IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RAMP3 Ensembl ENSG00000122679 Chromosome 7 Start 45163892 End 45190372
Description Receptor activity-modifying protein 3 Precursor (Calcitonin-receptor-like receptor activity-modifying protein 3)(CRLR activity-modifying protein 3) [Source:UniProtKB/Swiss-Prot;Acc:O60896]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 9845
     Entrez Gene : 10268
     UCSC : uc003tnb.2
     GeneCards : 9845
     RefSeq : NM_005856
     CCDS : CCDS5503.1
     Uniprot : O60896
     Interpro : O60896
     OMIM : 605155
     GeneTests : RAMP3
     CGAP : RAMP3

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35152_at  -1.65  7.21e-46  2.28e-42  -1.82  1.07e-16  4.88e-15
 HG_U133A  205326_at  -2.32  8.14e-107  6.04e-104  -3.81  1.02e-83  4.53e-83
 HG_U133_Plus2  205326_at  -2.51  5.47e-46  2.30e-43  -2.17  7.66e-24  1.66e-22
 Agilent_HS_21.6K  18332  -0.38  1.00e-15  2.23e-13  -0.38  2.97e-17  1.42e-14

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205326_at  0.38  1.64e-1  8.15e-1  -0.25  1.11e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35152_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205326_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205326_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18332    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ramp3 glioblastoma In the present study we also demonstrate the presence of mRNA encoding the putative AM receptors, calcitonin receptor-like receptor/receptor activity-modifying protein-2 and -3 (CRLR/RAMP2; CRLR/RAMP3) in both glioma tissues and glioblastoma cell lines an 11943713 Human
ramp3 glioma In the present study we also demonstrate the presence of mRNA encoding the putative AM receptors, calcitonin receptor-like receptor/receptor activity-modifying protein-2 and -3 (CRLR/RAMP2; CRLR/RAMP3) in both glioma tissues and glioblastoma cell lines an 11943713 Human
ramp3 prostate hyperplasias Conventional reverse transcription (RT)-polymerase chain reaction (PCR) demonstrated the expression of pAM, PAM, CRLR and RAMP(1-3) mRNAs in both prostate hyperplasias (PH) and carcinomas (PC), and semiquantitative PCR showed that pAM, PAM and RAMP3 mRNA 15547717 Human
ramp3 carcinomas Conventional reverse transcription (RT)-polymerase chain reaction (PCR) demonstrated the expression of pAM, PAM, CRLR and RAMP(1-3) mRNAs in both prostate hyperplasias (PH) and carcinomas (PC), and semiquantitative PCR showed that pAM, PAM and RAMP3 mRNA 15547717 Human
ramp3 tumor Taken together, our findings allow us to suggest that: i) endogenous AM system plays an important autocrine-paracrine growth promoting action in the human prostate, being possibly involved in the development of the malignant phenotype of epithelial cells; 15547717 Human
ramp3 glioma Our studies show RAMP3 down regulation on staurosporine treatment of astrocytes, suggesting protein kinase C inhibition as a possible strategy for inhibiting AM activity and thereby growth of glioma cells. 16376586 Human

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