IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IGFBP1 Ensembl ENSG00000146678 Chromosome 7 Start 45894484 End 45899791
Description Insulin-like growth factor-binding protein 1 Precursor (IGF-binding protein 1)(IGFBP-1)(IBP-1)(Placental protein 12)(PP12) [Source:UniProtKB/Swiss-Prot;Acc:P08833]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5469
     Entrez Gene : 3484
     UCSC : uc003tnp.2
     GeneCards : 5469
     RefSeq : NM_000596
     CCDS : CCDS5504.1
     Uniprot : P08833
     Interpro : P08833
     OMIM : 146730
     GeneTests : IGFBP1
     CGAP : IGFBP1
     PMID : 2461294

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1232_s_at  0.10  5.54e-1  6.53e-1  -0.09  5.96e-1  6.88e-1
 HG_U133A  205302_at  0.47  1.47e-2  2.24e-2  2.59  1.50e-46  3.23e-46
 HG_U133_Plus2  205302_at  0.41  1.62e-1  2.31e-1  -0.32  2.24e-1  2.77e-1
 HG_U133_Plus2  237989_at  0.12  5.16e-1  6.02e-1  0.26  1.95e-1  2.45e-1
 Stanford  7869  -0.81  3.22e-1  5.24e-1  0.29  6.53e-1  8.20e-1
 Stanford  16638  -1.97  3.96e-3  3.53e-2  -1.25  9.30e-2  2.60e-1
 Agilent_HS_21.6K  9910  0.11  4.33e-2  1.31e-1  0.08  2.65e-2  7.64e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205302_at  0.08  9.05e-1  9.94e-1  0.62  4.89e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1232_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205302_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205302_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 237989_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7869    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16638    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9910    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
igfbp-1 hepatocellular carcinoma We studied insulin, proinsulin and IGFBP-1 in normal subjects (NL, N=47, 43+/-12 yr), cirrhosis (CIR, N=29, 54+/-14 yr), hepatocellular carcinoma (HCC, N=42, 61+/-11 yr), and other liver tumors (TUM, N=8, 60+/-17 yr). 14624764 Human
igfbp-1 liver tumors We studied insulin, proinsulin and IGFBP-1 in normal subjects (NL, N=47, 43+/-12 yr), cirrhosis (CIR, N=29, 54+/-14 yr), hepatocellular carcinoma (HCC, N=42, 61+/-11 yr), and other liver tumors (TUM, N=8, 60+/-17 yr). 14624764 Human
igfbp-1 breast cancer We examined whether the concentrations of estrone, E2, IGF-I, IGF-II, and IGF-binding protein-1 (IGFBP-1), -2, and -3 in umbilical cord blood plasma differed in female neonates of three racial/ethnic groups with contrasting breast cancer risk. 11836326 Human
igfbp-1 cancers These effects include reduced synthesis of IGF-I and apolipoprotein(a), and increased synthesis of IGFBP-1--shifts which arguably could decrease risk for vascular disease and certain cancers. 12944101 Human
igfbp-1 postmenopausal advanced breast cancer We evaluated total IGF-1, IGF-2, IGF binding protein (IGFBP)-1 and IGFBP-3 in the blood of 34 postmenopausal advanced breast cancer patients (median age 63 years, range 41-85) treated with anastrozole, a non-steroidal structure aromatase inhibitor (NSS-AI 11983488 Human
igfbp-1 breast cancer In a subcohort where blood samples had been collected after at least four hours of fasting, breast cancer risk showed no clear associations with levels of insulin, IGFBP-1, or IGFBP-2. 12074500 Human
insulin-like growth factor binding protein-1 polycythemia vera Another potential candidate for such a rheologic effect of the GH-IGF axis is insulin-like growth factor binding protein-1 (IGF-BP1) which is increased in trained people and correlated to fitness: IGF-BP1 is elevated in patients with polycythemia vera and 12082253 Human
igfbp-1 cancer Circulating IGF binding protein (IGFBP)-1 levels have been associated with insulin sensitivity, the metabolic syndrome, several cardiovascular risk factors, and possibly with cancer. 15070959 Human
igfbp-1 breast cancer Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility. 12154042 Human
insulin-like growth factor binding protein-1 breast cancer Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility. 12154042 Human
igfbp-1 cancer Moreover, IGFBP-1 could have dual effects on cancer cell motility by disrupting both receptor systems. 12154042 Human
igfbp-1 breast cancer Serum IGFBP-1 was not associated with breast cancer risk in either pre- or postmenopausal women. 12496045 Human
igfbp-1 pancreatic cancer Pancreatic cancer tissue and serum of patients with pancreatic cancer showed significant increases in IGF-I, IGFBP-3 and IGFBP-1 content, accompanied by dramatic increases in IGF-I tissue receptor expression, compared to controls. 12641820 Human
igfbp-1 pancreatic cancer The data suggest that disturbances in tissue collagen metabolism during pancreatic diseases may result from deregulation of IGF-I homeostasis and that elevated serum levels of IGF-I, IGFBP-3 and IGFBP-1 may serve as markers of pancreatic cancer. 12641820 Human
igfbp-1 hepatoma Immunoprecipitation showed that mouse hepatoma (Hepa 1-6) cells (exposed to [32P]H3PO4) secrete 32P-labeled IGFBP-1. 11147791 Mouse
igfbp-1 benign prostatic hyperplasia Up-regulation of hepatic IGFBP-1 production as a strategy for preventing benign prostatic hyperplasia. 11133245 Human
igfbp-1 tumor LF mice had significantly lower levels of serum insulin, tumor IGF-1 mRNA expression, and tumor IGFBP-2 immunostaining and higher levels of serum IGFBP-1 (by Western ligand blot) relative to the HF mice. 12855654 Mouse
igfbp-1 tumor The labeling score of IGFBP-1 accumulation in endothelial cells correlated negatively (P: = 0.0229), and that of IGFBP-2 accumulation in glioma cells correlated positively (P: < 0.0006) with the tumor grade of the gliomas. 11250947 Human
igfbp-1 glioma The labeling score of IGFBP-1 accumulation in endothelial cells correlated negatively (P: = 0.0229), and that of IGFBP-2 accumulation in glioma cells correlated positively (P: < 0.0006) with the tumor grade of the gliomas. 11250947 Human
igfbp-1 glioma Small amounts of IGFBP-1 and -3 mRNA, but high amounts of IGFBP-2 mRNA, were detectable in macrophage-like and glioma cell lines. 11250947 Human
igfbp-1 glial tumors The results suggest cell type-specific accumulation of IGFBP-1, -2, and -3 in human glial tumors of the brain. 11250947 Human
igfbp-1 hepatoma The role of AMP-activated protein kinase (AMPK), an important signaling system in lipid and carbohydrate metabolism, in regulating IGFBP-1 was studied in H4-II-E rat hepatoma cells. 11302732 Rat
igfbp-1 lung cancer Our study does not offer evidence in support of an association between prediagnostic serum levels of IGF-I or IGFBP-1, -2 and -3 and lung cancer risk in women. 11351312 Human
igfbp-1 prostate cancer To assess whether IGF-I, IGF-II, IGFBP-1, or IGFBP-3 are also associated with prostate cancer in a low-risk population, we measured plasma levels of these factors among 128 newly diagnosed prostate cancer cases and 306 randomly selected population control 11352850 Human
igfbp-1 prostate cancer Our findings in a low-risk population provide evidence that IGF-I, IGFBP-3, and IGFBP-1 are determinants of prostate cancer and indicate that additional studies are needed to evaluate their effects on ethnic and geographic incidence differentials and to e 11352850 Human
igfbp-1 prostate cancer Similarly, IGFBP-1 was inversely associated with prostate cancer risk only among men with the ff FokI genotype (odds ratio, 0.25; 95% confidence interval, 0.07-0.85; P(trend) = 0.02). 11389055 Human
igfbp-1 tumour CONCLUSIONS: IGFBP-1 and intact IGFBP-3 expression both enhance IGF bioavailability which promotes tumour growth. 11464872 Human
igfbp-1 gastric cancer IGFBP-2 was expressed in all of the gastric cancer cell lines, whereas IGFBP-1 was not detected in any cell lines. 11677116 Human
igfbp-1 hepatoma The IGFBP-1 promoter shares common regulatory response elements with phosphoenol pyruvate carboxykinase (PEPCK), the expression and activity of which is inhibited by lithium chloride, associated with an inhibition of glycogen synthase kinase (GSK)-3 activ 11739024 Human
igfbp-1 atypical hyperplasia Significantly higher IGFBP-1 concentrations were found in the serum of patients with the atypical hyperplasia of endometrium and endometrial carcinoma. 11928553 Human
igfbp-1 endometrial carcinoma Significantly higher IGFBP-1 concentrations were found in the serum of patients with the atypical hyperplasia of endometrium and endometrial carcinoma. 11928553 Human
igfbp-1 hepatoma Cotransfection of mouse FKHR increased IGFBP-1 promoter activity 2-3-fold in H4IIE rat hepatoma cells; insulin inhibited FKHR-stimulated promoter activity approximately 70%. 10702299 Rat
igfbp-i polycystic ovary syndrome (pcos) The objective of the present study was to investigate whether metformin affected plasma concentrations of insulin-like growth factor (IGF) I and IGF-binding protein I (IGFBP-I) in polycystic ovary syndrome (PCOS) patients. 10770203 Human
igfbp-1 hepatocellular carcinoma In the present study, we employed Northern blotting techniques to document the expression of IGFBP-1, 3 and 4 in normal human livers, cirrhotic and hepatocellular carcinoma tissues. 10888233 Human
igfbp-1 human hepatoma The liver is the principal site of IGFBP-1 synthesis, and we have previously shown that proinflammatory cytokines can directly stimulate IGFBP-1 secretion in a human hepatoma cell line (HepG2). 10965886 Human
