IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC26A4 Ensembl ENSG00000091137 Chromosome 7 Start 107088316 End 107145490
Description Pendrin (Sodium-independent chloride/iodide transporter)(Solute carrier family 26 member 4) [Source:UniProtKB/Swiss-Prot;Acc:O43511]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8818
     Entrez Gene : 5172
     UCSC : uc003vep.2
     GeneCards : 8818
     RefSeq : NM_000441
     CCDS : CCDS5746.1
     Uniprot : O43511
     Interpro : O43511
     OMIM : 605646
     GeneTests : SLC26A4
     CGAP : SLC26A4
     PMID : 9500541

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36376_at  0.22  4.33e-1  5.40e-1  -0.02  9.50e-1  9.66e-1
 HG_U133A  206529_x_at  0.09  5.56e-1  6.07e-1  3.56  1.80e-90  9.52e-90
 HG_U133_Plus2  206529_x_at  -0.38  8.68e-2  1.36e-1  -0.73  4.09e-4  8.36e-4
 Agilent_HS_21.6K  19981  0.05  3.39e-1  5.27e-1  0.06  2.98e-1  4.55e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206529_x_at  -0.64  5.52e-2  7.11e-1  -0.20  3.76e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36376_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206529_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206529_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19981    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pds differentiated thyroid cancer (dtc) We assessed the accuracy of real-time RT-PCR-based detection of a panel of thyroid-specific markers, including TG, TPO, TSHR, NIS and PDS, in comparison with serum TG measurements in a series of 55 patients operated for differentiated thyroid cancer (DTC) 15170676 Human
pds metastases Qualitative analysis of baseline and stimulated TG, NIS and PDS mRNA showed high sensitivity but low specificity in the prediction of thyroid cancer recurrence or metastases (accuracy under THST = 51%, 43% and 54%, respectively), whereas TPO and TSHR mRNA 15170676 Human
pds thyroid cancer Qualitative analysis of baseline and stimulated TG, NIS and PDS mRNA showed high sensitivity but low specificity in the prediction of thyroid cancer recurrence or metastases (accuracy under THST = 51%, 43% and 54%, respectively), whereas TPO and TSHR mRNA 15170676 Human
pendrin tumors Pendrin was assayed by semiquantitative Western blot in thyroid membrane fractions from 25 hyper- or hypofunctioning tumors and paired normal tissue samples. 11932304 Human
pendrin follicular adenoma Pendrin was increased 2-fold in toxic adenomas, was not significantly altered in follicular adenoma, and was decreased, on the average, by 35% in papillary carcinomas compared with levels in paired normal tissue. 11932304 Human
pendrin papillary carcinomas Pendrin was increased 2-fold in toxic adenomas, was not significantly altered in follicular adenoma, and was decreased, on the average, by 35% in papillary carcinomas compared with levels in paired normal tissue. 11932304 Human
pendrin toxic adenomas Pendrin was increased 2-fold in toxic adenomas, was not significantly altered in follicular adenoma, and was decreased, on the average, by 35% in papillary carcinomas compared with levels in paired normal tissue. 11932304 Human
pendrin tumors The variations in the pendrin tissue content and PDS transcript levels, assayed by RT-PCR on duplicate samples of the same tumors, were similar. 11932304 Human
pds tumors The variations in the pendrin tissue content and PDS transcript levels, assayed by RT-PCR on duplicate samples of the same tumors, were similar. 11932304 Human
pds thyroid cancer CONCLUSIONS: In thyroid cancer cell lines, TSA dramatically increased NIS gene expression and reduced PDS expression. 12490845 Human
pds tumors The increased NIS expression and reduced PDS expression may make radioiodine therapy more effective in patients with thyroid cancer, especially when the tumors have no or low uptake of radioiodine. 12490845 Human
pds thyroid cancer The increased NIS expression and reduced PDS expression may make radioiodine therapy more effective in patients with thyroid cancer, especially when the tumors have no or low uptake of radioiodine. 12490845 Human
pendrin human thyroid carcinoma Expression pattern of the pendrin and sodium/iodide symporter genes in human thyroid carcinoma cell lines and human thyroid tumors. 11454507 Human
pendrin thyroid tumors Expression pattern of the pendrin and sodium/iodide symporter genes in human thyroid carcinoma cell lines and human thyroid tumors. 11454507 Human
pds thyroid carcinoma OBJECTIVE: In the present study we analyzed the pattern of pendrin (PDS) and sodium/iodide symporter (NIS) gene expression in some thyroid carcinoma cell lines and a series of thyroid tumoral tissues. 11454507 Human
pendrin thyroid carcinoma OBJECTIVE: In the present study we analyzed the pattern of pendrin (PDS) and sodium/iodide symporter (NIS) gene expression in some thyroid carcinoma cell lines and a series of thyroid tumoral tissues. 11454507 Human
pds differentiated thyroid carcinomas (dtc) PDS gene expression was not detected in 5 of 25 differentiated thyroid carcinomas (DTC) while NIS gene was not expressed in six carcinomas. 11454507 Human
pds carcinomas PDS gene expression was not detected in 5 of 25 differentiated thyroid carcinomas (DTC) while NIS gene was not expressed in six carcinomas. 11454507 Human
pds thyroid carcinomas In contrast, 2 neoplastic thyroid tissues carrying undetectable PDS mRNA maintained NIS transcript, and 3 thyroid carcinomas negative for NIS mRNA retained the expression of PDS gene. 11454507 Human
