IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CAV1 Ensembl ENSG00000105974 Chromosome 7 Start 115952075 End 115988469
Description Caveolin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03135]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1527
     Entrez Gene : 857
     UCSC : uc003vif.1
     GeneCards : 1527
     RefSeq : NM_001172895
     CCDS : CCDS5767.1
     Uniprot : Q03135
     Interpro : Q03135
     OMIM : 601047
     GeneTests : CAV1
     CGAP : CAV1
     PMID : 10087206

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
down 82/159(52%) IHC- 15095482 J Pathol 2004, 203(1): 584-93

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36119_at  -2.94  1.46e-33  6.82e-31  -2.94  2.72e-22  5.05e-20
 HG_U133A  203065_s_at  -2.74  1.27e-72  1.80e-70  -3.68  8.68e-86  4.06e-85
 HG_U133A  212097_at  -3.15  8.00e-104  4.69e-101  -4.18  3.09e-145  8.66e-144
 HG_U133_Plus2  203065_s_at  -2.27  5.92e-35  7.00e-33  -2.08  9.02e-22  1.53e-20
 HG_U133_Plus2  212097_at  -2.46  7.46e-48  3.96e-45  -2.56  1.08e-34  8.98e-33
 Stanford  84  -3.00  4.53e-8  1.48e-5  -3.29  7.05e-7  7.47e-5
 Stanford  13136  -3.03  1.59e-7  3.76e-5  -3.32  1.44e-8  5.51e-6
 Agilent_HS_21.6K  4887  -0.65  5.78e-15  1.17e-12  -0.69  1.10e-11  9.01e-10

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203065_s_at  0.42  3.31e-1  8.86e-1  -0.35  2.68e-1  1.00e+0
 HG_U133A  212097_at  0.13  7.76e-1  9.78e-1  -0.24  4.67e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36119_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203065_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212097_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203065_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212097_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 84    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13136    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4887    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cav1 tumour In addition, several genes, such as caveolin-1 (CAV1) and caveolin-2 (CAV2), were constantly deregulated in all types of tumour sample, compared with normal tissue. 15095482 Human
caveolin-1 tumour In addition, several genes, such as caveolin-1 (CAV1) and caveolin-2 (CAV2), were constantly deregulated in all types of tumour sample, compared with normal tissue. 15095482 Human
cav1 tumours Immunostaining for CAV1 was negative in 48% of tumours, whereas 28% of the tumours did not express CAV2. 15095482 Human
caveolin-1 tumor Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. 14706341 Human
caveolin-1 tumor Antisense RNA-mediated reduction of caveolin-1 expression in EGFR-overexpressing tumor cells recapitulated these EGF-induced effects and enhanced invasion into collagen gels. 14706341 Human
caveolin-1 metastasis We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis. 14706341 Human
caveolin-1 carcinomas Multiple studies reveal a reduction in the expression level of caveolin-1 mRNA and protein in many carcinomas as well as transformed cells. 11857686 Human
caveolin-1 tumor The human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). 11857686 Human
caveolin-1 tumor Collectively, these data have been taken to imply that caveolin-1 may function in a tumor suppressor capacity. 11857686 Human
caveolin-1 glioblastoma To determine if a reduction in the expression level of caveolin-1 mRNA and protein accompanied the transformation of astrocytes, we undertook studies of two transformed rat astroglial cell lines, C6 and DI TNC(1), as well as several cell lines derived fro 11857686 Human
caveolin-1 tumors To determine if a reduction in the expression level of caveolin-1 mRNA and protein accompanied the transformation of astrocytes, we undertook studies of two transformed rat astroglial cell lines, C6 and DI TNC(1), as well as several cell lines derived fro 11857686 Human
caveolin-1 glioma Ultrastructural, immunolocalization, immunoblot, and Northern blot analyses demonstrated that caveolin-1 message and protein were expressed in all rat and human glioma cells. 11857686 Human
caveolin-1 glioma Nucleotide sequence analyses of caveolin-1 cDNAs indicate that mutations are not present in the caveolin-1 sequence in any of the glioma cell types. 11857686 Human
caveolin-1 ovarian carcinoma Caveolin-1 expression in ovarian carcinoma is MDR1 independent. 11863219 Human
caveolin-1 ovarian carcinoma We studied the role of caveolin-1 in tumor progression and prognosis in serous ovarian carcinoma and the association between caveolin-1 and MDR1 expression. 11863219 NA
caveolin-1 tumor We studied the role of caveolin-1 in tumor progression and prognosis in serous ovarian carcinoma and the association between caveolin-1 and MDR1 expression. 11863219 NA
caveolin-1 tumors The study involved immunohistochemical analysis for caveolin-1 and P-glycoprotein (P-gp) expression in 75 effusions and 90 solid lesions from ovarian and primary peritoneal carcinoma; in situ hybridization for MDR1 messenger RNA (mRNA) expression in 62 ef 11863219 Human
caveolin-1 primary peritoneal carcinoma The study involved immunohistochemical analysis for caveolin-1 and P-glycoprotein (P-gp) expression in 75 effusions and 90 solid lesions from ovarian and primary peritoneal carcinoma; in situ hybridization for MDR1 messenger RNA (mRNA) expression in 62 ef 11863219 Human
caveolin-1 tumors Immunohistochemical analysis localized caveolin-1 to the cell membrane in 43 effusions and 24 tumors. 11863219 Human
caveolin-1 cancer Caveolin-1 is a novel diagnostic marker for effusions; expression is moderately elevated in tumor cells in effusions, possibly owing to altered signal transduction and metabolism in cancer cells at this site. 11863219 Human
caveolin-1 tumor Caveolin-1 is a novel diagnostic marker for effusions; expression is moderately elevated in tumor cells in effusions, possibly owing to altered signal transduction and metabolism in cancer cells at this site. 11863219 Human
caveolin-1 cancer The level of caveolin-1 expression closely correlates with the oncogenic transformation of NIH 3T3 cells, the proliferation of human cancer cells, and the differentiation of adipocytes and muscle cells. 11748236 Human
caveolin-1 astrocytic tumors In this study we determined the expression levels of 3 small GTP binding proteins (RhoA, RhoB and Rac1), of their inhibitor RhoGDI and of caveolin-1 in 24 human astrocytic tumors of grades I to IV. 11918088 NA
caveolin-1 astrocytic tumors The amount of caveolin-1 immunodetected was not significantly different from normal brain samples while the Rac1 expression level was diminished in astrocytic tumors of grades III and IV. 11918088 Human
caveolin-1 lymph-node metastasis Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. 11920460 Human
caveolin-1 esophageal squamous-cell carcinoma Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. 11920460 Human
caveolin-1 prostate carcinoma Recently caveolin-1 was identified as a metastasis-related gene in prostate carcinoma. 11920460 Human
caveolin-1 esophageal carcinoma However, the clinical impact of caveolin-1 expression in esophageal carcinoma remains unknown. 11920460 Human
caveolin-1 esophageal squamous-cell carcinoma METHODS: One hundred thirty surgical specimens of esophageal squamous cell carcinoma were immunohistochemically assessed for caveolin-1 expression by polyclonal antibody. 11920460 NA
caveolin-1 lymph-node metastasis CONCLUSIONS: Over-expression of caveolin-1 is associated with lymph node metastasis and a worse prognosis after surgery in esophageal squamous cell carcinoma. 11920460 Human
caveolin-1 esophageal squamous-cell carcinoma CONCLUSIONS: Over-expression of caveolin-1 is associated with lymph node metastasis and a worse prognosis after surgery in esophageal squamous cell carcinoma. 11920460 Human
caveolin-1 mcf-7 human breast cancer Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. 11948420 Human
caveolin-1 cancer Expression of recombinant caveolin-1 inhibits anchorage-independent growth in cancer cells. 11948420 Human
caveolin-1 breast adenocarcinoma Utilizing MCF-7 human breast adenocarcinoma cells stably transfected with caveolin-1 (MCF-7/Cav1), we demonstrate that caveolin-1 expression decreases MCF-7 cell proliferation rate and markedly reduces their capacity to form colonies in soft agar. 11948420 Human
caveolin-1 human breast cancer We conclude that high expression level of caveolin-1 in human breast cancer cells exerts a negative modulatory effect on anchorage-independent growth by inhibiting cell proliferation even though matrix-independent cell survival is enhanced. 11948420 Human
caveolin-1 cancer The inhibitory effect of caveolin-1 on these transformation-dependent processes supports the hypothesis that caveolin-1 acts as a tumor suppressor protein which may impose major phenotypic changes when expressed in human cancer cells. 11948420 Human
caveolin-1 tumor The inhibitory effect of caveolin-1 on these transformation-dependent processes supports the hypothesis that caveolin-1 acts as a tumor suppressor protein which may impose major phenotypic changes when expressed in human cancer cells. 11948420 Human
caveolin-1 papillary carcinoma of the thyroid Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid. 11953823 Human
caveolin-1 carcinoma Previous in vitro and in vivo studies on the function of caveolin-1 in carcinoma showed controversial results, indicating that the physiological role of caveolin-1 varies according to the origin of carcinoma. 11953823 Human
caveolin-1 thyroid neoplasms In this study, we investigated caveolin-1 expression in thyroid neoplasms by means of immunohistochemistry using a rabbit polyclonal antibody against caveolin-1. 11953823 NA
caveolin-1 papillary carcinoma In papillary carcinoma, caveolin-1 expression was observed in high incidence, and especially in microcancer (less than 1.0 cm in diameter), caveolin-1 was positive in all cases except one. 11953823 Human
caveolin-1 follicular carcinoma On the other hand, all cases of follicular carcinoma and adenoma were classified as negative for caveolin-1. 11953823 Human
caveolin-1 adenoma On the other hand, all cases of follicular carcinoma and adenoma were classified as negative for caveolin-1. 11953823 Human
caveolin-1 papillary carcinoma These results suggest that caveolin-1 may play a role predominantly in the early phase of papillary carcinoma, whereas it has little influence on follicular tumours. 11953823 Human
caveolin-1 tumours These results suggest that caveolin-1 may play a role predominantly in the early phase of papillary carcinoma, whereas it has little influence on follicular tumours. 11953823 Human
caveolin-1 cell tumor Nitric oxide modulates caveolin-1 and matrix metalloproteinase-9 expression and distribution at the endothelial cell/tumor cell interface. 15064242 Human
caveolin 1 tumor This analysis has permitted us to implicate several genes (caveolin 1, glypican 1, growth arrest-specific 6 protein, cysteine-rich angiogenic inducer 61) in tumor progression. 12000726 Human
caveolin-1 testicular cancer The aim of this study was to examine the expressions of caveolin-1 and caveolin-3 (which is a caveolin-1 homologue localized predominantly in muscle tissue) in testicular cancer. 12119442 Human
caveolin-1 testicular cancer METHODS: We evaluated the expressions of caveolin-1, caveolin-3, and iNOS in 16 seminoma and 10 non-seminoma testicular cancer specimens as well as normal testicular tissue, using a streptavidin-biotin bridge technique on cryostat sections. 12119442 NA
caveolin-1 seminoma METHODS: We evaluated the expressions of caveolin-1, caveolin-3, and iNOS in 16 seminoma and 10 non-seminoma testicular cancer specimens as well as normal testicular tissue, using a streptavidin-biotin bridge technique on cryostat sections. 12119442 NA
caveolin-1 teratoma RESULTS: Immunohistochemistry revealed that caveolin-3, but not caveolin-1, was frequently expressed in seminomas (12 positive out of 16 specimens) without positive staining in their normal counterparts or in nonseminomatous germ cell tumors, except for m 12119442 Human
caveolin-1 nonseminomatous germ-cell tumors RESULTS: Immunohistochemistry revealed that caveolin-3, but not caveolin-1, was frequently expressed in seminomas (12 positive out of 16 specimens) without positive staining in their normal counterparts or in nonseminomatous germ cell tumors, except for m 12119442 Human
caveolin-1 tumor Interestingly, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). 12134086 Human
caveolin-1 tumor Taken together, these results clearly indicate a central role for caveolin-1 in promoting cellular senescence and they suggest the hypothesis that premature senescence may represent a tumor suppressor function mediated by caveolin-1 in vivo. 12134086 Human
caveolin-1 tumor angiogenesis Our results showed an NF-kappaB-dependent induction of ephrin-A1 and caveolin-1 mRNAs after stimulation with TNF-alpha and IL-1beta, confirming that NF-kappaB controls target genes implied in tumor angiogenesis and cell transformation. 12213581 Human
caveolin-1 cervical cancers Mutational, epigenetic and expressional analyses of caveolin-1 gene in cervical cancers. 12888893 Human
cav-1 tumor CAV-1 gene is regarded as a candidate for the tumor suppressor gene and it can be inactivated in several ways, including point mutations, chromosomal deletions and promoter methylation. 12888893 Human
cav-1 cervical cancer We used direct sequencing, methylation specific PCR, and immunohistochemical staining methods to explore the role of CAV-1 gene in the development of cervical cancer. 12888893 Human
cav-1 cervical cancer Three types of CAV-1 expression patterns were observed in cervical cancer tissues, and the expression pattern had no relationship with mutation status. 12888893 Human
cav-1 cervical cancer From these results, we suggest that CAV-1 gene can be inactivated through mutations, and does not play a role, through methylation of promoter, or an unknown mechanism which may play a role, in the development of cervical cancer. 12888893 Human
caveolin-1 androgen insensitive prostate cancer The role of caveolin-1 in androgen insensitive prostate cancer. 12352463 Human
caveolin-1 androgen insensitive prostate cancer PURPOSE: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. 12352463 NA
caveolin-1 prostate cancer MATERIALS AND METHODS: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. 12352463 NA
caveolin-1 metastatic human prostate cancer RESULTS: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. 12352463 Human
caveolin-1 prostate cancer Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. 12352463 Human
caveolin-1 androgen insensitive prostate cancer CONCLUSIONS: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. 12352463 Human
caveolin-1 cell hyperplasia Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. 12368209 Mouse
caveolin-1 breast cancer Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. 12368209 Mouse
cav1 mammary tumors Recently, we mapped the human CAV1 gene to a suspected tumor suppressor locus (7q31.1/D7S522) that is deleted in a variety of human cancers, as well as mammary tumors. 12368209 Human
cav1 cancers Recently, we mapped the human CAV1 gene to a suspected tumor suppressor locus (7q31.1/D7S522) that is deleted in a variety of human cancers, as well as mammary tumors. 12368209 Human
cav1 tumor Recently, we mapped the human CAV1 gene to a suspected tumor suppressor locus (7q31.1/D7S522) that is deleted in a variety of human cancers, as well as mammary tumors. 12368209 Human
cav1 human breast cancers In addition, the CAV1 gene is mutated (P132L) in up to approximately 16% of human breast cancers. 12368209 Human
cav-1 human breast cancers To understand the role of the Cav-1 (P132L) mutation in the pathogenesis of human breast cancers, we generated the same mutation in wild-type (WT) Cav-1 and studied its behavior in cultured cells. 12368209 Human
cav1 breast cancer These data provide a molecular explanation for why only a single mutated CAV1 allele is found in patients with breast cancer. 12368209 Human
cav-1 cell hyperplasia Interestingly, we show that inactivation of Cav-1 gene expression leads to mammary epithelial cell hyperplasia, even in 6-week-old virgin female mice. 12368209 Mouse
cav-1 cell hyperplasia These data clearly implicate loss of functional Cav-1 in the pathogenesis of mammary epithelial cell hyperplasia, and suggest that Cav-1-null mice represent a novel animal model to study premalignant mammary disease. 12368209 Mouse
caveolin-1 epidermoid carcinoma Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation. 12372346 Human
caveolin-1 carcinoma Altogether, these data indicate that multiple human carcinoma cells exhibit an EGF receptor-dependent tyrosine phosphorylation of caveolin-1 and that this process is sensitive to Src family kinase inhibitors. 12372346 Human
caveolin-1 human prostate cancer Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells. 12185081 Human
caveolin-1 tumors Caveolin-1, androgen receptor, c-Myc, and protein kinase Cepsilon (PKCepsilon) proteins are overrepresented in most advanced prostate cancer tumors. 12185081 Human
caveolin-1 advanced prostate cancer Caveolin-1, androgen receptor, c-Myc, and protein kinase Cepsilon (PKCepsilon) proteins are overrepresented in most advanced prostate cancer tumors. 12185081 Human
caveolin-1 prostate cancer Previously, we demonstrated that PKCepsilon has the capacity to enhance the expression of both caveolin-1 and c-Myc in cultured prostate cancer cells and is sufficient to induce the growth of androgen-independent tumors. 12185081 Human
caveolin-1 tumors Previously, we demonstrated that PKCepsilon has the capacity to enhance the expression of both caveolin-1 and c-Myc in cultured prostate cancer cells and is sufficient to induce the growth of androgen-independent tumors. 12185081 Human
caveolin-1 pancreatic ductal adenocarcinoma Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. 12402154 Human
caveolin-1 prostate cancer Caveolin-1 was recently identified as a metastasis-related gene in prostate cancer. 12402154 Human
caveolin-1 pancreatic carcinoma The clinical effects of caveolin-1 expression in pancreatic carcinoma, however, remain unknown. 12402154 Human
caveolin-1 pancreatic adenocarcinoma In this study, we have investigated the relationship between caveolin-1 expression and the clinicopathologic variables and clinical outcome in 79 patients with pancreatic adenocarcinoma undergoing surgical resection. 12402154 NA
caveolin-1 tumour Positive caveolin-1 expression was correlated with tumour diameter (P=0.0079), histopathologic grade (P=0.0272) and poor prognosis (P=0.0008). 12402154 Human
caveolin-1 pancreatic carcinoma These results suggest that caveolin-1 overexpression is associated with tumour progression, thereby indicating a poor prognosis for certain patients undergoing surgical resection for pancreatic carcinoma. 12402154 Human
caveolin-1 tumour These results suggest that caveolin-1 overexpression is associated with tumour progression, thereby indicating a poor prognosis for certain patients undergoing surgical resection for pancreatic carcinoma. 12402154 Human
caveolin-1 metastasis Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. 12414512 Human
