IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTPRZ1 Ensembl ENSG00000106278 Chromosome 7 Start 121300395 End 121489324
Description Receptor-type tyrosine-protein phosphatase zeta Precursor (R-PTP-zeta)(EC 3.1.3.48)(R-PTP-zeta-2)(Protein-tyrosine phosphatase receptor type Z polypeptide 1)(Protein-tyrosine phosphatase receptor type Z polypeptide 2) [Source:UniProtKB/Swiss-Prot;Acc:P23471]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9685
     Entrez Gene : 5803
     UCSC : uc003vjy.2
     GeneCards : 9685
     RefSeq : NM_002851
     CCDS : CCDS34740.1
     Uniprot : P23471
     Interpro : P23471
     OMIM : 176891
     GeneTests : PTPRZ1
     CGAP : PTPRZ1
     PMID : 7736789

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1364_at  0.18  5.74e-1  6.70e-1  3.75  6.93e-11  9.60e-10
 HG_U133A  204469_at  0.02  9.28e-1  9.39e-1  0.27  1.67e-2  1.80e-2
 HG_U133_Plus2  204469_at  -0.02  9.35e-1  9.53e-1  3.88  2.34e-26  6.80e-25
 Stanford  22720  -0.23  4.08e-1  6.03e-1  1.29  3.69e-3  3.45e-2
 Agilent_HS_21.6K  19884  0.18  1.04e-1  2.42e-1  0.69  4.30e-6  5.46e-5

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204469_at  0.14  8.12e-1  9.83e-1  -0.42  3.64e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1364_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204469_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204469_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22720    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19884    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ptprz1 glioblastoma The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration and proliferation, initiating its oncogenic activities through two cell surface receptors, the protein tyrosine phosphatase receptor zeta (PTPRZ1) and the anaplastic lymphoma ki 15908427 Human
ptprz1 human tumors To demonstrate clinical relevance, we show that PTN15, PTN18, and PTPRZ1 are significantly overexpressed in glioblastoma relative to normal brain at both mRNA and protein levels using microarray, Western blot, and tissue microarray analyses on human tumor 15908427 Human
ptprz1 glioblastoma To demonstrate clinical relevance, we show that PTN15, PTN18, and PTPRZ1 are significantly overexpressed in glioblastoma relative to normal brain at both mRNA and protein levels using microarray, Western blot, and tissue microarray analyses on human tumor 15908427 Human
ptprz1 anaplastic lymphoma The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration and proliferation, initiating its oncogenic activities through two cell surface receptors, the protein tyrosine phosphatase receptor zeta (PTPRZ1) and the anaplastic lymphoma ki 15908427 Human
rptpbeta human colorectal cancers We examined the expression of PTN, its putative receptor, namely protein tyrosine phosphatase zeta (PTPzeta, also known as RPTPbeta), and a related protein, receptor-type protein tyrosine phosphatase gamma (RPTPgamma), in human colorectal cancers and the 10077226 Human
rptpbeta astrocytoma We observed a strong binding of F3IgFc-coated fluorospheres to astrocytes in neural primary cultures and to C6 astrocytoma cells, and demonstrated, in antibody perturbation experiments, that F3-Ig binding on astrocytes depends on its interaction with PTPz 10103110 Mouse
rptpbeta glial tumor Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. 11313993 Mouse
rptpbeta astrocytoma Adhesion and spreading of SF763T astrocytoma cells expressing RPTPbeta on tenascin C was specifically abolished by the addition of a soluble fragment containing the FNIII domain of the receptor. 11313993 Mouse
rptpbeta glial tumor These results demonstrate that the FNIII domain of RPTPbeta binds to tenascin C and suggest that RPTPbeta present on glial tumor cells is a primary adhesion receptor system to the extracellular matrix. 11313993 Mouse
rptpbeta glioblastomas Using subtractive cloning combined with cDNA array analysis, we previously identified the genes encoding for the protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta (PTPzeta/RPTPbeta) and its ligand pleiotrophin (PTN) as over 14692702 Human
rptpbeta malignancy PTPzeta/RPTPbeta immunoreactivity was associated with increasing malignancy grade and localized predominantly to the tumor cells. 14692702 Human
rptpbeta tumor PTPzeta/RPTPbeta immunoreactivity was associated with increasing malignancy grade and localized predominantly to the tumor cells. 14692702 Human
rptpbeta glioblastoma Haptotaxis of glioblastoma cells towards PTN was specifically inhibited by an anti-PTPzeta/RPTPbeta antibody. 14692702 Human
