IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PRKAR2B Ensembl ENSG00000005249 Chromosome 7 Start 106472375 End 106589491
Description cAMP-dependent protein kinase type II-beta regulatory subunit [Source:UniProtKB/Swiss-Prot;Acc:P31323]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9392
     Entrez Gene : 5577
     UCSC : uc003vdx.2
     GeneCards : 9392
     RefSeq : NM_002736
     CCDS : CCDS5740.1
     Uniprot : P31323
     Interpro : P31323
     OMIM : 176912
     GeneTests : PRKAR2B
     CGAP : PRKAR2B
     PMID : 1358799

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37221_at  -0.35  2.55e-2  5.21e-2  -0.48  3.03e-2  6.00e-2
 HG_U133A  203680_at  -0.56  9.36e-6  2.18e-5  1.28  2.02e-31  3.46e-31
 HG_U133_Plus2  203680_at  -0.77  9.00e-7  4.09e-6  -1.38  8.29e-15  6.37e-14
 Stanford  3069  0.56  3.65e-2  1.39e-1  0.43  1.28e-1  3.21e-1
 Stanford  21029  -0.57  7.01e-2  1.95e-1  -0.21  5.91e-1  7.79e-1
 Agilent_HS_21.6K  16780  -0.09  2.07e-1  3.82e-1  -0.16  8.15e-3  3.04e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203680_at  0.06  8.91e-1  9.93e-1  0.09  6.67e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37221_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203680_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203680_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3069    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21029    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16780    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
riibeta cancer Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression. 10639166 Human
riibeta tumor Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression. 10639166 Human
riibeta cancer Since type II protein kinase A and RIIbeta have been known to play important role(s) in the growth inhibition and differentiation of cancer cells, we further investigated the role of the increased type II protein kinase A by overexpressing RIIbeta in SH-S 10653609 Human
rii tumor The loss of RI by the antisense results in rapid increase in the half-life of the competitor molecule, RII protein, via its stabilization in a holoenzyme complex (PKA-II) that insures depletion of PKA-I and sustained inhibition of tumor growth. 10577386 Human
rii tumor Our past studies on the mechanism of cyclic AMP (cAMP)-mediated control of tumor growth, using the experimental rat mammary tumor models as well as human breast cancer cell lines, indicated that the action of cAMP is mediated by the RII cAMP receptor prot 2830966 Rat
rii human breast cancer Our past studies on the mechanism of cyclic AMP (cAMP)-mediated control of tumor growth, using the experimental rat mammary tumor models as well as human breast cancer cell lines, indicated that the action of cAMP is mediated by the RII cAMP receptor prot 2830966 Human
rii rat mammary tumor Our past studies on the mechanism of cyclic AMP (cAMP)-mediated control of tumor growth, using the experimental rat mammary tumor models as well as human breast cancer cell lines, indicated that the action of cAMP is mediated by the RII cAMP receptor prot 2830966 Rat
rii cancer Two species of RII (the regulatory subunit of protein kinase type II) with apparent Mr 52,000 (RII52) and Mr 56,000 (RII56) and a single species of RI (the regulatory subunit of protein kinase type I) with Mr 48,000 were identified in the cancer cells. 3413098 Human
rii beta human neuroblastoma We have previously reported that overexpression of RII beta subunit of protein kinase A, which markedly reduces RI alpha protein, induces growth inhibition in SK-N-SH human neuroblastoma cells. 9125203 Human
rii beta human colon carcinoma Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta. 8654392 Human
rii tumours These effects were associated with an apparent modulation of the types of cyclic AMP binding proteins, 8-Cl-cyclic AMP-treated xenografts displaying a reduced ratio of RI/RII isoforms compared with untreated control tumours. 7646930 Human
rii tumor Lung tumors showed a decrease in photodetectable RII which correlated in degree with tumor size and extent of anaplasticity. 2990675 Mouse
rii tumors Lung tumors showed a decrease in photodetectable RII which correlated in degree with tumor size and extent of anaplasticity. 2990675 Mouse