caveolin-1 lung adenocarcinoma Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. 12414512 Human
caveolin-1 tumor Caveolin-1, a 21- to 24-kd integral membrane protein, is primarily implicated as a tumor suppressor gene. 12414512 Human
caveolin-1 prostate adenocarcinomas Re-expression of caveolin-1 is found in advanced human and mouse prostate adenocarcinomas. 12414512 Mouse
caveolin-1 human lung cancers To explore its potential role in tumorigenesis and tumor progression of human lung cancers, we used the well-characterized cell line (CL) series of lung adenocarcinoma cells with increasing cellular invasiveness to show that expression of caveolin-1 mRNA 12414512 Human
caveolin-1 tumor To explore its potential role in tumorigenesis and tumor progression of human lung cancers, we used the well-characterized cell line (CL) series of lung adenocarcinoma cells with increasing cellular invasiveness to show that expression of caveolin-1 mRNA 12414512 Human
caveolin-1 lung adenocarcinoma To explore its potential role in tumorigenesis and tumor progression of human lung cancers, we used the well-characterized cell line (CL) series of lung adenocarcinoma cells with increasing cellular invasiveness to show that expression of caveolin-1 mRNA 12414512 Human
caveolin-1 lung adenocarcinoma Immunohistochemical examination of caveolin-1 was performed in 95 specimens obtained retrospectively from patients who had lung adenocarcinoma either with (35 patients) or without (60 patients) ipsilateral hilar/peribronchial tumor-metastasized lymph node 12414512 Human
caveolin-1 regional lymph node metastasis Caveolin-1 immunoreactivity was either totally absent or just barely detectable in a few lung adenocarcinoma cells from cases diagnosed as lung adenocarcinoma without regional lymph node metastasis. 12414512 Human
caveolin-1 lung adenocarcinoma Caveolin-1 immunoreactivity was either totally absent or just barely detectable in a few lung adenocarcinoma cells from cases diagnosed as lung adenocarcinoma without regional lymph node metastasis. 12414512 Human
caveolin-1 cancer In contrast, increased caveolin-1 immunoreactivity both in number and intensity was detected in primary lung adenocarcinoma cells as well as in cancer cells that metastasized to regional lymph nodes from the cases diagnosed as advanced lung adenocarcinoma 12414512 Human
caveolin-1 metastases In contrast, increased caveolin-1 immunoreactivity both in number and intensity was detected in primary lung adenocarcinoma cells as well as in cancer cells that metastasized to regional lymph nodes from the cases diagnosed as advanced lung adenocarcinoma 12414512 Human
caveolin-1 lung adenocarcinoma In contrast, increased caveolin-1 immunoreactivity both in number and intensity was detected in primary lung adenocarcinoma cells as well as in cancer cells that metastasized to regional lymph nodes from the cases diagnosed as advanced lung adenocarcinoma 12414512 Human
caveolin-1 lung adenocarcinoma We further revealed that up-regulated caveolin-1 in CL cells is necessary for mediating filopodia formation, which may enhance the invasive ability of lung adenocarcinoma cells. 12414512 Human
cav-1 human colon cancer In this work, we showed that in Caco-2 cells, a polarized cell line derived from human colon cancer that does not express caveolin 1 (Cav-1), there was no detectable expression of caveolin 2 (Cav-2). 12414992 Human
caveolin 1 human colon cancer In this work, we showed that in Caco-2 cells, a polarized cell line derived from human colon cancer that does not express caveolin 1 (Cav-1), there was no detectable expression of caveolin 2 (Cav-2). 12414992 Human
caveolin-1 tumor Caveolae and caveolae-like membrane domains in cellular signaling and disease: identification of downstream targets for the tumor suppressor protein caveolin-1. 12415732 Human
caveolin-1 tumor In particular, the protein caveolin-1 is suggested to function as a tumor suppressor protein. 12415732 Human
caveolin-1 human colon carcinoma Evidence demonstrating such a role for caveolin-1 in human colon carcinoma cells will be discussed together with data from microarray experiments seeking to identify caveolin-1 target genes responsible for such behavior. 12415732 Human
caveolin-1 colon carcinoma In particular, we were interested in the possibility that caveolin-1, a protein that functions as a tumor suppressor in colon carcinoma cells (Bender et al., 2002; this issue), might regulate iNOS activity. 12415733 Human
caveolin-1 tumor In particular, we were interested in the possibility that caveolin-1, a protein that functions as a tumor suppressor in colon carcinoma cells (Bender et al., 2002; this issue), might regulate iNOS activity. 12415733 Human
caveolin-1 tumor These observations are important in the context of tumor biology, since down-regulation of caveolin-1 is predicted to promote uncontrolled iNOS activity, genotoxic damage and thereby facilitate tumor development in humans. 12415733 Human
cav-1 breast cancers Mutations in the gene encoding CAV-1 are associated with the development and progression of breast cancers, whereas mutations in the CAV-3 gene result in Rippling Muscle Disease and a form of Limb-Girdle Muscular Dystrophy. 14993453 Human
caveolin-1 tumor Keratin 10 and caveolin-1 transcripts were more abundant in tumor cells from squamous and invasive origin. 12460915 Human
cav1 lymphoma Increased expression of MPHOSPH1, RUVBL1, CHN2, PSA and CDC10 genes, and reduced expression of COL1A2, COL4A1, FBLN5, CLECSF6, MIC2, CAV1 and S100A10 genes in the advanced lymphoma group were confirmed by semi-quantitative reverse transcription-PCR. 12716467 Human
caveolin-1 metastasis Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. 14764125 Human
caveolin-1 clear-cell renal cell carcinoma Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. 14764125 Human
caveolin-1 metastasis OBJECTIVE: To investigate the relationship of caveolin-1 expression and microvessel density (MVD), a reflection of angiogenesis, with metastasis and prognosis in patients with clear cell renal cell carcinoma (RCC). 14764125 NA
caveolin-1 clear-cell renal cell carcinoma OBJECTIVE: To investigate the relationship of caveolin-1 expression and microvessel density (MVD), a reflection of angiogenesis, with metastasis and prognosis in patients with clear cell renal cell carcinoma (RCC). 14764125 NA
caveolin-1 metastasis Caveolin-1 intensity was significantly correlated with tumour size (P = 0.005), TNM stage (P = 0.028), M stage (P = 0.012), grade (P = 0.015), and metastasis (synchronous or metachronous; P < 0.001). 14764125 Human
caveolin-1 tumour Caveolin-1 intensity was significantly correlated with tumour size (P = 0.005), TNM stage (P = 0.028), M stage (P = 0.012), grade (P = 0.015), and metastasis (synchronous or metachronous; P < 0.001). 14764125 Human
caveolin-1 metastasis The caveolin-1 proportion (P = 0.037) and MVD (P = 0.011) were significantly correlated with metastasis. 14764125 Human
caveolin-1 metastasis CONCLUSIONS: Increased expression of caveolin-1 and MVD is associated with metastasis and a worse prognosis in clear cell RCC. 14764125 Human
caveolin-1 prostate cancer Hypermethylation of the caveolin-1 gene promoter in prostate cancer. 11170154 Human
caveolin-1 tumor Caveolin-1 (Cav-1), a gene coding for the structural component of cellular caveolae, is involved in cell signaling and has been proposed to be a tumor suppressor gene in several malignancies. 11170154 Human
cav-1 tumor Caveolin-1 (Cav-1), a gene coding for the structural component of cellular caveolae, is involved in cell signaling and has been proposed to be a tumor suppressor gene in several malignancies. 11170154 Human
cav-1 prostate cancer We chose to examine the methylation status of the promoter region of Cav-1 to determine whether this gene could function as a tumor suppressor in prostate cancer METHODS: Genomic DNA from both tumor and normal prostate epithelial cells was obtained from p 11170154 Human
cav-1 tumor We chose to examine the methylation status of the promoter region of Cav-1 to determine whether this gene could function as a tumor suppressor in prostate cancer METHODS: Genomic DNA from both tumor and normal prostate epithelial cells was obtained from p 11170154 Human
cav-1 tumor Elevated immunoreactivity with a Cav-1 antibody was observed in tumor cells from 7 of 26 prostate samples tested; this was associated with a Gleason score but not correlated with PSA failure or Methylation Index CONCLUSIONS: CpG sites at the 5' promo 11170154 Human
cav-1 cancer Hypermethylation of the Cav-1 promoter supports the notion that Cav-1 may function as a tumor suppressor gene in prostate cancer and evidence is presented suggesting that methylation status of this gene is not only a marker for cancer but also may be pred 11170154 Human
cav-1 prostate cancer Hypermethylation of the Cav-1 promoter supports the notion that Cav-1 may function as a tumor suppressor gene in prostate cancer and evidence is presented suggesting that methylation status of this gene is not only a marker for cancer but also may be pred 11170154 Human
cav-1 tumor Hypermethylation of the Cav-1 promoter supports the notion that Cav-1 may function as a tumor suppressor gene in prostate cancer and evidence is presented suggesting that methylation status of this gene is not only a marker for cancer but also may be pred 11170154 Human
caveolin-1 sarcomas Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. 11238032 Human
caveolin-1 tumor Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. 11238032 Human
caveolin-1 tumor Previous studies suggest that caveolin-1, the main structural protein of caveolae, could function as a tumor suppressor. 11238032 Human
caveolin-1 malignant mesenchymal tumors To study whether caveolin-1 is a possible tumor suppressor in human mesenchymal tumors, we have analyzed the expression using immunohistochemistry in normal mesenchymal tissues, 22 benign and 79 malignant mesenchymal tumors. 11238032 Human
caveolin-1 mesenchymal tumors To study whether caveolin-1 is a possible tumor suppressor in human mesenchymal tumors, we have analyzed the expression using immunohistochemistry in normal mesenchymal tissues, 22 benign and 79 malignant mesenchymal tumors. 11238032 Human
caveolin-1 tumor To study whether caveolin-1 is a possible tumor suppressor in human mesenchymal tumors, we have analyzed the expression using immunohistochemistry in normal mesenchymal tissues, 22 benign and 79 malignant mesenchymal tumors. 11238032 Human
caveolin-1 lipomas Caveolin-1 was found to be expressed in fibromatoses, leiomyomas, hemangiomas, and lipomas at high levels comparable to normal mesenchymal tissues. 11238032 Human
caveolin-1 synovial sarcomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 fibrosarcoma In contrast, in HT-1080 human fibrosarcoma cells, caveolin-1 is strongly down-regulated. 11238032 Human
caveolin-1 fibrosarcoma In addition, re-expression of caveolin-1 in HT-1080 fibrosarcoma cells potently inhibited colony formation. 11238032 Human
caveolin-1 sarcomas From these we conclude that caveolin-1 is likely to act as a tumor suppressor gene in human sarcomas. 11238032 Human
caveolin-1 tumor From these we conclude that caveolin-1 is likely to act as a tumor suppressor gene in human sarcomas. 11238032 Human
caveolin-1 bladder carcinoma Conversely, recombinant stable expression of caveolin-1 in T24 bladder carcinoma cells sensitizes these cells to caspase 3 activation. 11245599 Human
caveolin-1 breast cancers Invasion activating caveolin-1 mutation in human scirrhous breast cancers. 11289096 Human
caveolin-1 primary human breast cancers We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. 11289096 Human
caveolin-1 human breast cancer These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer. 11289096 Human
caveolin-1 prostate cancer Recent results correlate caveolin-1 expression with androgen sensitivity in murine prostate cancer. 11278309 Human
caveolin-1 ovarian carcinoma Caveolin-1 expression in advanced-stage ovarian carcinoma--a clinicopathologic study. 11330944 Human
caveolin-1 ovarian carcinomas OBJECTIVE: The aim of this study was to analyze the correlation among the expression of caveolin-1, the protein constituent of caveolae, and disease outcome in advanced-stage ovarian carcinomas. 11330944 NA
caveolin-1 ovarian carcinoma METHODS: Sections from 76 primary ovarian carcinomas and metastatic lesions from 45 patients diagnosed with advanced-stage ovarian carcinoma (FIGO stages III-IV) were evaluated for caveolin-1 expression using immunohistochemistry. 11330944 NA
caveolin-1 primary ovarian carcinomas METHODS: Sections from 76 primary ovarian carcinomas and metastatic lesions from 45 patients diagnosed with advanced-stage ovarian carcinoma (FIGO stages III-IV) were evaluated for caveolin-1 expression using immunohistochemistry. 11330944 NA
caveolin-1 carcinomas Despite its role in tyrosine-kinase-mediated signal transduction in vitro studies, caveolin-1 expression in carcinomas showed no association with the protein expression of c-erbB-2 and epidermal growth factor receptor, evaluated in a previous study of thi 11330944 Human
caveolin-1 ovarian carcinoma Caveolin-1 is often expressed in advanced-stage ovarian carcinoma, but does not appear to be a powerful predictor of disease outcome in these tumors. 11330944 Human
caveolin-1 tumors Caveolin-1 is often expressed in advanced-stage ovarian carcinoma, but does not appear to be a powerful predictor of disease outcome in these tumors. 11330944 Human
caveolin-1 carcinomas The reduced expression level in carcinomas compared to nonneoplastic epithelium may point to a role for caveolin-1 as a tumor suppressor gene. 11330944 Human
caveolin-1 tumor The reduced expression level in carcinomas compared to nonneoplastic epithelium may point to a role for caveolin-1 as a tumor suppressor gene. 11330944 Human
caveolin-1 adenocarcinoma of the colon Elevated expression of caveolin-1 in adenocarcinoma of the colon. 11345836 Human
caveolin-1 adenocarcinoma of the colon We studied the expression of caveolin-1 and caveolin-2 in normal epithelium, adenoma, and adenocarcinoma of the colon and their possible role in tumorigenesis. 11345836 NA
caveolin-1 adenoma We studied the expression of caveolin-1 and caveolin-2 in normal epithelium, adenoma, and adenocarcinoma of the colon and their possible role in tumorigenesis. 11345836 NA
caveolin-1 adenocarcinomas The expression of caveolin-1 was elevated in the overwhelming majority of the adenocarcinomas, while most normal colonic epithelium and adenomas showed little or no staining. 11345836 Human
caveolin-1 adenomas The expression of caveolin-1 was elevated in the overwhelming majority of the adenocarcinomas, while most normal colonic epithelium and adenomas showed little or no staining. 11345836 Human
caveolin-1 adenocarcinoma There was significant statistical correlation of the expression of caveolin-1 with adenocarcinoma but not with tumor stage. 11345836 Human
caveolin-1 tumor There was significant statistical correlation of the expression of caveolin-1 with adenocarcinoma but not with tumor stage. 11345836 Human
caveolin-1 metastasis Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer. 11358800 Human
caveolin-1 prostate cancer Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer. 11358800 Human
caveolin-1 metastatic human prostate cancer We demonstrate that caveolin-1 expression is significantly increased in primary and metastatic human prostate cancer after androgen ablation therapy. 11358800 Human
caveolin-1 prostate cancer We also show that caveolin-1 is secreted by androgen-insensitive prostate cancer cells, and that this secretion is regulated by steroid hormones. 11358800 Human
caveolin-1 advanced prostate cancer Significantly, caveolin-1 was detected in the MDL(3) fraction of serum specimens from patients with advanced prostate cancer and to a lesser extent in normal subjects. 11358800 Human
caveolin-1 prostate cancer Conditioned media from high passage caveolin-1 secreting, androgen-insensitive, LNCaP cells stimulated increased viability and clonal growth of low passage, caveolin-1-negative, androgen-sensitive, LNCaP cells in vitro, and this effect was blocked by trea 11358800 Human
caveolin-1 spontaneous metastasis Conditioned media from high passage caveolin-1 secreting, androgen-insensitive, LNCaP cells stimulated increased viability and clonal growth of low passage, caveolin-1-negative, androgen-sensitive, LNCaP cells in vitro, and this effect was blocked by trea 11358800 Human
caveolin-1 prostate cancer Overall, our results establish caveolin-1 as an autocrine/paracrine factor that is associated with androgen-insensitive prostate cancer. 11358800 Human
caveolin-1 prostate cancer Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells. 11389065 Human
caveolin-1 metastasis Previously, we demonstrated that up-regulation of caveolin-1 (cav-1) was associated with prostate cancer metastasis, biochemical recurrence after radical prostatectomy, and androgen insensitivity. 11389065 Human
cav-1 metastasis Previously, we demonstrated that up-regulation of caveolin-1 (cav-1) was associated with prostate cancer metastasis, biochemical recurrence after radical prostatectomy, and androgen insensitivity. 11389065 Human
caveolin-1 prostate cancer Previously, we demonstrated that up-regulation of caveolin-1 (cav-1) was associated with prostate cancer metastasis, biochemical recurrence after radical prostatectomy, and androgen insensitivity. 11389065 Human
cav-1 prostate cancer Previously, we demonstrated that up-regulation of caveolin-1 (cav-1) was associated with prostate cancer metastasis, biochemical recurrence after radical prostatectomy, and androgen insensitivity. 11389065 Human
cav-1 prostate cancer The objective of this study was to characterize the regulation of cav-1 by testosterone (T) and to test the effects of cav-1 on prostate cancer cell survival/clonal growth and metastatic activities. 11389065 Human
cav-1 prostate cancer Our results demonstrated that T up-regulated cav-1 protein levels in part through transcriptional regulation and significantly enhanced survival of prostate cancer cell lines ABAC3 and LNCaP after serum starvation (>40% and >60% increased viability, respe 11389065 Human
cav-1 metastasis Analysis of spontaneous metastasis in stably transfected antisense cav-1 mouse prostate cancer cell clones demonstrated reduction of spontaneous lymph node metastasis incidence (13%), spontaneous lymph node metastasis volume (46%), and experimental lung m 11389065 Mouse
cav-1 prostate cancer Analysis of spontaneous metastasis in stably transfected antisense cav-1 mouse prostate cancer cell clones demonstrated reduction of spontaneous lymph node metastasis incidence (13%), spontaneous lymph node metastasis volume (46%), and experimental lung m 11389065 Mouse
cav-1 lymph-node metastasis Analysis of spontaneous metastasis in stably transfected antisense cav-1 mouse prostate cancer cell clones demonstrated reduction of spontaneous lymph node metastasis incidence (13%), spontaneous lymph node metastasis volume (46%), and experimental lung m 11389065 Mouse