rptpbeta astrocytic tumor Our findings suggest that upregulated expression of PTN and PTPzeta/RPTPbeta in human astrocytic tumor cells can create an autocrine loop that is important for glioma cell migration. 14692702 Human
rptpbeta glioma Our findings suggest that upregulated expression of PTN and PTPzeta/RPTPbeta in human astrocytic tumor cells can create an autocrine loop that is important for glioma cell migration. 14692702 Human
rptpbeta mf Identifying the mechanism by which keratanase produced MF misrouting is complicated by the presence of splice variants of the phosphacan gene that include the extracellular form of phosphacan and the transmembrane receptor protein tyrosine phosphatase bet 14724244 Rat
rptpbeta glioblastoma Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. 15831233 Human
rptpbeta glioblastoma The receptor protein tyrosine phosphatase beta (RPTPbeta/PTPzeta) is overexpressed in glioblastoma tumors and plays a functional role in tumor cell migration and adhesion. 15831233 Human
rptpbeta tumor cell migration The receptor protein tyrosine phosphatase beta (RPTPbeta/PTPzeta) is overexpressed in glioblastoma tumors and plays a functional role in tumor cell migration and adhesion. 15831233 Human
rptpbeta tumors The receptor protein tyrosine phosphatase beta (RPTPbeta/PTPzeta) is overexpressed in glioblastoma tumors and plays a functional role in tumor cell migration and adhesion. 15831233 Human
rptpbeta glioblastomas Glioblastomas express at least three splice variants of RPTPbeta, including long and short receptor forms and a secreted chondroitin sulfate proteoglycan called phosphacan. 15831233 Human
rptpbeta astrocytomas A study of normal brain tissue and graded astrocytomas indicates that long and short RPTPbeta forms have an overlapping expression pattern. 15831233 Human
rptpbeta glioblastoma In order to study functional differences between long and short RPTPbeta, we created stable U87 glioblastoma cells that expressed these receptors. 15831233 Human
rptpbeta glioblastoma Because of their tumor-restricted and largely overlapping expression patterns in glioblastoma, both RPTPbeta splice forms are potential therapeutic targets. 15831233 Human
rptpbeta cancer The involvement of long and short RPTPbeta in glioma tumor cell biology also contributes to the value of RPTPbeta as a cancer target. 15831233 Human
rptpbeta glioma The involvement of long and short RPTPbeta in glioma tumor cell biology also contributes to the value of RPTPbeta as a cancer target. 15831233 Human
rptpbeta tumor The involvement of long and short RPTPbeta in glioma tumor cell biology also contributes to the value of RPTPbeta as a cancer target. 15831233 Human
rptpbeta glioblastomas The protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta (PTPzeta/RPTPbeta) and its ligand pleiotrophin (PTN) are overexpressed in human glioblastomas. 16923162 Human
rptpbeta glioma In addition, PTN can induce glioma cell migration which is at least in part mediated through binding to PTPzeta/RPTPbeta. 16923162 Human
rptpbeta glioblastoma To study the relevance of this ligand-receptor pair for glioma growth in vitro and in vivo, we transfected the human glioblastoma cell line U251-MG with small interfering RNA (siRNA) directed against PTPzeta/RPTPbeta. 16923162 Human
rptpbeta glioma To study the relevance of this ligand-receptor pair for glioma growth in vitro and in vivo, we transfected the human glioblastoma cell line U251-MG with small interfering RNA (siRNA) directed against PTPzeta/RPTPbeta. 16923162 Human
rptpbeta tumour When injected subcutaneously into nude mice, clones that expressed normal levels of PTPzeta/RPTPbeta (PTPzeta + clones) formed exponentially growing tumours, whereas tumour growth was almost completely abrogated for clones that expressed reduced PTPzeta/R 16923162 Mouse
rptpbeta tumours When injected subcutaneously into nude mice, clones that expressed normal levels of PTPzeta/RPTPbeta (PTPzeta + clones) formed exponentially growing tumours, whereas tumour growth was almost completely abrogated for clones that expressed reduced PTPzeta/R 16923162 Human
rptpbeta glioma Our findings suggest that antagonization of PTPzeta/RPTPbeta expression can inhibit glioma growth in vivo and may thus represent a potentially promising treatment strategy. 16923162 Human
rptpbeta solid tumor The receptor protein tyrosine phosphatase beta (RPTPbeta) is a functional biomarker for several solid tumor types. 16489031 Human
rptpbeta astrocytic tumors RPTPbeta expression is largely restricted to the central nervous system and overexpressed primarily in astrocytic tumors. 16489031 Human