rii tumor This decreased RII photolabeling during tumor growth was associated with increased RII autophosphorylation. 2990675 Mouse
rii lung adenoma In the neonate, the proportion of high-affinity sites is reduced to 20% while, in lung adenoma, only low-affinity RII binding is observed. 6327022 Mouse
rii tumors An indirect immunofluorescence revealed that, during regression of MCF-7 tumors, the intensity of immunofluorescence of RII proteins dramatically increased in the nucleoli, whereas immunofluorescence of RI remained the same in the nuclei. 6331652 Human
rii breast tumors These results suggest that, during hormone-induced regression of human breast tumors, the Mr 50,000 and Mr 52,000 RII cAMP-binding proteins are translocated to the nucleoli from cytoplasm. 6331652 Human
rii mda-mb-231 human breast cancer Affinity purified RI and RII antibodies of regulatory subunits (R) of type I (RI) and type II (RII) cAMP-dependent protein kinase were utilized to determine the immunological characterization and specific compartmentalization of R in estrogen receptor neg 6299590 Human
rii prostatic tumors Marked differences in the proportions of photoincorporation of 8-N3-[32P]cAMP into the regulatory subunit of type I (RI) and type II (RII) protein kinases and the proteolytic fragment of these regulatory subunits (Rpf) were observed in normal prostate (ve 6303579 Human
rii tumors Marked differences in the proportions of photoincorporation of 8-N3-[32P]cAMP into the regulatory subunit of type I (RI) and type II (RII) protein kinases and the proteolytic fragment of these regulatory subunits (Rpf) were observed in normal prostate (ve 6303579 Human
rii anaplastic tumors Comparison between tumor tissues revealed that the proportion of photoincorporation of 8-N3-[32P]cAMP into RII versus RI was 4.2-fold higher in hormone-dependent than in hormone-independent or anaplastic tumors, whereas the ratio of photoincorporation int 6303579 Human
rii tumor Comparison between tumor tissues revealed that the proportion of photoincorporation of 8-N3-[32P]cAMP into RII versus RI was 4.2-fold higher in hormone-dependent than in hormone-independent or anaplastic tumors, whereas the ratio of photoincorporation int 6303579 Human
rii tumors In the nuclear extracts of growing tumors the RI antibody immunoprecipitated cAMP receptor protein of 47,000 daltons, whereas the RII antibody precipitated 44,000- and 34,000-dalton cAMP receptor proteins. 6360384 Mouse
rii tumors Indirect immunofluorescence revealed that during regression of MCF-7 tumors, the intensity of immunofluorescence of RII antibody crossreacting cAMP binding proteins dramatically increased in the nucleoli whereas the immunofluorescence of RI remained the s 6360384 Mouse
rii mammary cancer These results suggest a regulatory role of RII in mammary cancer regression. 6360384 Mouse
rii teratocarcinoma To determine what effect retinoic acid might have in modulating cyclic AMP-mediated events at the nucleus of teratocarcinoma cells, we have investigated the effect of retinoic acid treatment of F9 and PC13 cells on cyclic AMP-dependent protein kinase acti 3664484 Human
rii hepatoma 2-fold increase in the RII and C subunits in nuclear extracts of dibutyryl cyclic AMP-treated hepatoma cells. 2548485 Rat
rii hepatoma These results provide qualitative as well as quantitative evidence for a modulation by cyclic AMP of the nuclear RII and C subunit levels in rat H4IIE hepatoma cells, and indicate a relatively rapid but temporarily limited dibutyryl cyclic AMP-induced tra 2548485 Rat
rii beta tumor The tumor regression correlated with the changing levels of cAMP receptor proteins, RI alpha and RII beta, the regulatory subunits of cAMP-dependent protein kinase type I and type II, respectively. 2676146 Human
rii beta tumors By photoaffinity labeling with 8-N3-[32P]cAMP and immunoblotting with a monospecific anti-RII antibody, RI alpha (Mr 49,000) and RII beta (Mr 51,000) were identified in the untreated control tumors. 2676146 Human
rii beta tumor 8-Cl-cAMP treatment induced a rapid increase of both RI alpha and RII beta in tumor cytosols and translocation (within 1 h) of only RII beta from the cytosol to the nucleus. 2676146 Human
