IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LAMB1 Ensembl ENSG00000091136 Chromosome 7 Start 107351484 End 107431040
Description Laminin subunit beta-1 Precursor (Laminin B1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P07942]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6486
     Entrez Gene : 3912
     UCSC : uc003vew.2
     GeneCards : 6486
     RefSeq : NM_002291
     CCDS : CCDS5750.1
     Uniprot : P07942
     Interpro : P07942
     OMIM : 150240
     GeneTests : LAMB1
     CGAP : LAMB1
     PMID : 2563160

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  581_at  -0.75  8.09e-7  5.45e-6  -0.55  6.95e-4  2.25e-3
 HG_U133A  201505_at  -0.78  2.20e-13  1.04e-12  2.21  3.24e-80  1.32e-79
 HG_U133A  211651_s_at  -0.50  1.05e-7  2.98e-7  0.89  5.78e-9  7.12e-9
 HG_U133_Plus2  201505_at  -0.77  3.35e-10  2.50e-9  -0.78  2.27e-7  7.24e-7
 HG_U133_Plus2  211651_s_at  -0.63  2.85e-7  1.41e-6  -0.25  3.43e-2  5.07e-2
 HG_U133_Plus2  238608_at  -0.34  3.84e-2  6.69e-2  -0.54  2.41e-3  4.36e-3
 Stanford  4352  0.66  1.33e-1  3.00e-1  0.42  3.77e-1  6.14e-1
 Stanford  6108  0.24  5.95e-1  7.52e-1  -0.03  9.31e-1  9.70e-1
 Stanford  10672  0.13  6.97e-1  8.25e-1  0.16  7.35e-1  8.71e-1
 Agilent_HS_21.6K  6128  -0.07  4.50e-1  6.31e-1  -0.05  5.86e-1  7.20e-1
 Agilent_HS_21.6K  9952  -0.37  1.98e-2  7.56e-2  -0.42  6.68e-3  2.59e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201505_at  0.05  8.90e-1  9.93e-1  -0.05  8.08e-1  1.00e+0
 HG_U133A  211651_s_at  -0.11  7.19e-1  9.72e-1  -0.11  6.45e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 581_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201505_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211651_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201505_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211651_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 238608_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4352    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6108    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10672    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6128    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9952    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lamb1 teratocarcinoma Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. 9419418 Mouse
lamb1 uterine leiomyoma These results suggested that alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma. 15706419 Human
laminin beta1 embryonal carcinoma Mouse embryonal carcinoma F9 cells expressing partial mouse laminin beta1 covering either the C-terminal end (delta beta1S) or the whole (delta beta1L) of the long arm were established to study the assembly and interchain disulfide-bonding of beta1 to end 9000515 Mouse
laminin beta1 prostate cancer In situ hybridization analysis of genes coding collagen IV alpha1 chain, laminin beta1 chain, and S-laminin in prostate tissue and prostate cancer: increased basement membrane gene expression in high-grade and metastatic lesions. 9687985 Human
laminin beta1 lymph-node metastases METHODS: In the present study, we used in situ hybridization techniques to determine steady-state levels of genes coding BM components (alpha1 chain of collagen IV, laminin beta1 chain, and S-laminin) in prostate tissue obtained from 15 radical prostatect 9687985 Human
laminin beta1 prostatic adenocarcinomas METHODS: In the present study, we used in situ hybridization techniques to determine steady-state levels of genes coding BM components (alpha1 chain of collagen IV, laminin beta1 chain, and S-laminin) in prostate tissue obtained from 15 radical prostatect 9687985 Human
laminin beta1 fibrosarcoma We sought to identify cell adhesive sequences from the mouse laminin beta1 chain by testing HT-1080 fibrosarcoma and B16-F10 melanoma cells for binding to 187 overlapping synthetic peptides which covered the entire chain. 10860548 Human
laminin beta1 melanoma We sought to identify cell adhesive sequences from the mouse laminin beta1 chain by testing HT-1080 fibrosarcoma and B16-F10 melanoma cells for binding to 187 overlapping synthetic peptides which covered the entire chain. 10860548 Human
laminin beta1 metastasis The YIGSR (Tyr-Ile-Gly-Ser-Arg) laminin beta1 chain sequence has an inhibitory effect on tumour growth and the metastasis of melanoma and fibrosarcoma cells. 10471037 Human
laminin beta1 fibrosarcoma The YIGSR (Tyr-Ile-Gly-Ser-Arg) laminin beta1 chain sequence has an inhibitory effect on tumour growth and the metastasis of melanoma and fibrosarcoma cells. 10471037 Human
laminin beta1 melanoma The YIGSR (Tyr-Ile-Gly-Ser-Arg) laminin beta1 chain sequence has an inhibitory effect on tumour growth and the metastasis of melanoma and fibrosarcoma cells. 10471037 Human
laminin beta1 tumour The YIGSR (Tyr-Ile-Gly-Ser-Arg) laminin beta1 chain sequence has an inhibitory effect on tumour growth and the metastasis of melanoma and fibrosarcoma cells. 10471037 Human
laminin beta1 carcinomas In contrast, laminin beta1 chain (a constituent of laminin-8) was typically found in vessel walls of carcinomas and their metastases but not in those of normal breast. 15987446 Human
laminin beta1 metastases In contrast, laminin beta1 chain (a constituent of laminin-8) was typically found in vessel walls of carcinomas and their metastases but not in those of normal breast. 15987446 Human
laminin beta 1 tumor metastasis The YIGSR (Tyr-Ile-Gly-Ser-Arg) peptide, derived from the laminin beta 1 chain, decreases tumor metastasis and growth in experimental animals. 8069868 others
laminin beta 1 teratocarcinoma Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity. 9419418 Mouse

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