IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ST7 Ensembl ENSG00000004866 Chromosome 7 Start 116380528 End 116657393
Description Suppressor of tumorigenicity protein 7 (Protein HELG) [Source:UniProtKB/Swiss-Prot;Acc:Q9NRC1]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11351
     Entrez Gene : 7982
     UCSC : uc003vin.2
     GeneCards : 11351
     RefSeq : NM_018412
     CCDS : CCDS5769.1
     Uniprot : Q9BWX3
     Interpro : Q9BWX3
     OMIM : 600833
     GeneTests : ST7
     CGAP : ST7
     PMID : 8105370

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40038_at  -0.79  4.05e-4  1.42e-3  -1.17  8.12e-5  3.31e-4
 HG_U95  40039_g_at  -0.50  6.23e-7  4.31e-6  -1.05  4.10e-14  1.08e-12
 HG_U95  40040_at  -0.97  1.19e-6  7.70e-6  -1.53  1.02e-8  9.33e-8
 HG_U133A  207524_at  -0.45  3.15e-15  1.72e-14  -2.09  4.02e-58  1.05e-57
 HG_U133A  207871_s_at  -0.62  1.57e-12  6.96e-12  -3.62  2.99e-65  8.89e-65
 HG_U133_Plus2  207524_at  -0.02  8.73e-1  9.06e-1  0.24  1.01e-1  1.36e-1
 HG_U133_Plus2  207871_s_at  -0.80  3.95e-14  4.83e-13  -1.58  4.68e-32  2.75e-30
 Stanford  4964  -0.57  2.31e-2  1.10e-1  -1.02  2.04e-3  2.27e-2
 Stanford  5059  -0.56  4.77e-2  1.50e-1  -1.14  9.58e-5  2.66e-3
 Stanford  13537  -0.75  2.19e-3  2.41e-2  -1.07  1.84e-3  2.12e-2
 Stanford  22653  -0.57  2.31e-2  1.10e-1  -1.02  2.04e-3  2.27e-2
 Agilent_HS_21.6K  2651  -0.12  2.52e-3  1.60e-2  -0.16  1.44e-3  7.35e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207524_at  0.07  7.03e-1  9.69e-1  -0.15  2.03e-1  1.00e+0
 HG_U133A  207871_s_at  0.03  9.56e-1  9.98e-1  -0.18  5.78e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40038_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40039_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40040_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207524_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207871_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207524_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207871_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4964    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 5059    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13537    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22653    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2651    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
st7 tumor Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. 12012006 Human
st7 tumor ST7 is a tumor suppressor gene, which is clustered with WNT2 gene in human chromosome 7q31 region. 12012006 Human
st7 tumor Human ST7R (ST7-like, ST7L) is a paralog of tumor suppressor gene ST7 in the human genome. 12060862 Human
st7 tumor ST7R is a paralog of tumor suppressor gene ST7 in the human genome. 12063568 Human
st7 tumour ST7 is a candidate tumour suppressor gene at human chromosome locus 7q31.1. 12107844 Human
st7 breast cancer We have performed mutational analysis of ST7 in a wide-range of cell lines and primary epithelial cancers and detected only one missense change in a breast cancer cell line. 12107844 Human
st7 epithelial cancers We have performed mutational analysis of ST7 in a wide-range of cell lines and primary epithelial cancers and detected only one missense change in a breast cancer cell line. 12107844 Human
st7 tumour These results imply that another tumour suppressor gene at this locus may be more important than ST7 in carcinogenesis. 12107844 Human
st7 cancer Absence of ST7 gene alterations in human cancer. 12231539 Human
st7 tumor The ST7 gene was cloned and mapped to chromosome 7q31.1-q31.2, a region suspected of containing a tumor suppressor gene involved in a variety of human cancers. 12231539 Human
st7 cancers The ST7 gene was cloned and mapped to chromosome 7q31.1-q31.2, a region suspected of containing a tumor suppressor gene involved in a variety of human cancers. 12231539 Human
st7 breast tumors Subsequent investigation described the presence of ST7 mutations in human cell lines derived from breast tumors and primary colon carcinoma. 12231539 Human
st7 colon carcinoma Subsequent investigation described the presence of ST7 mutations in human cell lines derived from breast tumors and primary colon carcinoma. 12231539 Human
st7 adenocarcinomas To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
st7 head and neck squamous cell carcinomas To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
st7 cancer To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
st7 invasive ductal carcinomas To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
st7 cancers We believe that the ST7 gene is not a primary target of inactivation in most human cancers with loss of heterozygosity at 7q31.1-q31.2. 12231539 Human