rii beta tumor Northern blot analyses demonstrated that the RII beta mRNA level increased within 6 h of 8-Cl-cAMP treatment and remained elevated during treatment, whereas the RI alpha mRNA level decreased to below that of the untreated control tumor level after its tra 2676146 Human
rii beta cancer This dual effect on growth may be explained by relative amounts of the regulatory subunit (RI alpha or RII beta) of PKA within the cancer cells. 8047985 Human
rii beta human colon cancer We determined whether ASO to either the RI alpha or RII beta subunit altered the cAMP-mediated growth of HCT116 and LoVo human colon cancer cells. 8047985 Human
rii beta human leukemia Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. 7947390 Human
rii beta human leukemia We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. 7947390 Human
rii beta tumor These results suggest that the RII beta cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation. 7947390 Human
rii beta cancer The selective down-regulation of RI alpha and the following induction of RII beta determine cell-growth arrest and differentiation of several cancer cells. 7960245 others
rii tumors After 8 weeks of DES treatment, we have shown that the ratio of regulatory subunits of the cAMP-dependent protein kinase (RI/RII) increased in the tumors. 7981127 Rat
rii beta cancer These results demonstrate that two isoforms of cyclic AMP receptor proteins, RI alpha and RII beta, are reciprocally related in the growth control of cancer cells and that the RI alpha antisense oligodeoxynucleotide, which efficiently depletes the growth 8428367 Human
rii beta leukemia 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. 8449943 Human
rii beta tumour Large amounts of RII beta mRNA were found in Leydig tumour cells, whereas the amount of immunoreactive protein was low. 8107013 Human
rii melanomas Differences were noted for the ratios of RI/RII and RI holoenzyme/free RI subunit among different melanomas. 8117614 Human
rii beta cancer 8-Cl-cAMP and RI antisense oligodeoxynucleotide, those that effectively down-regulate RI alpha and up-regulate RII beta, provide new approaches toward the treatment of cancer. 8022860 Human
rii tumor IMPLICATIONS: We plan studies to investigate the effects on tumor growth of the site-selective analogue 8-chloro-cAMP, which binds to RII and causes the elevated levels of the RI subunit of the tumor cells to return to normal levels. 1328659 Rat
rii cancer The physiologic balance between the two regulatory subunit isoforms, RI and RII, of cAMP-dependent protein kinase is disrupted in cancer cells; growth arrest and differentiation of malignant cells can be achieved when the normal ratio of these intracellul 1329084 Human
rii beta mouse neuroblastoma The 5'-flanking DNA of the mouse RII beta subunit of the cAMP-dependent protein kinase gene was characterized by transient transfection of RII beta-CAT constructs into mouse neuroblastoma cells (NB2a) and Chinese hamster ovary (CHO) cells and by gel 1332964 Mouse
rii mouse neuroblastoma The 5'-flanking DNA of the mouse RII beta subunit of the cAMP-dependent protein kinase gene was characterized by transient transfection of RII beta-CAT constructs into mouse neuroblastoma cells (NB2a) and Chinese hamster ovary (CHO) cells and by gel 1332964 Mouse
rii mammary adenocarcinomas The expression of the regulatory (RI and RII) and catalytic (C) subunits of cAMP-dependent protein kinase was found to depend on the growth-state in oestrogen-dependent DMBA-induced mammary adenocarcinomas as well as in uteri of the rat. 1457341 Human
rii cancer The growth stimulatory RI and inhibitory RII are in a strict balance to maintain normal cells, and departure from such balance can cause a great variety of human diseases, including cancer. 1286157 Human
rii beta cancer A marked decrease in the type I cAMP-dependent protein kinase regulatory subunit (RI alpha) and an increase in the type II protein kinase regulatory subunit (RII beta) correlate with growth inhibition and differentiation induced in a variety of types of h 2000408 Human
rii cancer In normal cells RI and RII exist at a specific physiological ratio whereas in cancer cells such physiological balance of these receptor proteins is disrupted. 1653961 Human
