IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HBP1 Ensembl ENSG00000105856 Chromosome 7 Start 106596696 End 106630209
Description HMG box-containing protein 1 (HMG box transcription factor 1)(High mobility group box transcription factor 1) [Source:UniProtKB/Swiss-Prot;Acc:O60381]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 23200
     Entrez Gene : 26959
     UCSC : uc003vdy.2
     GeneCards : 23200
     RefSeq : NM_012257
     CCDS : CCDS5741.1
     Uniprot : O60381
     Interpro : O60381
     GeneTests : HBP1
     CGAP : HBP1
     PMID : 9030690

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39809_at  -0.46  3.36e-8  3.02e-7  -0.55  3.64e-7  2.49e-6
 HG_U133A  207361_at  0.35  7.91e-4  1.46e-3  2.24  1.01e-48  2.25e-48
 HG_U133A  209102_s_at  -0.40  2.65e-15  1.45e-14  -3.85  1.41e-129  2.29e-128
 HG_U133_Plus2  207361_at  -0.10  4.69e-1  5.58e-1  -0.38  1.56e-2  2.47e-2
 HG_U133_Plus2  209102_s_at  -0.26  1.18e-5  4.44e-5  -0.39  9.97e-9  3.76e-8
 HG_U133_Plus2  236645_at  0.02  9.40e-1  9.57e-1  -0.58  1.24e-2  2.00e-2
 Stanford  6837  -0.32  1.35e-1  3.03e-1  -0.19  5.57e-1  7.57e-1
 Stanford  16400  0.79  1.56e-1  3.33e-1  0.73  2.18e-1  4.49e-1
 Agilent_HS_21.6K  882  -0.25  1.36e-2  5.74e-2  -0.33  6.91e-4  4.01e-3
 Agilent_HS_21.6K  3523  0.02  8.54e-1  9.19e-1  -0.04  6.03e-1  7.32e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207361_at  -0.31  3.56e-1  8.92e-1  0.09  7.92e-1  1.00e+0
 HG_U133A  209102_s_at  -0.35  6.58e-2  7.28e-1  -0.01  9.75e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39809_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207361_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209102_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207361_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209102_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 236645_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6837    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16400    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 882    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3523    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hbp1 retinoblastoma We previously isolated HBP1 as a target of the retinoblastoma (RB) and p130 family members and as the first of the HMG box transcriptional repressors. 11486012 Human
hbp1 retinoblastoma Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. 10958660 Human
hbp1 retinoblastoma Interestingly, our cloning strategy led to the isolation of a retinoblastoma protein (RB) partner known as HBP1. 10958660 Human
hbp1 retinoblastoma Regulation of differentiation by HBP1, a target of the retinoblastoma protein. 9671483 Human
hbp1 retinoblastoma To probe the functions of the retinoblastoma protein (RB) family in cell differentiation, we isolated HBP1 as a specific target of RB and p130. 9671483 Human
hbp1 retinoblastoma In contrast, HBP1 (HMG-box protein-1), a novel retinoblastoma protein-binding protein, can repress the p21 promoter and inhibit induction of p21 expression by E2F. 10030670 Human
hbp1 retinoblastoma HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. 9030690 Human
hbp1 rb We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells. 9030690 Human
hbp1 rb First, inspection of the HBP1 protein sequence revealed two consensus RB interaction motifs (LXCXE and IXCXE). 9030690 Human
hbp1 rb Second, HBP1 interaction was selective for RB and p130, but not p107. 9030690 Human
hbp1 rb HBP1, RB, and p130 levels are all up-regulated with differentiation; in contrast, p107 levels decline. 9030690 Human
hbp1 rb We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells. 9178770 Human
hbp1 rb Two distinct RB binding sites are present within HBP1--a high affinity binding site, mediated by an LXCXE motif and a separate low affinity binding site present within an activation domain. 9178770 Human
hbp1 rb The RB family and targets such as E2F and HBP1 have functions in each step. 9616132 Human
hbp1 rb RB. p130, HBP1, and other proteins appear to have unexpected functions in regulating tissue-specific gene expression. 9616132 Human
hbp1 rb To probe the functions of the retinoblastoma protein (RB) family in cell differentiation, we isolated HBP1 as a specific target of RB and p130. 9671483 Human
hbp1 rb The induction of HBP1, RB, and p130 upon differentiation in the muscle C2C12 cells suggested a coordinated role. 9671483 Human
hbp1 rb The inhibition of MyoD family function by HBP1 required binding to RB and/or p130. 9671483 Human
hbp1 rb Further investigation implicated the relative ratio of RB to HBP1 as a determinant of whether cell cycle exit or full differentiation occurred. 9671483 Human
hbp1 rb At a low RB/HBP1 ratio cell cycle exit occurred but there was no tissue-specific gene expression. 9671483 Human
hbp1 rb At elevated RB/HBP1 ratios full differentiation occurred. 9671483 Human
hbp1 rb Similar changes in the RB/HBP1 ratio have been observed in normal C2 differentiation. 9671483 Human
hbp1 rb Thus, we postulate that the relative ratio of RB to HBP1 may be one signal for activation of the MyoD family. 9671483 Human
hbp1 rb Interestingly, our cloning strategy led to the isolation of a retinoblastoma protein (RB) partner known as HBP1. 10958660 Human
hbp1 rb Finally, we demonstrated that both HBP1 and RB were involved in the activation of H1(0) gene expression. 10958660 Human
hbp1 rb We previously isolated HBP1 as a target of the retinoblastoma (RB) and p130 family members and as the first of the HMG box transcriptional repressors. 11486012 Human
hbp1 rb Finally, transgenic mice expressing a mutant HBP1 lacking the N-terminal RB interacting domain showed a stronger S-phase response following partial hepatectomy. 11486012 Human
hbp1 tumor The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression. 15225871 Human
hbp1 tumor This review will focus on the HMG-box protein 1 (HBP1) transcriptional repressor and its roles in cell cycle progression and tumor suppression. 15225871 Human

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