rptpbeta tumor RPTPbeta is known to facilitate tumor cell adhesion and migration through interactions with extracellular matrix components and the growth factor pleiotrophin. 16489031 Human
rptpbeta solid tumor Here, we show that RPTPbeta is expressed in a variety of solid tumor types with low expression in normal tissue. 16489031 Human
rptpbeta glioblastoma To assess RPTPbeta as a potential target for treatment of glioblastoma and other cancers, antibodies directed to RPTPbeta have been developed and profiled in vitro and in vivo. 16489031 Human
rptpbeta other cancers To assess RPTPbeta as a potential target for treatment of glioblastoma and other cancers, antibodies directed to RPTPbeta have been developed and profiled in vitro and in vivo. 16489031 Human
ptprz neuroblastoma Pleiotrophin, a ligand for Ptprz, increased tyrosine phosphorylation of p190 RhoGAP in B103 neuroblastoma cells. 16513268 Mouse
phosphacan fibrosarcoma Using portions of tenascin-C expressed as recombinant proteins in human fibrosarcoma cells, we have demonstrated both by direct radioligand binding assays and inhibition studies that phosphacan binding is retained in all deletion variants except those lac 9182584 Human
phosphacan c6 glioma C6 glioma cells, which express phosphacan, adhered to dishes coated with Ng-CAM, and low concentrations of phosphacan inhibited adhesion to Ng-CAM but not to laminin and fibronectin. 7528221 Rat
phosphacan c6 glioma In studies of cell adhesion to proteins adsorbed to Petri dishes, phosphacan inhibited adhesion of C6 glioma cells to tenascin whereas neurocan had no effect. 7512960 Human
phosphacan glioblastoma Indeed, the action of recombinant, short-RPTPbeta extracellular domain protein is similar to that of phosphacan as a repulsive substrate for glioblastoma cells. 15831233 Human
phosphacan glioblastomas Glioblastomas express at least three splice variants of RPTPbeta, including long and short receptor forms and a secreted chondroitin sulfate proteoglycan called phosphacan. 15831233 Human
ptprz1 glioblastoma Using a panel of glioblastoma cell lines, including low passage patient-derived cultures, we demonstrate that PTN15 promotes glioblastoma proliferation in an ALK-dependent fashion, whereas immobilized PTN18 promotes haptotactic migration of glioblastoma c 15908427 Human
ptprz1 glioblastoma These results indicate that the PTN18-PTPRZ1 and the PTN15-ALK signaling pathways represent potentially important therapeutic targets for glioblastoma invasion and growth. 15908427 Human
rptpbeta glial tumor Here, we demonstrate that the fibronectin type III domain (FNIII) of RPTPbeta binds to glial tumor-derived cell lines and primary astrocytes. 11313993 Human
rptpbeta tumor Because of their tumor-restricted and largely overlapping expression patterns in glioblastoma, both RPTPbeta splice forms are potential therapeutic targets. 15831233 Human
ptprz gastric cancer Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal 16338072 Human
rptpbeta human breast cancer We now demonstrate that RPTPbeta/zeta is expressed in each of these same 63 human breast cancers that previously were found to express ALK and in 10 additional samples of human breast cancer. 17706593 Human
rptpbeta human breast cancers We now demonstrate that RPTPbeta/zeta is expressed in each of these same 63 human breast cancers that previously were found to express ALK and in 10 additional samples of human breast cancer. 17706593 Human
rptpbeta infiltrating ductal carcinomas RPTPbeta/zeta furthermore was localized not only in its normal association with the cell membrane but also scattered in cytoplasm and in nuclei in different breast cancer cells and, in the case of infiltrating ductal carcinomas, the distribution of RPTPbe 17706593 Human
rptpbeta breast cancer RPTPbeta/zeta furthermore was localized not only in its normal association with the cell membrane but also scattered in cytoplasm and in nuclei in different breast cancer cells and, in the case of infiltrating ductal carcinomas, the distribution of RPTPbe 17706593 Human
ptprz1 carcinogenesis These results demonstrate that chronic oxidative stress can induce genomic amplification of ptprz1, activating beta-catenin pathways without the involvement of Wnt signaling for carcinogenesis. 18055543 Human
rptpbeta gliomas Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker. 18003890 Human
rptpbeta oligodendroglioma Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker. 18003890 Human
rptpbeta oligodendroglioma Furthermore, the results from the immunohistochemical analyses of rPTPbeta/zeta expression should prompt further evaluation of this protein as a novel oligodendroglioma marker. 18003890 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.