IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene WNT2 Ensembl ENSG00000105989 Chromosome 7 Start 116704518 End 116750579
Description Protein Wnt-2 Precursor (Int-1-related protein)(IRP protein) [Source:UniProtKB/Swiss-Prot;Acc:P09544]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12780
     Entrez Gene : 7472
     UCSC : uc003viz.2
     GeneCards : 12780
     RefSeq : NM_003391
     CCDS : CCDS5771.1
     Uniprot : P09544
     Interpro : P09544
     OMIM : 147870
     GeneTests : WNT2
     CGAP : WNT2
     PMID : 2971536

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205648_at  -1.02  6.90e-21  5.78e-20  -2.27  1.66e-77  6.32e-77
 HG_U133_Plus2  205648_at  -0.65  3.84e-7  1.85e-6  -0.87  1.64e-11  8.59e-11
 Stanford  310  -0.19  7.21e-1  8.41e-1  0.25  6.56e-1  8.21e-1
 Stanford  964  -0.77  1.08e-1  2.61e-1  -0.40  5.80e-1  7.73e-1
 Stanford  1517  -0.55  2.56e-1  4.55e-1  -0.35  4.51e-1  6.77e-1
 Agilent_HS_21.6K  9656  0.03  5.74e-1  7.33e-1  0.02  6.66e-1  7.79e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205648_at  0.12  7.80e-1  9.79e-1  -0.03  9.16e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 205648_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205648_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 310    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 964    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1517    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9656    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
wnt2 colon cancer For example, Wnt2 mRNA was detected in colon cancer but was undetectable in normal colonic mucosa. 12147710 Human
wnt2 cancer Wnt2, and possibly Wnt5a, may be involved in the progression from normal mucosa to cancer and the expression of Fz1/2 receptors may be involved in processes associated with tumour invasion. 12147710 Human
wnt2 primary gastric cancer We have also reported frequent up-regulation of WNT2 and WNT5A in primary gastric cancer, which is probably due to cancer-stromal interaction. 12165812 Human
wnt2 colorectal cancer Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer. 11605001 Human
wnt2 primary gastric cancer Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer. 11605001 Human
wnt2 primary tumor In 3 cases of prostate cancer and 1 case each of lung cancer and cervical cancer, WNT2 was over-expressed in non-cancerous portion as well as in primary tumor. 11605001 Human
wnt2 prostate cancer In 3 cases of prostate cancer and 1 case each of lung cancer and cervical cancer, WNT2 was over-expressed in non-cancerous portion as well as in primary tumor. 11605001 Human
wnt2 cervical cancer In 3 cases of prostate cancer and 1 case each of lung cancer and cervical cancer, WNT2 was over-expressed in non-cancerous portion as well as in primary tumor. 11605001 Human
wnt2 lung cancer In 3 cases of prostate cancer and 1 case each of lung cancer and cervical cancer, WNT2 was over-expressed in non-cancerous portion as well as in primary tumor. 11605001 Human
wnt2 primary colorectal cancer WNT2 was up-regulated in 14 out of 18 cases of primary colorectal cancer, 4 out of 7 cases of uterus tumor, 2 out of 9 cases of breast cancer, and in 2 out of 14 cases of kidney tumor. 11605001 Human
wnt2 breast cancer WNT2 was up-regulated in 14 out of 18 cases of primary colorectal cancer, 4 out of 7 cases of uterus tumor, 2 out of 9 cases of breast cancer, and in 2 out of 14 cases of kidney tumor. 11605001 Human
wnt2 tumor WNT2 was up-regulated in 14 out of 18 cases of primary colorectal cancer, 4 out of 7 cases of uterus tumor, 2 out of 9 cases of breast cancer, and in 2 out of 14 cases of kidney tumor. 11605001 Human
wnt2 primary gastric cancer Up-regulation of WNT2 was also detected in 4 out of 8 cases of primary gastric cancer by using expression array filter hybridization, and in 10 out of another 10 cases of primary gastric cancer by using cDNA-PCR. 11605001 Human
