes for glioma. 15141944 Human
paternally expressed gene 3 glioma The human paternally expressed gene 3 (PEG3) on chromosome 19q13.4 is one of the candidate tumor suppressor genes for glioma. 15141944 Human

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