igfbp-1 tumours RESULTS: In the 37 tumour samples analysed (nine gastrinomas, 10 insulinomas, nine tumours associated with carcinoid syndrome and nine functionally inactive tumours) IGFBP-2 was found in all tumour samples while the IGFBP-1 was expressed only at low frequ 10964166 Human
igfbp-1 insulinomas RESULTS: In the 37 tumour samples analysed (nine gastrinomas, 10 insulinomas, nine tumours associated with carcinoid syndrome and nine functionally inactive tumours) IGFBP-2 was found in all tumour samples while the IGFBP-1 was expressed only at low frequ 10964166 Human
igfbp-1 carcinoid syndrome RESULTS: In the 37 tumour samples analysed (nine gastrinomas, 10 insulinomas, nine tumours associated with carcinoid syndrome and nine functionally inactive tumours) IGFBP-2 was found in all tumour samples while the IGFBP-1 was expressed only at low frequ 10964166 Human
igfbp-1 tumour RESULTS: In the 37 tumour samples analysed (nine gastrinomas, 10 insulinomas, nine tumours associated with carcinoid syndrome and nine functionally inactive tumours) IGFBP-2 was found in all tumour samples while the IGFBP-1 was expressed only at low frequ 10964166 Human
igfbp-1 prostate cancer RESULTS: Expression of the IGF system, except IGFBP-1, was detected in all prostate cancer tissue samples. 11020056 Human
igfbp-1 colorectal cancer A statistically significant decrease in colorectal cancer risk was observed for increasing levels of IGFBP-1 (P:(trend) =.02; OR in the upper quintile = 0.48 [95% CI = 0.23-1. 00]), as well as for the highest quintile of IGFBP-2 levels (P:(trend) =.06; OR 11018095 Human
igfbp-1 colorectal cancer CONCLUSIONS: Chronically high levels of circulating insulin and IGFs associated with a Western lifestyle may increase colorectal cancer risk, possibly by decreasing IGFBP-1 and increasing the bioactivity of IGF-I. 11018095 Human
igfbp-1 polycystic ovarian syndrome This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms. 11045880 Human
igfbp-1 endometrial neoplasms This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms. 11045880 Human
igfbp-1 liver cancer In summary, these studies show a striking induction by dietary n-6 PUFAs of hepatic IGFBP-1, a protein that has been implicated in liver cancer development. 11044255 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome Clomiphene citrate increases insulin-like growth factor binding protein-1 and reduces insulin-like growth factor-I without correcting insulin resistance associated with polycystic ovarian syndrome. 11056123 Human
igfbp-1 prostate cancer We measured levels of IGF-I, IGFBP-1, IGFBP-2, IGFBP-3, and insulin in plasma samples from 149 men who had a diagnosis of prostate cancer between 1 month and 10 years after blood collection and among 298 control men. 11106682 Human
igfbp-1 prostate cancer Prostate cancer risk was not associated with levels of IGFBP-1, IGFBP-2, or insulin. 11106682 Human
igfbp-1 tumour Northern blot analysis of total mRNA isolated from the tumour demonstrated high expression of the IGF-II gene and abundant 1.1 kb IGFBP-6 transcript, while the genes encoding IGFBP-3, -4 and -5 were only weakly expressed and mRNA of IGFBP-1, -2 and IGF-I 10468998 Human
igfbp-1 breast cancer In this study, we evaluated IGFBP-3 binding sites on breast cancer cell membranes by competitive binding studies with IGFBP-1 through -6 and various forms of IGFBP-3, including synthetic IGFBP-3 fragments. 10067859 NA
igfbp-1 breast cancer We sought to investigate the differences in serum IGFs, IGFBP-1, -3 and -6, and PSA between patients with surgically proven breast cancer and patients with benign breast disease. 10069662 Human
igfbp-1 breast cancer DESIGN AND METHODS: Concentrations of IGFs, IGFBP-1, -3 and -6, and PSA were determined in the sera from 57 patients with breast cancer (CA), and 46 women with benign breast disease (BBD) using immunoassays for IGFs and IGFBPs and an ultrasensitive ELISA 10069662 NA
insulin-like growth factor binding protein-1 human breast cancer Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells. 10194517 Human
igfbp-1 hepatoma Cell culture studies show that cytokines exert direct effects on the production of IGFBP-1 by HepG2 hepatoma cells, increasing IGFBP-1 levels in conditioned medium and the abundance of IGFBP-1 mRNA approximately 3-fold. 10226804 Human
insulin-like growth factor binding protein-1 human hepatoblastoma Insulin and variation in glucose levels modify the secretion rates of the growth hormone-independent insulin-like growth factor binding protein-1 in the human hepatoblastoma cell line Hep G2. 2481706 Human
igf-bp25 polycystic ovarian disease Some women with polycystic ovarian disease have a subnormal level of IGF-bp25 in serum. 2854652 Human
igfbp-1 tumors In endometrial cancers, IGFBP-1, -2, -3 and IGF-1 receptor (IGF-1R) mRNAs were detected in 8.7, 89.1, 95.6, and 91.3% of tumors, respectively, and the corresponding proteins in 54.3, 54.3, 95.6, and 91.3% of tumors, respectively. 15032278 Human
igfbp-1 endometrial cancers In endometrial cancers, IGFBP-1, -2, -3 and IGF-1 receptor (IGF-1R) mRNAs were detected in 8.7, 89.1, 95.6, and 91.3% of tumors, respectively, and the corresponding proteins in 54.3, 54.3, 95.6, and 91.3% of tumors, respectively. 15032278 Human
insulin-like growth factor binding protein-1 human hepatoma Estradiol increases the production of sex hormone-binding globulin but not insulin-like growth factor binding protein-1 in cultured human hepatoma cells. 10439005 Human
igfbp-1 hepatoma OBJECTIVE: To study the effects of E2 on insulin-like growth factor binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production with cultured human HepG2 hepatoma cells. 10439005 NA
insulin-like growth factor binding protein-1 hepatoma OBJECTIVE: To study the effects of E2 on insulin-like growth factor binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production with cultured human HepG2 hepatoma cells. 10439005 NA
igfbp-1 tumour The tumour did not express IGFBP-1 or IGFBP-2. 10985756 Human
igfbp-1 glioma By means of polymerase chain reaction (PCR), we detected mRNA transcripts for IGFBP-1 in 42%, IGFBP-2 in 65%, IGFBP-3 in 97%, IGFBP-4 in 3%, IGFBP-5 in 74%, IGFBP-6 in 94% and IGFBP-7 in 87% of the glioma cell lines. 9454896 Human
igfbp-1 hepatoma Insulin lowers IGFBP-1 mRNA levels, inhibits IGFBP-1 promoter activity, and activates PKB/Akt in HepG2 hepatoma cells through a PI3K-dependent, rapamycin-insensitive mechanism. 9497382 Human
igfbp-1 tumour We measured serum levels of free IGF-I and free IGF-II, total IGF-I, total IGF-II, big IGF-II and IGFBP-1, IGFBP-2 and IGFBP-3 in patients with NICTH before (n=14) and after surgical removal of the tumour (n=3). 9628278 Human
igfbp-1 human hepatoma Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells. 14568572 Human
igfbp-1 human hepatoma We compared the regulation of IGFBP-1 and SHBG production by insulin and insulin-like growth factors (IGF-I and IGF-II) in human hepatoma cell cultures. 14568572 Human
igfbp-1 human hepatoma We conclude that IGFBP-1 and SHBG are equally sensitive to ambient insulin concentrations in human hepatoma cell cultures, and the production of both proteins is also attenuated by the IGFs. 14568572 Human
igfbp-1 epidermoid carcinoma A human epidermoid carcinoma cell line, KB 3.1, which produces IGFBP-1 and -3 and small amounts of IGFBP-4, but no IGFBP-2, was stably transfected with an expression vector comprising IGFBP-2 complementary DNA (cDNA), whose expression was placed under the 9714057 Human
igfbp-1 tumours Concomitant with IGFBP-2 expression in these tumours, were a decrease in IGFBP-1 expression and an increase in IGFBP-3 proteolysis, both of which increase the bioavailability of the IGF-II produced by the cells. 9714057 Human
igfbp-1 hepatoma Phosphopeptide analysis of 32P-labeled, immunoprecipitated rat IGFBP-1 synthesized by H-4-II-EC3 rat hepatoma cells indicated that it is phosphorylated on two sites that were deduced to be ser107 and ser132 in the central nonconserved domain. 9721188 Human
igfbp-1 endometrial cancer We investigated for the first time in a prospective study the association of pre-diagnostic blood concentrations of C-peptide (a marker of pancreatic insulin production), IGF-I, IGFBP-1, -2 and -3 with endometrial cancer risk. 14639613 Human
igfbp-1 endometrial cancer IGFBP-1 levels were inversely related to endometrial cancer [ptrend = 0.002; OR in the upper quintile = 0.30 (0.15-0.62)], but the association was weakened and lost statistical significance after adjustment for confounders [ptrend = 0.06; OR in the upper 14639613 Human
igfbp-1 tumors IGFBP-1 mRNA levels were too low to be detected by Northern blot analysis, but could be found by RT-PCR in some tumors and hyperplastic adrenals. 9851669 Human
igfbp-1 endometrial cancer Clinical conditions that are known to increase the risk of endometrial cancer are all characterized by the absence of IGFBP-1. 10065165 Human
igfbp-1 human hepatoma Immunoaffinity chromatography was used to isolate IGFBP-1 from normal human plasma and from human hepatoma (Hep G2) cell medium as an alternative source of the IGFBP-1 phosphoform in the circulation. 9048619 Human
igfbp-1 endometrial cancer We performed a population-based case-control study in Sweden, including 288 endometrial cancer patients and 392 control women and analysed total serum IGF-I, IGFBP-1, IGFBP-3, insulin and BMI levels stratified by disease and hormone replacement therapy st 14583772 Human
