IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SPAM1 Ensembl ENSG00000106304 Chromosome 7 Start 123352565 End 123398695
Description Hyaluronidase PH-20 Precursor (Hyal-PH20)(EC 3.2.1.35)(Hyaluronoglucosaminidase PH-20)(Sperm surface protein PH-20)(Sperm adhesion molecule 1) [Source:UniProtKB/Swiss-Prot;Acc:P38567]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11217
     Entrez Gene : 6677
     UCSC : uc003vle.2
     GeneCards : 11217
     RefSeq : NM_001174044
     CCDS : CCDS5790.1
     Uniprot : P38567
     Interpro : P38567
     OMIM : 600930
     GeneTests : SPAM1
     CGAP : SPAM1
     PMID : 8282124

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35129_at  0.09  6.24e-1  7.13e-1  0.57  5.38e-2  9.73e-2
 HG_U133A  210536_s_at  -0.54  5.37e-6  1.29e-5  -1.70  2.79e-20  4.07e-20
 HG_U133A  216972_at  -0.20  1.01e-1  1.32e-1  1.87  1.06e-34  1.89e-34
 HG_U133A  216989_at  -0.26  1.39e-4  2.84e-4  -1.70  9.55e-39  1.81e-38
 HG_U133_Plus2  210536_s_at  0.35  7.49e-2  1.20e-1  0.79  3.86e-4  7.92e-4
 HG_U133_Plus2  216972_at  0.05  8.18e-1  8.63e-1  0.04  8.60e-1  8.85e-1
 HG_U133_Plus2  216989_at  0.41  1.57e-2  3.05e-2  1.06  6.63e-9  2.56e-8
 Agilent_HS_21.6K  3529  0.03  5.35e-1  7.02e-1  0.01  9.32e-1  9.61e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210536_s_at  0.59  1.91e-1  8.25e-1  -0.15  5.05e-1  1.00e+0
 HG_U133A  216972_at  -0.29  3.86e-1  8.96e-1  0.07  7.94e-1  1.00e+0
 HG_U133A  216989_at  -0.13  7.04e-1  9.69e-1  0.01  9.49e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35129_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210536_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216972_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216989_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210536_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216972_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216989_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3529    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ph-20 tumor Hyaluronidase (PH-20) degrades HA, resulting in the disruption of basement membrane integrity and possible tumor dissemination. 11922735 Human
ph-20 metastases PH-20 was present in 12/12 (100%) normal breast tissues; 8/12 (66.7%) DCIS; 13/13 (100%) invasive breast cancers; and 8/14 (57.1%) metastases. 11922735 Human
ph-20 invasive breast cancers PH-20 was present in 12/12 (100%) normal breast tissues; 8/12 (66.7%) DCIS; 13/13 (100%) invasive breast cancers; and 8/14 (57.1%) metastases. 11922735 Human
ph-20 invasive breast cancer Of those specimens in which PH-20 was detected, there were increased levels of PH-20 in metastatic breast cancer to lymph nodes compared to DCIS and invasive breast cancer. 11922735 Human
ph-20 metastatic breast cancer Of those specimens in which PH-20 was detected, there were increased levels of PH-20 in metastatic breast cancer to lymph nodes compared to DCIS and invasive breast cancer. 11922735 Human
ph-20 cancer Stratification of specimen by race revealed that African American women had higher levels of PH-20 with invasive and metastatic beast cancer. 11922735 Human
ph-20 metastatic breast cancer CONCLUSIONS: Increased levels of PH-20 are noted in invasive and metastatic breast cancer compared to DCIS. 11922735 Human
ph-20 tumors Tumors from African American women with invasive and metastatic breast cancer demonstrated higher levels of PH-20 than Caucasians. 11922735 Human
ph-20 metastatic breast cancer Tumors from African American women with invasive and metastatic breast cancer demonstrated higher levels of PH-20 than Caucasians. 11922735 Human
ph-20 metastasis Varying levels of PH-20 in mammary tissue may contribute to early invasion and metastasis of breast cancer. 11922735 Human