wnt2 colorectal cancer Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer might play a key role in carcinogenesis through activation of the WNT - beta-catenin - TCF signaling pathway. 11605001 Human
wnt2 primary gastric cancer Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer might play a key role in carcinogenesis through activation of the WNT - beta-catenin - TCF signaling pathway. 11605001 Human
wnt2 cancer Differential regulation of WNT2 and WNT2B expression in human cancer. 11712082 Human
wnt2 breast cancer Here, regulation of WNT2, WNT2B1, and WNT2B2 mRNAs in MCF-7 cells (breast cancer), NT2 cells (teratocarcinoma), and MKN45 cells (gastric cancer) were investigated. 11712082 Human
wnt2 teratocarcinoma Here, regulation of WNT2, WNT2B1, and WNT2B2 mRNAs in MCF-7 cells (breast cancer), NT2 cells (teratocarcinoma), and MKN45 cells (gastric cancer) were investigated. 11712082 Human
wnt2 gastric cancer Here, regulation of WNT2, WNT2B1, and WNT2B2 mRNAs in MCF-7 cells (breast cancer), NT2 cells (teratocarcinoma), and MKN45 cells (gastric cancer) were investigated. 11712082 Human
wnt2 cancer This is the first report on differential regulation of WNT2, WNT2B1, and WNT2B2 mRNAs in human cancer cell lines. 11712082 Human
wnt2 human breast cancer Up-regulation of WNT2 mRNA by estrogen might play a key role in some cases of human breast cancer through activation of the beta-catenin - TCF signaling pathway. 11712082 Human
wnt2 human breast cancer Synchronous up-regulation of FZD10 and WNT2 mRNAs might lead to activation of the WNT signaling pathway in human breast cancer. 11743650 Human
wnt2 malignant melanoma METHODS: The expression of Wnt2, Wnt5a, Wnt5b, Wnt7b, and Wnt10b was defined by in situ, antisense RNA hybridisation of paraffin wax embedded sections of benign naevi and malignant melanoma. 14514922 Human
wnt2 melanomas In contrast, melanomas characterised by large, pleomorphic cells expressed Wnt10b but did not express Wnt2 and had low levels of expression of Wnt5a. 14514922 Human
wnt 2 adenoma Wnt 2 and wnt 5a were significantly up-regulated in the progression from normal through adenoma to carcinoma. 10507776 Human
wnt 2 carcinoma Wnt 2 and wnt 5a were significantly up-regulated in the progression from normal through adenoma to carcinoma. 10507776 Human
wnt2 gastric adenocarcinoma Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, and ERBB2. 9824203 Human
wnt2 tumor Of the seven tested candidates, MYCN, MET, WNT2, and ERBB2 were found to participate in the amplicons of the respective tumor samples. 9824203 Human
wnt2 stomach cancer Of these four presumably activated oncogenes, two, MYCN and WNT2, were previously not assumed to play a pathogenic role in stomach cancer. 9824203 Human
wnt2 endometrial carcinoma Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. 9099960 Human
wnt 2 cancer To assess their role in another endocrine-responsive human cancer, the expression of seven Wnt genes (Wnt 2, 3, 4, 5a, 7a, 7b and 10b) in normal human endometrium and endometrial cells, and endometrial carcinoma tissues and cell lines was investigated by 9099960 Human
wnt 2 endometrial carcinoma To assess their role in another endocrine-responsive human cancer, the expression of seven Wnt genes (Wnt 2, 3, 4, 5a, 7a, 7b and 10b) in normal human endometrium and endometrial cells, and endometrial carcinoma tissues and cell lines was investigated by 9099960 Human
wnt2 endometrial carcinoma In contrast, in four endometrial carcinoma cell lines (RL95-2, HEC-1-A, AN3 CA and Ishikawa), Wnt2 and Wnt3 mRNAs were absent. 9099960 Human
wnt2 endometrial carcinoma Wnt2, 3 and 5a mRNAs were also lower in endometrial carcinoma compared with normal endometrium. 9099960 Human