igfbp-1 endometrial cancer There was an increasing risk of endometrial cancer according to the serum levels of IGFBP-1, which was observed only among women who had ever used HRT. 14583772 Human
igfbp-1 endometrial cancer Serum IGF-I, IGFBP-1, IGFBP-3 and insulin levels seem unrelated to endometrial cancer risk. 14583772 Human
igfbp-1 endometrial cancer Among users of HRT, increasing IGFBP-1 levels seem to increase endometrial cancer risk. 14583772 Human
insulin-like growth factor binding protein-1 polycythemia vera Insulin-like growth factor binding protein-1 is elevated in patients with polycythemia vera and stimulates erythroid burst formation in vitro. 9058705 Human
igfbp-1 cancer Up-regulation of IGFBP-1 production can be expected to decrease IGF activity and thereby diminish cancer risk. 9160283 Human
igfbp-1 hyperplasia Immunohistochemistry performed using a specific IGFBP-1 antibody revealed hyperplasia of distal nephron segments along with an increase in IGFBP-1 in potassium-depleted rats. 9176378 Human
insulin-like growth factor binding protein-1 endometrial cancer Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer. 9279518 Human
igfbp-1 endometrial cancer Our purpose was to compare circulating levels of IGF-I and IGFBP-1 in women with and without endometrial cancer. 9279518 Human
igfbp-1 endometrial cancer We assessed circulating levels of IGF-I and IGFBP-1 and IGFBP-3 in 23 patients with endometrial cancer, 11 patients with uterine cervical cancer and 27 healthy control women. 9279518 Human
igfbp-1 uterine cervical cancer We assessed circulating levels of IGF-I and IGFBP-1 and IGFBP-3 in 23 patients with endometrial cancer, 11 patients with uterine cervical cancer and 27 healthy control women. 9279518 Human
igfbp-1 cancer The mean circulating level of IGFBP-1 was significantly lower in postmenopausal cancer patients than in postmenopausal control subjects. 9279518 Human
igfbp-1 cervical cancer There were no significant differences in the serum levels of IGF-I and IGFBP-1 in the patients with cervical cancer and the control group. 9279518 Human
igfbp-1 endometrial cancer In conclusion, an increased circulating concentration of IGF-I and a decreased circulating concentration of IGFBP-1 are associated with endometrial cancer especially in postmenopausal women. 9279518 Human
igfbp-1 tumor To elucidate the physiological role of human stromelysin-3 (hST-3) in tumor progression and/or wound healing, insulin-like growth factor-binding protein-1 (IGFBP-1) was analyzed as a potential physiological substrate. hST-3 proteolysis generates two fragm 9325295 Human
igfbp-1 breast adenocarcinoma IGFBP-1 also inhibits IGF-I-induced proliferation of the MCF-7 breast adenocarcinoma, and this inhibition was not seen in hST-3-transfected MCF-7 cells. 9325295 Human
igfbp-1 breast cancer Polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice. 9376191 Mouse
insulin-like growth factor binding protein-1 breast cancer Polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice. 9376191 Mouse
igfbp-1 breast cancer Here we examined whether recombinant human wild-type IGFBP-1 (WT-BP-1) and IGFBP-1 conjugated with polyethylene glycol (PEG-BP-1) could inhibit breast cancer growth. 9376191 Mouse
igfbp-1 hepatoma The synthetic glucocorticoid, dexamethasone, increases IGFBP-1 mRNA abundance and gene transcription in rat liver and in H4-II-E rat hepatoma cells. 9369450 Human
igfbp-1 neuroblastoma While both SKNMC and CHP neuroblastoma cells expressed mRNAs for IGFBP-2, -4, and -6 no signal was detected for IGFBP-1, and -3 and only SK-N-MC cells expressed IGFBP-5 mRNA. 9404729 Human
igfbp-1 human hepatoma In this study we compared the effect of T3 on IGFBP-1 and -4 expression in rat hepatocyte primary cultures and in the human hepatoma cell line HepG2. 9540232 Human
igfbp-1 polycystic ovaries The aim of this study was to identify production of IGF-I and -II and IGFBP-1 to -4 by unstimulated normal and polycystic ovaries. 8550764 Human
igfbp-1 hepatoma A sensitive RIA was used to examine regulation of IGFBP-1 in H4IIE rat hepatoma cells. 8557761 Human
igfbp-1 breast cancer Influence of droloxifene on plasma levels of insulin-like growth factor (IGF)-I, Pro-IGF-IIE, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 in breast cancer patients. 8645625 Human
igfbp-1 breast cancer As IGF-I is a potent mitogen for breast cancer cells in vitro, a decrease in the plasma level of this growth factor with an increase in the concentration of IGFBP-1 may contribute to the anti-tumour effects of droloxifene. 8645625 Human
igfbp-1 human osteosarcoma IGFBP-1 expression was not observed in U-2, TE-85, or MG-63 human osteosarcoma cell lines or in normal human fibroblasts. 8754754 Human
igfbp-i advanced breast cancer Plasma levels of IGF-I, IGFBP-I and IGFBP-3 were measured before and during treatment with tamoxifen up to 19+ months in 34 post-menopausal patients with advanced breast cancer. 8797879 Human
igfbp-1 human thyroid carcinomas AIM: The aim of this study was to examine the expression of the IGF-I gene and of genes for IGFBP-1, -2, -3, and -4 in cells from nodular goiters (NG), and from different human thyroid carcinomas (papillary--PTC, anaplastic--ATC, and medullary--MTC), cult 15098919 Human
igfbp-1 human hepatoma This study was designed to characterize the IGFBP-1 kinase activity in HepG2 human hepatoma cells, a cell line that secretes IGFBP-1 primarily as phosphorylated isoforms. 8867814 Human
insulin-like growth factor binding protein-1 breast cancer Neutralization of insulin-like growth factor action by insulin-like growth factor binding protein-1 inhibits the in vitro growth of breast cancer cells. 8881372 Mouse
igfbp-1 human tumor We performed this study to determine the pharmacokinetic profile of recombinant human IGFBP-1 (rhIGFBP-1) in athymic mice as a prelude to testing this protein in a human tumor xenograft model. 8881372 Human
igfbp-1 primary breast cancer In this study, we have measured PSA, IGF-I, IGF-II, IGFBP-1 and IGFBP-3 in tumour tissue cytosols from 200 women with primary breast cancer, and have examined relationships between IGFs or IGFBPs and PSA along with other markers, including p53 protein, st 8883411 Human
igfbp-1 tumour In this study, we have measured PSA, IGF-I, IGF-II, IGFBP-1 and IGFBP-3 in tumour tissue cytosols from 200 women with primary breast cancer, and have examined relationships between IGFs or IGFBPs and PSA along with other markers, including p53 protein, st 8883411 Human
igfbp-1 hepatoma Dexamethasone increases IGFBP-1 mRNA abundance and gene transcription in rat liver and in H4-II-E rat hepatoma cells. 9121490 Rat
insulin-like growth factor binding protein-1 post-menopausal breast cancer Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-I and insulin-like growth factor binding protein-1 in post-menopausal breast cancer patients. 7534218 Human
igfbp-1 breast cancer The aim of this study was to examine relations between sex hormones, IGF-I and insulin-like growth factor binding protein-1 (IGFBP-1) in post-menopausal women with breast cancer. 7534218 Human
insulin-like growth factor binding protein-1 breast cancer The aim of this study was to examine relations between sex hormones, IGF-I and insulin-like growth factor binding protein-1 (IGFBP-1) in post-menopausal women with breast cancer. 7534218 Human
igfbp-1 breast cancer DESIGN: To measure plasma sex steroids, sex hormone binding globulin (SHBG), IGF-I, IGFBP-1, insulin and urinary oestrogen metabolites in post-menopausal women with breast cancer not receiving any endocrine therapy. 7534218 Human
igfbp-1 post-menopausal breast cancer CONCLUSION: Our results do not suggest any influence of plasma sex steroids in physiological concentrations on IGF-I or IGFBP-1 in post-menopausal breast cancer patients, nor do they indicate IGF-I at physiological concentrations influences the ratios bet 7534218 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome The relationship between circulating androgens, obesity, and hyperinsulinemia on serum insulin-like growth factor binding protein-1 in the polycystic ovarian syndrome. 7534449 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome OBJECTIVE: Our purpose was to evaluate the relationship of obesity, hyperinsulinemia, and hyperandrogenemia on serum insulin-like growth factor binding protein-1 levels in women with the polycystic ovarian syndrome. 7534449 NA
insulin-like growth factor binding protein-1 polycystic ovarian syndrome STUDY DESIGN: Insulin-like growth factor binding protein-1, insulin, and androgen levels were studied during a 3-hour intravenous glucose tolerance test in 16 women with polycystic ovarian syndrome (nine obese and seven nonobese) and 20 healthy control wo 7534449 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome RESULTS: Positive correlations were observed between basal (r = 0.77, p = 0.04) and area under curve (r = 0.86, p < 0.001) insulin-like growth factor binding protein-1 with basal androstenedione in the nonobese women with polycystic ovarian syndrome but n 7534449 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome An inverse relationship was observed between log area under curve insulin-like growth factor binding protein-1 levels and log body mass index in polycystic ovarian syndrome (r = -0.54, p = 0.03) and in normal women (r = -0.43, p = 0.06). 7534449 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome The log area under curve insulin-like growth factor binding protein-1 level was approximately an inverse linear function of log area under curve insulin response for both women with polycystic ovarian syndrome (r = -0.70, p < 0.001) and control women (r = 7534449 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome Additionally, after the area under curve insulin response during intravenous glucose tolerance testing was controlled for, the decline in area under curve insulin-like growth factor binding protein-1 responses was on average 66% less in both obese and non 7534449 Human
