IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TES Ensembl ENSG00000135269 Chromosome 7 Start 115637857 End 115686071
Description Testin (TESS) [Source:UniProtKB/Swiss-Prot;Acc:Q9UGI8]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 14620
     Entrez Gene : 26136
     UCSC : uc003vho.2
     GeneCards : 14620
     RefSeq : NM_015641
     CCDS : CCDS5763.1
     Uniprot : Q9UGI8
     Interpro : Q9UGI8
     OMIM : 606085
     GeneTests : TES
     CGAP : TES
     PMID : 10950921

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32134_at  -0.18  1.56e-1  2.39e-1  -0.17  2.44e-1  3.43e-1
 HG_U133A  202719_s_at  0.14  8.45e-2  1.12e-1  -0.17  9.81e-2  1.03e-1
 HG_U133A  202720_at  -0.01  9.17e-1  9.30e-1  -1.64  2.71e-35  4.89e-35
 HG_U133_Plus2  202719_s_at  0.48  2.18e-7  1.10e-6  0.47  1.36e-5  3.42e-5
 HG_U133_Plus2  202720_at  0.16  2.47e-2  4.56e-2  -0.12  1.05e-1  1.40e-1
 HG_U133_Plus2  244870_at  -0.11  5.70e-1  6.51e-1  0.00  9.85e-1  9.88e-1
 Stanford  16169  -0.59  4.06e-2  1.39e-1  -0.59  5.12e-2  1.74e-1
 Agilent_HS_21.6K  14675  -0.05  1.48e-2  6.10e-2  -0.07  4.13e-3  1.74e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202719_s_at  -0.54  4.85e-2  7.08e-1  0.11  4.98e-1  1.00e+0
 HG_U133A  202720_at  -0.53  4.54e-3  6.53e-1  0.08  6.27e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32134_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202719_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202720_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202719_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202720_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 244870_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16169    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14675    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tes tumours The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. 11420696 Human
tes tumour The TES gene lies within the minimal region of overlap of several LOH studies and appears to possess the properties of a tumour suppressor. 11420696 Human
tes breast cancer Mutation analysis of the coding TES exons in 21 human tumour-derived cell lines revealed the presence of a frameshift mutation in one allele in the breast cancer cell line ZR-75. 11420696 Human
tes ovarian carcinomas Methylation of the CpG island at the 5' end of TES appears to be a remarkably frequent finding, occurring in seven out of 10 ovarian carcinomas and in each of the 30 tumour-derived cell lines tested. 11420696 Human
tes tumour We believe that TES is a tumour suppressor gene that is inactivated primarily by transcriptional silencing resulting from CpG island methylation. 11420696 Human
testin cancer Although TESTIN mRNA is expressed in all normal human tissues examined, we observed lack of expression in 22% of cancer cell lines and 44% of the cell lines derived from hematological malignancies. 10950921 Human
testin hematological malignancies Although TESTIN mRNA is expressed in all normal human tissues examined, we observed lack of expression in 22% of cancer cell lines and 44% of the cell lines derived from hematological malignancies. 10950921 Human
testin tumor Analysis of the TESTIN coding region in 26 tumor cell lines revealed three missense mutations. 10950921 Human
testin tumor Our findings suggest that TESTIN may represent a candidate tumor suppressor gene at 7q31.2. 10950921 Human
testin cancer Identification of a CTL-directed epitope encoded by an intron of the putative tumor suppressor gene Testin of the common fragile site 7G region: a peptide vaccine candidate for HLA-B52+ and HLA-62+ cancer patients. 14579264 Human
testin tumors Other Sertoli cell marker genes, such as cyclic protein 2 and sulfated glycoprotein 2, were expressed in all 8 tumors analyzed, and testin and steel factor (SLF), the c-kit receptor ligand, were also expressed in some of the tumors (testin, 75%; SLF, 25%) 9369931 Human
testin tumor FRA7G is a common fragile site containing the candidate tumor suppressor genes CAV1, CAV2, and TESTIN (TES). 12620387 Human
tes tumor FRA7G is a common fragile site containing the candidate tumor suppressor genes CAV1, CAV2, and TESTIN (TES). 12620387 Human
testin gastric cancer The results show that CAV1, CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer. 12620387 Human
testin tumor The results show that CAV1, CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer. 12620387 Human
tes tumour Previously, we identified TES as a novel candidate tumour suppressor gene that mapped to human chromosome 7q31.1. 12571287 Human
tes breast carcinoma We now show that Tes is a component of focal adhesions that, when expressed, negatively regulates proliferation of T47D breast carcinoma cells. 12695497 Human
tes tumour Previously we identified TES as a candidate tumour suppressor gene that is located at human chromosome 7q31.1. 14743347 Human
tes prostate tumors Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. 15252854 Human
tes tumor Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. 15252854 Human
tes tumor It has been shown previously that the main region of LOH at 7q31 spans the interval between the D7S486 and D7S2460 microsatellite loci, which contains several candidate tumor suppressor genes (TSG) such as TES, CAV2, CAV1, MET, CAPZA2, ST7 and WNT2. 15252854 Human
tes prostate tumors We found that CAV1, CAV2, MET and TES mRNA expression was lower in prostate tumors than in normal prostate tissues. 15252854 Human
tes tumor Our immunohistochemical results and previously published data on the compartmental expression of these messenger RNAs in stromal and epithelial cells suggest that TES is the best candidate tumor suppressor gene at 7q31. 15252854 Human