wnt2 endometrial carcinoma In vitro, progesterone and/or 17beta-oestradiol had no effect on Wnt2, 3, 4, 5a and 7b mRNA expression in NES and all endometrial carcinoma cell lines. 9099960 Human
wnt 2 endometrial carcinoma The data indicate that all Wnt genes were expressed in vitro, six out of seven Wnt genes (Wnt 2, 3, 4, 5a, 7a and 7b) were expressed endogenously in the human endometrium, their mRNA expression was hormonally independent and Wnt4 gene down-regulation as w 9099960 Human
wnt 2 human colorectal cancer Evidence for the involvement of the Wnt 2 gene in human colorectal cancer. 8552386 Human
wnt-2 liver metastases In contrast, the Wnt-2 gene, which was expressed at low levels in normal colon, exhibited overexpression in all tumor tissue samples at the different Dukes' stages of CRC progression, including premalignant polyps and liver metastases. 8552386 Human
wnt-2 polyps In contrast, the Wnt-2 gene, which was expressed at low levels in normal colon, exhibited overexpression in all tumor tissue samples at the different Dukes' stages of CRC progression, including premalignant polyps and liver metastases. 8552386 Human
wnt-2 tumor In contrast, the Wnt-2 gene, which was expressed at low levels in normal colon, exhibited overexpression in all tumor tissue samples at the different Dukes' stages of CRC progression, including premalignant polyps and liver metastases. 8552386 Human
wnt-2 neoplasms Overexpression of the Wnt-2 gene occurred also in other digestive neoplasms such as gastric and esophageal carcinomas, as well as in diverticulitis associated with stenosis or pseudo-tumor. 8552386 Human
wnt-2 esophageal carcinomas Overexpression of the Wnt-2 gene occurred also in other digestive neoplasms such as gastric and esophageal carcinomas, as well as in diverticulitis associated with stenosis or pseudo-tumor. 8552386 Human
wnt-2 human gastric cancer In search of the Wnt gene(s) expressed in human gastric cancer, a WTGC1 cDNA fragment sharing 66.9% amino-acid homology with human and mouse Wnt-2 was isolated by degenerate polymerase chain reaction. 8761309 Human
wnt-2 breast tumors Compartment switching of WNT-2 expression in human breast tumors. 8813115 Human
wnt-2 cancer WNT-2 is a secreted polypeptide with mitogenic effects in murine mammary epithelial cells, but its role in human cancer is unknown. 8813115 Human
wnt-2 infiltrating carcinomas WNT-2 was found to be expressed at high levels in both the epithelium and stroma of 5 of 11 infiltrating carcinomas and 2 of 6 fibroadenomas. 8813115 Human
wnt-2 tumor The high level of WNT-2 expression in tumor epithelium suggests that tumorigenesis may involve the ectopic expression of WNT-2 and the creation of an autocrine Wnt signaling loop. 8813115 Human
wnt2 primary gastric cancer We have cloned and characterized human WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT10A, WNT10B, WNT11, WNT14 and WNT14B/WNT15 using bioinformatics and cDNA-PCR, and also reported frequent up-regulation of WNT2 in primary gastric cancer. 12469206 Human
wnt2 tumours Epithelial Wnt5a overexpression and stromal Wnt2 overexpression were associated with abnormal, nuclear localization of beta-catenin in the stromal cells of these tumours. 12898599 Human
wnt2 prostate cancer While SFRP4, FZD4, FZD6, DVL1, TCF4, and MYC are up-regulated, WIF1, WNT2, PPP2CB, CCND2, and CD44 are down-regulated in certain prostate cancer patients. 14517837 Human
wnt-2 tumors We show two examples of series of transplanted tumors that in later hormone-independent passages contain an amplified and overexpressed Wnt-2 gene, a novel mode of activation of these genes. 1549363 Mouse
wnt2 human gastric cancer MYC, ERBB2, MET, FGFR2, CCNE1, MYCN, WNT2, CD44, MDM2, NCOA3, IQGAP1 and STK6 loci are amplified in human gastric cancer. 12739007 Human

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