cav-1 spontaneous metastasis Analysis of spontaneous metastasis in stably transfected antisense cav-1 mouse prostate cancer cell clones demonstrated reduction of spontaneous lymph node metastasis incidence (13%), spontaneous lymph node metastasis volume (46%), and experimental lung m 11389065 Mouse
cav-1 prostate cancer Our studies demonstrate that cav-1 is a downstream effector of T-mediated prostate cancer cell survival/clonal growth and that modest levels of cav-1 can independently promote prostate cancer cell survival/clonal growth and metastatic activities. 11389065 Human
caveolin-1 tumors Annexin-2 and Caveolin-1 were not methylated in any of the tumors examined. 15036650 Human
caveolin-1 tumour Caveolin-1, a putative tumour suppressor gene. 11498016 Human
caveolin-1 tumor Interestingly, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). 11514613 Human
caveolin-1 rous sarcoma Caveolin-1 was initially identified as a phosphoprotein in Rous sarcoma virus-transformed cells. 11451957 Human
caveolin-1 mammary adenocarcinoma Expression of caveolin-1 in the human mammary adenocarcinoma cell line MCF-7 causes ligand-independent concentration of oestrogen receptor alpha (ERalpha) in the nucleus, and potentiates ligand-independent and ligand-dependent transcription from an oestro 11563984 Human
caveolin-1 prostate cancer Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells. 11571633 Human
caveolin-1 cancer BACKGROUND: Caveolin-1 (Cav-1), a principal component of caveolae membranes, may function as a tumor suppressor in several types of human cancer. 14981899 Human
cav-1 cancer BACKGROUND: Caveolin-1 (Cav-1), a principal component of caveolae membranes, may function as a tumor suppressor in several types of human cancer. 14981899 Human
caveolin-1 tumor BACKGROUND: Caveolin-1 (Cav-1), a principal component of caveolae membranes, may function as a tumor suppressor in several types of human cancer. 14981899 Human
cav-1 tumor BACKGROUND: Caveolin-1 (Cav-1), a principal component of caveolae membranes, may function as a tumor suppressor in several types of human cancer. 14981899 Human
cav-1 tumor However, haploinsufficiency of Cav-1 expression did not induce significant tumor formation when tested in nude mice. 14981899 Mouse
cav-1 cancer Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human cancer. 11457855 Human
cav-1 tumor Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human cancer. 11457855 Human
caveolin-1 glioma To ascertain whether caveolins influence G protein-mediated signal transduction, we stably expressed caveolin-1 and -3 isoforms in the neuroblastoma x glioma NG108-15 hybrid cell line, lacking endogenous caveolins. 11600672 Human
caveolin-1 neuroblastoma To ascertain whether caveolins influence G protein-mediated signal transduction, we stably expressed caveolin-1 and -3 isoforms in the neuroblastoma x glioma NG108-15 hybrid cell line, lacking endogenous caveolins. 11600672 Human
caveolin-1 human ovarian carcinoma Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. 11696424 Human
caveolin-1 tumor Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. 11696424 Human
caveolin-1 ovarian carcinoma This analysis revealed down-regulation of the caveolin-1 gene (CAV1) in ovarian carcinoma samples. 11696424 Human
cav1 ovarian carcinoma This analysis revealed down-regulation of the caveolin-1 gene (CAV1) in ovarian carcinoma samples. 11696424 Human
cav1 human tumor Suppression of CAV1 in ovarian carcinomas was confirmed using a tumor tissue array consisting of 68 cDNA pools from different matched human tumor and normal tissues. 11696424 Human
cav1 ovarian carcinomas Suppression of CAV1 in ovarian carcinomas was confirmed using a tumor tissue array consisting of 68 cDNA pools from different matched human tumor and normal tissues. 11696424 Human
cav1 tumor Suppression of CAV1 in ovarian carcinomas was confirmed using a tumor tissue array consisting of 68 cDNA pools from different matched human tumor and normal tissues. 11696424 Human
caveolin-1 ovarian carcinomas Immunohistochemistry demonstrated expression of caveolin-1 in normal and benign ovarian epithelial cells, but loss of expression in serous ovarian carcinomas. 11696424 Human
caveolin-1 carcinomas In low-grade carcinomas, redistribution of caveolin-1 from a membrane-associated pattern observed in normal epithelium to a cytoplasmic localization pattern was observed. 11696424 Human
caveolin-1 ovarian carcinoma No expression of caveolin-1 was detectable in four of six ovarian carcinoma cell lines investigated. 11696424 Human
caveolin-1 carcinoma In SKOV-3 and ES-2 carcinoma cells, which express high levels of the caveolin-1 protein, phosphorylation of the 22-kd caveolin-1 isoform was detected. 11696424 Human
cav1 ovarian carcinoma Expression of CAV1 in the ovarian carcinoma cell line OVCAR-3, resulted in suppression of tumor cell survival in vitro, suggesting that the CAV1 gene is likely to act as a tumor suppressor gene in human ovarian epithelium. 11696424 Human
cav1 tumor Expression of CAV1 in the ovarian carcinoma cell line OVCAR-3, resulted in suppression of tumor cell survival in vitro, suggesting that the CAV1 gene is likely to act as a tumor suppressor gene in human ovarian epithelium. 11696424 Human
caveolin-1 high-grade bladder cancer Caveolin-1 expression is associated with high-grade bladder cancer. 11711373 Human
caveolin-1 tumors RESULTS: A statistically significant association was observed between caveolin-1 immunoreactivity and tumor grade (P = 0.0118, chi-square test), with 8 (21%) of 38 G3, 1 (3%) of 30 G2, and 0 of 21 G1 tumors positive for caveolin-1. 11711373 Human
caveolin-1 tumor RESULTS: A statistically significant association was observed between caveolin-1 immunoreactivity and tumor grade (P = 0.0118, chi-square test), with 8 (21%) of 38 G3, 1 (3%) of 30 G2, and 0 of 21 G1 tumors positive for caveolin-1. 11711373 Human
caveolin-1 tumor When the clinical data were examined in conjunction with caveolin-1 status, no statistically significant relationship was seen between caveolin-1 expression and tumor multiplicity, tumor recurrence, tumor progression, or patient survival. 11711373 Human
caveolin-1 high-grade bladder cancers CONCLUSIONS: The results of our study demonstrate that altered expression of caveolin-1 protein is a component of tumor dedifferentiation in a subset of high-grade bladder cancers. 11711373 Human
caveolin-1 tumor CONCLUSIONS: The results of our study demonstrate that altered expression of caveolin-1 protein is a component of tumor dedifferentiation in a subset of high-grade bladder cancers. 11711373 Human
caveolin-1 tumor This pilot study provides a basis for further investigation of the role of caveolin-1 and the function of caveolae in the most aggressive forms of this tumor. 11711373 Human
caveolin-1 prostate cancer In situ prostate cancer gene therapy using a novel adenoviral vector regulated by the caveolin-1 promoter. 11751529 Human
caveolin-1 prostate cancer Caveolin-1, a structural component of caveolae, is overexpressed in metastatic and androgen-resistant prostate cancer and highly expressed in tumor-associated endothelial cells. 11751529 Human
cav-1 rous sarcoma The mouse cav-1 promoter was cloned and placed upstream of the HSV-tk gene in an adenoviral vector (Adcav-1tk) and compared with a cytomegalovirus (CMV) or Rous sarcoma virus (RSV) promoter-driven HSV-tk, AdCMVtk and AdRSVtk vectors, respectively. 11751529 Human
cav-1 prostate cancer Our results suggest that the cav-1 promoter may have unique benefits in targeting gene therapy to prostate cancer and its associated vasculature. 11751529 Human
caveolin-1 human neuroblastoma Although caveolin proteins were long thought to be absent from the brain, we have shown that the human neuroblastoma cell line LAN-1 expresses both caveolin-1 and caveolin-2. 10646519 Human
caveolin-1 cell hyperplasia Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. 15044451 Mouse
caveolin-1 tumor Here, we evaluate the transformation suppressor potential of caveolin-1 (Cav-1) and its ability to cooperate with a well established tumor suppressor, the INK4a locus. 15044451 Human
cav-1 tumor Here, we evaluate the transformation suppressor potential of caveolin-1 (Cav-1) and its ability to cooperate with a well established tumor suppressor, the INK4a locus. 15044451 Human
cav-1 tumor Importantly, in cells lacking Cav-1 expression, transformation by activated oncogenes (H-Ras(G12V) or v-Src) results in increased tumor growth in vivo (up to >40-fold). 15044451 Mouse
cav-1 tumor Our results provide important new evidence for the transformation suppressor properties of Cav-1 and the first molecular genetic evidence that Cav-1 cooperates with a tumor suppressor, namely the INK4a genetic locus. 15044451 Mouse
cav tumor The corresponding genes in humans (CAV and CAV2, respectively), have been mapped to a common locus in chromosome 7q31.1, and are possible candidates for the tumor suppressor gene postulated in this region. 10675615 Human
caveolin-1 glioma Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy. 14705150 Human
caveolin-1 brain tumor By using an in vivo brain tumor model, we purified ECs from gliomas as well as from normal brain to investigate possible regulation of caveolin-1 expression in tumoral brain vasculature. 14705150 Human
caveolin-1 glioma We show that caveolin-1 expression is strikingly down-regulated in glioma ECs, whereas an increase of phosphorylated caveolin-1 is observed. 14705150 Human
caveolin-1 tumor Whole-brain radiation treatment, a classical way in which GB is currently being treated, resulted in increased caveolin-1 expression in tumor isolated ECs. 14705150 Human
caveolin-1 mammary adenocarcinoma Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). 10748172 Rat
caveolin-1 cancers For example, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (D7S522; 7q31.1) that is deleted in human cancers, including mammary carcinomas. 10748172 Human
caveolin-1 tumor For example, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (D7S522; 7q31.1) that is deleted in human cancers, including mammary carcinomas. 10748172 Human
caveolin-1 mammary carcinomas For example, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (D7S522; 7q31.1) that is deleted in human cancers, including mammary carcinomas. 10748172 Human
caveolin-1 tumor Enrichment and localization of ganglioside G(D3) and caveolin-1 in shed tumor cell membrane vesicles. 10903477 Human
caveolin-1 advanced prostate cancer Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with mali 10918582 Human
caveolin-1 human prostate cancer Further we established human prostate cancer cell lines with the mycER construct and show that clones with increased caveolin-1 are more resistant to myc-induced apoptosis and have increased capacity for growth in soft agar when c-myc is activated. 10918582 Human
caveolin-1 tumor Here we show that a cell-permeable peptide derived from caveolin-1, termed cavtratin, reduces microvascular hyperpermeability and delays tumor progression in mice. 12892711 Mouse
caveolin-1 prostate cancer Elevated caveolin-1 levels in African-American versus white-American prostate cancer. 10999725 Human
caveolin-1 prostate cancer To address this issue, we used specific quantitative immunostaining protocols to determine whether a panel of biomarkers related to apoptosis including caveolin-1, bcl-2, p53, and c-myc were differentially expressed in AA versus white prostate cancer pati 10999725 Human
caveolin-1 prostate cancer Interestingly, our results indicated that only the incidence of caveolin-1 staining was significantly different between these two ethnic/racial groups of prostate cancer patients. 10999725 Human
caveolin-1 prostate cancer Because caveolin-1 has been shown previously to demonstrate antiapoptotic activities in prostate cancer cells, our results suggest that differences in caveolin-1 expression may in part underlie the apparent differences in the clinical virulence of this di 10999725 Human
caveolin-1 human ovarian carcinoma Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. 11032026 Human
cav-1 tumor Several studies in tumor cells independently reported cav-1 downregulation and alphaFR overexpression. 11032026 Human
cav-1 ovarian tumor Whereas normal ovary surface epithelial cells displayed only cav-1 expression, ovarian tumor surgical samples and cell lines (COR, IGROV1, OVCAR3 and OVCA432) displayed high alphaFR and low-level or no cav-1 expression, except those cell lines (SKOV3 and 11032026 Human
cav-1 ovary cancer Together these results support the notion that alphaFR and cav-1 protein expression is reciprocally regulated in ovary cancer cells. 11032026 Human
caveolin-1 human colon tumors Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. 11059785 Human
caveolin-1 colon carcinoma Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. 11059785 Human
caveolin-1 human colon cancer Caveolin-1 expression and function were investigated in human colon cancer. 11059785 Human
caveolin-1 colon carcinoma Low levels of caveolin-1 mRNA and protein were detected in several colon carcinoma cell lines. 11059785 Human
caveolin-1 human tumor Moreover, caveolin-1 protein levels were significantly reduced in human tumor epithelial mucosa (3.6 +/- 1.4-fold) when compared with normal colon mucosa for a majority (10 of 15) of the patients characterized. 11059785 Human
caveolin-1 colon carcinoma To directly assess the role of caveolin-1 in tumor development, caveolin-1 was reexpressed in the HT29 and DLD1 colon carcinoma cells, and the resulting HT29-cav-1 or DLD1-cav-1 cells were tested for tumorigenicity in nude mice. 11059785 Human
caveolin-1 tumor To directly assess the role of caveolin-1 in tumor development, caveolin-1 was reexpressed in the HT29 and DLD1 colon carcinoma cells, and the resulting HT29-cav-1 or DLD1-cav-1 cells were tested for tumorigenicity in nude mice. 11059785 Human
caveolin-1 tumors Interestingly, basal caveolin-1 levels were significantly reduced in HT29-cav-1 and DLD1-cav-1 cells isolated from tumors. 11059785 Mouse
caveolin-1 tumors Likewise, endogenous caveolin-1 mRNA and protein levels were found to be reduced in NIH-3T3 cells recovered from tumors after injection into nude mice. 11059785 Mouse
caveolin-1 tumors Thus, reexpression of caveolin-1 in colon carcinoma lines reduced the probability of tumor formation in vivo, and when tumors did develop from either HT29-cav-1, DLD1-cav-1, or NIH-3T3 cells, lower basal levels of caveolin-1 were detected. 11059785 Mouse
caveolin-1 colon carcinoma Thus, reexpression of caveolin-1 in colon carcinoma lines reduced the probability of tumor formation in vivo, and when tumors did develop from either HT29-cav-1, DLD1-cav-1, or NIH-3T3 cells, lower basal levels of caveolin-1 were detected. 11059785 Mouse
caveolin-1 tumor Thus, reexpression of caveolin-1 in colon carcinoma lines reduced the probability of tumor formation in vivo, and when tumors did develop from either HT29-cav-1, DLD1-cav-1, or NIH-3T3 cells, lower basal levels of caveolin-1 were detected. 11059785 Mouse
caveolin-1 colon cancer Finally, evidence was obtained indicating that initial caveolin-1 down-regulation in colon cancer cells need not be an entirely irreversible process because cell survival on selection for either drug resistance or increased metastatic potential correlated 11059785 Human
caveolin-1 rous sarcoma Caveolin-1 was first identified as a phosphoprotein in Rous sarcoma virus (RSV)-transformed chicken embryo fibroblasts. 11075810 Human
caveolin-1 cervical cancer Here, we show that caveolin-1 protein expression is consistently reduced in a panel of lung and cervical cancer derived cell lines and that this reduction is not due to hyperactivation of p42/44 MAP kinase (a known negative regulator of caveolin-1 transcr 11076533 Human
caveolin-1 tumor Furthermore, we demonstrate that p53-a tumor suppressor inactivated by E6-is a positive regulator of caveolin-1 gene transcription and protein expression. 11076533 Human
caveolin-1 cervical squamous carcinoma SiHa cells are derived from a human cervical squamous carcinoma, harbor a fully integrated copy of the HPV 16 genome (including E6), and show dramatically reduced levels of caveolin-1 expression. 11076533 Human
caveolin-1 human colon carcinoma Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. 11114180 Human
caveolin-1 carcinoma To investigate whether caveolin-1 (cav-1) may modulate inducible nitric oxide synthase (iNOS) function in intact cells, the human intestinal carcinoma cell lines HT29 and DLD1 that have low endogenous cav-1 levels were transfected with cav-1 cDNA. 11114180 Human
cav-1 carcinoma To investigate whether caveolin-1 (cav-1) may modulate inducible nitric oxide synthase (iNOS) function in intact cells, the human intestinal carcinoma cell lines HT29 and DLD1 that have low endogenous cav-1 levels were transfected with cav-1 cDNA. 11114180 Human
cav c6 glioma Here, we have undertaken the immunochemical identification of CAV and the known caveolin isoforms (1alpha, 1beta, 2 and 3) in cultured rat C6 glioma cells. 10568687 Rat
caveolin-1 c6 glioma Immunoblot analysis revealed that particulate fractions from rat C6 glioma cells express caveolin-1 and caveolin-2. 10568687 Rat
cav c6 glioma In addition, they demonstrate that cultured C6 glioma cells can be useful as a model system to study the role of CAV and caveolins in subcellular transport and signal transduction events in glial cells and the brain. 10568687 Rat
caveolin-1 human prostate cancer Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. 10582690 Human
caveolin-1 human prostate cancer We demonstrated previously elevated caveolin-1 expression in metastatic mouse and human prostate cancer cells both in vitro and in vivo. 10582690 Human
caveolin-1 cancers Positive caveolin-1 immunostaining was detected in 47 of the 189 cancers (25%) and correlated positively with Gleason score, positive surgical margin, as well as lymph node involvement (P = 0.0071, 0.0267, and 0.0399, respectively). 10582690 Human
caveolin-1 cancers In lymph node-negative cancers (n = 162), caveolin-1 immunoreactivity predicts a shorter time to disease progression after surgery (P = 0.0033, univariate analysis). 10582690 Human
caveolin-1 human prostate cancer Thus, our study establishes caveolin-1 as a novel prognostic marker for clinically confined human prostate cancer. 10582690 Human
caveolin 1 cancer Caveolin 1 expression is down-regulated in various cancer cell lines. 12679732 Human
caveolin 1 drug-resistant cancer Interestingly, in several drug-resistant cancer cells, a strong induction of caveolin 1 expression has been reported, suggesting a role for caveolin 1 in the acquisition and/or the maintenance of the multidrug-resistance phenotype. 12679732 Human
caveolin 1 lung cancer Here, we show, in drug-sensitive lung cancer cells (A549, Calu-6 or NCI-H69), that exposure to cytotoxic drugs (taxol, doxorubicin or etoposide) is sufficient to strongly up-regulate caveolin 1 and 2 protein levels. 12679732 Human
caveolin-1 squamous cell carcinoma of the lung Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung. 14568687 Human
caveolin-1 cancer Previous studies of caveolin-1 in cancer showed two contrary results. 14568687 Human
