IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DOCK4 Ensembl ENSG00000128512 Chromosome 7 Start 111153404 End 111431423
Description Dedicator of cytokinesis protein 4 [Source:UniProtKB/Swiss-Prot;Acc:Q8N1I0]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 19192
     Entrez Gene : 9732
     UCSC : uc003vfx.2
     GeneCards : 19192
     RefSeq : NM_014705
     CCDS : CCDS47688.1
     Uniprot : Q8N1I0
     Interpro : Q8N1I0
     OMIM : 607679
     GeneTests : DOCK4
     CGAP : DOCK4
     PMID : 12432077

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41620_at  -1.54  2.20e-30  6.46e-28  -2.03  9.88e-26  5.42e-23
 HG_U133A  205003_at  -1.86  9.24e-77  1.54e-74  -3.79  4.21e-67  1.29e-66
 HG_U133_Plus2  1558691_a_at  0.04  8.67e-1  9.01e-1  -0.38  4.97e-2  7.12e-2
 HG_U133_Plus2  205003_at  -1.80  4.15e-49  2.58e-46  -2.75  9.53e-42  2.61e-39
 HG_U133_Plus2  241313_at  -0.67  1.22e-4  3.80e-4  -0.75  3.32e-4  6.87e-4
 HG_U133_Plus2  244840_x_at  -1.17  1.36e-14  1.75e-13  -1.48  4.52e-16  4.01e-15
 Agilent_HS_21.6K  5553  -0.23  1.08e-5  1.86e-4  -0.33  5.58e-8  1.32e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205003_at  -0.01  9.63e-1  9.98e-1  -0.03  8.73e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41620_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205003_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558691_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205003_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241313_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 244840_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5553    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dock4 cancer DOCK4 mutations are present in a subset of human cancer cell lines; a recurrent missense mutant identified in human prostate and ovarian cancers encodes a protein that is defective in Rap1 activation. 12628187 Human
dock4 ovarian cancers DOCK4 mutations are present in a subset of human cancer cell lines; a recurrent missense mutant identified in human prostate and ovarian cancers encodes a protein that is defective in Rap1 activation. 12628187 Human
dock4 tumor Expression of wild-type, but not mutant, DOCK4 in mouse osteosarcoma cells with a deletion of the endogenous gene suppresses growth in soft agar and tumor invasion in vivo. 12628187 Mouse
dock4 mouse osteosarcoma Expression of wild-type, but not mutant, DOCK4 in mouse osteosarcoma cells with a deletion of the endogenous gene suppresses growth in soft agar and tumor invasion in vivo. 12628187 Mouse

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