rii beta cancer The type II beta regulatory subunit of cAMP-dependent protein kinase (RII beta) has been hypothesized to play an important role in the growth inhibition and differentiation induced by site-selective cAMP analogs in human cancer cells, but direct proof of 1689049 Human
rii beta leukemia These results show that the RII beta regulatory subunit of protein kinase plays a critical role in the cAMP-induced growth regulation of HL-60 leukemia cells. 1689049 Human
rii lung tumors Lung tumors showed a decrease in photodetectable RII which correlated in degree with tumor size and extent of anaplasticity. 2990675 Mouse
rii neoplasia Decreased PKA I expression and alterations in RII phosphorylation in lung neoplasia may contribute to anomalous regulation by cAMP, thereby diminishing cAMP-mediated growth inhibitory effects. 1646708 Mouse
rii nsclc Expression of the RI and RII regulatory subunits of cAMP-dependent protein kinase was similar in CT-resistant and CT-sensitive SCLC or NSCLC cell lines. 1375868 Human
rii hyperplastic A hyperplastic burst caused by high-dose oestrogen-replacement treatment was associated with an increased level of RI and little change in RII and C levels. 1457341 Human
rii mammary tumours Only minor differences were noted for the expression of mRNA for the alpha and beta subtypes of RI, RII and C between rat uteri from castrated and oestrogen-treated animals, or between mammary tumours from normal and castrated animals. 1457341 Rat
rii malignancy Experimental approaches using site-selective cAMP analogues, antisense oligodeoxynucleotides, and gene transfer have shown that restoration of the normal balance of RI/RII provides a biological means to the suppression of malignancy. 1286157 Human
rii hepatocellular carcinoma HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling. 15373827 Human
rii glioma In this study we tested the hypothesis that ribosomal protein extracts (RSW) from glioma cells contain PKA regulatory (RII) and catalytic (C) subunits that, in combination with a protein kinase A anchoring protein (AKAP 95) and CSR-BPs participate in form 15878851 Human
rii beta malignancy These results demonstrate that two isoforms of cyclic AMP receptor proteins, RI alpha and RII beta, are reciprocally related in the growth control of cancer cells and that the RI alpha antisense oligodeoxynucleotide, which efficiently depletes the growth 8428367 Human
riibeta tumor Only the RIIbeta and mutant RIalpha-P (a functional mimic of RIIbeta) transfectants exhibited growth inhibition in vitro, reverted phenotype, and apoptosis, and inhibited in vivo tumor growth. 15480415 Human
riibeta carney complex These lesions were associated with allelic losses of the mouse chromosome 11 Prkar1a locus, an increase in total type II PKA activity, and higher RIIbeta protein levels; the latter biochemical and protein changes were also documented in Carney complex tum 15591278 Mouse
riibeta tumours These lesions were associated with allelic losses of the mouse chromosome 11 Prkar1a locus, an increase in total type II PKA activity, and higher RIIbeta protein levels; the latter biochemical and protein changes were also documented in Carney complex tum 15591278 Mouse
rii tumor The tumor regression correlated with the changing levels of cAMP receptor proteins, RI alpha and RII beta, the regulatory subunits of cAMP-dependent protein kinase type I and type II, respectively. 2676146 Human
rii tumors By photoaffinity labeling with 8-N3-[32P]cAMP and immunoblotting with a monospecific anti-RII antibody, RI alpha (Mr 49,000) and RII beta (Mr 51,000) were identified in the untreated control tumors. 2676146 Human
rii tumor 8-Cl-cAMP treatment induced a rapid increase of both RI alpha and RII beta in tumor cytosols and translocation (within 1 h) of only RII beta from the cytosol to the nucleus. 2676146 Human
rii tumor Northern blot analyses demonstrated that the RII beta mRNA level increased within 6 h of 8-Cl-cAMP treatment and remained elevated during treatment, whereas the RI alpha mRNA level decreased to below that of the untreated control tumor level after its tra 2676146 Human
