IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MZF1 Ensembl ENSG00000099326 Chromosome 19 Start 63765097 End 63776754
Description Myeloid zinc finger 1 (MZF-1)(Zinc finger protein 42)(Zinc finger and SCAN domain-containing protein 6) [Source:UniProtKB/Swiss-Prot;Acc:P28698]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 13108
     Entrez Gene : 7593
     UCSC : uc002qtn.2
     GeneCards : 13108
     RefSeq : NM_003422
     CCDS : CCDS12988.1
     Uniprot : P28698
     Interpro : P28698
     OMIM : 194550
     GeneTests : MZF1
     CGAP : MZF1
     PMID : 1860835

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40569_at  -0.14  9.60e-2  1.59e-1  -0.25  1.30e-2  2.90e-2
 HG_U133A  204138_s_at  0.75  2.82e-10  1.04e-9  0.63  4.09e-8  4.96e-8
 HG_U133A  204139_x_at  -0.11  2.89e-1  3.41e-1  0.55  1.56e-9  1.94e-9
 HG_U133A  210336_x_at  0.07  5.71e-1  6.20e-1  1.92  3.62e-47  7.87e-47
 HG_U133A  40569_at  -0.36  4.43e-9  1.45e-8  -0.30  1.96e-6  2.30e-6
 HG_U133_Plus2  204138_s_at  0.81  1.04e-4  3.30e-4  1.39  7.69e-9  2.94e-8
 HG_U133_Plus2  204139_x_at  -0.10  2.34e-1  3.15e-1  -0.30  4.98e-3  8.55e-3
 HG_U133_Plus2  210336_x_at  -0.18  6.45e-2  1.05e-1  -0.67  9.90e-8  3.30e-7
 HG_U133_Plus2  40569_at  -0.17  2.91e-2  5.25e-2  -0.38  5.92e-6  1.56e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204138_s_at  -0.42  3.25e-1  8.83e-1  -0.15  5.21e-1  1.00e+0
 HG_U133A  204139_x_at  0.49  2.46e-1  8.50e-1  0.39  2.78e-1  1.00e+0
 HG_U133A  210336_x_at  0.54  2.13e-1  8.38e-1  0.19  4.94e-1  1.00e+0
 HG_U133A  40569_at  0.42  3.87e-2  7.08e-1  0.23  7.95e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40569_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204138_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204139_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210336_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 40569_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204138_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204139_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210336_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 40569_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mzf1 tumor These findings demonstrate that Mzf1 can act as a tumor/growth suppressor in the hemopoietic compartment. 11445537 Mouse
mzf-1 myeloid leukemia The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells. 9593266 Human
mzf-1 leukemia Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly. 8637224 Human
mzf-1 myeloblastic leukemia Additional putative regulatory binding sites included conserved MZF-1 zinc finger binding sequences, the importance of which was suggested by the enhanced expression of the endogenous MZF-1 gene following vector-driven expression of MZF-1 constructs in K5 8845378 Human

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