IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PPP1R3A Ensembl ENSG00000154415 Chromosome 7 Start 113301622 End 113346300
Description Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit)(Protein phosphatase type-1 glycogen targeting subunit) [Source:UniProtKB/Swiss-Prot;Acc:Q16821]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9291
     Entrez Gene : 5506
     UCSC : uc010ljy.1
     GeneCards : 9291
     RefSeq : NM_002711
     CCDS : CCDS5759.1
     Uniprot : Q16821
     Interpro : Q16821
     OMIM : 600917
     GeneTests : PPP1R3A
     CGAP : PPP1R3A
     PMID : 7926294

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35518_at  0.09  6.85e-1  7.66e-1  0.44  8.33e-2  1.41e-1
 HG_U133A  206895_at  -0.27  4.00e-2  5.67e-2  2.24  1.13e-39  2.17e-39
 HG_U133A  211169_s_at  -0.45  1.15e-2  1.79e-2  3.32  1.93e-54  4.71e-54
 HG_U133_Plus2  206895_at  0.29  1.56e-1  2.24e-1  0.72  4.30e-3  7.48e-3
 HG_U133_Plus2  211169_s_at  0.05  8.25e-1  8.69e-1  0.25  3.78e-1  4.39e-1
 Agilent_HS_21.6K  3292  0.02  7.13e-1  8.30e-1  0.01  8.91e-1  9.35e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206895_at  -0.31  4.50e-1  9.15e-1  0.24  3.94e-1  1.00e+0
 HG_U133A  211169_s_at  -0.31  6.38e-1  9.59e-1  -0.35  4.25e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35518_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206895_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211169_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206895_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211169_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3292    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ppp1r3 polycystic-ovary syndrome Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. 15181086 Human
ppp1r3 cancers Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers. 10698503 Human
ppp1r3 cancer Recently, we found nonsense and missense mutations of the PPP1R3 (protein phosphatase 1, regulatory subunit 3) gene in diverse human cancer cell lines and primary lung carcinomas, indicating that PPP1R3 functions as a tumor suppressor in human carcinogene 10698503 Human
ppp1r3 tumor Recently, we found nonsense and missense mutations of the PPP1R3 (protein phosphatase 1, regulatory subunit 3) gene in diverse human cancer cell lines and primary lung carcinomas, indicating that PPP1R3 functions as a tumor suppressor in human carcinogene 10698503 Human
ppp1r3 lung carcinomas Recently, we found nonsense and missense mutations of the PPP1R3 (protein phosphatase 1, regulatory subunit 3) gene in diverse human cancer cell lines and primary lung carcinomas, indicating that PPP1R3 functions as a tumor suppressor in human carcinogene 10698503 Human
ppp1r3 primary cancers In this study, to assess the prevalence of PPP1R3 mutations in human primary cancers and the genetic diversity of the PPP1R3 gene in the human population, somatic mutations and genetic polymorphisms in the PPP1R3 gene were examined in 137 pairs of cancero 10698503 Human
ppp1r3 cancers In this study, to assess the prevalence of PPP1R3 mutations in human primary cancers and the genetic diversity of the PPP1R3 gene in the human population, somatic mutations and genetic polymorphisms in the PPP1R3 gene were examined in 137 pairs of cancero 10698503 Human
ppp1r3 hematological malignancies Alterations of the PPP1R3 gene in hematological malignancies. 10995882 Human
ppp1r3 cancers PPP1R3 (protein phosphatase 1, regulatory subunit 3) is a candidate tumor suppressor gene at chromosome 7q31, since nonsense and missense mutations of the PPP1R3 gene have been detected in a variety of human cancers. 10995882 Human
ppp1r3 tumor PPP1R3 (protein phosphatase 1, regulatory subunit 3) is a candidate tumor suppressor gene at chromosome 7q31, since nonsense and missense mutations of the PPP1R3 gene have been detected in a variety of human cancers. 10995882 Human
ppp1r3 lymphoma To evaluate the possible involvement of the PPP1R3 gene in the development of hematological malignancies, we examined 72 leukemia and lymphoma cell lines for alterations of the PPP1R3 gene by PCR-SSCP and direct sequence analyses. 10995882 Human
