IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TRIM28 Ensembl ENSG00000130726 Chromosome 19 Start 63747648 End 63753894
Description Transcription intermediary factor 1-beta (TIF1-beta)(Tripartite motif-containing protein 28)(Nuclear corepressor KAP-1)(KRAB-associated protein 1)(KAP-1)(KRAB-interacting protein 1)(KRIP-1)(RING finger protein 96) [Source:UniProtKB/Swiss-Prot;Acc:Q13263]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 16384
     Entrez Gene : 10155
     UCSC : uc002qtg.1
     GeneCards : 16384
     RefSeq : NM_005762
     CCDS : CCDS12985.1
     Uniprot : Q13263
     Interpro : Q13263
     OMIM : 601742
     GeneTests : TRIM28
     CGAP : TRIM28
     PMID : 11331580

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33425_at  0.30  1.39e-4  5.48e-4  0.58  2.46e-8  2.11e-7
 HG_U133A  200990_at  0.46  1.22e-11  5.02e-11  -1.06  1.11e-37  2.08e-37
 HG_U133_Plus2  200990_at  0.63  2.62e-10  1.98e-9  1.33  2.06e-17  2.13e-16
 Stanford  8580  0.57  4.31e-2  1.40e-1  0.59  7.64e-2  2.27e-1
 Stanford  22432  -0.25  3.56e-1  5.56e-1  0.11  7.68e-1  8.89e-1
 Agilent_HS_21.6K  18539  -0.14  5.07e-2  1.47e-1  0.02  8.44e-1  9.04e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200990_at  0.29  1.55e-1  8.12e-1  0.13  4.61e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33425_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200990_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200990_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8580    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22432    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18539    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
kap1 breast cancer Moreover, the KAP1 sumoylation level was transiently decreased upon Dox exposure, and transfection with the KAP1 sumoylation mimetic, SUMO-1-KAP1, desensitizes breast cancer MCF-7 cells to Dox-elicited cell death. 17079232 Human
kap-1 myeloid leukaemia Association of endogenous Fes and KAP-1 was also observed in HL-60 myeloid leukaemia cells. 16792528 Human
kap1 cancer KAP1 may serve as a therapeutic target against cancer in combination with actinomycin D. 17056014 Human
kap1 cancer We found that a large number of genes of ZNF transcription factors were bound by both KAP1 and H3me3K9 in normal and cancer cells. 17542650 Human
trim28 embryonic carcinoma (ec) TRIM28 is a transcriptional corepressor which is required for primer binding site (PBS)-dependent restriction of murine leukemia virus (MLV) replication in embryonic stem and embryonic carcinoma (EC) cells. 18287239 Human
trim28 cancer In the protein immunoprecipitation assay, we found that endogenous SMARCAD1/KIAA1122 binds with TRIM28, a recently highlighted transcriptional regulator in the cancer field. 18675275 Human
kap1 melanoma Here, we show that suppression of class I MAGE proteins induces apoptosis in the Hs-294T, A375, and S91 MAGE-positive melanoma cell lines and that members of all three families of MAGE class I proteins form complexes with KAP1, a scaffolding protein that 17942928 Human

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