IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ING3 Ensembl ENSG00000071243 Chromosome 7 Start 120378053 End 120402938
Description Inhibitor of growth protein 3 (p47ING3 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9NXR8]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 14587
     Entrez Gene : 54556
     UCSC : uc003vjn.2
     GeneCards : 14587
     RefSeq : NM_019071
     CCDS : CCDS5778.1
     Uniprot : Q9HC99
     Interpro : Q9HC99
     OMIM : 607493
     GeneTests : ING3
     CGAP : ING3
     PMID : 12080476

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31808_at  -0.82  4.36e-5  1.95e-4  -1.21  4.96e-6  2.69e-5
 HG_U133A  205070_at  -0.45  1.25e-12  5.58e-12  -3.74  5.37e-84  2.40e-83
 HG_U133_Plus2  205070_at  -0.72  4.46e-16  6.80e-15  -1.24  4.42e-23  8.77e-22
 HG_U133_Plus2  231863_at  -0.18  2.22e-2  4.15e-2  -0.26  1.11e-2  1.79e-2
 HG_U133_Plus2  242293_at  -0.28  1.40e-3  3.52e-3  -0.70  1.70e-9  7.06e-9
 Stanford  12011  0.04  9.33e-1  9.65e-1  0.13  7.72e-1  8.91e-1
 Stanford  22590  -0.13  6.98e-1  8.25e-1  -0.07  8.49e-1  9.32e-1
 Agilent_HS_21.6K  19290  -0.14  2.06e-2  7.78e-2  -0.22  3.13e-4  2.06e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205070_at  0.10  5.93e-1  9.51e-1  0.05  7.01e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31808_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205070_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205070_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 231863_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242293_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12011    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22590    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19290    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ing3 head-and-neck cancers Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. 12080476 Human
ing3 tumors Especially, about 63% of tongue and larynx tumors showed the decrease and a tendency of higher mortality was observed in cases with decreased ING3 expression. 12080476 Human
p47ing3 cancer Such motifs are common in proteins involved in chromatin remodeling. p47ING3 is highly expressed in some normal human tissues or organs, including the spleen, testis, skeletal muscle, and heart. p47ING3 expression levels varied among cancer cell lines. p4 12545155 Human
ing3 primary tumors Reverse-transcription-PCR analysis demonstrated decreased or no expression of ING3 mRNA in 50% of primary tumors as compared with that of matched normal samples. 12080476 Human
ing3 larynx tumors Especially, about 63% of tongue and larynx tumors showed the decrease and a tendency of higher mortality was observed in cases with decreased ING3 expression. 12080476 Human
ing3 tumor We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. 15935570 Human
ing3 head-and-neck cancer We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. 15935570 Human

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