IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC26A3 Ensembl ENSG00000091138 Chromosome 7 Start 107193156 End 107230888
Description Chloride anion exchanger (Down-regulated in adenoma)(Protein DRA)(Solute carrier family 26 member 3) [Source:UniProtKB/Swiss-Prot;Acc:P40879]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3018
     Entrez Gene : 1811
     UCSC : uc003ver.2
     GeneCards : 3018
     RefSeq : NM_000111
     CCDS : CCDS5748.1
     Uniprot : P40879
     Interpro : P40879
     OMIM : 126650
     GeneTests : SLC26A3
     CGAP : SLC26A3
     PMID : 8020951

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  928_at  0.27  3.48e-1  4.56e-1  0.16  6.52e-1  7.38e-1
 HG_U133A  206143_at  0.08  6.71e-1  7.13e-1  3.41  1.39e-43  2.85e-43
 HG_U133A  215657_at  -0.20  1.73e-1  2.16e-1  4.93  1.82e-87  8.87e-87
 HG_U133_Plus2  206143_at  -0.05  8.59e-1  8.95e-1  0.09  7.62e-1  7.99e-1
 HG_U133_Plus2  215657_at  0.15  4.79e-1  5.67e-1  0.53  3.29e-2  4.88e-2
 Stanford  6684  -0.33  5.50e-1  7.20e-1  0.10  8.15e-1  9.15e-1
 Agilent_HS_21.6K  9957  0.03  6.11e-1  7.61e-1  0.02  8.28e-1  8.94e-1
 Agilent_HS_21.6K  19334  0.00  9.96e-1  9.98e-1  -0.01  4.41e-1  5.97e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206143_at  0.31  6.44e-1  9.60e-1  0.17  7.05e-1  1.00e+0
 HG_U133A  215657_at  0.34  4.70e-1  9.22e-1  0.46  1.66e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 928_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206143_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215657_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206143_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215657_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6684    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9957    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19334    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dra adenocarcinomas The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
down-regulated in adenoma adenocarcinomas The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
dra colon cancer The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
down-regulated in adenoma colon cancer The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
dra adenomas The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
down-regulated in adenoma adenomas The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
cld adenoma Recent studies have demonstrated that mutations in human downregulated in adenoma gene (DRA) result in congenital chloride diarrhea (CLD), and that DRA may be involved in chloride transport across the intestinal apical domains. 11682697 Human
cld inflammatory bowel disease In inflammatory bowel disease and ischemic colitis, expression of CLD mRNA in colon epithelium was similar to histologically normal colon epithelium, but the protein was found deeper in crypts, including proliferative epithelial cells. 10857479 Human
cld adenocarcinomas In intestinal tumors, the expression pattern of CLD was dependent on the differentiation status of the tissue studied: epithelial polyps with no or minor dysplasia showed abundant expression, whereas adenocarcinomas were negative. 10857479 Human
cld tumors In intestinal tumors, the expression pattern of CLD was dependent on the differentiation status of the tissue studied: epithelial polyps with no or minor dysplasia showed abundant expression, whereas adenocarcinomas were negative. 10857479 Human
cld polyps In intestinal tumors, the expression pattern of CLD was dependent on the differentiation status of the tissue studied: epithelial polyps with no or minor dysplasia showed abundant expression, whereas adenocarcinomas were negative. 10857479 Human
dra intestinal cancer Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene. 9482116 Human
down-regulated in adenoma intestinal cancer Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene. 9482116 Human
dra cancer Although DRA was originally reported as a candidate tumor suppressor, these studies have questioned the relevance of DRA in cancer. 9482116 Human
dra tumor Although DRA was originally reported as a candidate tumor suppressor, these studies have questioned the relevance of DRA in cancer. 9482116 Human
dra intestinal cancer To evaluate whether further studies on the role of DRA in tumorigenesis are still of interest, we examined whether individuals carrying germline DRA mutations have an excess of intestinal cancer. 9482116 Human
congenital chloride diarrhea cancer Cancer status of 229 members of 36 Finnish congenital chloride diarrhea families (44 homozygous patients, 70 heterozygous parents, and 115 grandparents at 50% risk of being a DRA mutation carrier) was checked at the Finnish Cancer Registry and the risk of 9482116 Human
dra intestinal cancer Cancer status of 229 members of 36 Finnish congenital chloride diarrhea families (44 homozygous patients, 70 heterozygous parents, and 115 grandparents at 50% risk of being a DRA mutation carrier) was checked at the Finnish Cancer Registry and the risk of 9482116 Human
dra cancer While this result does not unambiguously demonstrate an increased intestinal cancer risk in DRA mutation carriers, it should promote further studies to determine the possible role of DRA in cancer. 9482116 Human
dra intestinal cancer While this result does not unambiguously demonstrate an increased intestinal cancer risk in DRA mutation carriers, it should promote further studies to determine the possible role of DRA in cancer. 9482116 Human
dra adenocarcinomas DRA is a gene that is down-regulated in colon adenomas and adenocarcinomas in humans. 9473459 Human
dra adenomas DRA is a gene that is down-regulated in colon adenomas and adenocarcinomas in humans. 9473459 Human
dra colon tumor Down-regulation of the down-regulated in adenoma (DRA) gene correlates with colon tumor progression. 9717812 Human
down-regulated in adenoma colon tumor Down-regulation of the down-regulated in adenoma (DRA) gene correlates with colon tumor progression. 9717812 Human