insulin-like growth factor binding protein-1 polycystic ovarian syndrome CONCLUSION: These data indicate that insulin and body mass index are the major determinants of circulating insulin-like growth factor binding protein-1 and that chronic hyperandrogenemia does not appear to further reduce serum insulin-like growth factor b 7534449 Human
igfbp-1 thyroid tumors To determine if immunohistochemical detection of growth factors and/or their receptors correlates with morphological alterations in proliferative lesions of thyroid, we examined the localization of epidermal growth factor (EGF), transforming growth factor 7787437 Human
igfbp-1 human hepatoma Western ligand blot analysis of IGFBPs secreted by HepG2 human hepatoma cells showed that 24 h treatment with forskolin increased IGFBP-1 secretion by approximately 100%, whereas similar treatment with insulin resulted in a 50% reduction. 7542954 Human
igfbp-1 pituitary adenoma In conclusion, octreotide induces in acromegaly the production of IGFBP-1, which occurs independently of the number of somatostatin receptors on the GH-secreting pituitary adenoma. 7544670 Human
insulin-like growth factor binding protein-1 polycystic-ovary syndrome Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome. 7554310 Human
igfbp-1 cysts IGFBP-1 levels were significantly lower in patients with type I than in controls and type II cysts. 12590636 Human
igfbp-1 hepatoma We conclude that the 32 K IGFBP produced by H4EIIC3 hepatoma cells in culture represents the rat form of IGFBP-1 (rIGFBP-1). 2164920 Rat
igfbp-1 multicystic ovaries As an initial step towards this we have investigated the presence of the various binding proteins by Western ligand blotting and have measured the levels of one of them, IGFBP-1, in follicular fluid (FF) obtained from unstimulated dominant and cohort foll 1698131 Human
igfbp-1 colon cancer Chronically elevated plasma insulin levels have been postulated to increase colon cancer risk, either directly through colonic insulin receptors or indirectly through downregulation of IGFBP-1 and/or IGFBP-2, thus increasing IGF activity. 12925961 Human
igfbp-1 rectal cancer Plasma IGFBP-1 and IGFBP-2 showed no association with risk of colon and/or rectal cancer, either in the full study population or among the fasting subjects. 12925961 Human
igfbp-1 hepatoma We now examine the regulation of IGFBP-1 and IGFBP-I mRNA in H4-II-E cells, a rat cell line derived from the minimal deviation H35 Reuber hepatoma previously reported to synthesize IGFBP-1 as its predominant IGF-binding protein. 1704485 Rat
igfbp-i hepatoma We now examine the regulation of IGFBP-1 and IGFBP-I mRNA in H4-II-E cells, a rat cell line derived from the minimal deviation H35 Reuber hepatoma previously reported to synthesize IGFBP-1 as its predominant IGF-binding protein. 1704485 Rat
insulin-like growth factor binding protein-1 human endometrial adenocarcinoma Activation of human insulin-like growth factor binding protein-1 gene promoter by a distal regulatory sequence in a human endometrial adenocarcinoma cell line. 8544848 Human
igfbp-1 human endometrial adenocarcinoma To understand IGFBP-1 gene regulation in human endometrium, we studied the IGFBP-1 gene promoter activity in human endometrial adenocarcinoma cell line HEC-1B. 8544848 Human
igfbp-1 human hepatoma Using human hepatoma cells in vitro the somatostatin analogue, octreotide, has been shown to increase IGFBP-1 mRNA within 24 h indicative of a direct stimulatory effect of octreotide on IGFBP-1 synthesis. 8543925 Human
igfbp-1 hepatoma Using an improved procedure for transient transfection of H4-II-E rat hepatoma cells, we characterized the cis elements in the proximal promoter of the rat insulin-like growth factor binding protein-1 (rat IGFBP-1) gene that are required for basal (unstim 8817654 Rat
insulin-like growth factor binding protein-1 hepatoma Using an improved procedure for transient transfection of H4-II-E rat hepatoma cells, we characterized the cis elements in the proximal promoter of the rat insulin-like growth factor binding protein-1 (rat IGFBP-1) gene that are required for basal (unstim 8817654 Rat
insulin-like growth factor binding protein-1 polycystic-ovary syndrome Altered regulation of insulin-like growth factor binding protein-1 in patients with polycystic ovary syndrome. 9420884 Human
igfbp-1 polycystic ovary syndrome (pcos) Because serum IGF binding protein-1 (IGFBP-1) levels have been found to be decreased in patients with polycystic ovary syndrome (PCOS), we tested the hypothesis that regulation of IGFBP-1 secretion may be different in patients with PCOS compared with norm 9420884 Human
igfbp-1 ovarian carcinoma By Northern blot analyses using cDNAs or oligonucleotides specific for the six types of IGFBP (IGFBP-1 to IGFBP-6), mRNA for all IGFBPs tested except for IGFBP-1 could be detected in the ovarian carcinoma cell extracts. 7505272 Human
igfbp-1 ovarian carcinoma It is concluded that ovarian carcinoma cells frequently express IGFBP-3, -4, and -6 and, to a lesser extent, IGFBP-2; the expression of IGFBP-5 appears as a rather rare event, while IGFBP-1 was not found to be expressed in ovarian carcinoma cells. 7505272 Human
igfbp-1 hepatoma To identify DNA sequences mediating the effects of glucocorticoids and insulin on IGFBP-1 promoter activity we created luciferase reporter gene constructs and performed transfection studies in H4IIE hepatoma cells. 7507835 Human
insulin-like growth factor binding protein 1 breast cancer Insulin-like growth factor binding protein 1 expression inhibits insulin-like growth factor I action in MCF-7 breast cancer cells. 7510125 Human
igfbp-1 breast cancer These results suggest that IGFBP-1 expression in MCF-7 breast cancer cells inhibits IGF-I induced growth by interrupting the interaction between IGF-I and its receptor. 7510125 Human
igfbp-1 polycystic ovaries The present study was designed to investigate whether, in addition to the mean levels, the overnight pattern of GH, IGF-1, IGFBP-1 and SHBG differed in obese women with polycystic ovaries as compared to that observed in the non-obese PCOD patients. 7511134 Human
igfbp-1 polycystic-ovary syndrome We have studied the effects of pirenzepine on plasma insulin, plasma glucose, growth hormone (GH), androstenedione, testosterone, insulin-like growth factor-I (IGF-I) and IGF binding protein 1 (IGFBP-1) responses to a mixed meal in obese clinically hypera 7516827 NA
igfbp-i postmenopausal breast cancer Plasma concentrations of IGF-I, IGFBP-I, and IGFBP-3 were compared between 40 postmenopausal breast cancer patients receiving long term tamoxifen therapy and 39 breast cancer patients receiving no hormonal treatment. 7518340 Human
igfbp-i breast cancer Plasma concentrations of IGF-I, IGFBP-I, and IGFBP-3 were compared between 40 postmenopausal breast cancer patients receiving long term tamoxifen therapy and 39 breast cancer patients receiving no hormonal treatment. 7518340 Human
igfbp-1 human endometrial adenocarcinoma Identification of a distal regulatory sequence of the human IGFBP-1 gene promoter and regulation by the progesterone receptor in a human endometrial adenocarcinoma cell line. 7520702 Human
igfbp-1 human endometrial adenocarcinoma The activity of the insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter was studied in the human endometrial adenocarcinoma cell line HEC-1B. 7520702 Human
insulin-like growth factor binding protein-1 human endometrial adenocarcinoma The activity of the insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter was studied in the human endometrial adenocarcinoma cell line HEC-1B. 7520702 Human
insulin-like growth factor binding protein-1 endometrial cancer Suppressed expression of insulin-like growth factor binding protein-1 mRNA in the endometrium: a molecular mechanism associating endometrial cancer with its risk factors. 7523316 Human
igfbp-1 endometrial cancer In this study, we used a quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to investigate IGFBP-1, IGFBP-2, IGFBP-4, IGFBP-5 and IGFBP-6 gene expression in endometrial cancer tissues. 7523316 NA
igfbp-1 endometrial cancer In endometrial cancer tissues, the IGFBP-1 mRNA was undetectable or minimally expressed when studied by RT-PCR. 7523316 Human
igfbp-1 hepatoma In rat H4-II-E hepatoma cells, IGFBP-1 messenger RNA is stimulated by dexamethasone, cAMP, and phorbol esters, and dominantly inhibited by insulin. 7523864 Rat
igfbp-1 hepatoma Mutation of this HNF-3 binding sequence disrupts this effect as well as the ability of glucocorticoids to stimulate and of insulin to inhibit IGFBP-1 promoter activity in H4IIE and HepG2 hepatoma cells. 7524494 Human