rii tumor Subtle differences did, however, exist between the regulatory moieties [regulatory subunit of cAMP-dependent protein kinase II (RII)] of isozyme II from the two tumors: autophosphorylated RII from the hormone-independent tumor migrated as a doublet corres 3032409 Rat
rii tumors Subtle differences did, however, exist between the regulatory moieties [regulatory subunit of cAMP-dependent protein kinase II (RII)] of isozyme II from the two tumors: autophosphorylated RII from the hormone-independent tumor migrated as a doublet corres 3032409 Rat
rii tumor This study thus shows that the lack of cAMP-responsiveness of one tumor is related either to a defect distal to the cAMP-dependent protein kinases or to the appearance of the new subtype of RII in the resistant tumor. 3032409 Rat
rii retinoblastoma Effect of butyrate. An indirect immunofluorescence technique was employed to determine the intracellular distribution of the regulatory subunit of type II cyclic adenosine 3':5'-monophosphate-dependent protein kinase (RII) in Y-79 human retinobl 3528034 Human
rii lung tumor This is in contrast to the case with lung tumor cytosol, in which only low-affinity binding is observed and no apparent dissociation of the type II isozyme occurs. cAMP does promote RII dephosphorylation within the holoenzyme, however, suggesting that cAM 6327022 Mouse
rii cancer 8-Cl-cAMP and RI antisense oligodeoxynucleotide, those that effectively down-regulate RI alpha and up-regulate RII beta, provide new approaches toward the treatment of cancer. 8022860 Human
rii tumour Large amounts of RII beta mRNA were found in Leydig tumour cells, whereas the amount of immunoreactive protein was low. 8107013 Human
rii cancer These results demonstrate that two isoforms of cyclic AMP receptor proteins, RI alpha and RII beta, are reciprocally related in the growth control of cancer cells and that the RI alpha antisense oligodeoxynucleotide, which efficiently depletes the growth 8428367 Human
rii malignancy These results demonstrate that two isoforms of cyclic AMP receptor proteins, RI alpha and RII beta, are reciprocally related in the growth control of cancer cells and that the RI alpha antisense oligodeoxynucleotide, which efficiently depletes the growth 8428367 Human
rii sclc Expression of the RI and RII regulatory subunits of cAMP-dependent protein kinase was similar in CT-resistant and CT-sensitive SCLC or NSCLC cell lines. 1375868 Human
rii cancer The type II beta regulatory subunit of cAMP-dependent protein kinase (RII beta) has been hypothesized to play an important role in the growth inhibition and differentiation induced by site-selective cAMP analogs in human cancer cells, but direct proof of 1689049 Human
rii pheochromocytoma We investigated the role of type I and type II protein kinase in the cAMP-induced gene expression by either stable or co-transfection of RI alpha, RII alpha, or RII beta gene in an expression vector together with somatostatin-chloramphenicol acetyltransfe 1976635 Human
rii cancer A marked decrease in the type I cAMP-dependent protein kinase regulatory subunit (RI alpha) and an increase in the type II protein kinase regulatory subunit (RII beta) correlate with growth inhibition and differentiation induced in a variety of types of h 2000408 Human
rii hormone-dependent tumor Subtle differences did, however, exist between the regulatory moieties [regulatory subunit of cAMP-dependent protein kinase II (RII)] of isozyme II from the two tumors: autophosphorylated RII from the hormone-independent tumor migrated as a doublet corres 3032409 Rat
rii human leukemia Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. 7947390 Human
rii human leukemia We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. 7947390 Human
rii tumor These results suggest that the RII beta cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation. 7947390 Human
rii cancer The selective down-regulation of RI alpha and the following induction of RII beta determine cell-growth arrest and differentiation of several cancer cells. 7960245 Mouse
rii cancer This dual effect on growth may be explained by relative amounts of the regulatory subunit (RI alpha or RII beta) of PKA within the cancer cells. 8047985 Human