dra colon tumors The down-regulated in adenoma (DRA) gene was originally identified as a gene that was down-regulated in colon tumors. 9717812 Human
down-regulated in adenoma colon tumors The down-regulated in adenoma (DRA) gene was originally identified as a gene that was down-regulated in colon tumors. 9717812 Human
dra adenomatous polyps In this study, expression of DRA and its cellular distribution have been investigated in a series of benign adenomatous polyps and malignant colorectal tumors and in corresponding normal colonic mucosa. 9717812 Human
dra colorectal tumors In this study, expression of DRA and its cellular distribution have been investigated in a series of benign adenomatous polyps and malignant colorectal tumors and in corresponding normal colonic mucosa. 9717812 Human
dra tumors The levels of DRA mRNA transcripts were down-regulated in all colon tumors examined relative to matched normal mucosa, with most specimens showing undetectable levels of DRA mRNA (77 of 104 tumors). 9717812 Human
dra colon tumors The levels of DRA mRNA transcripts were down-regulated in all colon tumors examined relative to matched normal mucosa, with most specimens showing undetectable levels of DRA mRNA (77 of 104 tumors). 9717812 Human
dra adenocarcinoma DRA down-regulation was positively associated with colonic tumor progression according to Dukes' stage and was particularly significant in the early transition from normal mucosa to polyp to adenocarcinoma. 9717812 Human
dra tumor DRA down-regulation was positively associated with colonic tumor progression according to Dukes' stage and was particularly significant in the early transition from normal mucosa to polyp to adenocarcinoma. 9717812 Human
dra polyp DRA down-regulation was positively associated with colonic tumor progression according to Dukes' stage and was particularly significant in the early transition from normal mucosa to polyp to adenocarcinoma. 9717812 Human
dra adenocarcinomas The protein product of the DRA gene, a gene whose expression is down-regulated in colon adenomas and adenocarcinomas, is a membrane glycoprotein and a member of a family of sulfate transporters. 8570216 Human
dra adenomas The protein product of the DRA gene, a gene whose expression is down-regulated in colon adenomas and adenocarcinomas, is a membrane glycoprotein and a member of a family of sulfate transporters. 8570216 Human
dra adenoma The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein. 7744840 Human
dra adenocarcinomas A gene has been described, Down Regulated in Adenoma (dra), which is expressed in normal colon but is absent in the majority of colon adenomas and adenocarcinomas. 7744840 Human
dra adenoma A gene has been described, Down Regulated in Adenoma (dra), which is expressed in normal colon but is absent in the majority of colon adenomas and adenocarcinomas. 7744840 Human
dra adenomas A gene has been described, Down Regulated in Adenoma (dra), which is expressed in normal colon but is absent in the majority of colon adenomas and adenocarcinomas. 7744840 Human
dra colon carcinoma Caco-2 cells, a colon carcinoma cell line that differentiates over time in culture, demonstrated a marked induction of dra mRNA as cells progressed from the preconfluent (undifferentiated) to the postconfluent (differentiated) state. 7744840 Human
dra adenomas Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 7683425 Human
dra adenocarcinomas Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 7683425 Human
dra polyps Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 7683425 Human
cld intestinal tumors In intestinal tumors, the expression pattern of CLD was dependent on the differentiation status of the tissue studied: epithelial polyps with no or minor dysplasia showed abundant expression, whereas adenocarcinomas were negative. 10857479 Human
dra colon adenomas A gene has been described, Down Regulated in Adenoma (dra), which is expressed in normal colon but is absent in the majority of colon adenomas and adenocarcinomas. 7744840 Human
dra colon adenomas DRA is a gene that is down-regulated in colon adenomas and adenocarcinomas in humans. 9473459 Human
dra malignant colorectal tumors In this study, expression of DRA and its cellular distribution have been investigated in a series of benign adenomatous polyps and malignant colorectal tumors and in corresponding normal colonic mucosa. 9717812 Human
dra colonic tumor DRA down-regulation was positively associated with colonic tumor progression according to Dukes' stage and was particularly significant in the early transition from normal mucosa to polyp to adenocarcinoma. 9717812 Human
dra adenocarcinomas of the colon The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human
slc26a3 adenoma The mRNA expression of Slc26a3 (downregulated in adenoma) and Slc26a6 (putative anion exchanger-1) was similar between WT and CF duodena. 15650130 Human
slc26a3 adenoma However, apical NH(4)(+) inhibition of current was prevented by 10 min of pretreatment of the apical surface with 500 microM DIDS, 100 microM 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS), or 25 microM niflumic acid, suggesting a role for NH( 16002564 Human
the dra gene adenocarcinomas of the colon Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 7683425 Human
the dra gene adenomas Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 7683425 Human
the dra gene polyps Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. 7683425 Human
the dra gene adenocarcinomas The protein product of the DRA gene, a gene whose expression is down-regulated in colon adenomas and adenocarcinomas, is a membrane glycoprotein and a member of a family of sulfate transporters. 8570216 Human
the dra gene colon adenomas The protein product of the DRA gene, a gene whose expression is down-regulated in colon adenomas and adenocarcinomas, is a membrane glycoprotein and a member of a family of sulfate transporters. 8570216 Human
down-regulated in adenoma adenocarcinomas of the colon The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon cancer cell lines. 12208765 Human

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