ph-20 breast cancer Varying levels of PH-20 in mammary tissue may contribute to early invasion and metastasis of breast cancer. 11922735 Human
ph-20 cancer PH-20 sensitizes various cancer cells to tumor necrosis factor (TNF) cytotoxicity by upregulating proapoptotic p53 and WW domain-containing oxidoreductase (WOX1). 11960552 Human
hyal1 tumors Grade 1 tumors demonstrated 1+ (50%) to 2+ (50%) staining for HA and 1+ to 3+ staining for HYAL1 (37%, 37% and 26%, respectively). 11371930 Human
hyal1 tumors Grades 2 and 3 tumors showed 2+ to 3+ HA (94%) and HYAL1 (79%) staining. 11371930 NA
hyal1 tumor HA was expressed in tumor associated stroma and in tumor cells, whereas only tumor cells expressed HYAL1. 11371930 NA
hyal1 bladder cancer In 33 of the 34 patients (97%) with bladder cancer from whom urine and tumor tissue specimens were obtained at the same time 2+ to 3+ staining of HA and/or HYAL1 in 12 and 21, respectively, constituted a positive HA-HAase urine test (kappa = 0.945). 11371930 NA
hyal1 tumor In 33 of the 34 patients (97%) with bladder cancer from whom urine and tumor tissue specimens were obtained at the same time 2+ to 3+ staining of HA and/or HYAL1 in 12 and 21, respectively, constituted a positive HA-HAase urine test (kappa = 0.945). 11371930 NA
hyal1 tumor CONCLUSIONS: To our knowledge this is the first report of HA localization in bladder tissues and of HYAL1 in any normal or tumor tissue. 11371930 NA
hyal1 bladder cancer A close correlation of elevated HA and HYAL1 levels in tumor tissues with a positive HA-HAase urine test indicates that in patients with bladder cancer tumor associated HA and HYAL1 are secreted in urine, causing the HA-HAase test to be positive. 11371930 NA
hyal1 tumor A close correlation of elevated HA and HYAL1 levels in tumor tissues with a positive HA-HAase urine test indicates that in patients with bladder cancer tumor associated HA and HYAL1 are secreted in urine, causing the HA-HAase test to be positive. 11371930 NA
ph20 laryngeal cancer PH20: a novel tumor marker for laryngeal cancer. 10722016 Human
ph20 tumor PH20: a novel tumor marker for laryngeal cancer. 10722016 Human
ph-20 laryngeal cancer OBJECTIVE: To determine whether levels of PH-20, a hyaluronidase similar to that found in human sperm, are elevated in laryngeal cancer tissue. 10722016 Human
ph-20 laryngeal cancer CONCLUSIONS: We report the first data on PH-20 expression in laryngeal cancer tissue. 10722016 Human
ph20 tumor The mRNA levels of hyal-1, hyal-2, LUCA3 and PH20, the 4 hyaluronidases with demonstrated endoglucosaminidase activity, were extensively profiled in normal and tumor tissues and cell lines, using dot blot analysis and quantitative PCR. 11802201 Human
ph20 tumor In ex vivo xenograft tumor cell lines, however, hyal-1 or hyal-2 mRNA levels were frequently elevated, whereas LUCA3 was only infrequently elevated and PH20 not at all. 11802201 Human
hyal1 prostate cancer Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer. 12750291 Human
hyal-1 prostate cancer Comparison of the prognostic potential of hyaluronic acid, hyaluronidase (HYAL-1), CD44v6 and microvessel density for prostate cancer. 15305383 Human
hyal1 bph Immunohistochemistry showed minimal HA and HYAL1 staining in NAP and BPH tissues. 11278412 Human
hyal1 bladder tumor The staining intensity of HA and HYAL1 increased in 71 bladder tumor specimens on chi-square analysis (p <0.001). 11371930 NA
hyal1 bladder tumor In bladder tumor tissues HYAL1 expression was confirmed by immunoblot analysis. 11371930 NA
hyal1 bladder tumor HYAL1 Hyaluronidase: A Molecular Determinant of Bladder Tumor Growth and Invasion. 15781637 Human