tes leukemia PURPOSE: The human TESTIN (TES) gene is a putative tumor suppressor gene in the fragile chromosomal region FRA7G at 7q31.1/2 that was reported to be altered in leukemia and lymphoma cell lines. 15701871 Human
tes lymphoma PURPOSE: The human TESTIN (TES) gene is a putative tumor suppressor gene in the fragile chromosomal region FRA7G at 7q31.1/2 that was reported to be altered in leukemia and lymphoma cell lines. 15701871 Human
tes breast tumors EXPERIMENTAL DESIGN: We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. 15701871 Human
tes uterine cancers EXPERIMENTAL DESIGN: We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. 15701871 Human
tes breast cancer EXPERIMENTAL DESIGN: We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. 15701871 Human
tes uterine sarcoma EXPERIMENTAL DESIGN: We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. 15701871 Human
tes breast tumor EXPERIMENTAL DESIGN: We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. 15701871 Human
tes tumor Furthermore, TES expression significantly reduced the tumorigenic potential of both T47D and MES-SA in nude mice, whereas the untreated cells and Ad-GFP-infected cells showed tumor growth in vivo. 15701871 Mouse
tes uterine cancer CONCLUSIONS: Ad-TES expression inhibit the growth of breast and uterine cancer cells lacking of TES expression through caspase-dependent and caspase-independent apoptosis, respectively, suggesting that Ad-TES infection should be explored as a therapeutic 15701871 Human
tes cancer EXPERIMENTAL DESIGN: We have analyzed the expression of TES gene in a panel of 25 breast tumors and 17 cell lines of breast, colon, and uterine cancers. 15701871 Human
tes breast cancer Furthermore, TES expression significantly reduced the tumorigenic potential of both T47D and MES-SA in nude mice, whereas the untreated cells and Ad-GFP-infected cells showed tumor growth in vivo. 15701871 Human
tes uterine sarcoma Furthermore, TES expression significantly reduced the tumorigenic potential of both T47D and MES-SA in nude mice, whereas the untreated cells and Ad-GFP-infected cells showed tumor growth in vivo. 15701871 Human
tes breast tumor Furthermore, TES expression significantly reduced the tumorigenic potential of both T47D and MES-SA in nude mice, whereas the untreated cells and Ad-GFP-infected cells showed tumor growth in vivo. 15701871 Human
tes tumour TES was originally identified as a candidate tumour suppressor gene and has subsequently been found to encode a novel focal adhesion protein. 15662727 Human
tes tumour Using yeast two-hybrid screening of kidney libraries, we identified two partners of the alpha9-alpha10 repeats: the potential tumour suppressor Tes, an actin-binding protein mainly located at focal adhesions; and EVL (Ena/vasodilator-stimulated phosphopro 15656790 Human
tes epithelial tumors The Testin (TES) gene was previously identified as a putative human tumor suppressor gene at 7q31.2, a region that is frequently deleted in hematopoietic malignancies, as well as in epithelial tumors. 16033868 Human
tes hematopoietic malignancies The Testin (TES) gene was previously identified as a putative human tumor suppressor gene at 7q31.2, a region that is frequently deleted in hematopoietic malignancies, as well as in epithelial tumors. 16033868 Human
tes tumor To determine whether TES acts as a tumor suppressor in vivo, we generated a Tes knockout mouse and then used it in an established model of carcinogen-induced gastric cancer. 16033868 Human
tes gastric cancer To determine whether TES acts as a tumor suppressor in vivo, we generated a Tes knockout mouse and then used it in an established model of carcinogen-induced gastric cancer. 16033868 Human
tes tumor These data suggest that Tes functions as a tumor suppressor gene in vivo. 16033868 Human
testin tumor Adenoviral Transduction of TESTIN Gene into Breast and Uterine Cancer Cell Lines Promotes Apoptosis and Tumor Reduction In vivo. 15701871 Human
testin uterine cancer Adenoviral Transduction of TESTIN Gene into Breast and Uterine Cancer Cell Lines Promotes Apoptosis and Tumor Reduction In vivo. 15701871 Human
testin leukemia PURPOSE: The human TESTIN (TES) gene is a putative tumor suppressor gene in the fragile chromosomal region FRA7G at 7q31.1/2 that was reported to be altered in leukemia and lymphoma cell lines. 15701871 Human
testin lymphoma PURPOSE: The human TESTIN (TES) gene is a putative tumor suppressor gene in the fragile chromosomal region FRA7G at 7q31.1/2 that was reported to be altered in leukemia and lymphoma cell lines. 15701871 Human
testin tumor Knockout mice reveal a tumor suppressor function for Testin. 16033868 Human
testin human tumor The Testin (TES) gene was previously identified as a putative human tumor suppressor gene at 7q31.2, a region that is frequently deleted in hematopoietic malignancies, as well as in epithelial tumors. 16033868 Human
testin epithelial tumors The Testin (TES) gene was previously identified as a putative human tumor suppressor gene at 7q31.2, a region that is frequently deleted in hematopoietic malignancies, as well as in epithelial tumors. 16033868 Human
testin hematopoietic malignancies The Testin (TES) gene was previously identified as a putative human tumor suppressor gene at 7q31.2, a region that is frequently deleted in hematopoietic malignancies, as well as in epithelial tumors. 16033868 Human
the tes gene tumours The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. 11420696 Human
the tes gene tumour The TES gene lies within the minimal region of overlap of several LOH studies and appears to possess the properties of a tumour suppressor. 11420696 Human

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