IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene INHBA Ensembl ENSG00000122641 Chromosome 7 Start 41695126 End 41709231
Description Inhibin beta A chain Precursor (Activin beta-A chain)(Erythroid differentiation protein)(EDF) [Source:UniProtKB/Swiss-Prot;Acc:P08476]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6066
     Entrez Gene : 3624
     UCSC : uc003thr.2
     GeneCards : 6066
     RefSeq : NM_002192
     CCDS : CCDS5464.1
     Uniprot : P08476
     Interpro : P08476
     OMIM : 147290
     GeneTests : INHBA
     CGAP : INHBA
     PMID : 3345731

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
5 2.66 188 5 2.66 188 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16951 AD c.1160_1161insA p.K388fs*18 Insertion - Frameshift Heterozygous 7:41695893-4169589418948947
17055 AD c.603G>T p.R201S Substitution - Missense Heterozygous 7:41696451-4169645118948947
17210 AD c.451G>T p.E151* Substitution - Nonsense Heterozygous 7:41696603-4169660318948947
17218 AD c.694G>T p.D232Y Substitution - Missense Heterozygous 7:41696360-4169636018948947
17262 AD c.65C>A p.P22H Substitution - Missense Heterozygous 7:41706433-4170643318948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1203_at  0.98  3.83e-6  2.18e-5  1.11  2.13e-3  5.99e-3
 HG_U95  40357_at  0.25  1.58e-1  2.41e-1  0.50  3.48e-2  6.76e-2
 HG_U133A  204926_at  -0.02  8.77e-1  8.96e-1  5.68  2.16e-124  2.98e-123
 HG_U133A  210511_s_at  -0.34  2.42e-2  3.56e-2  -0.01  9.54e-1  9.56e-1
 HG_U133_Plus2  204926_at  -0.42  1.86e-2  3.54e-2  -0.35  1.13e-1  1.50e-1
 HG_U133_Plus2  210511_s_at  -0.44  1.98e-2  3.75e-2  -0.26  2.53e-1  3.09e-1
 Stanford  3186  -0.94  4.16e-2  1.39e-1  -1.32  2.82e-2  1.16e-1
 Agilent_HS_21.6K  2193  -0.08  5.59e-1  7.22e-1  -0.07  6.31e-1  7.53e-1
 Agilent_HS_21.6K  14979  -0.27  5.02e-2  1.46e-1  -0.22  8.42e-2  1.83e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204926_at  -0.82  1.20e-1  7.89e-1  0.22  3.88e-1  1.00e+0
 HG_U133A  210511_s_at  -0.50  4.14e-1  9.07e-1  -0.22  5.96e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1203_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40357_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204926_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210511_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204926_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210511_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3186    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2193    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14979    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
edf acute monocytic leukemia Furthermore, cells which were resistant to methotrexate (MTX : 0.5 microM) secreted r-EDF up to 1 microgram/ml. r-EDF was identical to natural EDF (n-EDF) produced by human acute monocytic leukemia cell line, THP-1, as regards its dimeric structure and a 3348775 Human
edf human leukemia Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1. 3470005 Human
frp breast cancer To explore the role of Frp and its relationship to the Wnt-signalling pathway in breast cancer, in situ hybridization and immunohistochemical analyses of Frp, Wnt-1, APC, beta-catenin, and its target genes c-myc and cyclin D1 were conducted in 70 specimen 11793365 Human
frp invasive ductal carcinomas To explore the role of Frp and its relationship to the Wnt-signalling pathway in breast cancer, in situ hybridization and immunohistochemical analyses of Frp, Wnt-1, APC, beta-catenin, and its target genes c-myc and cyclin D1 were conducted in 70 specimen 11793365 Human
frp tumors METHODS: Forty patients (21 men and 19 women; mean age, 36.5 yr) with cortical lesions (12 arteriovenous malformations and 28 tumors) in the vicinity of the sensorimotor cortex were classified into high-, medium-, or low-risk categories by using the MEG-d 9149251 Human
frp arteriovenous malformations METHODS: Forty patients (21 men and 19 women; mean age, 36.5 yr) with cortical lesions (12 arteriovenous malformations and 28 tumors) in the vicinity of the sensorimotor cortex were classified into high-, medium-, or low-risk categories by using the MEG-d 9149251 Human