st7 breast tumors Analysis of a series of cell lines derived from breast tumors and primary colon carcinomas revealed the presence of mutations in ST7. 11279520 Human
st7 colon carcinomas Analysis of a series of cell lines derived from breast tumors and primary colon carcinomas revealed the presence of mutations in ST7. 11279520 Human
st7 cancer Our data indicate that ST7 is a TSG within chromosome 7q31 and may have an important role in the development of some types of human cancer. 11279520 Human
st7 colorectal cancers Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers. 11726923 Human
st7 tumor Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers. 11726923 Human
st7 tumor The gene ST7 has recently been implicated as the broad-range tumor suppressor on human chromosome 7q31.1. 11726923 Human
st7 colon carcinomas We did not detect somatic mutations in ST7 in any of 149 primary ovarian, breast or colon carcinomas. 11726923 Human
st7 tumor These data suggest that epigenetic downregulation or haploinsufficiency, rather than somatic genetic alterations, may be the primary mechanism of abrogation of ST7 function in these tumor types. 11726923 Human
st7 tumors Absence of ST7 mutations in tumor-derived cell lines and tumors. 11726924 Human
st7 tumor Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC. 14669308 Human
st7 gastric carcinoma Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC. 14669308 Human
st7 stomach cancer ST7 gene, a candidate tumor suppressor gene identified recently at human chromosome 7q31.1, was also detected because LOH at this site has also been widely reported in stomach cancer. 14669308 Human
st7 tumor ST7 gene, a candidate tumor suppressor gene identified recently at human chromosome 7q31.1, was also detected because LOH at this site has also been widely reported in stomach cancer. 14669308 Human
st7 gastric carcinoma ST7 gene may not be the target gene of inactivation at 7q31 site in gastric carcinoma. 14669308 Human
st7 tumor Mutational analysis of the ST7 gene in human myeloid tumor cell lines. 14534688 Human
st7 tumor We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
st7 chronic myelogenous leukemia (cml) We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
st7 acute myelogenous leukemia (aml) We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
st7 breast tumor In addition, our analysis of two breast tumor cell lines, which had been reported to harbour ST7 mutations, provided no evidence for such mutations. 14534688 Human
st7 tumors Thus, our results strongly suggest that somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors and further raise questions regarding the pathological role of ST7 as a tumor suppressor gene (TSG) 14534688 Human
st7 tumor Thus, our results strongly suggest that somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors and further raise questions regarding the pathological role of ST7 as a tumor suppressor gene (TSG) 14534688 Human
st7 colorectal cancer Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer. 14670621 Human
ray1 colorectal cancer Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer. 14670621 Human
st7 tumor However, the role of ST7 as a tumor suppressor is uncertain as somatic mutations have been difficult to demonstrate. 14670621 Human
st7 colorectal cancers In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. 14670621 Human
ray1 colorectal cancers In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. 14670621 Human
st7 cancers The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5' and 3' sequences of 15/124 (12%) informative cancers with LOH were characterized. 14670621 Human
ray1 cancers The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5' and 3' sequences of 15/124 (12%) informative cancers with LOH were characterized. 14670621 Human
st7 colorectal cancer Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene. 14670621 Human
ray1 colorectal cancer Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene. 14670621 Human
st7 tumor Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene. 14670621 Human
ray1 tumor Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene. 14670621 Human
st7 human esophageal carcinoma An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. 12545169 Human
st7 tumor Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this region. 12545169 Human
st7 tumors To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors 12545169 Human
st7 esophageal carcinomas To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors 12545169 Human
st7 tumors The peak LOH locus was D7S480, lying 4.2 Mb telomeric to ST7 and showing LOH in eight of 37 informative tumors, or 22%. 12545169 Human
st7 tumors No mutations were found in the entire coding or flanking intronic regions of the ST7 gene among 12 tumors with 7q-LOH. 12545169 Human
