IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene POT1 Ensembl ENSG00000128513 Chromosome 7 Start 124249677 End 124357273
Description Protection of telomeres protein 1 (hPot1)(POT1-like telomere end-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9NUX5]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17284
     Entrez Gene : 25913
     UCSC : uc003vlm.2
     GeneCards : 17284
     RefSeq : NM_001042594
     CCDS : CCDS5793.1
     Uniprot : Q9NUX5
     Interpro : Q9NUX5
     OMIM : 606478
     GeneTests : POT1
     CGAP : POT1
     PMID : 11349150

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39653_at  -0.02  9.41e-1  9.57e-1  -0.02  9.50e-1  9.66e-1
 HG_U133A  204353_s_at  0.27  6.00e-5  1.28e-4  -2.93  5.58e-39  1.06e-38
 HG_U133A  204354_at  0.24  1.11e-3  2.01e-3  0.42  3.51e-4  3.95e-4
 HG_U133_Plus2  204353_s_at  0.15  2.04e-1  2.81e-1  0.23  4.04e-2  5.88e-2
 HG_U133_Plus2  204354_at  0.35  5.07e-5  1.70e-4  0.27  1.04e-3  2.00e-3
 Agilent_HS_21.6K  14040  0.09  7.17e-3  3.56e-2  0.10  1.85e-3  9.03e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204353_s_at  0.07  7.68e-1  9.76e-1  -0.03  8.29e-1  1.00e+0
 HG_U133A  204354_at  -0.20  4.97e-1  9.27e-1  0.10  6.97e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39653_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204353_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204354_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204353_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204354_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14040    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pot1 tumor Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. 14744765 Human
pot1 gastric carcinoma Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. 14744765 Human
pot1 cancers No study has been performed regarding Pot1 expression status in human cancers. 14744765 Human
pot1 gastric cancer (gc) Thus, we examined POT1 mRNA expression in 51 gastric cancer (GC) tissues and evaluated telomere length and 3' telomeric overhang signals in 20 of the 51 GC tissues. 14744765 Human
pot1 tumors Quantitative reverse transcription-PCR analysis showed that POT1 expression levels in the tumor relative to those in nonneoplastic mucosa (T/N ratio) were significantly higher in stage III/IV tumors than in stage I/II tumors (P = 0.005). 14744765 Human
pot1 tumor Quantitative reverse transcription-PCR analysis showed that POT1 expression levels in the tumor relative to those in nonneoplastic mucosa (T/N ratio) were significantly higher in stage III/IV tumors than in stage I/II tumors (P = 0.005). 14744765 Human

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