edf mouse erythroleukemia (mel) To further characterize activin A/erythroid differentiation factor (EDF) action on hematopoietic cell differentiation, we examined the effects of activin A/EDF on megakaryocytic and erythroid differentiation by determining acetylcholinesterase (AchE) acti 7875239 Human
edf rhabdomyosarcoma Glycosaminoglycans of cultured nickel-induced rat rhabdomyosarcoma cell lines with different metastatic potentials, grown in the presence or in the absence of hydrocortisone and of growth factor (EDF and EDGF) were investigated comparatively. 3878251 Human
edf friend murine erythroleukemia We examined an early action of erythroid differentiation factor (EDF), a polypeptide which induces differentiation of Friend murine erythroleukemia (MEL) cells. 3038104 Human
frp leukaemia A factor from conditioned medium of a leukaemia cell line has been isolated which can induce mouse Friend cells to become benzidine-positive, and which shares a similar N-terminal sequence with porcine FRP. 3696240 Human
edf tumor EDF increased the capacity of human blood eosinophils, but not neutrophils, to kill antibody-coated tumor cells and to phagocytose serum-opsonized yeast cells. 3486243 Human
edf acute myeloid leukemia Upon treatment with the phorbol ester, tetradecanoylphorbol 13-acetate (PMA), peripheral mononuclear blood cells from patients with acute myeloid leukemia secrete into serum-free cell-conditioned media (PMA-CCM) at least three distinct nondialysable &apos 1702323 Human
edf mouse erythroleukemia EDF was identified by its ability to stimulate erythroid differentiation in mouse erythroleukemia cell lines, its identical retention times to those of authentic EDF on three successive reverse-phase HPLC columns and characterization of its penultimate N- 1702323 Mouse
edf murine erythroleukemia Erythroid differentiation factor (EDF), which is structurally related to transforming growth factor-beta family and induces differentiation of murine erythroleukemia cell clone F5-5, has been labeled with 125I to characterize its interaction with cellular 2542329 Human
edf leukemia Identification of the two types of specific receptor for activin/EDF expressed on Friend leukemia and embryonal carcinoma cells. 2545199 Human
edf embryonal carcinoma Identification of the two types of specific receptor for activin/EDF expressed on Friend leukemia and embryonal carcinoma cells. 2545199 Human
edf murine erythroleukemia Media conditioned by phorbol myristate acetate (PMA)-stimulated murine bone marrow stromal cell lines, MC3T3-G2/PA6 and ST2, contained activin A/EDF, assayed as the activity inducing erythroid differentiation of an activin A/EDF-responsive murine erythrol 1730078 Human
edf murine erythroleukemia Activin A/erythroid differentiation factor (EDF) is a human protein that induces differentiation of a murine erythroleukemia cell (the Friend cell). 1542647 Human
edf murine friend erythroleukemia Activin A/EDF, initially found as a differentiation inducer of murine Friend erythroleukemia, also has a stimulatory effect on erythropoiesis in vitro and in vivo. 1543498 Mouse
edf erythroleukemia Activin A/erythroid differentiation factor (EDF), a dimeric polypeptide hormone composed of two beta A subunits, regulates growth and erythroid differentiation of human hematopoietic progenitor and erythroleukemia cells. 1402687 Human
edf murine erythroleukemia Activin A, a protein homologous to transforming growth factor beta, was shown to induce hemoglobin synthesis in murine erythroleukemia (MEL) cells and was also termed erythroid differentiation factor (EDF) (Eto, Y., Tsuji, T., Takezawa, M., Takano, S., Yo 1995639 Mouse
edf human leukemia Thus combinations of VD3 and TGF-beta (TGF-beta 1, -beta 2, or EDF) acted synergistically in inhibiting cell proliferation and inducing monocytic differentiation of human leukemia cells. 2018352 Human
edf leukemia These results suggest that inducers of monocytic differentiation may switch off cellular regulatory mechanisms for induction by TGF-beta and EDF of erythroid differentiation of leukemia cells. 1895752 Human
edf tumor Daily intra-tumor treatment with EDF for 10 days resulted in 73% suppression of tumor growth on day 25. 2323849 Human
edf erythroleukemia These results indicate the possibility of differentiation therapy for erythroleukemia using EDF. 2323849 Human