caveolin-1 tumor In most in vitro studies, caveolin-1 played a role as a tumor suppressor. 14568687 Human
caveolin-1 cancer These results indicate differential biological functions of caveolin-1 depending on the development and progression stage of cancer in vivo. 14568687 Human
caveolin-1 pulmonary squamous cell carcinomas METHODS: To clarify the correlation between the clinicopathologic profiles of pulmonary squamous cell carcinomas and the expression of caveolin-1, 107 cases of formalin-fixed and paraffin-embedded tissues of pulmonary squamous cell carcinomas were immunoh 14568687 NA
caveolin-1 pulmonary squamous cell carcinoma RESULTS: Caveolin-1 was expressed in 34 cases (31.7%) among 107 cases of pulmonary squamous cell carcinoma. 14568687 Human
caveolin-1 pulmonary squamous cell carcinomas The patients with caveolin-1 expression in pulmonary squamous cell carcinomas showed a poorer prognosis than those in caveolin-1-negative group (P=0.0345). 14568687 Human
caveolin-1 pulmonary squamous cell carcinoma CONCLUSION: The expression of caveolin-1 is significantly correlated with advanced pathologic stage and poor prognosis in pulmonary squamous cell carcinoma. 14568687 Human
caveolin-1 pulmonary squamous cell carcinoma The results of current study suggest that the expression level of caveolin-1 may be a candidate factor for predicting prognosis in patients with pulmonary squamous cell carcinoma. 14568687 Human
caveolin 1 lung carcinoma Reduction of caveolin 1 gene expression in lung carcinoma cell lines. 10049753 Human
caveolin-1 tumor However, caveolin-1 is down-regulated in transformed cells and may have a potential tumor suppressor activity. 10049753 Human
caveolin-1 lung cancer We thus tested for caveolin-1 and -2 expression several bronchial epithelial primary cell lines as well as eight lung cancer cell lines and one larynx tumor cell line. 10049753 Human
caveolin-1 tumor We thus tested for caveolin-1 and -2 expression several bronchial epithelial primary cell lines as well as eight lung cancer cell lines and one larynx tumor cell line. 10049753 Human
caveolin-1 cancer With the exception of Calu-1 cell line, all cancer cell lines showed very low or no expression of caveolin-1 while caveolin-2 expression was similar to the one observed in normal bronchial epithelial cells. 10049753 Human
caveolin-1 primary tumours Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. 10086342 Human
caveolin-1 tumour We identified CAVEOLIN-1 as a candidate for a tumour suppressor gene mapping to human chromosome 7q31.1. 10086342 Human
caveolin-1 primary tumours We have analysed the status and expression of the human CAVEOLIN-1 gene in primary tumours and tumour-derived cell lines. 10086342 Human
caveolin-1 cancers We found no evidence for mutation of CAVEOLIN-1 in human cancers. 10086342 Human
caveolin-1 primary tumours Additionally, we found that while the first two exons of CAVEOLIN-1 are associated with a CpG island, this is not methylated in either primary tumours or in tumour-derived cell lines in which Caveolin-1 expression is low or undetectable. 10086342 Human
caveolin-1 tumours CAVEOLIN-1 is however highly expressed in breast myoepithelial cells and its expression is retained in tumours derived from breast myoepithelium. 10086342 Human
caveolin-1 tumour Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo. 10086342 Human
caveolin-1 tumors Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. 10087206 Human
caveolin-1 tumor Caveolin-1, a suspected tumor suppressor, is a principal protein component of caveolae in vivo. 10094502 Human
caveolin-1 human breast cancer Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. 10218480 Human
caveolin-1 human breast cancer In support of this notion, we show here that the CGs in the 5' promoter region of the caveolin-1 gene are functionally methylated in two human breast cancer cell lines (MCF7 and T-47D) that fail to express the caveolin-1 protein. 10218480 Human
caveolin-1 cancer These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease. 12689915 Human
cav metastasis The median duration of response to CAV, after extraneural metastasis, was 17 months (4-65 months). 3200378 Human
caveolin-1 prostate cancer Development of an immunoassay for serum caveolin-1: a novel biomarker for prostate cancer. 14506154 Human
cav-1 metastatic human prostate cancer We have previously shown that cav-1 expression is increased in metastatic human prostate cancer and that cav-1 cellular protein expression is predictive of recurrence of the disease after radical prostatectomy. 14506154 Human
cav-1 prostate cancer Recently, we reported that cav-1 is secreted by androgen-insensitive prostate cancer cells, and we detected, by Western blotting, cav-1 in the high-density lipoprotein(3) fraction of serum specimens from patients with prostate cancer. 14506154 Human
cav-1 prostate cancer The median serum cav-1 level in 102 prostate cancer patients with clinically localized disease (0.463 ng/ml) was significantly higher than 81 healthy control men (0.324 ng/ml; P = 0.0446, Mann-Whitney test) or 107 men with benign prostatic hyperplasia (0. 14506154 Human
cav-1 benign prostatic hyperplasia The median serum cav-1 level in 102 prostate cancer patients with clinically localized disease (0.463 ng/ml) was significantly higher than 81 healthy control men (0.324 ng/ml; P = 0.0446, Mann-Whitney test) or 107 men with benign prostatic hyperplasia (0. 14506154 Human
cav-1 prostate cancer CONCLUSIONS: Our results indicate that serum cav-1 has the power to differentiate between prostate cancer and benign prostatic hyperplasia patients and the potential to be an important biomarker for prostate cancer. 14506154 Human
cav-1 benign prostatic hyperplasia CONCLUSIONS: Our results indicate that serum cav-1 has the power to differentiate between prostate cancer and benign prostatic hyperplasia patients and the potential to be an important biomarker for prostate cancer. 14506154 Human
cav-1 prostate cancer Additional studies to test the potential of serum cav-1 as a diagnostic and/or prognostic marker in prostate cancer are warranted. 14506154 Human
caveolin-1 human breast cancer In human vascular smooth muscle or MCF-7 (human breast cancer) cell membranes, coimmunoprecipitation shows that ER associates with caveolin-1 and -2. 11773442 Human
caveolin-1 tumor Recently we demonstrated that in multidrug-resistant tumor cells there is a dramatic increase in the number of caveolae and in the level of caveolin-1, an essential structural constituent of caveolae. 10419089 Human
caveolin-1 cancer In order to better understand potential functions of caveolin-1 in cancer development, we have studied expression levels of caveolin-1 in human breast cancer cells, and have found that caveolin expression is significantly reduced in human breast cancer ce 9525738 Human
caveolin-1 human breast cancer In order to better understand potential functions of caveolin-1 in cancer development, we have studied expression levels of caveolin-1 in human breast cancer cells, and have found that caveolin expression is significantly reduced in human breast cancer ce 9525738 Human
caveolin-1 mammary cancer When the caveolin cDNA linked to the CMV promoter is transfected into human mammary cancer cells having no detectable endogenous caveolin, overexpression of caveolin-1 resulted in substantial growth inhibition, as seen by the 50% decrease in growth rate a 9525738 Human
caveolin-1 tumor In summary, the overall expression patterns, its ability to inhibit tumor growth in culture, its regulation during the cell cycle, and the loss of expression in p53-deficient cells all are consistent with an important growth regulating function for caveol 9525738 Human
cav-1 carcinomas For example, the human CAV-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31.1) that is frequently deleted in a number of carcinomas, including breast cancers. 12631721 Human
cav-1 breast cancers For example, the human CAV-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31.1) that is frequently deleted in a number of carcinomas, including breast cancers. 12631721 Human
cav-1 tumor For example, the human CAV-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31.1) that is frequently deleted in a number of carcinomas, including breast cancers. 12631721 Human
cav-1 human breast cancers In addition, up to 16% of human breast cancers harbor a dominant-negative mutation, P132L, in the CAV-1 gene. 12631721 Human
caveolin-1 tumor Despite these genetic associations, the tumor suppressor role of caveolin-1 still remains controversial. 12631721 Human
cav-1 tumor Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31). 9662443 Human
caveolin-1 tumor As this region (6-A2/7q31) is the site of an as yet unidentified tumor suppressor gene(s), our mapping studies clearly define caveolin-1 and caveolin-2 as candidate genes that may be deleted at these loci. 9662443 Human
cav-1 tumors Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveol 12812318 Human
caveolin-1 tumors Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveol 12812318 Human
cav-1 tumor Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveol 12812318 Human
caveolin-1 tumor Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveol 12812318 Human
caveolin-1 prostate cancer Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. 14645548 Human
cav-1 prostate cancer Previously it has been reported that caveolin-1 (cav-1) has antiapoptotic activities in prostate cancer cells and functions downstream of androgenic stimulation. 14645548 Human
caveolin-1 prostate cancer Previously it has been reported that caveolin-1 (cav-1) has antiapoptotic activities in prostate cancer cells and functions downstream of androgenic stimulation. 14645548 Human
caveolin-1 tumor However, the in vivo tumor growth of CGL4 cells was not altered when caveolin-1 was stably overexpressed through the transfection of a human caveolin-1 cDNA. 9685730 Human
caveolin-1 mammary tumors Our results indicate that dramatic reduction of caveolin-1 expression occurs in mammary tumors derived from c-Neu-expressing transgenic mice and other transgenic mice expressing downstream effectors of Neu-mediated signal transduction, such as Src and Ras 9685399 Mouse
caveolin-1 prostate cancer Here we show that suppression of caveolin expression by a stably transfected antisense caveolin-1 cDNA vector converted androgen-insensitive metastatic mouse prostate cancer cells to an androgen-sensitive phenotype. 9734401 Mouse
caveolin-1 tumor Interactions with caveolin-1 control the intracellular locale and degradation of iNOS in tumor cells. 14510776 Human
caveolin-1 cancer EGF induced phosphorylation of caveolin-1 was detected by Western blotting with an anti-phosphotyrosine antibody to immunoprecipitated caveolin-1 from BLEC and human cancer cells. 14667829 others
caveolin-1 renal-cell carcinoma Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. 14612902 Human
caveolin-1 tumour Immunohistochemistry for caveolin-1 was performed on sections of peripheral tumour from 114 consecutative nonmetastatic RCCs. 14612902 Human
caveolin-1 tumour We conclude that cytoplasmic overexpression of caveolin-1 predicts a poor prognosis in RCC; that this is likely to be a useful prognostic marker and that it may have importance in tumour progression. 14612902 Human
caveolin-1 cancers Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. 9801158 Human
caveolin-1 tumor (1997) J. Biol. Chem. 272, 16374-16381), we propose that the caveolin-1 gene may represent the candidate tumor suppressor gene at the D7S522 locus on human chromosome 7q31.1. 9801158 Human
caveolin-1 tumor Interestingly, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). 9822607 Human
caveolin-1 tumors NIH 3T3 cells harboring antisense caveolin-1 exhibit anchorage-independent growth, form tumors in immunodeficient mice and show hyperactivation of the p42/44 MAP kinase cascade. 9822607 Human
caveolin-1 human colon adenocarcinoma Here we report that multidrug-resistant HT-29 human colon adenocarcinoma cells exhibit a 12-fold overexpression of caveolin-1, a 21-kDa coat/adaptor protein of caveolae. 9829965 Human
caveolin-1 human t-cell leukemia Expression of caveolin-1 in human T cell leukemia cell lines. 9878546 Human
caveolin-1 t-cell leukemia We identified caveolin-1 in one T cell leukemia cell line, a subline of Jurkat cells, by immunostaining and Western blotting. 9878546 Human
caveolin-1 prostate cancer Metastasis-related genes in prostate cancer: the role of caveolin-1. 10453288 Human
caveolin-1 prostate cancer Caveolin-1 was found to be overexpressed not only in metastatic mouse prostate cancer, but also human metastatic disease. 10453288 Mouse
caveolin-1 metastatic disease Caveolin-1 was found to be overexpressed not only in metastatic mouse prostate cancer, but also human metastatic disease. 10453288 Human
caveolin-1 hormone-resistant prostate cancer Caveolin-1, therefore, is a metastasis-related gene and a candidate gene for hormone-resistant prostate cancer in man. 10453288 Human
cav1 tumor FRA7G is a common fragile site containing the candidate tumor suppressor genes CAV1, CAV2, and TESTIN (TES). 12620387 Human
cav1 gastric cancer The results show that CAV1, CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer. 12620387 Human
cav1 tumor The results show that CAV1, CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer. 12620387 Human
cav-1 oral cancer BACKGROUND: The increased expression of Cav-1 is seen in various cancers from prostate, esophagus, colon, breast and pancreas yet the information regarding the correlation between the expression of Cav-1 and oral cancer is blind. 12901727 Human
cav-1 cancers BACKGROUND: The increased expression of Cav-1 is seen in various cancers from prostate, esophagus, colon, breast and pancreas yet the information regarding the correlation between the expression of Cav-1 and oral cancer is blind. 12901727 Human
cav-1 oral squamous-cell carcinoma METHODS: Immunohistochemistry was used to detect Cav-1 expression in non-cancerous matched tissues (NCMT; n=12), and tissue from normal oral mucosa (NOM; n=12), oral pre-cancer lesions (OPL; n=17), primary oral squamous cell carcinoma (POSCC; n=47) and me 12901727 NA
caveolin-1 cancers Expression of caveolin-1 in gastrointestinal and extraintestinal cancers. 12898235 Human
caveolin-1 cancers The contribution of caveolin-1 to carcinogenesis has been widely investigated; however, the expression pattern of caveolin-1 is controversial both in gastrointestinal and extraintestinal cancers. 12898235 Human
caveolin-1 cancer Most of the results based on cancer cell line experiments suggest that caveolin-1 might act as a tumor-suppressor gene. 12898235 Human
caveolin-1 tumor On the contrary, several studies on the expression of caveolin-1 in tumor tissues indicate a possible tumor-promoting effect of caveolin-1. 12898235 Human
caveolin-1 cancer In this article we summarize the divergent results of caveolin-1 expression in gastrointestinal and extraintestinal cancer regarding possible future therapeutic implications. 12898235 Human
caveolin-1 cancer Immunocytochemistry revealed that immunoreactivities toward Rec within the cancer cells were almost identical to those toward GRKs and caveolin-1. 12507501 Human
caveolin-1 multiple myeloma In the present study, we examined the role of caveolin-1 in multiple myeloma cells. 12482878 Human
caveolin-1 multiple myeloma We show for the first time that caveolin-1, which is usually absent in blood cells, is expressed in multiple myeloma cells. 12482878 Human
caveolin-1 myeloma Analysis of myeloma cell-derived plasma membrane fractions shows that caveolin-1 is co-localized with interleukin-6 receptor signal transducing chain gp130 and with insulin-like growth factor-I receptor. 12482878 Human
caveolin-1 myeloma Cholesterol depletion by beta-cyclodextrin results in the loss of caveola structure in myeloma cells, as shown by transmission electron microscopy, and loss of caveolin-1 function. 12482878 Human
caveolin-1 multiple myeloma Interleukin-6 and insulin-like growth factor-I, growth and survival factors in multiple myeloma, induce caveolin-1 phosphorylation, which is abrogated by pre-treatment with beta-cyclodextrin. 12482878 Human
caveolin-1 multiple myeloma Therefore, cholesterol depletion by beta-cyclodextrin abrogates both interleukin-6- and insulin-like growth factor-I-triggered multiple myeloma cell survival via negative regulation of caveolin-1. 12482878 Human
caveolin-1 multiple myeloma Taken together, this study identifies caveolin-1 and other structural membrane components as potential new therapeutic targets in multiple myeloma. 12482878 Human
caveolin-1 prostate carcinoma Caveolin-1 expression is a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients. 12599229 Human
caveolin-1 human prostate carcinoma BACKGROUND: The authors previously identified elevated caveolin-1 expression in human prostate carcinoma and determined that caveolin-1 levels as detected by immunohistochemistry of radical prostatectomy specimens offered novel prognostic information. 12599229 Human
caveolin-1 prostate carcinoma To explore these ethnic/racial differences in caveolin-1 expression further, the authors evaluated caveolin-1 expression as a predictive marker in Japanese men with prostate carcinoma. 12599229 Human
caveolin-1 tumors RESULTS: Positive caveolin-1 immunostaining was detected in 46 of the 152 tumors (30.3%) and was found to be associated significantly with a positive surgical margin (P = 0.022). 12599229 Human
caveolin-1 tumors A higher incidence of caveolin-1 expression tended to be found in patients with poorly differentiated tumors (Gleason score > 7, 6-7, and < 6, 35.0% vs. 34.9% vs. 20.4%, respectively) or in patients with extraprostatic extension versus those without extra 12599229 Human
caveolin-1 prostate carcinoma CONCLUSIONS: The results of the current study confirm that positive caveolin-1 expression is associated with clinical markers of disease progression and is predictive of poor clinical outcome after surgery in Japanese patients with pT2N0 prostate carcinom 12599229 Human
caveolin-1 parathyroid adenomas Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas. 12970324 Human
caveolin-1 adenomas In PT cells from adenomas, there are high levels of caveolin-2, variably reduced caveolin-1, and hyperactivation of ERK1/2, which colocalizes with caveolin-1 in some cells, but localizes in the cytosol and nucleus in others. 12970324 others
caveolin-1 adenomas Thus, CaR and caveolin-1 colocalize in PT cells, and reduced levels of caveolin-1 could participate in the abnormal cellular function and proliferation of cultured bovine PT cells and PT adenomas. 12970324 others
caveolin-1 breast cancer Analysis of 16 breast cancer cell lines established that caveolin-1 expression was either absent or reduced compared with breast epithelial cells, and that PDK1 was elevated in all of the cell lines. 14500370 Human
caveolin-1 breast cancer Caveolin-1 as tumor suppressor gene in breast cancer. 14506991 Human
caveolin-1 tumor Caveolin-1 as tumor suppressor gene in breast cancer. 14506991 Human