hyal1 tumors HYAL1-S and vector tumors expressed significantly higher amounts of HYAL1 (in tumor cells) and hyaluronic acid (in tumor-associated stroma) than HYAL1-AS tumors. 15781637 Human
hyal1 tumor HYAL1-S and vector tumors expressed significantly higher amounts of HYAL1 (in tumor cells) and hyaluronic acid (in tumor-associated stroma) than HYAL1-AS tumors. 15781637 Human
hyal1 tumor These results show that HYAL1 expression in bladder cancer cells regulates tumor growth and progression and therefore serves as a marker for high-grade bladder cancer. 15781637 Human
hyal1 bladder cancer These results show that HYAL1 expression in bladder cancer cells regulates tumor growth and progression and therefore serves as a marker for high-grade bladder cancer. 15781637 Human
hyal1 high-grade bladder cancer These results show that HYAL1 expression in bladder cancer cells regulates tumor growth and progression and therefore serves as a marker for high-grade bladder cancer. 15781637 Human
hyal1 prostate cancer HYAL1 Hyaluronidase in Prostate Cancer: A Tumor Promoter and Suppressor. 16140946 Human
hyal1 tumor HYAL1 Hyaluronidase in Prostate Cancer: A Tumor Promoter and Suppressor. 16140946 Human
hyal1 prostate cancer HYAL1 type hyaluronidase is an independent prognostic indicator of prostate cancer progression and a biomarker for bladder cancer. 16140946 Human
hyal1 bladder cancer HYAL1 type hyaluronidase is an independent prognostic indicator of prostate cancer progression and a biomarker for bladder cancer. 16140946 Human
hyal1 tumor However, it is controversial whether hyaluronidase (e.g., HYAL1) functions as a tumor promoter or as a suppressor. 16140946 Human
hyal1 prostate cancer Both blocking HYAL1 expression and high HYAL1 production resulted in a 4- to 5-fold decrease in prostate cancer cell proliferation. 16140946 Human
hyal1 tumors Blocking HYAL1 expression inhibited tumor growth by 4- to 7-fold, whereas high HYAL1 producing transfectants either did not form tumors (DU145) or grew 3.5-fold slower (PC-3 ML). 16140946 Human
hyal1 tumor Blocking HYAL1 expression inhibited tumor growth by 4- to 7-fold, whereas high HYAL1 producing transfectants either did not form tumors (DU145) or grew 3.5-fold slower (PC-3 ML). 16140946 Human
hyal1 tumors Whereas vector and moderate HYAL1 producers generated muscle and blood vessel infiltrating tumors, HYAL1-AS tumors were benign and contained smaller capillaries. 16140946 Human
hyal1 tumor Specimens of high HYAL1 producers were 99% free of tumor cells. 16140946 Human
hyal1 tumor This study shows that, depending on the concentration, HYAL1 functions as a tumor promoter and as a suppressor and provides a basis for anti-hyaluronidase and high-hyaluronidase treatments for cancer. 16140946 Human
hyal1 cancer This study shows that, depending on the concentration, HYAL1 functions as a tumor promoter and as a suppressor and provides a basis for anti-hyaluronidase and high-hyaluronidase treatments for cancer. 16140946 Human
hyal1 bladder tumor HYAL1 Hyaluronidase: A Molecular Determinant of Bladder Tumor Growth and Invasion. 16145484 Human
hyal 1 endometrial carcinomas Real-time RT-PCR was used to determine the mRNA expression of Hyal 1, Hyal 2 (n = 13) and Hyal 3 (n = 11) in endometrial carcinomas. 15936804 Human
hyal 1 other cancers Expression of Hyal 3 and Hyal 2 mRNA were >1000-fold and >30-fold greater respectively than that of Hyal 1 mRNA, the major Hyal expressed in other cancers. 15936804 Human
hyal 3 endometrial carcinomas Real-time RT-PCR was used to determine the mRNA expression of Hyal 1, Hyal 2 (n = 13) and Hyal 3 (n = 11) in endometrial carcinomas. 15936804 Human
hyal 3 other cancers Expression of Hyal 3 and Hyal 2 mRNA were >1000-fold and >30-fold greater respectively than that of Hyal 1 mRNA, the major Hyal expressed in other cancers. 15936804 Human