frp granulosa-cell tumors The levels of FRP in the serum of women with granulosa cell tumors, normal, menstruating women, and postmenopausal women were determined. 1693585 Human
edf solid tumor The anti-tumor activity of EDF was also examined in a nude mouse MEL solid tumor model. 2323849 Human
edf solid tumor A histological study revealed that EDF-treated solid tumor cells became hemoglobin-positive, indicating the anti-tumor activity of EDF through induction of differentiation in vivo. 2323849 Human
inhibin beta a adenomas Messenger RNAs for inhibin beta A were demonstrated in all of the pituitary tissues studied, namely in 3 GH, 2 ACTH, 6 PRL and 1 FSH producing adenomas and 17 non-functioning adenomas. 7599706 Human
inhibin beta a non-functioning adenomas Messenger RNAs for inhibin beta A were demonstrated in all of the pituitary tissues studied, namely in 3 GH, 2 ACTH, 6 PRL and 1 FSH producing adenomas and 17 non-functioning adenomas. 7599706 Human
inhibin beta a pituitary adenomas The results showed an abundance of beta A subunit mRNA compared with alpha subunit mRNA in all human pituitary adenomas and a local role for activin in its own production through inhibin beta A mRNA subunit expression. 8886632 Human
edf murine erythroleukemia [Function, molecular structure and gene expression regulation of erythroid differentiation factor (EDF/activin A)] Erythroid differentiation factor (EDF), initially found as a differentiation inducer of murine erythroleukemia cells, also acts on normal er 1331567 Mouse
edf erythroleukemia These results indicate the possibility of differentiation therapy for erythroleukemia using EDF. 2323849 Mouse
inhba cancer In this paper, we briefly introduced the cloning, structure, localization, polymorphism, expression, molecular regulation of inhibin-alpha(INHA), -betaA (INHBA) and -beta B (INHBB) subunit genes and their relationships with reproductive performance and ca 15640097 Human
edf erythroleukemia Activin A/erythroid differentiation factor (EDF), a dimeric polypeptide hormone composed of two beta A subunits, regulates growth and erythroid differentiation of human hematopoietic progenitor and erythroleukemia cells. 1402687 Human
inhba neoplasia The majority of the cooperative targets display increased expression in tumors derived from either Min (many intestinal neoplasia) or mouse mammary tumor virus (MMTV)-Wnt1 mice, two models of Wnt-induced tumors, with nine of these genes (Ankrd1, Ccnd1, Ct 17210685 Mouse
inhba tumors The majority of the cooperative targets display increased expression in tumors derived from either Min (many intestinal neoplasia) or mouse mammary tumor virus (MMTV)-Wnt1 mice, two models of Wnt-induced tumors, with nine of these genes (Ankrd1, Ccnd1, Ct 17210685 Mouse
inhba mammary tumor Reduction of TGF-beta signaling by expression of a dominant-negative TGF-beta type II receptor in bigenic MMTV-Wnt1/DNIIR mice increased mammary tumor latency and was correlated with a decrease in expression of Gpc1, Inhba, and Robo1, three of the TGF-bet 17210685 Mouse
inhba tumor When a representative predictor set of 92 genes was examined, pathways of 'focal adhesion' (with gene components of THBS2, PDGFD, MAPK1, COL1A2, COL6A3), 'ECM-receptor interaction' pathway (THBS2, COL1A2, COL6A3, FN1) and 'TGF-bet 17601708 Human
inhba gastric cancer When a representative predictor set of 92 genes was examined, pathways of 'focal adhesion' (with gene components of THBS2, PDGFD, MAPK1, COL1A2, COL6A3), 'ECM-receptor interaction' pathway (THBS2, COL1A2, COL6A3, FN1) and 'TGF-bet 17601708 Human
inhba oncogene ANLN and INHBA showed a strong positive correlation between mRNA expression and genomic DNA levels and a similar relationship was shown for the known oncogene, EGFR, at 7p11.2. 17982635 Human
inhba tumors In clinical samples, ANLN and INHBA showed a significantly higher expression in tumors than in normal tissues. 17982635 Human
inhba hnscc Therefore, INHBA may be a promising prognostic marker of HNSCC. 17982635 Human
edf mouse erythroleukemia To further characterize activin A/erythroid differentiation factor (EDF) action on hematopoietic cell differentiation, we examined the effects of activin A/EDF on megakaryocytic and erythroid differentiation by determining acetylcholinesterase (AchE) acti 7875239 Mouse

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