caveolin-1 tumors PURPOSE. Many articles have reported the caveolin-1 gene to be downregulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors, but in bladder tumors the caveolin-1 gene was expressed and related to the pathological grade. 14506991 NA
caveolin-1 tumor PURPOSE. Many articles have reported the caveolin-1 gene to be downregulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors, but in bladder tumors the caveolin-1 gene was expressed and related to the pathological grade. 14506991 NA
caveolin-1 bladder tumors PURPOSE. Many articles have reported the caveolin-1 gene to be downregulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors, but in bladder tumors the caveolin-1 gene was expressed and related to the pathological grade. 14506991 Human
caveolin-1 breast tumors We investigated the function of caveolin-1 protein in breast tumors. 14506991 Human
caveolin-1 mcf-7 human breast cancer METHODS. We introduced the caveolin-1 gene into a MCF-7 human breast cancer cell line, and examined its cell growth, cell viability, and anchorage-independent growth. 14506991 NA
caveolin-1 tumor CONCLUSION. In MCF-7 cells, the caveolin-1 gene may influence the tumor suppressor efficacy. 14506991 Human
caveolin-1 hepatoma Double immunolabeling confocal microscopy showed SCP-2 significantly colocalized with caveolin-1 in the cytoplasm (punctate) and plasma membrane of SCP-2 overexpressing hepatoma cells (72%), HT-29 cells (58%), and SCP-2 overexpressing L-cells (37%). 12641450 Human
cav hyperplasia Accelerated coronary atherosclerosis in cardiac transplants (cardiac allograft vasculopathy, CAV) is characterized by coronary intimal hyperplasia. 7521891 Human
caveolin-1 tumor Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. 12759258 Mouse
caveolin-1 hyperplasia Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. 12759258 Mouse
cav-1 tumors The human CAV-1 gene is located at a putative tumor suppressor locus (7q31.1/D7S522) and a known fragile site (FRA7G) that is deleted in a variety of epithelial-derived tumors. 12759258 Human
caveolin-1 tumor However, it remains unknown whether caveolin-1 functions as a tumor suppressor gene in vivo. 12759258 Human
cav-1 tumor Here, we examine the tumor suppressor function of caveolin-1 using Cav-1 (-/-) null mice as a model system. 12759258 Human
caveolin-1 tumor Here, we examine the tumor suppressor function of caveolin-1 using Cav-1 (-/-) null mice as a model system. 12759258 Human
cav-1 tumors We demonstrate that Cav-1 null mice are dramatically more susceptible to carcinogen-induced tumorigenesis, as they develop skin tumors at an increased rate. 12759258 Mouse
cav-1 tumor After 16 weeks of DMBA-treatment, Cav-1 null mice showed a 10-fold increase in tumor incidence, a 15-fold increase in tumor number per mouse (multiplicity), and a 35-fold increase in tumor area per mouse, as compared with wild-type littermate mice. 12759258 Mouse
cav-1 tumors Moreover, before the development of tumors, DMBA-treatment induced severe epidermal hyperplasia in Cav-1 null mice. 12759258 Mouse
cav-1 hyperplasia Moreover, before the development of tumors, DMBA-treatment induced severe epidermal hyperplasia in Cav-1 null mice. 12759258 Mouse
cav-1 hyperplasia In addition, cyclin D1 and phospho-ERK1/2 levels were up-regulated during epidermal hyperplasia, suggesting a possible mechanism for the increased susceptibility of Cav-1 null mice to tumorigenesis. 12759258 Mouse
cav-1 hyperplasia However, the skin of untreated Cav-1 null mice appeared normal, without any evidence of epidermal hyperplasia, despite the fact that Cav-1 null keratinocytes failed to express caveolin-1 and showed a complete ablation of caveolae formation. 12759258 Mouse
caveolin-1 hyperplasia However, the skin of untreated Cav-1 null mice appeared normal, without any evidence of epidermal hyperplasia, despite the fact that Cav-1 null keratinocytes failed to express caveolin-1 and showed a complete ablation of caveolae formation. 12759258 Mouse
cav-1 tumor Thus, Cav-1 null mice require an appropriate oncogenic stimulus, such as DMBA treatment, to reveal their increased susceptibility toward epidermal hyperplasia and skin tumor formation. 12759258 Mouse
cav-1 hyperplasia Thus, Cav-1 null mice require an appropriate oncogenic stimulus, such as DMBA treatment, to reveal their increased susceptibility toward epidermal hyperplasia and skin tumor formation. 12759258 Mouse
caveolin-1 tumor Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo. 12759258 Mouse
cav-1 melanoma We also examined the necessity of Cav-1 to support the angiogenic response of an exogenous tumor by subcutaneously injecting Cav-1 KO mice with the melanoma cell line, B16-F10. 12759260 Human
cav-1 tumor We also examined the necessity of Cav-1 to support the angiogenic response of an exogenous tumor by subcutaneously injecting Cav-1 KO mice with the melanoma cell line, B16-F10. 12759260 Human
cav-1 tumor We show that tumor weight, volume, and vessel density are all reduced in Cav-1 KO mice, consistent with diminished angiogenesis. 12759260 Mouse
cav-1 tumors Ultrastructural analysis of newly formed capillaries within the exogenous tumors reveals a lack of endothelial caveolae and incomplete capillary formation in Cav-1 KO mice. 12759260 Mouse
caveolin-1 prostate cancer More importantly, we show that caveolin-2 is phosphorylated in vivo at two serine residues and that the phosphorylation of caveolin-2 is necessary for its actions as a positive regulator of caveolin-1 during organelle biogenesis in prostate cancer cells. 12743374 Human
caveolin-1 tumor Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis. 12782592 Human
caveolin-1 tumor Caveolin-1 is of particular functional interest because it has been shown to interact with PTEN, the tumor suppressor gene mutated in Cowden syndrome, an inherited multiple hamartoma syndrome that includes predisposition to FTC. 12782592 Human
caveolin-1 multiple hamartoma syndrome Caveolin-1 is of particular functional interest because it has been shown to interact with PTEN, the tumor suppressor gene mutated in Cowden syndrome, an inherited multiple hamartoma syndrome that includes predisposition to FTC. 12782592 Human
caveolin-1 anaplastic thyroid carcinomas PTC and anaplastic thyroid carcinomas did not show significant down-regulation, and thus, caveolin-1 may become a useful molecular marker to differentiate the various histologies of thyroid malignancies. 12782592 Human
caveolin-1 thyroid malignancies PTC and anaplastic thyroid carcinomas did not show significant down-regulation, and thus, caveolin-1 may become a useful molecular marker to differentiate the various histologies of thyroid malignancies. 12782592 Human
caveolin-1 neuroblastoma Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease. alpha-Synuclein accumulation plays an important role 12787066 Human
caveolin-1 renal tumors There was a statistically significant difference in the expression of caveolin-1 between oncocytoma with a mean labeling index of 91.7 and the cases of malignant renal tumors with a mean labeling index of 26.9 for RCC, 24 for CDC, 21 for CRCR, and 19.2 fo 12810205 Human
caveolin-1 oncocytoma There was a statistically significant difference in the expression of caveolin-1 between oncocytoma with a mean labeling index of 91.7 and the cases of malignant renal tumors with a mean labeling index of 26.9 for RCC, 24 for CDC, 21 for CRCR, and 19.2 fo 12810205 Human
caveolin-1 carcinoma Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. 12813462 Human
caveolin-1 colon carcinoma In human HT-29 colon carcinoma cells, thiazolidinedione PPARgamma ligands increased the levels of caveolin-1 and caveolin-2 proteins two to fivefold in a concentration-dependent manner within 24 h. 12813462 Human
caveolin-1 carcinoma Our data indicate that PPARgamma participates in the regulation of caveolin gene expression in human carcinoma cells and suggest that caveolin-1 may mediate some of the phenotypic changes induced by this nuclear receptor in cancer cells. 12813462 Human
caveolin-1 cancer Our data indicate that PPARgamma participates in the regulation of caveolin gene expression in human carcinoma cells and suggest that caveolin-1 may mediate some of the phenotypic changes induced by this nuclear receptor in cancer cells. 12813462 Human
caveolin-1 human hepatoma Structural analyses of total cellular N-glycans indicated that the overexpression of GnT-III in human hepatoma cells, in which caveolin-1 is not expressed, failed to reduce branch formation, whereas expression of caveolin-1 led to a dramatic decrease in t 12716887 Human
caveolin-1 human hepatoma Indeed, when caveolin-1 was expressed in human hepatoma cells, it was found to be co-localized with GnT-III, as evidenced by the fractionation of Triton X-100-insoluble cellular membranes by density gradient ultracentrifugation. 12716887 Human
caveolin-1 tumor Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. 12866378 Human
caveolin-1 urothelial carcinoma Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. 12866378 Human
cav-1 urothelial carcinoma (uc) We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. 12866378 Human
cav-1 carcinoma in situ Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. 12866378 Human
cav-1 tumors The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (0/6), 0% (0/25), and 56% (35/63), respectively (P < .001), and for Cav-2, 0% (0/6), 13% (3/23), and 70% (42/60), respectively (P < .001). 12866378 Human
cav-1 tumor Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. 12866378 Human
cav-1 tumors Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43% (20/46) of grade 3 tumors without squamous differentiation (P < .001). 12866378 Human
cav-1 tumor These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation. 12866378 Human
cav hcc In comparison with the normal liver tissues from the healthy donors, it was found that while remained unmethylated the ABL, CAV, EPO, GATA3, LKB1, NEP, NFL, NIS and p27KIP1 genes, varying extents of the HCC specific hypermethylation were found associated 14672555 Human
cav tumor GFAP and CAV gene expression in the tumor in vivo was monitored by confocal microscopy and Northern blotting with GFAP and CAV complementary DNAs. 15471847 Human
cav brain cancer In contrast, brain cancer was selectively imaged with the 111In-CAV-PNA conjugated to SA-OX26 owing to upregulation of CAV gene expression in brain cancer. 15471847 Rat
cav tumor angiogenesis We show that delivery of Cav-1 amino acids 82-101 (Cav) fused to an internalization sequence from Antennapedia (AP) blocks NO release in vitro and inflammation and tumor angiogenesis in vivo. 15637154 Human
cav-1 skin tumors We demonstrate that Cav-1 null mice are dramatically more susceptible to carcinogen-induced tumorigenesis, as they develop skin tumors at an increased rate. 12759258 Mouse
cav-1 skin tumor Thus, Cav-1 null mice require an appropriate oncogenic stimulus, such as DMBA treatment, to reveal their increased susceptibility toward epidermal hyperplasia and skin tumor formation. 12759258 Mouse
cav-1 vascular tumors Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveol 12812318 Human
cav-1 hyperplasia The carotids of Cav-1 -/- mice showed significantly more intimal hyperplasia with subtotal luminal obstruction, as compared to wild-type mice. 15222744 Mouse
cav-1 neointimal hyperplasia In conclusion, using a carotid artery blood-flow cessation model, we show that genetic ablation of Cav-1 in mice stimulates SMC proliferation (neointimal hyperplasia), with concomitant activation of the p42/44 MAP kinase cascade and upregulation of cyclin 15222744 Mouse
cav-1 c6 glioma In a search for 5-HT(2A) receptor-interacting proteins, we discovered that caveolin-1 (Cav-1), a scaffolding protein enriched in caveolae, complexes with 5-HT(2A) receptors in a number of cell types including C6 glioma cells, transfected HEK-293 cells, an 15190056 Rat
cav-1 c6 glioma To address the functional significance of this interaction, we performed RNA interference-mediated knockdown of Cav-1 in C6 glioma cells, a cell type that endogenously expresses both 5-HT(2A) receptors and Cav-1. 15190056 Rat
cav-1 c6 glioma We discovered that the in vitro knockdown of Cav-1 in C6 glioma cells nearly abolished 5-HT(2A) receptor-mediated signal transduction as measured by calcium flux assays. 15190056 Rat
cav-1 metastasis Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo: ROLE OF CAV-1 IN CELL INVASIVENESS AND MATRIX METALLOPROTEINASE (MMP-2/9) SECRETION. 15355971 Mouse
cav-1 cancers There is now clear evidence that caveolin-1 influences the development of human cancers. 15355971 Human
cav-1 human breast cancer For example, a dominant-negative mutation (P132L) in the Cav-1 gene has been detected in up to 16% of human breast cancer samples. 15355971 Human
cav-1 metastasis Here, we examined the role of caveolin-1 in mammary tumorigenesis and lung metastasis using a molecular genetic approach. 15355971 Human
cav-1 breast cancer We interbred a well characterized transgenic mouse model of breast cancer, MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen), with Cav-1 (-/-)-null mice. 15355971 Human
cav-1 mouse mammary tumor We interbred a well characterized transgenic mouse model of breast cancer, MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen), with Cav-1 (-/-)-null mice. 15355971 Human
cav-1 mammary tumors Then, we followed the onset and progression of mammary tumors and lung metastases in female mice over a 14-week period. 15355971 Human
cav-1 lung metastases Then, we followed the onset and progression of mammary tumors and lung metastases in female mice over a 14-week period. 15355971 Human
cav-1 metastasis Conversely, recombinant expression of Cav-1 in a highly metastatic PyMT mammary carcinoma-derived cell line, namely Met-1 cells, suppressed lung metastasis by approximately 4.5-fold. 15355971 Mouse
cav-1 cancers For example, a dominant-negative mutation (P132L) in the Cav-1 gene has been detected in up to 16% of human breast cancer samples. 15355971 Human
cav-1 human breast cancer However, the exact functional role of caveolin-1 remains controversial. 15355971 Human
cav-1 metastasis We interbred a well characterized transgenic mouse model of breast cancer, MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen), with Cav-1 (-/-)-null mice. 15355971 Human
cav-1 breast cancer Then, we followed the onset and progression of mammary tumors and lung metastases in female mice over a 14-week period. 15355971 Human
cav-1 mouse mammary tumor Then, we followed the onset and progression of mammary tumors and lung metastases in female mice over a 14-week period. 15355971 Human
cav-1 metastatic lung disease Conversely, recombinant expression of Cav-1 in a highly metastatic PyMT mammary carcinoma-derived cell line, namely Met-1 cells, suppressed lung metastasis by approximately 4.5-fold. 15355971 Mouse
cav-1 metastasis In vitro, these Cav-1-expressing Met-1 cells (Met-1/Cav-1) demonstrated a approximately 4.8-fold reduction in invasion through Matrigel-coated membranes. 15355971 Mouse
cav-1 cancer Integrin-linked kinase (ILK) and caveolin-1 (cav-1) are implicated in the pathogenesis of cancer. 15654749 Human
cav-1 cancer Conversely, cav-1 expression is frequently downregulated in many forms of cancer. 15654749 Human
cav-1 human neuroblastoma We examined whether ILK and cav-1 interact in SHEP human neuroblastoma cells because ILK is present in caveolae-enriched membranes and contains a putative cav-binding domain. 15654749 NA
cav-1 human neuroblastoma These data suggest that the cav-binding domain of ILK and the cav-scaffolding domain of cav-1 mediate complex formation in human neuroblastoma cells. 15654749 Human
cav-1 tumor angiogenesis We show that delivery of Cav-1 amino acids 82-101 (Cav) fused to an internalization sequence from Antennapedia (AP) blocks NO release in vitro and inflammation and tumor angiogenesis in vivo. 15637154 Human
cav-1 human hepatoma Using a caveolin-1 (cav-1)-deficient cell line (human hepatoma 7) and embryonic fibroblasts from a cav-1 knockout mouse, we found that in the absence of caveolae, but also in wild-type embryonic fibroblasts, the virus exploits an alternative, cav-1-indepe 15668298 Human
cav-1 human tumor Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
cav-1 tumor Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
cav-1 metastasis Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
cav-1 human breast cancer Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
cav-1 c6 glioma The purpose of this study is to understand the interaction of Na + -Ca2+ exchanger (NCX1), that is one of the essential regulators of Ca2+ homeostasis, with caveolin (Cav)-1 and Cav-2 in Cav-3 null cell (rat C6 glioma cell). 15814461 Rat
cav-1 c6 glioma Both mRNA and protein expression of NCX1, Cav-1 and Cav-2 was observed, but no expression of mRNA and protein of Cav-3 were observed in C6 glioma cells. 15814461 Rat
cav-1 prostate cancer Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. 15802273 Mouse
cav-1 tumor Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. 15802273 Mouse
cav-1 prostate tumor Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. 15802273 Mouse
cav-1 human prostate cancer Despite an abundance of data suggesting that Cav-1 has transformation suppressor properties both in vitro and in vivo, Cav-1 is expressed at increased levels in human prostate cancer. 15802273 Human
cav-1 prostate cancer To investigate the role of Cav-1 in prostate cancer onset and progression, we interbred Cav-1(-/-) null mice with a TRAMP (transgenic adenocarcinoma of mouse prostate) model that spontaneously develops advanced prostate cancer and metastatic disease. 15802273 Human
cav-1 adenocarcinoma To investigate the role of Cav-1 in prostate cancer onset and progression, we interbred Cav-1(-/-) null mice with a TRAMP (transgenic adenocarcinoma of mouse prostate) model that spontaneously develops advanced prostate cancer and metastatic disease. 15802273 Human
cav-1 advanced prostate cancer To investigate the role of Cav-1 in prostate cancer onset and progression, we interbred Cav-1(-/-) null mice with a TRAMP (transgenic adenocarcinoma of mouse prostate) model that spontaneously develops advanced prostate cancer and metastatic disease. 15802273 Human
cav-1 metastatic disease To investigate the role of Cav-1 in prostate cancer onset and progression, we interbred Cav-1(-/-) null mice with a TRAMP (transgenic adenocarcinoma of mouse prostate) model that spontaneously develops advanced prostate cancer and metastatic disease. 15802273 Human
cav-1 invasive prostate cancer We found that, although the loss of Cav-1 did not affect the appearance of minimally invasive prostate cancer, its absence significantly impeded progression to highly invasive and metastatic disease. 15802273 Mouse
cav-1 metastatic disease We found that, although the loss of Cav-1 did not affect the appearance of minimally invasive prostate cancer, its absence significantly impeded progression to highly invasive and metastatic disease. 15802273 Mouse
cav-1 prostate tumor Inactivation of one (+/-) or both (-/-) alleles of Cav-1 resulted in significant reductions in prostate tumor burden, as well as decreases in regional lymph node metastases. 15802273 Mouse