hyal 3 endometrial cancer CONCLUSION: This is the first study to demonstrate the cellular localization of HA and its synthases and that Hyal 3 mRNA is predominant in endometrial cancer. 15936804 Human
ph-20 dcis PH-20 was present in 12/12 (100%) normal breast tissues; 8/12 (66.7%) DCIS; 13/13 (100%) invasive breast cancers; and 8/14 (57.1%) metastases. 11922735 Human
ph-20 dcis Of those specimens in which PH-20 was detected, there were increased levels of PH-20 in metastatic breast cancer to lymph nodes compared to DCIS and invasive breast cancer. 11922735 Human
ph-20 dcis CONCLUSIONS: Increased levels of PH-20 are noted in invasive and metastatic breast cancer compared to DCIS. 11922735 Human
ph20 human breast cancer METHODS: Full-length cDNA of human PH20 was transfected into human breast cancer cell line MDA231. 11953163 Human
ph20 metastatic breast cancer [Expression of PH20 in primary and metastatic breast cancer and its pathological significance] OBJECTIVE: To evaluate the expression pattern of PH20 in primary and metastatic breast cancer and its relationship to tumor metastatic potential. 15363315 Human
ph20 breast cancer It is possible that PH20 may play an important role in the invasive growth and metastasis of breast cancer cells, via mechanisms such as digestion of surrounding stromal tissue and release of FGF-2. 15363315 Human
ph20 human breast cancer [Promotion of growth of human breast cancer cells MDA231 by human sperm membrane-bound hyaluronidase: an experimental study] OBJECTIVE: To study the mechanism how human sperm membrane-bound hyaluronidase (PH20) promotes the gowth of human breast cancer. 11953163 Human
ph20 human breast cancer The same amount of empty vector pcDNA3, instead of PH20, was transfected into human breast cancer cell line MDA231 as control group. 11953163 Human
ph20 human breast cancer CONCLUSION: PH20 may promote the growth of human breast cancer by accelerating the release of FGF-2 from tumor cells, decomposing HA into small fragments, and promoting angiogenesis. 11953163 Human
ph20 tumor CONCLUSION: PH20 may promote the growth of human breast cancer by accelerating the release of FGF-2 from tumor cells, decomposing HA into small fragments, and promoting angiogenesis. 11953163 Human
ph20 tumor [Expression of PH20 in primary and metastatic breast cancer and its pathological significance] OBJECTIVE: To evaluate the expression pattern of PH20 in primary and metastatic breast cancer and its relationship to tumor metastatic potential. 15363315 Human
ph20 breast cancer Western blot was used to detect PH20 expression in 5 cases of breast cancer with available fresh tissue. 15363315 Human
ph20 breast cancer RESULTS: Normal breast tissue did not express PH20 (0/3), while 58.4% (31/53) of breast cancer cases did. 15363315 Human
ph20 breast cancer In-situ hybridization showed PH20 RNA in 75% of the breast cancer tissue (21/28). 15363315 Human
ph20 breast cancer CONCLUSIONS: The expression of PH20 has a positive correlation with metastatic potential in breast cancer. 15363315 Human
ph20 metastasis It is possible that PH20 may play an important role in the invasive growth and metastasis of breast cancer cells, via mechanisms such as digestion of surrounding stromal tissue and release of FGF-2. 15363315 Human
hyal3 sclc In a panel of SCLC and glioma cell lines the expression of HYAL1, HYAL2 and HYAL3 mRNA was examined. 12684632 Human
ph-20 laryngeal cancer RESULTS: Expression of PH-20 was significantly higher in nonirradiated laryngeal cancer specimens than in normal laryngeal tissue (P<.01). 10722016 Human
ph-20 laryngeal cancer Irradiated laryngeal cancer specimens had PH-20 levels comparable to normal. 10722016 Human