igfbp-1 insulinoma OBJECTIVE: Previous reports have shown an inverse relation between IGFBP-1 and insulin levels in healthy men, patients with insulin dependent diabetes mellitus, and insulinoma. 7525123 NA
igfbp-1 human hepatoma The effect of the thiazolidinedione troglitazone on IGFBP-1 production was studied in HepG2 human hepatoma cells, which were found to express PPAR alpha, PPAR gamma, and PXR. 12659874 Human
igfbp-1 breast cancer Here we present our studies using IGFBP-1 to inhibit growth of the breast cancer cell line MCF-7. 7529598 Human
igfbp-1 human hepatoma We have applied this technique to detect insulin-like growth factor binding protein-1 (IGFBP-1) secretion by a human hepatoma cell line (HepG2). 7530114 Human
insulin-like growth factor binding protein-1 human hepatoma We have applied this technique to detect insulin-like growth factor binding protein-1 (IGFBP-1) secretion by a human hepatoma cell line (HepG2). 7530114 Human
igfbp-1 hepatoma Our goal was the study of the kinetics of IGFBP-1 secretion from hepatoma cells and rat hepatocytes and to determine the heterogeneity of the cell population regarding the secretion of IGFBP-1. 7530114 Human
igfbp-1 hepatoma To evaluate the optimal conditions of IGFBP-1 secretion by hepatoma cells and rat hepatocytes and to evaluate the influence of cell dispersion on hepatocyte's behavior, we evaluated three techniques of cell dispersion: trypsin digestion, collagenase 7530114 Human
insulin-like growth factor binding protein 1 hepatoma Tissue-specific expression of insulin-like growth factor binding protein 1 (IGFBP-1) in the liver has been studied using differentiated (H4II and C2Rev7) and dedifferentiated (H5 and C2) rat hepatoma cell lines. 7678342 Human
igfbp-1 hepatoma Tissue-specific expression of insulin-like growth factor binding protein 1 (IGFBP-1) in the liver has been studied using differentiated (H4II and C2Rev7) and dedifferentiated (H5 and C2) rat hepatoma cell lines. 7678342 Human
igfbp-1 hepatoma Expression of this gene from the human IGFBP-1 promoter was 10-16 times more efficient in the H4II line than in the other hepatoma cell lines and 40 and approximately 12 times more so than in rat fibroblasts (FR3T3) and a human cervical carcinoma cell lin 7678342 Human
igfbp-1 cervical carcinoma Expression of this gene from the human IGFBP-1 promoter was 10-16 times more efficient in the H4II line than in the other hepatoma cell lines and 40 and approximately 12 times more so than in rat fibroblasts (FR3T3) and a human cervical carcinoma cell lin 7678342 Human
insulin-like growth factor binding protein-1 hepatoma Induction of insulin-like growth factor binding protein-1 gene expression in liver of protein-restricted rats and in rat hepatoma cells limited for a single amino acid. 7679969 Rat
igfbp-1 hepatoma To determine whether limitation for substrate (i.e. amino acids) might have a direct effect on IGFBP-1 gene expression, we examined the effect on IGFBP-1 gene expression of limitation of H4-II-E rat hepatoma cells for a single essential amino acid (phenyl 7679969 Rat
igfbp-1 human hepatoma We have studied the effects and mechanisms of thyroid hormone action on IGFBP-1 gene expression and secretion by human hepatoma cells in vitro. 7680863 NA
insulin-like growth factor binding protein-1 human hepatoma Dexamethasone stimulates expression of insulin-like growth factor binding protein-1 in HEP G2 human hepatoma cells. 7683515 Human
igfbp-1 hepatoma Human HEP G2 hepatoma cells respond to cAMP or insulin with stimulation or inhibition of IGFBP-1 expression, respectively; however, dexamethasone alone does not stimulate IGFBP-1 expression. 7683515 Human
igfbp-1 hepatoma The liver-specificity of insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter activity has been studied by transient transfection in rat hepatoma cell lines, rat fibroblasts and human cervical carcinoma cells, and shown to be dependent on 7683517 Rat
insulin-like growth factor binding protein-1 hepatoma The liver-specificity of insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter activity has been studied by transient transfection in rat hepatoma cell lines, rat fibroblasts and human cervical carcinoma cells, and shown to be dependent on 7683517 Rat
igfbp-1 cervical carcinoma The liver-specificity of insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter activity has been studied by transient transfection in rat hepatoma cell lines, rat fibroblasts and human cervical carcinoma cells, and shown to be dependent on 7683517 Human
insulin-like growth factor binding protein-1 cervical carcinoma The liver-specificity of insulin-like growth factor binding protein-1 (IGFBP-1) gene promoter activity has been studied by transient transfection in rat hepatoma cell lines, rat fibroblasts and human cervical carcinoma cells, and shown to be dependent on 7683517 Human
igfbp-1 endometrial adenocarcinoma Human ovarian follicular fluid, culture media from human granulosa cells and endometrial adenocarcinoma cells (HEC-1-B) consisted mostly of the non-phosphorylated form of IGFBP-1. 7683524 Human
igfbp-1 human hepatoma We have found immunoprecipitable [32P]IGFBP-1 in the conditioned media of both Chinese hamster ovary (CHO) cells (stabley transfected and secreting human IGFBP-1) and human hepatoma (HepG2) cells metabolically labelled with [32P]orthophosphate. 7683525 Human
igfbp-1 human hepatoma Previous studies showed that dibutyryl cAMP (Bt2cAMP) and theophylline increase IGFBP-1 promoter activity in HEP G2 human hepatoma cells and that insulin abolishes this increase. 7683658 Human
igfbp-1 hepatoma Basal IGFBP-1 promoter activity in human HEP G2 hepatoma cells is dependent upon a proximal promoter element that binds hepatic nuclear factor 1 (HNF1), a protein that is likely to be an important factor regulating the expression of many genes in liver an 7684229 Human
igfbp-1 papillary thyroid cancer We carried out a study on the effect of T4 withdrawal on serum insulin-like growth factor-binding protein-1 (IGFBP-1) levels in 10 thyroidectomized patients with papillary thyroid cancer receiving T4 replacement therapy. 7684392 Human
igfbp-1 polycystic ovaries Granulosa cells secreted IGFBP-1 in concentrations ranging from 20-500 pg/1000 cells.48 h, with cells from two of four normal and three of four polycystic ovaries showing a dose-related increase in IGFBP-1 production in response to FSH. 7684393 Human
igfbp-1 polycystic ovaries IGFBP-1 was detectable in fluid from all sizes of follicle tested, but there was no correlation of IGFBP-1 concentrations with follicle size and no difference between normal and polycystic ovaries. 7684393 Human
insulin-like growth factor binding protein-1 polycystic ovarian disease Serum levels of insulin-like growth factor binding protein-1 and ovulatory responses to clomiphene citrate in women with polycystic ovarian disease. 7685718 Human
igfbp-1 polycystic ovarian disease OBJECTIVE: To study the serum levels of insulin, insulin-like growth factor I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1) in relation to clomiphene citrate (CC) responsiveness in women with polycystic ovarian disease (PCOD). 7685718 Human
insulin-like growth factor binding protein-1 polycystic ovarian disease OBJECTIVE: To study the serum levels of insulin, insulin-like growth factor I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1) in relation to clomiphene citrate (CC) responsiveness in women with polycystic ovarian disease (PCOD). 7685718 Human
igfbp-1 endometrial cancer An oral glucose load resulted in a similar fall in serum IGFBP-1 levels in endometrial cancer patients and controls (51% and 55% at 3 h). 7686914 Human
igfbp-1 hepatoma Cycloheximide stabilizes insulin-like growth factor-binding protein-1 (IGFBP-1) mRNA and inhibits IGFBP-1 transcription in H4-II-E rat hepatoma cells. 7688368 Rat
igfbp-1 hepatoma Using the well differentiated H4-II-E rat hepatoma cell line as a model system, we demonstrated previously that IGFBP-1 transcription is positively regulated by dexamethasone and negatively regulated by insulin. 7688368 Rat
igfbp-1 tumors All tumors expressed mRNA for IGFBPs 2-6 but none expressed IGFBP-1 message. 7690042 Human
igfbp-1 polycystic ovarian disease OBJECTIVE: We studied the effects of ovarian electrocauterization on the serum levels of luteinizing hormone (LH), testosterone, insulin, sex hormone-binding globulin (SHBG) and insulin-like growth factor binding globulin-1 (IGFBP-1) in women with polycys 7690311 Human
igfbp-1 lung cancer We showed recently that insulin-like growth factor binding protein (IGFBP)-1, -2 and -3 are differentially expressed in lung cancer and permanent lung cancer cell lines. 7692907 Human
insulin-like growth factor binding protein-1 polycystic-ovary syndrome Response of sex hormone binding globulin and insulin-like growth factor binding protein-1 to an oral glucose tolerance test in obese women with polycystic ovary syndrome before and after calorie restriction. 7693380 Human
insulin-like growth factor binding protein-1 mcf-7 human breast cancer Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells. 7693722 Human
igfbp-1 human hepatoma The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells. 7505466 Human