cav-1 regional lymph node metastases Inactivation of one (+/-) or both (-/-) alleles of Cav-1 resulted in significant reductions in prostate tumor burden, as well as decreases in regional lymph node metastases. 15802273 Mouse
cav-1 tumors Utilizing prostate carcinoma cell lines (C1, C2, and C3) derived from TRAMP tumors, we also showed a positive correlation between Cav-1 expression and the ability of these cells to form tumors in vivo. 15802273 Human
cav-1 prostate carcinoma Utilizing prostate carcinoma cell lines (C1, C2, and C3) derived from TRAMP tumors, we also showed a positive correlation between Cav-1 expression and the ability of these cells to form tumors in vivo. 15802273 Human
cav-1 prostate tumors Mechanistically, we showed that loss or down-regulation of Cav-1 expression results in increased apoptosis, with increased prostate apoptosis response factor-4 and PTEN levels in Cav-1(-/-) null prostate tumors. 15802273 Human
cav-1 tumor Our current findings provide the first in vivo molecular genetic evidence that Cav-1 does indeed function as a tumor promoter during prostate carcinogenesis, rather than as a tumor suppressor. 15802273 Mouse
cav-1 metastasis BACKGROUND: In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. 15969750 Human
cav-1 pancreatic adenocarcinoma BACKGROUND: In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. 15969750 Human
cav-1 metastasis Recent evidence suggests a role for cav-1 in promoting cancer cell migration, invasion and metastasis; however, the molecular mechanisms have not been described. 15969750 Human
cav-1 cancer Recent evidence suggests a role for cav-1 in promoting cancer cell migration, invasion and metastasis; however, the molecular mechanisms have not been described. 15969750 Human
cav-1 primary tumors RESULTS: Analysis of 10 PC cell lines revealed high levels of cav-1 expression in lines derived from primary tumors and low expression in those derived from metastases. 15969750 Human
cav-1 metastases RESULTS: Analysis of 10 PC cell lines revealed high levels of cav-1 expression in lines derived from primary tumors and low expression in those derived from metastases. 15969750 Human
cav-1 primary tumor Comparison of the BxPC-3 (derived from a primary tumor) and HPAF-II (derived from a metastasis) demonstrates a reciprocal relationship between cav-1 expression and p42/p44 Erk activation with PC cell migration, invasion, RhoC GTPase and p38 MAPK activatio 15969750 Human
cav-1 metastasis Comparison of the BxPC-3 (derived from a primary tumor) and HPAF-II (derived from a metastasis) demonstrates a reciprocal relationship between cav-1 expression and p42/p44 Erk activation with PC cell migration, invasion, RhoC GTPase and p38 MAPK activatio 15969750 Human
cav-1 aggressive prostate cancer Association of a CAV-1 haplotype to familial aggressive prostate cancer. 15948133 Human
cav-1 prostate cancer BACKGROUND: Multiple lines of evidence have implicated the CAV-1 gene in prostate cancer progression. 15948133 Human
cav-1 prostate cancer CAV-1 is located within the prostate cancer aggressiveness locus at 7q31-33, and was identified as being overexpressed in prostate tumors. 15948133 Human
cav-1 prostate tumors CAV-1 is located within the prostate cancer aggressiveness locus at 7q31-33, and was identified as being overexpressed in prostate tumors. 15948133 Human
cav-1 prostate cancer Mutation screening was performed as well as a case-control study to examine if polymorphisms in CAV-1 are associated with prostate cancer aggressiveness in a German population. 15948133 Human
cav-1 prostate cancer METHODS: We sequenced the CAV-1 promoter region and its open reading frame in prostate cancer families with linkage to chromosome 7q31-33. 15948133 NA
cav-1 aggressive prostate cancer CONCLUSIONS: This is the first report providing evidence for CAV-1 being involved in predisposition to aggressive prostate cancer. 15948133 Human
cav-1 tumor The association of a potential risk haplotype agrees well with a role of CAV-1 in tumor progression but needs further confirmation. 15948133 Human
cav1 cancers Caveolin-1 (CAV1), an essential structural constituent of caveolae that plays an important role in cellular processes such as transport and signaling, has been implicated in the development of human cancers. 15205342 Human
cav1 tumor However, it is unclear whether CAV1 is acting like an oncogene or tumor suppressor gene. 15205342 Human
cav1 small-cell lung cancers We found that CAV1 expression was reduced or absent in 95% of small cell lung cancers (SCLCs; n = 21 lines), whereas it was retained in 76% of non-small cell lung cancers (NSCLCs; n = 25 lines) compared with normal human lung epithelial cultures, where it 15205342 Human
cav1 non-small cell lung cancers We found that CAV1 expression was reduced or absent in 95% of small cell lung cancers (SCLCs; n = 21 lines), whereas it was retained in 76% of non-small cell lung cancers (NSCLCs; n = 25 lines) compared with normal human lung epithelial cultures, where it 15205342 Human
cav1 nsclc CAV1 expression was tightly linked to the ability to grow attached to the plastic cell culture surface, whereas CAV1-nonexpressing lung cancers of both SCLC and NSCLC type grew as suspension cultures. 15205342 Human
cav1 lung cancers CAV1 expression was tightly linked to the ability to grow attached to the plastic cell culture surface, whereas CAV1-nonexpressing lung cancers of both SCLC and NSCLC type grew as suspension cultures. 15205342 Human
cav1 nsclc Importantly, CAV1 knockdown led to reduced phospho-focal adhesion kinase and RalA, but not RalB, levels in NSCLC cells. 15205342 Human
cav1 tumor These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth. 15205342 Human
cav1 nsclc These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth. 15205342 Human
cav1 tumor It has been shown previously that the main region of LOH at 7q31 spans the interval between the D7S486 and D7S2460 microsatellite loci, which contains several candidate tumor suppressor genes (TSG) such as TES, CAV2, CAV1, MET, CAPZA2, ST7 and WNT2. 15252854 Human
cav1 prostate tumors We found that CAV1, CAV2, MET and TES mRNA expression was lower in prostate tumors than in normal prostate tissues. 15252854 Human
cav1 breast cancer Caveolin-1 and -2 (CAV1, CAV2) are closely linked genes localised to the fragile region of 7q31 (FRA7G), and loss of heterozygosity involving this region has been reported in breast cancer. 15305200 Human
cav1 breast cancer However, the clinical significance of CAV1 in breast cancer has not yet been clarified. 15305200 Human
cav1 breast cancer We examined quantitatively the mRNA levels of CAV1, CAV2 and HER2/neu in 162 cases of breast cancer using real-time PCR. 15305200 NA
cav1 breast cancer We then evaluated for correlations between CAV1, CAV2 and HER2/neu gene expression and clinicopathologic factors in the 162 breast cancer cases. 15305200 Human
cav1 breast cancer Results showed higher HER2/neu mRMA levels and lower CAV1 and CAV2 mRMA levels in breast cancer tissues than in corresponding normal tissues (P<0.001). 15305200 Human
cav1 tumour Reduced CAV1 mRNA level was significantly associated with increasing tumour size (P=0.041), and negative oestrogen receptor status (P=0.021). 15305200 Human
cav1 breast cancer Our results indicated that CAV1 suppression correlated closely with that of CAV2 in breast cancer, that CAV1 level was inversely correlated with tumour size, and that CAV1 and CAV2 levels were correlated with hormonal receptor status. 15305200 Human
cav1 tumour Our results indicated that CAV1 suppression correlated closely with that of CAV2 in breast cancer, that CAV1 level was inversely correlated with tumour size, and that CAV1 and CAV2 levels were correlated with hormonal receptor status. 15305200 Human
cav1 breast cancer Therefore, CAV1 and CAV2 play an important role in tumour progression in breast cancer patients. 15305200 Human
cav1 tumour Therefore, CAV1 and CAV2 play an important role in tumour progression in breast cancer patients. 15305200 Human
cav1 osteosarcoma Although functional studies are needed to better define the role of CDH13 and CAV1 in the malignant behavior of osteosarcoma cells, the data presented here provide an aid to understanding the biological functions of L/B/K ALP in bone tumors. 15050898 Human
cav1 bone tumors Although functional studies are needed to better define the role of CDH13 and CAV1 in the malignant behavior of osteosarcoma cells, the data presented here provide an aid to understanding the biological functions of L/B/K ALP in bone tumors. 15050898 Human
cav1 breast cancer Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer. 15647832 Human
cav1 prostate cancer Among these were several known prostate cancer relevant genes, such as AMACR, TARP, LIM, GPR160 (all up-regulated), CAV1, NTN1, MT1X; CLU, TRIM29, SPARCL1 and HSPB8 (all down-regulated). 16077921 Human
caveolin-1 mammary tumors To further confirm or refute the relevance of our findings in vivo, we next examined the expression levels of caveolin-1 in mammary tumors derived from c-Neu transgenic mice. 9685399 Human
caveolin-1 malignancy In addition, the caveolin-1 expression may be a useful marker for the diagnosis of ATL malignancy. 9878546 Human
caveolin-1 prostate cancer Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer. 14634273 Human
caveolin-1 prostate cancer Caveolin-1 was found to be overexpressed not only in metastatic mouse prostate cancer, but also in human metastatic disease. 14634273 Mouse
caveolin-1 metastatic disease Caveolin-1 was found to be overexpressed not only in metastatic mouse prostate cancer, but also in human metastatic disease. 14634273 Human
caveolin-1 metastases Recent studies have indicated that suppression of caveolin-1 expression induces androgen sensitivity in high caveolin-1, androgen-insensitive mouse prostate cancer cells derived from metastases. 14634273 Mouse
caveolin-1 prostate cancer Recent studies have indicated that suppression of caveolin-1 expression induces androgen sensitivity in high caveolin-1, androgen-insensitive mouse prostate cancer cells derived from metastases. 14634273 Mouse
caveolin-1 prostate cancer Conversely, overexpression of caveolin-1 leads to androgen insensitivity in low caveolin, androgen-sensitive mouse prostate cancer cells. 14634273 Mouse
caveolin-1 prostate cancer Caveolin-1, therefore, is both a metastasis-related gene as well as a candidate androgen resistance gene for prostate cancer in man. 14634273 Human
caveolin-1 solid tumors The linkage of caveolin-1 expression with the androgen-resistant phenotype in prostate cancer and the multidrug resistance phenotype in various solid tumors establishes a novel paradigm for understanding these clinically important and now potentially rela 14634273 Human
caveolin-1 prostate cancer The linkage of caveolin-1 expression with the androgen-resistant phenotype in prostate cancer and the multidrug resistance phenotype in various solid tumors establishes a novel paradigm for understanding these clinically important and now potentially rela 14634273 Human
caveolin-1 larynx tumor We thus tested for caveolin-1 and -2 expression several bronchial epithelial primary cell lines as well as eight lung cancer cell lines and one larynx tumor cell line. 10049753 Human
caveolin-1 breast tumour Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo. 10086342 Human
caveolin-1 hemangiomas Caveolin-1 was found to be expressed in fibromatoses, leiomyomas, hemangiomas, and lipomas at high levels comparable to normal mesenchymal tissues. 11238032 Human
caveolin-1 leiomyosarcomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 well-differentiated liposarcomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 angiosarcomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 malignant fibrous histiocytomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 liposarcomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 fibrosarcomas The expression of caveolin-1 was slightly reduced in four of six well-differentiated liposarcomas and strongly reduced or lost in three of three fibrosarcomas, 17 of 20 leiomyosarcomas, 16 of 16 myxoid/round cell/pleomorphic liposarcomas, five of eight an 11238032 Human
caveolin-1 malignancy We demonstrate the potential for caveolin-1 as a therapeutic target for this important malignancy. 11358800 Human
caveolin-1 ibd In this study, we evaluated the changes in the caveolin-1 and caveolin-2 expression in the inflamed mucosa of patients with IBD. 11515846 NA
caveolin-1 bladder tumor OBJECTIVES: To assess the levels of caveolin-1 in a series of bladder tumor specimens of varying stage and grade and to identify possible links between caveolin-1 status and clinical behavior. 11711373 NA
caveolin-1 bladder tumor METHODS: Using a rabbit polyclonal antibody against caveolin-1 and immunohistochemistry, we assessed caveolin-1 protein expression in 89 formalin-fixed, paraffin-embedded bladder tumor sections. 11711373 NA
caveolin-1 astroglioma Caveolin-1 expression is maintained in rat and human astroglioma cell lines. 11857686 Human
caveolin-1 malignant tumors Caveolin has three isoforms, and recent studies suggest that in some malignant tumors an alteration of caveolin-1 expression correlates with oncogenetic changes. 12119442 Human
caveolin-1 seminomas RESULTS: Immunohistochemistry revealed that caveolin-3, but not caveolin-1, was frequently expressed in seminomas (12 positive out of 16 specimens) without positive staining in their normal counterparts or in nonseminomatous germ cell tumors, except for m 12119442 Human
caveolin-1 malignancy They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy. 12352463 Human
caveolin-1 tumour We have examined expression patterns of caveolin-1, which has been shown to function as a tumour suppressor in vitro, in EBDC using immunohistochemistry. 12737162 NA
caveolin-1 tumour Normal tissues adjacent to the tumour cells did not show immunoreactivity for caveolin-1. 12737162 Human
caveolin-1 cowden syndrome Caveolin-1 is of particular functional interest because it has been shown to interact with PTEN, the tumor suppressor gene mutated in Cowden syndrome, an inherited multiple hamartoma syndrome that includes predisposition to FTC. 12782592 Human
caveolin-1 malignant renal tumors There was a statistically significant difference in the expression of caveolin-1 between oncocytoma with a mean labeling index of 91.7 and the cases of malignant renal tumors with a mean labeling index of 26.9 for RCC, 24 for CDC, 21 for CRCR, and 19.2 fo 12810205 Human
caveolin-1 vascular tumors Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveol 12812318 Human
caveolin-1 necrosis In this study, an in vivo rat model of 30 min bilateral renal ischaemia followed by reperfusion times from 4 h to 1 week was used to map the temporal and spatial association between caveolin-1 and tubular epithelial damage (desquamation, apoptosis, necros 12845636 NA
caveolin-1 gliomas By using an in vivo brain tumor model, we purified ECs from gliomas as well as from normal brain to investigate possible regulation of caveolin-1 expression in tumoral brain vasculature. 14705150 Human
caveolin-1 oral squamous-cell carcinomas Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines. 14719121 Human
caveolin-1 oral cancer Mutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines. 14719121 Human
caveolin-1 cancers Caveolin-1, a tumor suppressor gene, was found to be inactivated by structural abnormalities or epigenetic changes in several types of human cancers. 14719121 Human
caveolin-1 tumor Caveolin-1, a tumor suppressor gene, was found to be inactivated by structural abnormalities or epigenetic changes in several types of human cancers. 14719121 Human
caveolin-1 oral squamous-cell carcinomas In order to investigate the role of Caveolin-1 in the pathogenesis of human oral squamous cell carcinoma, the exon 1 and 3 sequences of the Caveolin-1 were investigated in 74 oral squamous cell carcinomas and 15 oral cancer cell lines. 14719121 Human
caveolin-1 oral cancer In order to investigate the role of Caveolin-1 in the pathogenesis of human oral squamous cell carcinoma, the exon 1 and 3 sequences of the Caveolin-1 were investigated in 74 oral squamous cell carcinomas and 15 oral cancer cell lines. 14719121 Human
caveolin-1 oral squamous-cell carcinoma In order to investigate the role of Caveolin-1 in the pathogenesis of human oral squamous cell carcinoma, the exon 1 and 3 sequences of the Caveolin-1 were investigated in 74 oral squamous cell carcinomas and 15 oral cancer cell lines. 14719121 Human
caveolin-1 oral cancer In addition, Caveolin-1 expression was examined in 15 oral cancer cell lines. 14719121 Human
caveolin-1 cancers Mutations of the Caveolin-1 gene were identified in five cancers (1 missense and 4 silent mutations), with all mutations being detected in exon 3. 14719121 Human
caveolin-1 cancers Among the cancers containing the Caveolin-1 mutation, case 53 harbored a missense mutation from Ile (ATT) to Phe (TTT) at codon 141 and two silent mutations at codons 112 and 163 of the Caveolin-1 gene. 14719121 Human
caveolin-1 oral cancer However, mutations of the Caveolin-1 gene were not observed in normal human oral keratinocytes, the human papillomavirus-immortalized oral keratinocytes, and 15 oral cancer cell lines. 14719121 Human
caveolin-1 oral cancer Despite the intact Caveolin-1 gene, one oral cancer cell line, HEp-2, lacked the caveolin-1 protein. 14719121 Human
caveolin-1 cancer In contrast, two cancer cell lines, KOSCC-25C and -33B, had an insignificant amount of the caveolin-1 protein. 14719121 Human
caveolin-1 oral cancer These results provide genetic evidence showing that the inactivation of Caveolin-1 by a mutation or by reduced expression may play a role in the pathogenesis of oral cancer. 14719121 Human
caveolin-1 cancer Here, more recent data addressing the role of caveolin-1 in cellular signaling and the development of diseases like cancer will be preferentially discussed. 15052333 Human
caveolin-1 tumor Nitric oxide modulates caveolin-1 and matrix metalloproteinase-9 expression and distribution at the endothelial cell/tumor cell interface. 15064242 Human
caveolin-1 human lung carcinoma Caveolin-1 is down-regulated in human lung carcinoma and acts as a candidate tumor suppressor gene. 15136443 Human
caveolin-1 tumor Caveolin-1 is down-regulated in human lung carcinoma and acts as a candidate tumor suppressor gene. 15136443 Human
caveolin-1 tumor In response to EGF, tumor cells overexpressing EGF receptor display GSK-3beta-independent activation of beta-catenin, which may result from a combination of effects-EGF-stimulated, caveolin-1-dependent internalization of E-cadherin, resulting in release o 15107603 Human
caveolin-1 hepatoma Double immunolabeling and laser scanning fluorescence microscopy showed that a small but significant portion of SCP-2 colocalized with caveolin-1 primarily at the plasma membrane of L-cells and more so within intracellular punctuate structures in hepatoma 15182174 Human
caveolin-1 non-small cell lung cancer Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. 15205342 Human
caveolin-1 small-cell lung cancer Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. 15205342 Human