st7 tumor In addition, quantitative RT-PCR analyses of ST7 mRNA expression levels in 11/13 normal-tumor pairs failed to show more than a 50% decrease in tumor ST7 mRNA relative to matched normal tissues. 12545169 Human
st7 esophageal carcinomas These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event. 12545169 Human
st7 breast cancer Truncating mutations in the ST7 gene at this locus are seen frequently in primary colon cancer and breast cancer cell lines. 12799635 Human
st7 primary colon cancer Truncating mutations in the ST7 gene at this locus are seen frequently in primary colon cancer and breast cancer cell lines. 12799635 Human
st7 tumour Therefore, the ST7 gene represents a novel candidate gene for the tumour suppressor at this locus. 12799635 Human
st7 primary cancer However, more recent studies have reported that ST7 mutations are infrequent or absent in primary cancer and cell lines. 12799635 Human
st7 cancer To ascertain the frequency of mutations of the ST7 gene in cancer cells, we examined mutations in the ST7 coding sequence in 48 colorectal, 48 gastric, and 48 hepatocellular carcinomas using polymerase chain reaction-single-strand conformational polymorph 12799635 Human
st7 hepatocellular carcinomas To ascertain the frequency of mutations of the ST7 gene in cancer cells, we examined mutations in the ST7 coding sequence in 48 colorectal, 48 gastric, and 48 hepatocellular carcinomas using polymerase chain reaction-single-strand conformational polymorph 12799635 Human
st7 hepatocellular carcinomas We conclude that mutations in the ST7 gene are rare in primary colorectal, gastric, and hepatocellular carcinomas. 12799635 Human
st7 epithelial tumours Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours. 12107844 Human
st7 neoplasias The recently described ST7 (for suppression of tumorigenicity 7) gene has been suggested to be a major target gene on chromosome 7q31 for inactivation in a variety of human neoplasias. 14534688 Human
st7 neoplasias Thus, our results strongly suggest that somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors and further raise questions regarding the pathological role of ST7 as a tumor suppressor gene (TSG) 14534688 Human
st7 myeloid tumors Thus, our results strongly suggest that somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors and further raise questions regarding the pathological role of ST7 as a tumor suppressor gene (TSG) 14534688 Human
st7 tumor It has been shown previously that the main region of LOH at 7q31 spans the interval between the D7S486 and D7S2460 microsatellite loci, which contains several candidate tumor suppressor genes (TSG) such as TES, CAV2, CAV1, MET, CAPZA2, ST7 and WNT2. 15252854 Human
st7 tumor Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. 15485929 Human
suppression of tumorigenicity 7 neoplasias The recently described ST7 (for suppression of tumorigenicity 7) gene has been suggested to be a major target gene on chromosome 7q31 for inactivation in a variety of human neoplasias. 14534688 Human
the st7 gene cancers The ST7 gene was cloned and mapped to chromosome 7q31.1-q31.2, a region suspected of containing a tumor suppressor gene involved in a variety of human cancers. 12231539 Human
the st7 gene tumor The ST7 gene was cloned and mapped to chromosome 7q31.1-q31.2, a region suspected of containing a tumor suppressor gene involved in a variety of human cancers. 12231539 Human
the st7 gene adenocarcinomas of the colon To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
the st7 gene head and neck squamous cell carcinomas To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
the st7 gene invasive ductal carcinomas of the breast To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
the st7 gene cancer To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
the st7 gene cancers We believe that the ST7 gene is not a primary target of inactivation in most human cancers with loss of heterozygosity at 7q31.1-q31.2. 12231539 Human
the st7 gene human esophageal carcinoma An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. 12545169 Human
the st7 gene tumors To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors 12545169 Human
the st7 gene esophageal carcinomas To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors 12545169 Human
the st7 gene tumors No mutations were found in the entire coding or flanking intronic regions of the ST7 gene among 12 tumors with 7q-LOH. 12545169 Human
the st7 gene breast cancer Truncating mutations in the ST7 gene at this locus are seen frequently in primary colon cancer and breast cancer cell lines. 12799635 Human
the st7 gene primary colon cancer Truncating mutations in the ST7 gene at this locus are seen frequently in primary colon cancer and breast cancer cell lines. 12799635 Human
the st7 gene tumour Therefore, the ST7 gene represents a novel candidate gene for the tumour suppressor at this locus. 12799635 Human
