IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene WASL Ensembl ENSG00000106299 Chromosome 7 Start 123109237 End 123176352
Description Neural Wiskott-Aldrich syndrome protein (N-WASP) [Source:UniProtKB/Swiss-Prot;Acc:O00401]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12735
     Entrez Gene : 8976
     UCSC : uc003vkz.2
     GeneCards : 12735
     RefSeq : NM_003941
     CCDS : CCDS34743.1
     Uniprot : O00401
     Interpro : O00401
     OMIM : 605056
     GeneTests : WASL
     CGAP : WASL
     PMID : 9422512

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  321_at  -0.19  3.22e-1  4.27e-1  -0.45  8.48e-2  1.43e-1
 HG_U95  39875_at  -0.58  4.04e-3  1.07e-2  -1.25  1.17e-4  4.61e-4
 HG_U133A  205809_s_at  1.14  2.45e-9  8.21e-9  1.04  3.10e-7  3.70e-7
 HG_U133A  205810_s_at  0.67  1.18e-6  3.01e-6  3.39  1.28e-59  3.43e-59
 HG_U133_Plus2  205809_s_at  0.25  1.70e-1  2.41e-1  -0.31  4.69e-2  6.75e-2
 HG_U133_Plus2  205810_s_at  0.69  1.02e-4  3.22e-4  0.57  2.07e-3  3.79e-3
 HG_U133_Plus2  224813_at  -0.19  2.01e-2  3.80e-2  -0.43  1.40e-7  4.58e-7
 HG_U133_Plus2  230340_s_at  0.04  8.19e-1  8.64e-1  0.56  3.55e-3  6.26e-3
 HG_U133_Plus2  242756_at  0.23  1.65e-1  2.35e-1  0.33  2.00e-2  3.09e-2
 Agilent_HS_21.6K  8596  0.01  8.95e-1  9.42e-1  -0.05  6.04e-1  7.33e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205809_s_at  -0.70  1.86e-1  8.23e-1  0.52  6.93e-2  1.00e+0
 HG_U133A  205810_s_at  -0.16  7.21e-1  9.72e-1  0.22  4.47e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 321_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39875_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205809_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205810_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205809_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205810_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224813_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 230340_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242756_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8596    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
n-wasp cysts During tubulogenesis, endogenous N-WASP accumulated at cell extensions protruding from the walls of the cysts and at the tips of the extending tubules. 11980641 Human
n-wasp carcinoma Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells. 15084285 Human
n-wasp carcinoma To detect and image sites of N-WASP activity during cell motility and invasion in carcinoma cells, we designed an N-WASP fluorescence resonance energy transfer (FRET) biosensor that distinguishes between the active and inactive conformations and mimics th 15084285 Human
n-wasp invasive carcinoma Our data show that N-WASP is involved in lamellipodia extension, where it is activated at the leading edge, as well as in invadopodia formation of invasive carcinoma cells, where it is activated at the base. 15084285 Human
n-wasp carcinoma We show here that after EGF stimulation, N-WASP is recruited to the nucleation zone of the dynamic leading edge compartment of carcinoma cells, with maximal recruitment of N-WASP within 1 min after EGF stimulation. 15362118 Human
n-wasp breast carcinoma Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells. 15713627 Human
n-wasp metastatic human breast cancer Phosphoinositide 3-kinase (PI3K), small Rho GTPases, such as Cdc42 and Rac1, and neuronal Wiskott Aldrich syndrome protein (N-WASP) are key effectors that regulate dynamic changes in the actin cytoskeleton and cell migration. uPA- and EGF-stimulated chemo 11865026 Human
n-wasp ovarian tumor Hyaluronan-CD44 Interaction with Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Promotes Actin Polymerization and ErbB2 Activation Leading to beta-Catenin Nuclear Translocation, Transcriptional Up-regulation, and Cell Migration in Ovarian Tumor Cells. 17092940 Human
n-wasp ovarian tumor In this study we have investigated the interaction of hyaluronan (HA) and CD44 with the neuronal Wiskott-Aldrich syndrome protein (N-WASP) in regulating actin polymerization and ErbB2/beta-catenin signaling in human ovarian tumor cells (SK-OV-3.ipl cells) 17092940 Human
n-wasp ovarian tumor Biochemical and immunological analyses indicate that N-WASP is expressed in SK-OV-3.ipl cells and that the binding of HA stimulates N-WASP association with CD44 and Arp2/Arp3 leading to filamentous actin formation and ovarian tumor cell migration. 17092940 Human
n-wasp tumor cell migration Transfection of SK-OV-3.ipl cells with N-WASP-VCA (verpolin homology, cofilin homology, and acidic domain) fragment cDNA not only blocks HA/CD44-induced N-WASP-Arp2/3 complex formation but also inhibits actin polymerization/F-actin assembly and tumor cell 17092940 Human
n-wasp ovarian cancer Taken together, our findings strongly suggest that N-WASP plays a pivotal role in regulating HA-mediated CD44-ErbB2 interaction, beta-catenin signaling, and actin cytoskeleton functions that are required for tumor-specific behaviors and ovarian cancer pro 17092940 Human
neural wiskott-aldrich syndrome protein ovarian tumor Hyaluronan-CD44 Interaction with Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Promotes Actin Polymerization and ErbB2 Activation Leading to beta-Catenin Nuclear Translocation, Transcriptional Up-regulation, and Cell Migration in Ovarian Tumor Cells. 17092940 Human

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