insulin-like growth factor binding protein-1 human hepatoma The regulation of insulin-like growth factor binding protein-1 (IGFBP-1) by its ligands, IGF-I and IGF-II, was studied in continuous cultures of HepG2 human hepatoma cells. 7505466 Human
igfbp-1 cancer These results demonstrate that the serum of pregnant women, post-operative patients and patients with cancer contain circulating proteases which cause fragmentation of IGFBP-3 but have little effect on IGFBP-1. 7506292 Human
igfbp-1 hepatoma Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIE hepatoma cells. 1370614 Rat
insulin-like growth factor binding protein-1 hepatoma Divergent effects of phorbol esters and insulin on insulin-like growth factor binding protein-1 (IGFBP-1) production and mRNA in rat H4IIE hepatoma cells. 1370614 Rat
igfbp-1 hepatoma 125I-IGF-I binding assay, western ligand and immunoblotting, and northern analysis of total RNA reveal that phorbol ester agonists of protein kinase C rapidly enhance IGFBP-1 production and increase the abundance of IGFBP-1 mRNA in rat H4IIE hepatoma cell 1370614 Rat
igfbp-1 tumors IGF-I and IGFBP-1 mRNAs are not expressed in either NMU tumors or in normal breast. 1371457 Human
igfbp-1 tumor PURPOSE: To begin to elucidate the genetic basis for these observations, the present study examines the expression by lung tumor cell lines of three IGF-binding protein genes, namely, IGFBP-1, IGFBP-2, and IGFBP-3. 1372941 NA
igfbp-1 small-cell lung cancer METHODS: Gene expression was studied in four small-cell lung cancer (SCLC) and three non-small-cell lung cancer (NSCLC) cell lines using Northern blot analysis and reverse transcriptase polymerase chain reaction (RT-PCR) for IGFBP-1. 1372941 NA
igfbp-1 non-small-cell lung cancer METHODS: Gene expression was studied in four small-cell lung cancer (SCLC) and three non-small-cell lung cancer (NSCLC) cell lines using Northern blot analysis and reverse transcriptase polymerase chain reaction (RT-PCR) for IGFBP-1. 1372941 NA
igfbp-1 prostate cancer The present study evaluates the effects of IGF-I and IGFBP-1 on growth and apoptosis of prostate cancer cells in vitro. 12746292 Human
igfbp-1 prostate cancer DE results in a decrease in serum IGF-I with increased IGFBP-1 in vivo that is associated with apoptosis and reduced LNCaP and LAPC-4 prostate cancer cell growth in vitro. 12746292 Human
igfbp-1 colon carcinoma The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 neuroblastoma The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 burkitt's lymphoma The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 retinoblastoma The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 tumour The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 breast carcinomas The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 non-small-cell lung carcinoma The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 adenocarcinoma The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 burkitt's lymphoma All other cell lines, with the exception of the Burkitt's lymphoma, expressed the IGFBP-2 gene and, in addition, either the IGFBP-1 gene and/or the IGFBP-3 gene. 1377187 Human
igfbp-1 human hepatoma IGFBP-1 production is potently inhibited by insulin both in vivo and in HepG2 human hepatoma cells. 1379255 Human
igfbp-1 breast cancer Regulation of insulin-like growth factor-binding protein (IGFBP) expression by breast cancer cells: use of IGFBP-1 as an inhibitor of insulin-like growth factor action. 1379645 Human
igfbp-1 human mcf-7 breast cancer PURPOSE: We conducted this study to fully characterize the expression and hormonal regulation of IGF-binding protein expression in human MCF-7 breast cancer cells and to test the ability of purified IGFBP-1 to inhibit IGF-I action. 1379645 NA
igfbp-1 human hepatoma Primer extension of endometrial/decidual IGFBP-1 mRNA showed two transcription initiation sites identical to those found in HepG2 human hepatoma cell line. 1380842 Human
igfbp-i postmenopausal breast cancer Plasma levels of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein I (IGFBP-I) were measured in fasting blood samples obtained from 16 postmenopausal breast cancer patients before and during tamoxifen treatment for 1 to 6 1380889 Human
igfbp-i breast cancer A dual effect suppressing plasma IGF-I and elevating plasma IGFBP-I suggests that tamoxifen may have a significant influence on endocrine and possibly paracrine delivery of IGF-I to breast cancer cells in vivo. 1380889 Human
igfbp-1 advanced breast cancer The effect of endocrine therapy with medroxyprogesterone acetate, 4-hydroxyandrostenedione or tamoxifen on plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGFBP-1 in women with advanced breast cancer. 1381703 Human
igfbp-1 tumours Additionally, northern blot analysis of total RNA from NSCLC cell lines and tumours was performed using cDNAs coding for each of IGFBP-1, IGFBP-2, and IGFBP-3. 1382500 Human
igfbp-1 primary tumours In contrast all primary tumours analysed expressed predominantly IGFBP-2 and IGFBP-3 and none showed any evident expression of IGFBP-1. 1382500 Human
igfbp-1 breast tumors The results show that human breast tumors express mRNAs encoding IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-5. 1382838 Human
igfbp-1 hepatoma Immunoreactive IGFBP-1 was present in rat amniotic fluid and in the medium conditioned by isolated rat hepatocytes and HTC rat hepatoma cells. 1385101 Rat
igfbp-1 human hepatoma Somatostatin analog induces insulin-like growth factor binding protein-1 (IGFBP-1) expression in human hepatoma cells. 1385103 Human
insulin-like growth factor binding protein-1 human hepatoma Somatostatin analog induces insulin-like growth factor binding protein-1 (IGFBP-1) expression in human hepatoma cells. 1385103 Human
igfbp-1 human hepatoma As the somatostatin analog octreotide suppresses pituitary GH secretion and circulating IGF-1 levels, we examined its effects on human hepatoma (hep G2) cells which selectively express IGFBP-1. 1385103 Human
igfbp-1 endometrial adenocarcinoma These data establish a role for the PKC pathway in regulation of expression of IGFBP-1, -2, -3, and -5 in endometrial adenocarcinoma cells and illustrate the complexity of cell type-specific expression of the IGFBPs. 1280205 Human
insulin-like growth factor binding protein-1 human hepatoma Epidermal growth factor enhances insulin-like growth factor binding protein-1 synthesis in human hepatoma cells. 1281991 Human
igfbp-1 human hepatoma Epidermal growth factor (EGF) was found to induce a rapid 2-fold increase in the amount of insulin-like growth factor binding protein-1 (IGFBP-1) mRNA in human hepatoma Hep2G cells, and this was accompanied by a 2-fold increase in IGFBP-1 secretion. 1281991 Human
insulin-like growth factor binding protein-1 human hepatoma Epidermal growth factor (EGF) was found to induce a rapid 2-fold increase in the amount of insulin-like growth factor binding protein-1 (IGFBP-1) mRNA in human hepatoma Hep2G cells, and this was accompanied by a 2-fold increase in IGFBP-1 secretion. 1281991 Human
igfbp-1 hepatoma Insulin rapidly decreases IGFBP-1 mRNA and IGFBP-1 transcription in rat hepatoma cells. 1283442 Rat
igfbp-1 polycystic-ovary syndrome The role of insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 (IGFBP-1) in the pathogenesis of polycystic ovary syndrome. 1283982 Human
igfbp-1 polycystic ovary syndrome (pcos) The objective of this study was to elucidate the relationship and role of insulin-like growth factor-1 (IGF-1), IGF binding protein-1 (IGFBP-1), insulin and luteinizing hormone (LH) in the pathogenesis of polycystic ovary syndrome (PCOS). 1283982 Human
igfbp-1 postmenopausal breast cancer Our data do not support an association between postmenopausal circulating levels of IGF-I, IGFBP-1, -2, -3, C-peptide and postmenopausal breast cancer. 12794762 Human
igfbp-1 hepatoma IGFBP-1 expression has been shown to increase under low-insulin conditions such as diabetes, and the complex regulation of expression is indicated by our finding that insulin treatment of H35 rat hepatoma cells, which induces proliferation, also causes a 1705004 Rat
insulin-like growth factor binding protein-1 polycystic ovarian disease Oral contraceptives increase insulin-like growth factor binding protein-1 concentration in women with polycystic ovarian disease. 1708731 Human
igfbp-1 polycystic ovarian disease OBJECTIVE: To investigate the effect of oral contraceptive (OC) pills, given for 3 months, on serum gonadotropin, androgen, IGF-I, and IGFBP-1 concentrations, and glucose tolerance in seven women with polycystic ovarian disease (PCOD) and in five healthy 1708731 NA
igfbp-1 meningiomas Ligand blotting also showed that meningiomas produce an Mr 29,000 BP; immunoblotting and immunoprecipitation of affinity-labeled IGF-BP complexes confirmed that this BP is recognized by antiserum against IGFBP-1. 1709588 Human
igfbp-1 malignant gliomas Immunohistochemistry with specific monoclonal antibodies demonstrated that IGFBP-1 is abundant in pathological specimens of meningiomas and that lower amounts also are detected in malignant gliomas. 1709588 Human
igfbp-1 meningiomas Immunohistochemistry with specific monoclonal antibodies demonstrated that IGFBP-1 is abundant in pathological specimens of meningiomas and that lower amounts also are detected in malignant gliomas. 1709588 Human