the st7 gene hepatocellular carcinomas To ascertain the frequency of mutations of the ST7 gene in cancer cells, we examined mutations in the ST7 coding sequence in 48 colorectal, 48 gastric, and 48 hepatocellular carcinomas using polymerase chain reaction-single-strand conformational polymorph 12799635 Human
the st7 gene cancer To ascertain the frequency of mutations of the ST7 gene in cancer cells, we examined mutations in the ST7 coding sequence in 48 colorectal, 48 gastric, and 48 hepatocellular carcinomas using polymerase chain reaction-single-strand conformational polymorph 12799635 Human
the st7 gene hepatocellular carcinomas We conclude that mutations in the ST7 gene are rare in primary colorectal, gastric, and hepatocellular carcinomas. 12799635 Human
the st7 gene myeloid tumor Mutational analysis of the ST7 gene in human myeloid tumor cell lines. 14534688 Human
the st7 gene myeloid tumor We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
the st7 gene acute myelogenous leukemia (aml) We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
the st7 gene chronic myelogenous leukemia (cml) We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
st7 adenocarcinomas of the colon To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
st7 invasive ductal carcinomas of the breast To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. 12231539 Human
st7 hepatocellular carcinomas Mutations in the ST7/RAY1/HELG locus rarely occur in primary colorectal, gastric, and hepatocellular carcinomas. 12799635 Human
st7 myeloid tumor Mutational analysis of the ST7 gene in human myeloid tumor cell lines. 14534688 Human
st7 myeloid tumor We, therefore, sought to examine a total of 22 human malignant myeloid tumor cell lines comprising 17 of acute myelogenous leukemia (AML) cell lines and 5 chronic myelogenous leukemia (CML) cell lines for somatic mutations of the ST7 gene by means of bidi 14534688 Human
st7 tumor Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. 16307020 Mouse
st7 cancer In this study, we show that, functionally, ST7 behaves as a tumor suppressor in human cancer. 16474848 Human
st7 tumor In this study, we show that, functionally, ST7 behaves as a tumor suppressor in human cancer. 16474848 Human
st7 prostate cancer ST7 suppressed growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient mice, and increased the latency of tumor detection from 13 days in control tumors to 23 days. 16474848 Human
st7 tumor ST7 suppressed growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient mice, and increased the latency of tumor detection from 13 days in control tumors to 23 days. 16474848 Human
st7 tumors ST7 suppressed growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient mice, and increased the latency of tumor detection from 13 days in control tumors to 23 days. 16474848 Human
st7 breast cancer Re-expression of ST7 was also associated with suppression of colony formation under anchorage-independent conditions in MDA-MB-231 breast cancer cells and ST7 mRNA expression was downregulated in 44% of primary breast cancers. 16474848 Human
st7 primary breast cancers Re-expression of ST7 was also associated with suppression of colony formation under anchorage-independent conditions in MDA-MB-231 breast cancer cells and ST7 mRNA expression was downregulated in 44% of primary breast cancers. 16474848 Human
st7 tumor These data indicate that ST7 may mediate tumor suppression through modification of the tumor microenvironment. 16474848 Human
ray1 tumor The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. 12213198 Human
ray1 tumorigenesis In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. 14670621 Human
st7 tumor Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. 11279520 Human
st7 tumor The gene ST7 has been proposed as the multi-tissue tumor-suppressor gene (TSG) at chromosome 7q31.1. 11726924 Human
st7 tumour Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours. 12107844 Human
st7 carcinogenesis These results imply that another tumour suppressor gene at this locus may be more important than ST7 in carcinogenesis. 12107844 Human
st7 tumor The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. 12213198 Human
st7 prostate cancer Introduction of the ST7 cDNA into a prostate cancer-derived cell line abrogated in vivo tumorigenecity in nude mice. 12231539 Human
st7 carcinogenesis To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors 12545169 Human
st7 tumorigenesis In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. 14670621 Human
st7 tumorigenesis Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. 16307020 Mouse
st7 prostate cancer ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix. 16474848 Human

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