pendrin differentiated thyroid carcinoma CONCLUSIONS: Our data demonstrate that pendrin expression: (i) is present in the more differentiated thyroid carcinoma cell lines studied; (ii) is reduced or absent in DTC tissues; (iii) may not correlate with the NIS expression. 11454507 Human
pendrin tumor The expression of Duox proteins was related to tumor differentiation, being more frequently found in neoplastic tissues that were able to pick up radioiodine, and in those with a detectable expression of sodium iodide symporter (NIS), pendrin and TPO. 11762710 Human
pds adenomas In hyperfunctioning adenomas, the PDS messenger ribonucleic acid level was in the normal range, although immunohistochemical analysis showed strong staining in the majority of follicular cells. 10843192 Human
pds adenomas In hypofunctioning adenomas, mean PDS gene expression was similar to that detected in normal thyroid tissues, but pendrin immunostaining was highly variable. 10843192 Human
pendrin adenomas In hypofunctioning adenomas, mean PDS gene expression was similar to that detected in normal thyroid tissues, but pendrin immunostaining was highly variable. 10843192 Human
pds thyroid carcinomas In thyroid carcinomas, PDS gene expression was dramatically decreased, and pendrin immunostaining was low and was positive only in rare tumor cells. 10843192 Human
pendrin thyroid carcinomas In thyroid carcinomas, PDS gene expression was dramatically decreased, and pendrin immunostaining was low and was positive only in rare tumor cells. 10843192 Human
pendrin tumor In thyroid carcinomas, PDS gene expression was dramatically decreased, and pendrin immunostaining was low and was positive only in rare tumor cells. 10843192 Human
pds thyroid carcinomas In conclusion, our study demonstrates that pendrin is located at the apical membrane of thyrocytes and that PDS gene expression is decreased in thyroid carcinomas. 10843192 Human
pendrin thyroid carcinomas In conclusion, our study demonstrates that pendrin is located at the apical membrane of thyrocytes and that PDS gene expression is decreased in thyroid carcinomas. 10843192 Human
slc26a4 thyroid nodule Solitary thyroid nodule as presenting symptom of Pendred syndrome caused by a novel splice-site mutation in intron 8 of the SLC26A4 gene. 12920581 Human
pendrin mammary cancer Pendrin transporter carries out iodide uptake into MCF-7 human mammary cancer cells. 14530519 Human
pendrin follicular adenomas In follicular adenomas, pendrin was localized in the follicle-forming parts of the tumor but was negative in trabecular parts. 12533525 Human
pendrin tumor In follicular adenomas, pendrin was localized in the follicle-forming parts of the tumor but was negative in trabecular parts. 12533525 Human
pendrin medullary carcinoma Pendrin was negative in all follicular carcinomas, papillary carcinomas, and in one case of medullary carcinoma. 12533525 Human
pendrin follicular carcinomas Pendrin was negative in all follicular carcinomas, papillary carcinomas, and in one case of medullary carcinoma. 12533525 Human
pendrin papillary carcinomas Pendrin was negative in all follicular carcinomas, papillary carcinomas, and in one case of medullary carcinoma. 12533525 Human
pendrin papillary carcinoma In quantitive mRNA analysis, the relative values of pendrin mRNA were significantly low in papillary carcinoma (p<0.01), whereas the values in other diseased thyroids were not significantly different from those in normal thyroids. 12533525 Human
pendrin follicular carcinomas Pendrin was not expressed in carcinomas, except in follicular carcinomas, where weak staining persisted. 14557483 Human
pendrin carcinomas Pendrin was not expressed in carcinomas, except in follicular carcinomas, where weak staining persisted. 14557483 Human
pds thyroid tumors Expression of the recently cloned Pendred syndrome gene SLC26A4 or PDS has been found to be decreased or even absent in various thyroid tumors. 12727855 Human
slc26a4 thyroid tumors Expression of the recently cloned Pendred syndrome gene SLC26A4 or PDS has been found to be decreased or even absent in various thyroid tumors. 12727855 Human
slc26a4 adenomas We found aberrant hypermethylation of the SLC26A4 gene in 44% of histologically benign adenomas, 46% of follicular thyroid cancers, 71% of papillary thyroid cancers, 71% of anaplastic thyroid cancers, and 100% of cell lines. 12727855 Human
slc26a4 papillary thyroid cancers We found aberrant hypermethylation of the SLC26A4 gene in 44% of histologically benign adenomas, 46% of follicular thyroid cancers, 71% of papillary thyroid cancers, 71% of anaplastic thyroid cancers, and 100% of cell lines. 12727855 Human
slc26a4 anaplastic thyroid cancers We found aberrant hypermethylation of the SLC26A4 gene in 44% of histologically benign adenomas, 46% of follicular thyroid cancers, 71% of papillary thyroid cancers, 71% of anaplastic thyroid cancers, and 100% of cell lines. 12727855 Human
slc26a4 follicular thyroid cancers We found aberrant hypermethylation of the SLC26A4 gene in 44% of histologically benign adenomas, 46% of follicular thyroid cancers, 71% of papillary thyroid cancers, 71% of anaplastic thyroid cancers, and 100% of cell lines. 12727855 Human
slc26a4 adenomas SLC26A4 gene methylation in benign adenomas and the relatively well-differentiated WRO cell line suggest that this alteration is an early event in thyroid tumorigenesis. 12727855 Human

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