igfbp-1 tumors Immunohistochemistry with specific monoclonal antibodies against IGFBP-1 confirms that this BP is present in vivo, further supporting the concept that IGF BPs may contribute to the regulation of growth in human CNS tumors. 1709588 Human
igfbp-1 hepatoma We recently purified rat IGFBP-1 from medium conditioned by well differentiated rat H4IIE hepatoma cells. 1709855 Rat
igfbp-1 ovarian cancer RESULTS: Odds ratios and their 95% confidence intervals for risk of developing ovarian cancer over quartiles of peptides concentrations after adjustment for BMI and fasting were: 1.00, 0.66 (0.35-1.23), 0.96 (0.51-1.82) and 0.89 (0.44-1.81) for C-peptide; 12814208 Human
igfbp-1 ovarian cancer In women who had ovarian cancer diagnosis before age 55 the ORs for the top tertiles of IGFBP-1 and IGFBP-2 were 0.51 (0.18-1.49) and 0.53 (0.18-1.54), respectively. 12814208 Human
igfbp-1 ovarian cancer CONCLUSIONS: This study does not support an independent direct etiological role of C-peptide in ovarian cancer pathogenesis, but suggests a possible protective effect of circulating IGFBP-1 and -2 in women who develop ovarian cancer before age 55. 12814208 Human
insulin-like growth factor binding protein-1 human endometrial adenocarcinoma Human endometrial adenocarcinoma cell lines HEC 1B and KLE secrete insulin-like growth factor binding protein-1 and contain IGF-I receptors. 1710998 Human
igfbp-1 endometrial adenocarcinoma The production of insulin-like growth factor binding proteins (IGFBP) with special reference to human IGFBP-1 was evaluated in five endometrial adenocarcinoma cell lines (HEC 1A, HEC 1B, KLE, RL952 and AN3CA) in continuous culture. 1710998 Human
igfbp-1 endometrial cancer In addition to IGFBP-1, the endometrial cancer cells secreted several other forms of IGFBPs as determined by cross-linking. 1710998 Human
igfbp-1 endometrial carcinoma These studies were undertaken to determine which forms of IGFBP are secreted by endometrial carcinoma (HEC-1B) and breast carcinoma (MDA-231) cells, to characterize variables that control IGFBP secretion, and to study the effect of IGFBP-1 and IGFBP-2 on 1715344 Human
igfbp-1 breast carcinoma These studies were undertaken to determine which forms of IGFBP are secreted by endometrial carcinoma (HEC-1B) and breast carcinoma (MDA-231) cells, to characterize variables that control IGFBP secretion, and to study the effect of IGFBP-1 and IGFBP-2 on 1715344 Human
igfbp-1 human hepatoma Immunoprecipitation was used to show that Chinese hamster ovary cells (transfected with a human IGFBP-1 cDNA construct) and human hepatoma (HepG2) cells secrete 32P-labeled IGFBP-1 following incubation with [32P]orthophosphate. 1715565 Human
igfbp-1 hepatoma To understand the molecular basis for this regulation, we have examined the effects of insulin on IGFBP-1 and IGFBP-1 mRNA in the H4-II-E cell line derived from the well differentiated H35 rat hepatoma. 1719386 Rat
ibp-i human hepatoma Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells. 1690256 Human
ibp-i hepatoma Insulin, but not IGF-I, was also found to inhibit the secretion of a low molecular weight IGF-binding protein (IBP-I), which is also secreted by hepatoma cells. 1690256 Human
igfbp-1 human hepatoma A human hepatoma cell line, HepG2, secretes a discrete insulin-like growth factor-binding protein (IGFBP-1) into serum-free medium, which is identical to the 25K mol wt BP in amniotic fluid and plasma. 1690745 Human
igfbp-1 imt RESULTS: Partial correlations adjusted for age, sex, BMI, and diabetes duration showed an inverse association of IGFBP-1 with C-peptide (r = -0. 24, P = 0.018) and with maximal IMT (r = -0.42, P < 0.001), whereas IGF I and IGFBP-3 correlated positively wi 12351482 Human
afbp hepatoma AFBP immunoreactivity was demonstrable in serum of three orangoutan mothers and their three children and in medium of a hepatoma cell line (PLC/PRF/5) but not in bovine, porcine, rabbit, or rat serum or in medium of cell cultures of (pre-)term placentae. 6207200 Human
higfbp-1 neuroblastoma Proteins in conditioned medium were examined by ligand blotting, and by immunoprecipitation and immunoblotting using antibodies to rIGFBP-2 and hIGFBP-1; RNAs were hybridized to cDNA probes for rIGFBP-2 and hIGFBP-1. 1) C6 glial cells and B104 neuroblasto 1691442 Human
higfbp-1 human osteosarcoma The influence of a human insulin-like growth factor binding protein, hIGFBP-1, on the action of IGFs on human osteosarcoma cells was examined. hIGFBP-1 was found to block binding of IGFs to their receptors on MG-63 cells and subsequent IGF stimulation of 1721071 Human
higfbp-1 human osteosarcoma In chromatographic experiments, plasmin completely dissociated complexes of [125I] IGF-I-BP and [125I]IGF-II-BP formed with purified decidual IGFBP (hIGFBP-1) or IGFBPs present in medium conditioned by human osteosarcoma MG-63 cells. 1371448 Human
igf-bp 25 carcinomas [Determination of placental protein 12 (insulin-like growth factor binding protein 25) in pleural effusion of various origins] It is reported on the possible role of the radioimmunological estimation of placental protein 12 (PP 12; insulin-like growth fac 1695798 Human
igf-bp 25 lung cancer [Determination of placental protein 12 (insulin-like growth factor binding protein 25) in pleural effusion of various origins] It is reported on the possible role of the radioimmunological estimation of placental protein 12 (PP 12; insulin-like growth fac 1695798 Human
igfbp-1 cns tumors Immunohistochemistry with specific monoclonal antibodies against IGFBP-1 confirms that this BP is present in vivo, further supporting the concept that IGF BPs may contribute to the regulation of growth in human CNS tumors. 1709588 Human
igfbp-1 lung tumor PURPOSE: To begin to elucidate the genetic basis for these observations, the present study examines the expression by lung tumor cell lines of three IGF-binding protein genes, namely, IGFBP-1, IGFBP-2, and IGFBP-3. 1372941 NA
igfbp-1 nsclc METHODS: Gene expression was studied in four small-cell lung cancer (SCLC) and three non-small-cell lung cancer (NSCLC) cell lines using Northern blot analysis and reverse transcriptase polymerase chain reaction (RT-PCR) for IGFBP-1. 1372941 NA
igfbp-1 nsclc RESULTS: IGFBP-1 gene expression was detected by Northern blot analysis in one NSCLC cell line only. 1372941 Human
igfbp-1 nsclc However, RT-PCR revealed that the IGFBP-1 gene was expressed in all four SCLC cell lines and in two of the three NSCLC lines. 1372941 Human
igfbp-1 wilms' tumour The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a panel of cell lines derived from breast carcinomas, Wilms' tumour, neuroblastoma, retinobla 1377187 Human
igfbp-1 nsclc Additionally, northern blot analysis of total RNA from NSCLC cell lines and tumours was performed using cDNAs coding for each of IGFBP-1, IGFBP-2, and IGFBP-3. 1382500 Human
igfbp-1 crohn's disease Twenty nine children with Crohn's disease were studied before and after treatment with steroids or an elemental diet to assess the effect of disease activity and treatment on serum insulin like growth factor I (IGF-I), insulin like growth factor bind 7688335 Human
igfbp-1 nsclc The nine NSCLC cell lines used in this study showed messenger ribonucleic acid (mRNA) expression of all six IGFBPs known, as determined by PCR, and protein secretion of IGFBP-1, -2, -3, -4, and -5, as analyzed by Western immunoblots. 8675593 Human
igfbp-1 hyperplastic IGFBP-1 mRNA levels were too low to be detected by Northern blot analysis, but could be found by RT-PCR in some tumors and hyperplastic adrenals. 9851669 Human
igfbp-1 tumor Content of IGFII in tumor cells correlated with IGFBP-1, IGFBP-2, IGFBP-5. 10598264 Human
igfbp-1 carcinoma [Inhibited effect of phosphorylated insulin-like growth factor binding protein-1 on hepatoma cells in vitro] OBJECTIVE: To elucidate the inhibited effect and regulated mechanism of IGFBp-1 on the carcinoma cells. 10715798 NA
igfbp-1 hcc HCC arising in this model had decreased expressions of IGF-I and IGFBP-4 but IGFBP-1 expression was not significantly altered. 11005208 Human
igfbp-1 ca DESIGN AND METHODS: Concentrations of IGFs, IGFBP-1, -3 and -6, and PSA were determined in the sera from 57 patients with breast cancer (CA), and 46 women with benign breast disease (BBD) using immunoassays for IGFs and IGFBPs and an ultrasensitive ELISA 10069662 NA
igfbp-1 ca Mean serum IGFBP-1 concentrations were significantly lower in the CA group, 16 (2) ng/ml, versus 37 (4) ng/ml in the BBD group (P = 0.001). 10069662 Human
igfbp-1 ca In the CA group, statistically significant correlations between PSA and IGFBP-6 (r = 0.413; P = 0.001), and between PSA and IGFBP-1 (r = -0.329; P = 0.021) were seen. 10069662 Human
igfbp-1 hcc In contrast, the expression of Gal-4, UGT2B4, IGFBP-1, and RIG-E mRNAs was regulated in a cell density-dependent manner: the levels of Gal-4, UGT2B4, and IGFBP-1 were undetectably low, whereas the level of RIG-E was high in rapidly proliferating, subconfl 10519413 Human
igfbp-1 hcc In summary, therefore, high expression of Gal-4, UGT2B4, rpP0, dek, IGFBP-1, and vitronectin, together with low expression of RIG-E, was correlated with the malignant potential of HCC. 10519413 Human
igfbp-1 bph Systemic IGFBP-1, primarily of hepatic origin, is a functional antagonist of IGF-II; thus, boosting IGFBP-1 production might be expected to lessen risk for BPH. 11133245 Human