caveolin-1 cancers Caveolin-1 (CAV1), an essential structural constituent of caveolae that plays an important role in cellular processes such as transport and signaling, has been implicated in the development of human cancers. 15205342 Human
caveolin-1 cancer Caveolin-1 and cancer multidrug resistance: coordinate regulation of pro-survival proteins? 15234566 Human
caveolin-1 acute myeloid leukemias (aml) In four different groups of marrow samples (20 normal, 56 acute myeloid leukemias (AML) at diagnosis, 48 AMLs at relapse, and 51 regenerating marrows), caveolin-1 and MDR-1 gene expressions were positively correlated. 15234575 Human
caveolin-1 breast adenocarcinoma Overexpression of caveolin-1 induces alteration of multidrug resistance in Hs578T breast adenocarcinoma cells. 15239129 Human
caveolin-1 cancer Some studies have suggested that the level of caveolin-1 expression positively correlates with multi-drug resistance in cancer cells. 15239129 Human
caveolin-1 breast cancer In this report, we demonstrate for the first time that after overexpressing caveolin-1, the plasma membrane cholesterol level was decreased by about 12% and 30% for doxorubicin-sensitive and doxorubicin-resistant Hs578T breast cancer cells, respectively. 15240128 Human
caveolin-1 renal-cell carcinoma Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma. 15247769 Human
caveolin-1 cancer Previous studies of the expression and function of caveolin-1 in cancer have shown controversial results, indicating that the physiological role of caveolin-1 varies according to cancer type. 15247769 Human
caveolin-1 renal-cell carcinoma We evaluated caveolin-1 expression in renal cell carcinoma and investigated its association with pathological features and clinical outcome. 15247769 Human
caveolin-1 renal-cell carcinoma MATERIALS AND METHODS: Caveolin-1 expression was evaluated by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 60 paraffin embedded primary renal cell carcinoma specimens and 6 metastatic renal cell carcinoma specimens. 15247769 NA
caveolin-1 metastatic renal-cell carcinoma MATERIALS AND METHODS: Caveolin-1 expression was evaluated by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 60 paraffin embedded primary renal cell carcinoma specimens and 6 metastatic renal cell carcinoma specimens. 15247769 NA
caveolin-1 tumor When more than 50% of all cancer cell cytoplasm stained, the tumor was considered caveolin-1 positive. 15247769 Human
caveolin-1 cancer When more than 50% of all cancer cell cytoplasm stained, the tumor was considered caveolin-1 positive. 15247769 Human
caveolin-1 metastatic tumors RESULTS: Of 60 primary tumors 16 (26.7%) and 5 of 6 metastatic tumors (83.3%) were immunoreactive in more than 50% of cancer cells and considered caveolin-1 positive. 15247769 Human
caveolin-1 primary tumors RESULTS: Of 60 primary tumors 16 (26.7%) and 5 of 6 metastatic tumors (83.3%) were immunoreactive in more than 50% of cancer cells and considered caveolin-1 positive. 15247769 Human
caveolin-1 cancer RESULTS: Of 60 primary tumors 16 (26.7%) and 5 of 6 metastatic tumors (83.3%) were immunoreactive in more than 50% of cancer cells and considered caveolin-1 positive. 15247769 Human
caveolin-1 tumor Although no significant associations between caveolin-1 expression, pathological stage (T stage) and distant metastasis at initial presentation were observed, significant associations between positive caveolin-1 expression and high grade tumor (p = 0.0009 15247769 Human
caveolin-1 metastasis Although no significant associations between caveolin-1 expression, pathological stage (T stage) and distant metastasis at initial presentation were observed, significant associations between positive caveolin-1 expression and high grade tumor (p = 0.0009 15247769 Human
caveolin-1 regional lymph node metastasis Although no significant associations between caveolin-1 expression, pathological stage (T stage) and distant metastasis at initial presentation were observed, significant associations between positive caveolin-1 expression and high grade tumor (p = 0.0009 15247769 Human
caveolin-1 cancer There was no difference in cancer specific survival between caveolin-1 positive and negative groups. 15247769 Human
caveolin-1 metastasis However, in 43 patients without metastasis to regional lymph nodes or a distant site at initial presentation (N0M0) the caveolin-1 positive group had significantly shorter progression-free survival than the caveolin-1 negative group (p = 0.0332). 15247769 Human
caveolin-1 renal-cell carcinoma CONCLUSIONS: Caveolin-1 over expression could be a common finding in aggressive forms of renal cell carcinoma. 15247769 Human
caveolin-1 renal-cell carcinoma Caveolin-1 might have an important role in the invasion and metastatic progression of renal cell carcinoma. 15247769 Human
caveolin-1 sporadic colorectal cancer Promoter CpG methylation of caveolin-1 in sporadic colorectal cancer. 15274335 Human
caveolin-1 human colon cancer BACKGROUND: Caveolin-1 has been shown to be down-regulated in human colon cancer and involved in colon tumorigenesis. 15274335 Human
caveolin-1 tumor The methylation status of caveolin-1 had no clear relationship with age, cell grade, location of tumor or lymph node metastasis. 15274335 Human
caveolin-1 lymph-node metastasis The methylation status of caveolin-1 had no clear relationship with age, cell grade, location of tumor or lymph node metastasis. 15274335 Human
caveolin-1 sporadic colorectal cancer The immunohistochemistry study demonstrated that expression of caveolin-1 correlated with aberrant promoter methylation status in sporadic colorectal cancer tissues. 15274335 Human
caveolin-1 colorectal cancer CONCLUSION: Our findings suggested that aberrant promoter methylation of the caveolin-1 gene may occur at the precancerous stage, regulated by gender-related factors and is associated with gene silencing of caveolin-1 in the development of colorectal canc 15274335 Human
caveolin-1 c6 glioma In a search for 5-HT(2A) receptor-interacting proteins, we discovered that caveolin-1 (Cav-1), a scaffolding protein enriched in caveolae, complexes with 5-HT(2A) receptors in a number of cell types including C6 glioma cells, transfected HEK-293 cells, an 15190056 Rat
caveolin-1 human breast cancer Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer. 15305200 Human
caveolin-1 breast cancer Caveolin-1 and -2 (CAV1, CAV2) are closely linked genes localised to the fragile region of 7q31 (FRA7G), and loss of heterozygosity involving this region has been reported in breast cancer. 15305200 Human
caveolin-1 cancer Caveolin-1 and -2 protein expression levels were also suppressed in cancer tissues compared to normal tissues by Western blotting. 15305200 Human
caveolin-1 lung cancer We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. 15331180 Human
caveolin-1 tumors In adenocarcinomas (ADs) of positive staining for caveolin-1, pT1 tumors exhibited significantly higher staining than pT2-pT4 tumors (P=0.0240). 15331180 Human
caveolin-1 adenocarcinomas In adenocarcinomas (ADs) of positive staining for caveolin-1, pT1 tumors exhibited significantly higher staining than pT2-pT4 tumors (P=0.0240). 15331180 Human
caveolin-1 tumor In AD, loss of caveolin-1 may be essential for tumor extension and dedifferentiation. 15331180 Human
caveolin-1 tumor In contrast, caveolin-1 overexpression may be correlated with tumor extension in SCC. 15331180 Human
caveolin-1 glioblastoma Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae. 15273741 Human
caveolin-1 tumors Caveolin-1 expression, determined by RT-PCR, real-time quantitative PCR and Western blot, was upregulated in glioblastoma cell lines (two-fold) and tumors (20-300-fold) compared to primary human astrocytes and nonmalignant brain tissue, respectively. 15273741 Human
caveolin-1 glioblastoma Caveolin-1 expression, determined by RT-PCR, real-time quantitative PCR and Western blot, was upregulated in glioblastoma cell lines (two-fold) and tumors (20-300-fold) compared to primary human astrocytes and nonmalignant brain tissue, respectively. 15273741 Human
caveolin-1 glioblastoma AG1478 also increased caveolin-1 expression and reduced glioblastoma cell growth in a semi-solid agar. 15273741 Human
caveolin-1 colon adenocarcinomas Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines. 15069532 Rat
caveolin-1 human colon cancer Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines. 15069532 Human
caveolin-1 human colon cancer Expression of caveolin-1, -2, and -3 at protein and mRNA levels in human colon cancer cell lines Caco-2, HT-29 and HCT-116 was assessed by immunoblot and RT-PCR, respectively. 15069532 Human
caveolin-1 adenocarcinoma While caveolin-1 was overexpressed in all experimental adenocarcinoma tissues by comparison to normal-appearing colonic mucosa at both the mRNA and protein level, caveolin-2 was expressed equally only at the mRNA level in both tissues. 15069532 Rat
caveolin-1 adenocarcinomas Immunohistochemical analysis of experimental rat colon tissues also revealed a similar pattern with caveolin-1 being overexpressed in adenocarcinomas as compared to normal-appearing colonic mucosa. 15069532 Rat
caveolin-1 colon carcinoma Caveolin-1 mRNA expression was evident in all colon carcinoma cell lines tested; however, caveolin-2 mRNA was found only in HT-29 and HCT-116. 15069532 Human
caveolin-1 human colon cancer Caveolin-1 protein and mRNA transcript levels in human colon cancer cell lines were observed to be concordant with the growth rate of the cells, and followed the pattern of HCT-116 > HT-29 > Caco-2. 15069532 Human
caveolin-1 colon adenocarcinoma Taken together, our results indicate that caveolin-1 is overexpressed in experimental colon adenocarcinoma by comparison to adjacent normal mucosa, and its expression in human colon cancer cells is directly associated with the growth rate. 15069532 Rat
caveolin-1 human colon cancer Taken together, our results indicate that caveolin-1 is overexpressed in experimental colon adenocarcinoma by comparison to adjacent normal mucosa, and its expression in human colon cancer cells is directly associated with the growth rate. 15069532 Human
caveolin-1 human hepatoma We show using detergent-free sucrose gradients that SR-BI is found in membrane rafts devoid of caveolin-1 in the human hepatoma HepG2 cell. 15226391 Human
caveolin-1 tumor In conclusion, we have 1) determined the biochemical basis for the unusual size variation in CD147, 2) established that CD147 is a major carrier of beta1,6-branched polylactosamine sugars on tumor cells, and 3) determined that caveolin-1 can inhibit the c 15201341 Human
caveolin-1 tumor These results help explain the previously established tumor suppressor functions of caveolin-1. 15201341 Human
caveolin-1 neointimal hyperplasia Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia. 15361787 Human
caveolin-1 neointimal hyperplasia In contrast, in smooth muscle cells, the ability of caveolin-1 to negatively regulate cell proliferation (neointimal hyperplasia) may have an antiatherogenic effect. 15361787 Human
caveolin-1 breast cancers Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers. 15375584 Human
caveolin-1 tumor Caveolin-1, an integral membrane protein of caveolae found in many cell types, has been suggested as a candidate tumor suppressor. 15375584 Human
caveolin-1 breast cancer The purpose of this study is to investigate the role of aberrant promoter methylation in the regulation of caveolin-1 gene in breast cancer correlated with clinical findings. 15375584 Human
caveolin-1 breast cancer We used methylation specific PCR, direct sequencing and immunohistochemistry stain methods to explore the role of caveolin-1 gene in the development of breast cancer. 15375584 Human
caveolin-1 breast cancer There were four types of methylation pattern of caveolin-1 gene in the breast cancer tissues. 15375584 Human
caveolin-1 breast cancer The methylation status of caveolin-1 gene had no clear relationship with age, cell grade, stage of tumor, and status of estrogen receptor, p53 and c-erbB2 in the breast cancer tissues. 15375584 Human
caveolin-1 tumor The methylation status of caveolin-1 gene had no clear relationship with age, cell grade, stage of tumor, and status of estrogen receptor, p53 and c-erbB2 in the breast cancer tissues. 15375584 Human
caveolin-1 sporadic breast cancer Immunohistochemistry demonstrated that expression of caveolin-1 gene correlated with aberrant promoter methylation status in sporadic breast cancer tissues. 15375584 Human
caveolin-1 prostate cancer Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. 15466889 Human
caveolin-1 breast cancer Caveolin-1 inhibits breast cancer growth and metastasis. 15334058 Human
caveolin-1 metastasis Caveolin-1 inhibits breast cancer growth and metastasis. 15334058 Human
caveolin-1 breast cancer Caveolin-1 was identified in a screen for genes involved in breast cancer progression. 15334058 Human
caveolin-1 tumors Using an orthotopic model of spontaneous breast cancer metastasis, caveolin-1 was found to be expressed in low and non-metastatic primary tumors, but at much lower levels in highly metastatic 4T1.2 and 4T1.13 tumors. 15334058 Human
caveolin-1 primary tumors Using an orthotopic model of spontaneous breast cancer metastasis, caveolin-1 was found to be expressed in low and non-metastatic primary tumors, but at much lower levels in highly metastatic 4T1.2 and 4T1.13 tumors. 15334058 Human
caveolin-1 breast cancer metastasis Using an orthotopic model of spontaneous breast cancer metastasis, caveolin-1 was found to be expressed in low and non-metastatic primary tumors, but at much lower levels in highly metastatic 4T1.2 and 4T1.13 tumors. 15334058 Human
caveolin-1 primary tumor Exogenous expression of caveolin-1 at moderate levels in 4T1.2 cells was sufficient to suppress primary tumor growth after inoculation of cells into the mammary gland. 15334058 Human
caveolin-1 metastasis Expression of high levels of caveolin-1 also inhibited subsequent metastasis to distant organs. 15334058 Human
caveolin-1 metastasis to lung Cells expressing high levels of caveolin-1 showed reduced capacity to invade Matrigel, diminished response to laminin-1 stimulation and decreased metastasis to lung and bone. 15334058 Human
caveolin-1 breast cancer This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058 NA
caveolin-1 spontaneous metastasis This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058 NA
caveolin-1 breast tumor This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer. 15334058 NA
caveolin-1 multiple myeloma Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib. 15492276 Human
caveolin-1 multiple myeloma In the present study, we demonstrate that vascular endothelial growth factor (VEGF) triggers Src-dependent phosphorylation of caveolin-1, which is required for p130(Cas) phosphorylation and multiple myeloma cell migration. 15492276 Human
caveolin-1 multiple myeloma Conversely, depletion of caveolin-1 by antisense methodology abrogates p130(Cas) phosphorylation and VEGF-triggered multiple myeloma cell migration. 15492276 Human
caveolin-1 multiple myeloma Taken together, these studies demonstrate the requirement of caveolae for VEGF-triggered multiple myeloma cell migration and identify caveolin-1 in multiple myeloma cells and human umbilical vascular endothelial cells as a molecular target of bortezomib. 15492276 Human
caveolin-1 breast adenocarcinoma To elucidate the possible mechanism between caveolin-1 and P-gp expression, in the present study, we overexpressed caveolin-1 in the Hs578T/Dox breast adenocarcinoma cells, a multidrug resistant line, and then selected single clone cells highly expressing 15498565 Human
caveolin-1 lung cancer G2/M blockade by paclitaxel induces caveolin-1 expression in A549 lung cancer cells: caveolin-1 as a marker of cytotoxicity. 15514565 Human
caveolin-1 cancers The role of caveolin-1 in carcinogenesis has been a subject to numerous investigations, however, the expression pattern and the function of caveolin-1 are rather controversial both in gastrointestinal and extraintestinal cancers. 15553909 Human
caveolin-1 tumor The vast majority of results based on cancer cell line experiments indicate that caveolin-1 might act as a tumor suppressor gene. 15553909 Human
caveolin-1 cancer The vast majority of results based on cancer cell line experiments indicate that caveolin-1 might act as a tumor suppressor gene. 15553909 Human
caveolin-1 tumor In tumor tissues, however, caveolin-1 seem to fulfill a tumor promoting role, since the expression of caveolin-1 is increased when compared to normal tissue counterparts. 15553909 Human
caveolin-1 cancer In this review, the authors summarize the results of caveolin-1 expression in gastrointestinal and extraintestinal cancer emphasizing possible future therapeutic implications. 15553909 Human
caveolin-1 metastasis Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. 15355971 Mouse
caveolin-1 cancers There is now clear evidence that caveolin-1 influences the development of human cancers. 15355971 Human
caveolin-1 human breast cancer For example, a dominant-negative mutation (P132L) in the Cav-1 gene has been detected in up to 16% of human breast cancer samples. 15355971 Human
caveolin-1 metastasis Here, we examined the role of caveolin-1 in mammary tumorigenesis and lung metastasis using a molecular genetic approach. 15355971 Human
caveolin-1 breast cancer We interbred a well characterized transgenic mouse model of breast cancer, MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen), with Cav-1 (-/-)-null mice. 15355971 Human
caveolin-1 mouse mammary tumor We interbred a well characterized transgenic mouse model of breast cancer, MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen), with Cav-1 (-/-)-null mice. 15355971 Human
caveolin-1 metastasis No significant differences were detected between PyMT/Cav-1 (+/+) and PyMT/Cav-1 (+/-) mice, indicating that complete loss of caveolin-1 is required to accelerate both tumorigenesis and metastasis. 15355971 Mouse
caveolin-1 mammary tumor Molecularly, mammary tumor samples derived from PyMT/Cav-1 (-/-) mice showed ERK-1/2 hyperactivation, cyclin D1 up-regulation, and Rb hyperphosphorylation, consistent with dys-regulated cell proliferation. 15355971 Mouse
caveolin-1 cancers For example, a dominant-negative mutation (P132L) in the Cav-1 gene has been detected in up to 16% of human breast cancer samples. 15355971 Human
caveolin-1 human breast cancer However, the exact functional role of caveolin-1 remains controversial. 15355971 Human
caveolin-1 metastasis We interbred a well characterized transgenic mouse model of breast cancer, MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen), with Cav-1 (-/-)-null mice. 15355971 Human
caveolin-1 mammary tumors No significant differences were detected between PyMT/Cav-1 (+/+) and PyMT/Cav-1 (+/-) mice, indicating that complete loss of caveolin-1 is required to accelerate both tumorigenesis and metastasis. 15355971 Mouse
caveolin-1 tumor No significant differences were detected between PyMT/Cav-1 (+/+) and PyMT/Cav-1 (+/-) mice, indicating that complete loss of caveolin-1 is required to accelerate both tumorigenesis and metastasis. 15355971 Mouse