rii human colon carcinoma Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta. 8654392 Human
rii human neuroblastoma We have previously reported that overexpression of RII beta subunit of protein kinase A, which markedly reduces RI alpha protein, induces growth inhibition in SK-N-SH human neuroblastoma cells. 9125203 Human
riibeta cancer We demonstrate that the antisense depletion of RIalpha in cancer cells results in increased RIIbeta protein without increasing the rate of RIIbeta synthesis or RIIbeta mRNA levels. 10999726 Human
riibeta prostate carcinoma Pulse-chase experiments revealed a 3-6-fold increase in the half-life of RIIbeta protein in antisense-treated colon and prostate carcinoma cells with little or no change in the half-lives of RIalpha, RIIalpha, and Calpha proteins. 10999726 Human
riibeta tumor Compensation by RIIbeta stabilization may represent a novel biochemical adaptation mechanism of the cell in response to sequence-specific loss of RIalpha expression, which leads to sustained down-regulation of PKA-I activity and inhibition of tumor growth 10999726 Human
rii-beta gct The GCT had high expression of FSHR compared with normal ovaries and the other tumours. cycD2 and RII-beta and COX-2 genes were also highly expressed in the GCT. sgk and LHR expression was lower in all of the tumours than in normal ovaries. 11994539 Human
rii-beta tumours The GCT had high expression of FSHR compared with normal ovaries and the other tumours. cycD2 and RII-beta and COX-2 genes were also highly expressed in the GCT. sgk and LHR expression was lower in all of the tumours than in normal ovaries. 11994539 Human
riibeta tumor Conversely, the vector-mediated overexpression of RIIbeta, as opposed to those of RIalpha and Calpha, exhibits induction of differentiation genes along with suppression of cell proliferation and transformation genes leading to reversion of tumor phenotype 16394127 Human
rii neuroblastoma Greater than 95% of the total cAMP binding activity of N-18 neuroblastoma cells was identified as being regulatory subunits of the type I (RI) and type II (RII) species, with RI being the predominant form of the two (RI:RII = 3:1). 6258772 Human
rii leukemia 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. 8449943 Human
rii carcinogenesis The RI/RII ratio generally decreases during organ development, and increases during carcinogenesis. 9541468 Human
rii carcinogenesis Thus, an altered RI/RII ratio was not detected during early rat liver carcinogenesis, but may contribute to differentiation of putative liver stem cells to hepatocytes. 9541468 Rat
rii leukemia These results show that the RII beta regulatory subunit of protein kinase plays a critical role in the cAMP-induced growth regulation of HL-60 leukemia cells. 1689049 Human
rii neuroblastoma Neuroblastoma-glioma hybrid cells of line 108CC-5 were found to contain high levels of soluble adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase activity and high levels of two specific cAMP receptor proteins, RI and RII. 226964 Human
riibeta cancer Analyses on three human cancer cell lines confirmed the possible loss of RIIbeta expression and antiproliferative activity of PKA I-selective cAMP analogs ( approximately 60% at 200 microm in BRAF-mutated cells). 16887886 Human
prkar2b tumorigenesis CONCLUSION: This loss of PRKAR2B protein due to a post-transcriptional mechanism in ACA-S is a new mechanism of cAMP pathway dysregulation in adrenocortical tumorigenesis. 18505904 Human
rii acute lymphoblastic leukemia Using two human acute lymphoblastic leukemia cell (CEM) clones with respective GC-sensitive and GC-resistant phenotypes, we discovered that the PKA regulatory subunit isoform RII(beta) is preferentially expressed in the GC-sensitive clone C7-14 cells, whe 18544528 Human
rii lymphoid malignancy These results demonstrate that PKA RII(beta) is responsible for increased GC sensitivity, critical for cAMP-mediated synergistic cell killing in CEM cells, and may represent a novel therapeutic target for GC-resistant lymphoid malignancy. 18544528 Human
riibeta acute lymphoblastic leukemia Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. 18544528 Human

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