ppp1r3 hematological malignancies To evaluate the possible involvement of the PPP1R3 gene in the development of hematological malignancies, we examined 72 leukemia and lymphoma cell lines for alterations of the PPP1R3 gene by PCR-SSCP and direct sequence analyses. 10995882 Human
ppp1r3 leukemia To evaluate the possible involvement of the PPP1R3 gene in the development of hematological malignancies, we examined 72 leukemia and lymphoma cell lines for alterations of the PPP1R3 gene by PCR-SSCP and direct sequence analyses. 10995882 Human
ppp1r3 hematological malignancies These results indicate that PPP1R3 is not a major target of 7q deletions in myeloid leukemia, however, alterations of the PPP1R3 gene may contribute to the development of a subset of hematological malignancies. 10995882 Human
ppp1r3 myeloid leukemia These results indicate that PPP1R3 is not a major target of 7q deletions in myeloid leukemia, however, alterations of the PPP1R3 gene may contribute to the development of a subset of hematological malignancies. 10995882 Human
ppp1r3 cancer Alterations of the PPP1R3 gene in human cancer. 10485448 Human
ppp1r3 cancers Here we report genetic alterations of the PPP1R3 gene located at chromosome 7q31, which encodes regulatory subunit 3 of PP1, in various types of human cancers. 10485448 Human
ppp1r3 non-small cell lung cancer Mutations of the PPP1R3 gene were detected in 5 of 33 (15%) non-small cell lung cancer cell lines and 2 of 38 (5%) primary non-small cell lung cancers and were also observed in cell lines derived from a small cell lung cancer, an ovarian cancer, a colorec 10485448 Human
ppp1r3 colorectal cancer Mutations of the PPP1R3 gene were detected in 5 of 33 (15%) non-small cell lung cancer cell lines and 2 of 38 (5%) primary non-small cell lung cancers and were also observed in cell lines derived from a small cell lung cancer, an ovarian cancer, a colorec 10485448 Human
ppp1r3 small-cell lung cancer Mutations of the PPP1R3 gene were detected in 5 of 33 (15%) non-small cell lung cancer cell lines and 2 of 38 (5%) primary non-small cell lung cancers and were also observed in cell lines derived from a small cell lung cancer, an ovarian cancer, a colorec 10485448 Human
ppp1r3 gastric cancer Mutations of the PPP1R3 gene were detected in 5 of 33 (15%) non-small cell lung cancer cell lines and 2 of 38 (5%) primary non-small cell lung cancers and were also observed in cell lines derived from a small cell lung cancer, an ovarian cancer, a colorec 10485448 Human
ppp1r3 ovarian cancer Mutations of the PPP1R3 gene were detected in 5 of 33 (15%) non-small cell lung cancer cell lines and 2 of 38 (5%) primary non-small cell lung cancers and were also observed in cell lines derived from a small cell lung cancer, an ovarian cancer, a colorec 10485448 Human
ppp1r3 non-small cell lung cancers Mutations of the PPP1R3 gene were detected in 5 of 33 (15%) non-small cell lung cancer cell lines and 2 of 38 (5%) primary non-small cell lung cancers and were also observed in cell lines derived from a small cell lung cancer, an ovarian cancer, a colorec 10485448 Human
ppp1r3 tumor These findings suggest that PPP1R3 alteration plays a role in the development of human cancers and that PPP1R3 could act as a tumor suppressor gene. 10485448 Human
ppp1r3 cancers These findings suggest that PPP1R3 alteration plays a role in the development of human cancers and that PPP1R3 could act as a tumor suppressor gene. 10485448 Human
ppp1r3 metastasis PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis. 15870946 Human
ppp1r3 colorectal cancer PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis. 15870946 Human
ppp1r3 tumor We analyzed alterations in the PPP1R3 gene and its relationship to tumor progression and metastasis. 15870946 Human
ppp1r3 metastasis We analyzed alterations in the PPP1R3 gene and its relationship to tumor progression and metastasis. 15870946 Human
ppp1r3 colorectal cancers SSCP analysis of PPP1R3 showed abnormal patterns in 6 (12%) of the 50 colorectal cancers. 15870946 Human
ppp1r3 liver metastases PPP1R3 gene alterations correlated with lymph node and liver metastases. 15870946 Human

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