caveolin-1 metastasis Molecularly, mammary tumor samples derived from PyMT/Cav-1 (-/-) mice showed ERK-1/2 hyperactivation, cyclin D1 up-regulation, and Rb hyperphosphorylation, consistent with dys-regulated cell proliferation. 15355971 Mouse
caveolin-1 metastasis These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches. 15355971 Mouse
caveolin-1 mammary tumor These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches. 15355971 Mouse
caveolin-1 human neuroblastoma Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cells. 15654749 Human
caveolin-1 cancer Integrin-linked kinase (ILK) and caveolin-1 (cav-1) are implicated in the pathogenesis of cancer. 15654749 Human
caveolin-1 pituitary adenomas No immunoreactivity was seen for caveolin-1 and caveolin-2 in non-tumorous adenohypophysial and neurohypophysial cells and in the tumor cells, indicating that caveolins are not involved in the initiation and progression of pituitary adenomas. 15681859 Human
caveolin-1 tumor No immunoreactivity was seen for caveolin-1 and caveolin-2 in non-tumorous adenohypophysial and neurohypophysial cells and in the tumor cells, indicating that caveolins are not involved in the initiation and progression of pituitary adenomas. 15681859 Human
caveolin-1 pituitary tumors The expression of caveolin-1 and caveolin-2 in the endothelial cells did not depend on age, gender, endocrine status of the patients, morphologic features, and type of pituitary tumors. 15681859 Human
caveolin-1 human hepatoma Using a caveolin-1 (cav-1)-deficient cell line (human hepatoma 7) and embryonic fibroblasts from a cav-1 knockout mouse, we found that in the absence of caveolae, but also in wild-type embryonic fibroblasts, the virus exploits an alternative, cav-1-indepe 15668298 Human
caveolin-1 metastasis Caveolin-1 in oncogenic transformation, cancer, and metastasis. 15692148 Human
caveolin-1 cancer Caveolin-1 in oncogenic transformation, cancer, and metastasis. 15692148 Human
caveolin-1 metastasis Interestingly, caveolin-1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. 15692148 Human
caveolin-1 human tumor Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
caveolin-1 tumor Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
caveolin-1 metastasis Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
caveolin-1 human breast cancer Here, we review the available experimental evidence (gleaned from cultured cells, animal models, and human tumor samples) that caveolin-1 (Cav-1) functions as a "tumor and/or metastasis modifier gene." Genetic evidence from the study of Cav-1(-/ 15692148 Human
caveolin-1 tumor In contrast, caveolin-1 may function as a tumor promoter in prostate cancers. 15692148 Human
caveolin-1 prostate cancers In contrast, caveolin-1 may function as a tumor promoter in prostate cancers. 15692148 Human
caveolin-1 icc Caveolin-1 was present in punctate sites of the plasma membranes (PM) of all smooth muscles and diffusely in all classes of interstitial cells of Cajal (ICC; identified by c-kit immunoreactivity), ICC-myenteric plexus (MP), ICC-deep muscular plexus (DMP), 15472013 Human
caveolin-1 icc In general, all ICC also contained the L-type Ca(2+) (L-Ca(2+)) channel, the PM Ca(2+) pump, and the Na(+)/Ca(2+) exchanger-1 localized with caveolin-1. 15472013 Human
caveolin-1 icc The large-conductance Ca(2+)-activated K(+) channel was present in smooth muscle and skeletal muscle of esophagus and some ICC but was not colocalized with caveolin-1. 15472013 Human
caveolin-1 mcf-7 human breast cancer Utilizing MCF-7 human breast cancer cells, stably transfected with caveolin-1 (MCF-7/Cav1), we previously demonstrated that caveolin-1 expression decreases MCF-7 cell proliferation and colony formation in soft agar. 15592498 Human
caveolin-1 colon cancer Finally, the levels of caveolin-1 are dramatically elevated in a time-dependent manner upon detachment of anoikis-resistant MCF-7/Cav1 cells and HT-29-MDR human multidrug resistant colon cancer cells. 15592498 Human
caveolin-1 human breast cancer We conclude that expression of caveolin-1 in human breast cancer cells enhances matrix-independent cell survival that is mediated by upregulation of IGF-I receptor expression and signaling. 15592498 Human
caveolin-1 ovarian cancer Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. 15674352 Human
caveolin-1 tumor From the candidates selected, activating transcription factor-3 (ATF-3), caveolin-1, deleted in liver cancer-1 (DLC-1), and nonmetastatic clone 23 (NM23-H2) were chosen for post hoc functional studies based on their previously reported action as tumor sup 15674352 Human
caveolin-1 tumor However, their modes of action differ significantly; ATF-3 primarily functions as an apoptosis inducer, NM23-H2 as a suppressor of cell motility, and caveolin-1 and DLC-1 exhibiting features of classical tumor suppressors. 15674352 Human
caveolin-1 human prostate carcinoma Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression. 15712208 Human
caveolin-1 prostate carcinoma Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression. 15712208 Human
caveolin-1 prostate carcinoma Caveolin-1 is associated with prostate carcinoma progression and is a downstream target gene of c-Myc. 15712208 Human
caveolin-1 human prostate carcinoma In this study, the authors evaluated the prognostic potential of combined c-Myc and caveolin-1 expression in human prostate carcinoma progression. 15712208 NA
caveolin-1 prostate carcinoma The combination of positive c-Myc and caveolin-1 in patients with clinically confined prostate carcinoma was a significant prognostic marker for the time to disease progression after surgery in both univariate analysis (P = 0.0039; hazard ratio, 3.035) an 15712208 Human
caveolin-1 human prostate carcinoma CONCLUSIONS: The coexpression of c-Myc and caveolin-1 showed potential as a useful prognostic marker for human prostate carcinoma. 15712208 Human
caveolin-1 human prostate carcinoma The current results suggest interactions between c-Myc and caveolin-1 in the progression of human prostate carcinoma. 15712208 Human
caveolin-1 prostate cancer Further study showed that pretreatment of human keratinocytes with MMP inhibitor or Filipin inhibited UV-induced phosphorylation of p38 and JNK, which was however not observed in LnCap cells, a prostate cancer cell line lacking caveolin-1. 15754025 Human
caveolin-1 gastric carcinoma [Down-regulation of caveolin-1 in gastric carcinoma and its clinical biological significance] BACKGROUND & OBJECTIVE: Caveolin-1, a candidate tumor suppressor gene, aberrantly expressed in many kinds of carcinomas. 15757532 Human
caveolin-1 carcinomas [Down-regulation of caveolin-1 in gastric carcinoma and its clinical biological significance] BACKGROUND & OBJECTIVE: Caveolin-1, a candidate tumor suppressor gene, aberrantly expressed in many kinds of carcinomas. 15757532 Human
caveolin-1 tumor [Down-regulation of caveolin-1 in gastric carcinoma and its clinical biological significance] BACKGROUND & OBJECTIVE: Caveolin-1, a candidate tumor suppressor gene, aberrantly expressed in many kinds of carcinomas. 15757532 Human
caveolin-1 metaplasia This research was designed to check the expression of Caveolin-1 in non-cancerous gastric mucosa, intestinal metaplasia, atypical hyperplasia, gastric cancer tissues, and gastric cancer cell lines MGC803 and BGC823, and to analyze its clinical biological 15757532 Human
caveolin-1 atypical hyperplasia This research was designed to check the expression of Caveolin-1 in non-cancerous gastric mucosa, intestinal metaplasia, atypical hyperplasia, gastric cancer tissues, and gastric cancer cell lines MGC803 and BGC823, and to analyze its clinical biological 15757532 Human
caveolin-1 gastric cancer This research was designed to check the expression of Caveolin-1 in non-cancerous gastric mucosa, intestinal metaplasia, atypical hyperplasia, gastric cancer tissues, and gastric cancer cell lines MGC803 and BGC823, and to analyze its clinical biological 15757532 Human
caveolin-1 metaplasia METHODS: Frozen gastric tissue array-based immunohistochemistry (IHC) was used to examine the expression of Caveolin-1 in 56 specimens of gastric cancer, 29 specimens of non-cancerous mucosa, 11 specimens of intestinal metaplasia, and 7 specimens of atypi 15757532 NA
caveolin-1 atypical hyperplasia METHODS: Frozen gastric tissue array-based immunohistochemistry (IHC) was used to examine the expression of Caveolin-1 in 56 specimens of gastric cancer, 29 specimens of non-cancerous mucosa, 11 specimens of intestinal metaplasia, and 7 specimens of atypi 15757532 NA
caveolin-1 gastric cancer METHODS: Frozen gastric tissue array-based immunohistochemistry (IHC) was used to examine the expression of Caveolin-1 in 56 specimens of gastric cancer, 29 specimens of non-cancerous mucosa, 11 specimens of intestinal metaplasia, and 7 specimens of atypi 15757532 NA
caveolin-1 lymph-node metastasis Correlations of Caveolin-1 expression to clinical stage, lymph node metastasis, Lauren's type, and histological type were analyzed. 15757532 Human
caveolin-1 gastric cancer Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were used to detect mRNA and protein levels of Caveolin-1 in 56 specimens of gastric cancer and relevant adjuvant non-cancerous tissue, and cell lines MGC803 and BGC823. 15757532 Human
caveolin-1 metaplasia RESULTS: Positive rate of Caveolin-1 was significantly lower in gastric cancer than in non-cancerous mucosa, intestinal metaplasia, and atypical hyperplasia (17.9% vs. 84.8%, 81.8%, and 57.1%, P<0.05). 15757532 Human
caveolin-1 atypical hyperplasia RESULTS: Positive rate of Caveolin-1 was significantly lower in gastric cancer than in non-cancerous mucosa, intestinal metaplasia, and atypical hyperplasia (17.9% vs. 84.8%, 81.8%, and 57.1%, P<0.05). 15757532 Human
caveolin-1 gastric cancer RESULTS: Positive rate of Caveolin-1 was significantly lower in gastric cancer than in non-cancerous mucosa, intestinal metaplasia, and atypical hyperplasia (17.9% vs. 84.8%, 81.8%, and 57.1%, P<0.05). 15757532 Human
caveolin-1 gastric cancer Positive rate of Caveolin-1 was lower in advanced gastric cancers than in gastric cancer of early stage (16.0% vs. 33.3%), but the difference was not significant (P>0.05). 15757532 Human
caveolin-1 advanced gastric cancers Positive rate of Caveolin-1 was lower in advanced gastric cancers than in gastric cancer of early stage (16.0% vs. 33.3%), but the difference was not significant (P>0.05). 15757532 Human
caveolin-1 lymph-node metastases Positive rate of Caveolin-1 was significantly lower in diffuse gastric cancer than in gastric cancer of intestinal type (7.0% vs. 26.9%, P<0.05), significantly lower in the cases with lymph node metastases than in the cases without lymph node metastases ( 15757532 Human
caveolin-1 diffuse gastric cancer Positive rate of Caveolin-1 was significantly lower in diffuse gastric cancer than in gastric cancer of intestinal type (7.0% vs. 26.9%, P<0.05), significantly lower in the cases with lymph node metastases than in the cases without lymph node metastases ( 15757532 Human
caveolin-1 gastric cancer Positive rate of Caveolin-1 was significantly lower in diffuse gastric cancer than in gastric cancer of intestinal type (7.0% vs. 26.9%, P<0.05), significantly lower in the cases with lymph node metastases than in the cases without lymph node metastases ( 15757532 Human
caveolin-1 gastric cancer Protein and mRNA levels of Caveolin-1 in gastric cancer and relevant adjuvant non-cancerous tissues have no significant difference, but its expression was low in MGC803 and BGC823 cells. 15757532 Human
caveolin-1 human colorectal carcinoma Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. 15769846 Human
caveolin-1 colon cancer Based on these results, we hypothesize that caveolin-1 affects the expression and localization of cathepsin B and pro-uPA, and their receptors, thereby mediating cell-surface proteolytic events associated with invasion of colon cancer cells. 15769846 Human
caveolin-1 tumors In tumors, caveolin-1, the structural protein of caveolae, constitutes a key switch through its function as a tumor suppressor and a promoter of metastases. 15623570 Human
caveolin-1 tumor In tumors, caveolin-1, the structural protein of caveolae, constitutes a key switch through its function as a tumor suppressor and a promoter of metastases. 15623570 Human
caveolin-1 metastases In tumors, caveolin-1, the structural protein of caveolae, constitutes a key switch through its function as a tumor suppressor and a promoter of metastases. 15623570 Human
caveolin-1 c6 glioma Evidence for Na+/Ca2+ exchanger 1 association with caveolin-1 and -2 in C6 glioma cells. 15814461 Rat
caveolin-1 lung cancer Role of caveolin-1 in Etoposide resistance development in a549 lung cancer cells. 15326378 Human
caveolin-1 breast cancer Caveolin-1 in breast cancer. 15539932 Human
caveolin-1 tumor The hypothesis that caveolin-1 conveys a tumor/transformation suppressor function in the mammary gland is derived from several independent lines of evidence accumulated by genetic, molecular and clinical approaches. 15539932 Human
caveolin-1 tumor The human caveolin-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31.1) frequently deleted in human breast carcinomas. 15539932 Human
caveolin-1 human breast carcinomas The human caveolin-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31.1) frequently deleted in human breast carcinomas. 15539932 Human
caveolin-1 human breast carcinomas In addition, up to 16% of human breast carcinomas harbor a dominant-negative mutation, P132L, in the caveolin-1 gene. 15539932 Human
caveolin-1 breast carcinomas Caveolin-1 RNA and protein levels are also downregulated in human primary breast carcinomas and cell lines, with reintroduction of caveolin-1 in vitro sufficient to inhibit numerous tumorigenic properties, including anchorage independent growth and invasi 15539932 Human
caveolin-1 cell hyperplasia Most recently caveolin-1 knockout mice have provided breakthroughs in understanding the dynamic role of caveolin-1 in the pathogenesis of mammary epithelial cell hyperplasia, tumorigenesis and metastasis in a vivo setting. 15539932 Mouse
caveolin-1 metastasis Most recently caveolin-1 knockout mice have provided breakthroughs in understanding the dynamic role of caveolin-1 in the pathogenesis of mammary epithelial cell hyperplasia, tumorigenesis and metastasis in a vivo setting. 15539932 Mouse
caveolin-1 breast cancer This review concentrates on recent advances implicating caveolin-1 in breast cancer pathogenesis, with emphasis on the signaling pathways regulated during these processes. 15539932 Human
caveolin-1 human osteosarcoma Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells. 15886522 Human
caveolin-1 oral squamous-cell carcinoma Expression of caveolin-1 and its correlation with cisplatin sensitivity in oral squamous cell carcinoma. 15856296 Human
caveolin-1 metastasis Recently, caveolin-1 was identified as being associated with both metastasis and multidrug resistance. 15856296 Human
caveolin-1 tumor Growth inhibition at lower concentrations correlated with induction of the tumor suppressor gene caveolin-1 which is known to inhibit colon cancer cell growth. 15798084 Human
caveolin-1 colon cancer Growth inhibition at lower concentrations correlated with induction of the tumor suppressor gene caveolin-1 which is known to inhibit colon cancer cell growth. 15798084 Human
caveolin-1 prostate cancer Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. 15802273 Mouse
caveolin-1 tumor Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. 15802273 Mouse
caveolin-1 prostate tumor Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. 15802273 Mouse
caveolin-1 pancreatic cancer Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1. 15969750 Human
caveolin-1 metastasis BACKGROUND: In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. 15969750 Human
caveolin-1 pancreatic adenocarcinoma BACKGROUND: In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. 15969750 Human
caveolin-1 tumor Thus, we demonstrate that CO, by activating p38beta MAPK, up-regulates caveolin-1, which acts as a tumor suppressor protein that mediates the growth inhibitory properties of this gas. 16051704 Human
caveolin-1 tumor Chlamydia trachomatis modulates expression of tumor suppressor gene caveolin-1 and oncogene C-myc in the transformation zone of non-neoplastic cervical tissue. 16005053 Human
caveolin-1 tumor The cultures showed a 2-fold decrease in the expression of the gene coding for the tumor suppressor caveolin-1, and increased expression of the oncogene C-myc, a promoter of cervical carcinogenesis. 16005053 Human
caveolin-1 lung adenocarcinomas In addition, in a subgroup of 28 patients for whom the remaining tumor tissue was available, we examined the relationship among EGFR mutations, CA repeats in intron 1 of EGFR, EGFR and caveolin-1 mRNA levels, and increased EGFR gene copy numbers.RESULTS: 16115929 Human
caveolin-1 tumor In addition, in a subgroup of 28 patients for whom the remaining tumor tissue was available, we examined the relationship among EGFR mutations, CA repeats in intron 1 of EGFR, EGFR and caveolin-1 mRNA levels, and increased EGFR gene copy numbers. 16115929 Human
caveolin-1 lung adenocarcinomas EGFR mutations tended to be associated with increased numbers of CA repeats and increased EGFR gene copy numbers but not with EGFR and caveolin-1 mRNA overexpression (P = not significant).CONCLUSIONS: The presence of EGFR mutations is a major determinant 16115929 Human
caveolin-1 non-small cell lung cancer In addition, in a subgroup of 28 patients for whom the remaining tumor tissue was available, we examined the relationship among EGFR mutations, CA repeats in intron 1 of EGFR, EGFR and caveolin-1 mRNA levels, and increased EGFR gene copy numbers.RESULTS: 16115929 Human
caveolin-1 tumour These data define a novel molecular mechanism for growth and tumour suppression by caveolin-1. 16113676 Human
caveolin-1 human hepatoma We observed GR in low-density detergent-resistant membrane (DRM) rafts derived from human hepatoma Hep3B cells in complexes with caveolin-1, HSP90, and STAT3. 16125141 Human
caveolin-i extrahepatic bile duct carcinoma Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma. 12737162 Human
caveolin 1 tumor Because overexpression of caveolin 1 is known to suppress colon cancer cell and tumor growth, the growth inhibitory effects of rosiglitazone and the DIM compounds are associated with PPARgamma-dependent induction of caveolins. 15342379 Human
caveolin 1 colon cancer Because overexpression of caveolin 1 is known to suppress colon cancer cell and tumor growth, the growth inhibitory effects of rosiglitazone and the DIM compounds are associated with PPARgamma-dependent induction of caveolins. 15342379 Human
caveolin 1 cancer Caveolin 1 expression is downregulated in various cancer cell lines. 15326378 Human
caveolin 1 drug-resistant cancer Interestingly, in several drug-resistant cancer cells, a strong induction of caveolin 1 expression has been reported suggesting a role for caveolin 1 in the acquisition and/or the maintenance of multidrug resistance phenotype. 15326378 Human

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