ph-20 laryngeal cancer PH-20 may be a useful tumor marker and prognostic tool for laryngeal cancer. 10722016 Human
ph-20 tumor PH-20 may be a useful tumor marker and prognostic tool for laryngeal cancer. 10722016 Human
hyal1 bladder cancer Reverse transcription-polymerase chain reaction, cloning, and sequence analyses revealed the expression of an HYAL1 transcript in bladder cancer lines. 10485499 Human
hyal1 small cell lung cancer Four genes showed loss-of-expression or reduced mRNA levels in non-small cell lung cancer (CACNA2D2/alpha2delta-2, SEMA3B [formerly SEMA(V), BLU, and HYAL1] or small cell lung cancer (SEMA3B, BLU, and HYAL1) cell lines. 11085536 Human
hyal1 sclc In a panel of SCLC and glioma cell lines the expression of HYAL1, HYAL2 and HYAL3 mRNA was examined. 12684632 Human
hyal1 tumor In CaP specimens, HYAL1 was exclusively expressed in tumor cells. 12750291 Human
hyal1 human breast cancer [Effect of silencing of hyaluronidase gene HYAL1 by RNA interference on proliferation of human breast cancer cells] BACKGROUND & OBJECTIVE: It is reported that hyaluronidase is related to malignant potentiality of human breast cancer. 16831275 Human
hyal1 human breast cancer This study was to investigate whether HYAL1 RNA interference (RNAi) could effectively inhibit gene mRNA expression as well as cell proliferation in human breast cancer cells. 16831275 Human
hyal1 human breast cancer METHODS: Chemically synthesized double stranded RNA (dsRNA) targeting HYAL1 was transfected into human breast cancer cell lines MDA-MB-231, MDA-MB-453S, ZR-75 and ZR-75-30 using SiPORT lipid. 16831275 Human
ph-20 primary laryngeal cancer Metastatic lymph nodes also had higher levels of PH-20 expression than did primary laryngeal cancer tissue (P = .11) and normal laryngeal tissue (P<.01). 10722016 Human
ph-20 primary laryngeal cancer PH-20 expression is significantly elevated in primary laryngeal cancer tissue and seems to be even higher in metastatic lesions compared with normal laryngeal tissue. 10722016 Human
ph-20 cancer The analysis of mRNA indicated an aberrant expression of PH-20, the testicular-type hyaluronidase, at late stages of cancer and an overexpression of HYAL1 only at stage IV. 16713680 Human
hyal1 cancer The analysis of mRNA indicated an aberrant expression of PH-20, the testicular-type hyaluronidase, at late stages of cancer and an overexpression of HYAL1 only at stage IV. 16713680 Human
hyal1 prostate tumors Combined detection of HA and the HA processing hyaluronidase enzyme Hyal1 in prostate tumors correlates with poor outcome. 16816377 Human
hyal1 prostate tumor We investigated the respective roles of HAS2 and Hyal1 using 22Rv1 human prostate tumor cells that lack both enzyme activities. 16816377 Human
hyal1 prostate cancer Coexpression of Hyal1 with HAS2 diminished HA retention but restored growth kinetics, supporting a possible combined role for excess HA synthesis and processing in maximizing unrestricted growth of prostate cancer cells. 16816377 Human
ph-20 granuloma PH-20-induced EAO differed from EAO induced by crude testis antigens in two respects: 1) an absence of epididymitis with abscess and granuloma and 2) the presence of antibody on germ cells within seminiferous tubules and inside the cauda epididymidis. 9160711 others
ph20 tumor The transfectant MDA231-PH20 was then implanted into the chorio-allantoic membrane (CAM) of chicken embryo to form a tumor. 11953163 Human
ph20 tumor RESULTS: The average weight of tumor four days after implantation was 44.7 mg +/- 10.2 mg in the MDA231-PH20 group, and was 21.3 mg +/- 2.8 mg in the control group (t = 2.418, P = 0.038). 11953163 Human
ph20 tumor Neogenetic vessels increased remarkably in MDA231-PH20 tumor tissues. 11953163 Human

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