igfbp-1 gliomas To do so, we investigated by immunohistochemistry the accumulation of IGFBP-1, -2, and -3 in 50 human gliomas classified by the WHO Malignancy Scale. 11250947 Human
igfbp-1 gliomas The labeling score of IGFBP-1 accumulation in endothelial cells correlated negatively (P: = 0.0229), and that of IGFBP-2 accumulation in glioma cells correlated positively (P: < 0.0006) with the tumor grade of the gliomas. 11250947 Human
igfbp-1 gliomas In addition, RT-PCR analysis confirmed mRNA expression of IGFBP-1, -2, and -3 by the gliomas and glial cells. 11250947 Human
igfbp-1 polycystic ovary [Can hormonal contraceptives affect plasma levels of IGF-1 and IGFBP-1 in slim women with polycystic ovary syndrome?] BACKGROUND: Polycystic ovary syndrome (PCOS) represents a frequent endocrinopathy among fertile women. 11569168 Human
igfbp-1 atypical hyperplasia of endometrium Significantly higher IGFBP-1 concentrations were found in the serum of patients with the atypical hyperplasia of endometrium and endometrial carcinoma. 11928553 Human
igfbp-1 bph METHODS: Plasma levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 were determined from the fasting bloods of 206 BPH cases admitted for treatment and 306 randomly selected population controls in Shanghai, China. 12111701 NA
igfbp-1 bph No associations of BPH with IGF-II and IGFBP-1 were observed. 12111701 Human
igfbp-1 imt In linear regression analysis controlling for age, sex, BMI, diabetes duration, and presence or absence of oral antihyperglycemic or insulin medication, determinants of IMT were age, IGFBP-1, pulse pressure, Lp(a), diabetes duration, and insulin treatment 12351482 Human
igfbp-1 imt CONCLUSIONS: In summary, a decrease in IGFBP-1 is a marker of carotid IMT thickening in patients with type 2 diabetes. 12351482 Human
igfbp-1 hcc We studied insulin, proinsulin and IGFBP-1 in normal subjects (NL, N=47, 43+/-12 yr), cirrhosis (CIR, N=29, 54+/-14 yr), hepatocellular carcinoma (HCC, N=42, 61+/-11 yr), and other liver tumors (TUM, N=8, 60+/-17 yr). 14624764 NA
igfbp-1 hcc All three analytes were significantly increased in liver disease (mean+/-SEM; p-values relative to normals): IGFBP-1 (NL 24+/-4 ng/ml; CIR 235+/-53, p<0.0001; HCC 505+/-105, p<0.0001; TUM 118+/-36, p<0.0001), insulin (NL 72+/-4 pM; CIR 261+/-62, p<0.0002; 14624764 Human
igfbp-1 polycystic ovary syndrome (pcos) OBJECTIVES: Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, insulin resistance, compensatory hyperinsulinemia, and increased levels of free insulin-like growth factor-I (IGF-I), presumably due to a decline in IGF binding protein 1 (I 15063962 NA
igfbp-1 tumor In REMs with real samples, we detected organ-specific expression of albumin, Hnf-4 and Igfbp-1, in a set of mouse organ cDNA populations and c-Myc expression in tumor samples in paired tumor/normal tissue cDNA samples. 15329382 Human
igfbp-1 endometrial cancer RESULTS: The odds ratios for endometrial cancer comparing the highest versus the lowest tertile of various IGF components were as follows: 0.5 [95% confidence interval (CI) 0.2-1.2] for free IGF-I, 1.1 (95% CI 0.5-2.6) for total IGF-I, 1.2 (95% CI 0.6-2.6 15459496 Human
igfbp-1 endometrial cancer Increasing IGFBP-1 levels seem to be associated with endometrial cancer risk in older women and in women with a higher body mass index. 15459496 Human
igfbp-1 endometrial cancer OBJECTIVE: To assess whether circulating insulin-like growth factor-1 (IGF-1), IGF-2, insulin-like growth factor-binding protein-1 (IGFBP-1), or IGFBP-3 were associated with endometrial cancer in postmenopausal women. 15066926 NA
igfbp-1 endometrial cancer Endometrial cancer was inversely associated with IGF-2 (OR for the highest tertile = 0.35, 95% CI = 0.18-0.69) and IGFBP-3 (OR for the highest tertile = 0.40, 95% CI = 0.21-0.77), and not associated with IGFBP-1. 15066926 Human
igfbp-1 endometrial cancer CONCLUSION: Serum IGF-1, IGF-2, and IGFBP-3, but not IGFBP-1, were inversely associated with endometrial cancer in postmenopausal women. 15066926 Human
igfbp-1 cancer The roles of IGFBP-1 and -2 in relation to IGF-I bioactivity and cancer deserve further investigation. 15456992 Human
igfbp-1 ovarian cancer CONCLUSIONS: This study suggests a protective role of IGFBP-3 and a positive association of IGFBP-1 with ovarian cancer. 15557783 Human
igfbp-1 tumor The reduction in serum IGF-1 and increase in IGFBP-1 with diet and exercise appear to be the most significant, as these changes lead to an increase in tumor cell p53 protein and its down-stream effector p21, which are responsible for the reduction in cell 15648182 Human
igfbp-1 human hepatoma We showed that 2,3,7,8-tetrachorodibenzo-p-dioxin (TCDD) specifically induced IGFBP-1 mRNA in human hepatocytes and HepG2 human hepatoma cells (2.5- and 8-fold, respectively). 15496506 Human
igfbp-1 breast cancer Few studies have assessed IGF binding protein-1 (IGFBP-1) or free IGF and breast cancer risk. 15767352 Human
igfbp-1 in situ breast cancer Eight hundred women were identified who had a diagnosis of invasive or in situ breast cancer after blood collection, up to 1998, 27% of whom were premenopausal at blood collection. 15767352 Human
igfbp-1 breast cancer We used logistic regression models to estimate the relative risk (RR) of breast cancer associated with IGF levels.Findings: Among postmenopausal women, neither IGF-I, IGFBP-3, IGFBP-1, nor free IGF was associated with breast cancer risk [RRs, top versus b 15767352 Human
igfbp-1 breast cancer IGFBP-3, IGFBP-1, and free IGF are not associated with breast cancer risk in either premenopausal or postmenopausal women in this cohort. 15767352 Human
igfbp-1 colon cancer Fasting IGFBP-1 was inversely associated with risk of colon cancer (MVRR, 0.28; 95% CI, 0.11-0.75). 15824155 Human
igfbp-1 colon cancer The IGF-I to IGFBP-3 molar ratio was associated with colon cancer risk (MVRR, 2.82; 95% CI, 1.35-5.88), and women with low levels of both IGF-I/IGFBP-3 and C-peptide (or high IGFBP-1) were at low risk, and elevation of either was sufficient to increase ri 15824155 Human
igfbp-1 human hepatoma Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. 15862298 Human
igfbp-1 acute lymphoblastic leukemia Serum levels of IGF-I, IGF-II, IGF binding protein (IGFBP)-1, IGFBP-2, and IGFBP-3 were measured in 162 children with acute lymphoblastic leukemia treated by the Berlin Frankfurt Munster Study Group. 15687344 Human
igfbp-1 seminoma IGF-2, IR-B, IGFBP-1, IGFBP-4, and IGFBP-6 mRNA were downregulated in seminoma. 15967097 Human
igfbp1 sertoli cell tumors Quantification of RT-PCR products revealed significantly less expression of IGFBP1, IGF-I, and 5alpha-reductase type I in Sertoli cell tumors and seminomas. 12646054 Human
igfbp1 seminomas Quantification of RT-PCR products revealed significantly less expression of IGFBP1, IGF-I, and 5alpha-reductase type I in Sertoli cell tumors and seminomas. 12646054 Human
insulin-like growth factor binding protein-1 hepatoma [Inhibited effect of phosphorylated insulin-like growth factor binding protein-1 on hepatoma cells in vitro] OBJECTIVE: To elucidate the inhibited effect and regulated mechanism of IGFBp-1 on the carcinoma cells. 10715798 Human
insulin-like growth factor binding protein-1 polycystic-ovary syndrome Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. 15063962 Human
insulin-like growth factor binding protein-1 colorectal cancer A Prospective Study of C-Peptide, Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-1, and the Risk of Colorectal Cancer in Women. 15824155 Human
insulin-like growth factor binding protein-i polycystic ovarian syndrome Serum insulin-like growth factor binding protein-I levels are lower in polycystic ovarian syndrome with hyperinsulinaemia, probably as a consequence of insulin-mediated suppression of insulin-like growth factor binding protein-I. 9921024 Human
insulin-like growth factor binding protein i breast cancer Influence of tamoxifen on plasma levels of insulin-like growth factor I and insulin-like growth factor binding protein I in breast cancer patients. 1380889 Human
insulin-like growth factor binding protein i postmenopausal breast cancer Plasma levels of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein I (IGFBP-I) were measured in fasting blood samples obtained from 16 postmenopausal breast cancer patients before and during tamoxifen treatment for 1 to 6 1380889 Human
pp12 trophoblastic tumour Levels of placenta-specific tissue protein 12 (PP12) in serum during normal pregnancy and in patients with trophoblastic tumour. 6318674 Human
pp12 hydatidiform moles Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). 6318674 Human
pp12 invasive moles Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). 6318674 Human
pp12 trophoblastic tumours Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). 6318674 Human
pp12 choriocarcinomas Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). 6318674 Human
pp12 invasive mole In patients with invasive mole requiring chemotherapy the rate of fall of PP12 level was slower. 6318674 Human
pp12 choriocarcinoma Among the number of newly isolated placental proteins, PP5 and PP12 share some common characteristics: Both are present in the syncytiotrophoblast of normal placenta and hydatidiform mole, but less frequently, if at all, in choriocarcinoma. 6322659 Human
pp12 cancer We are pursuing this research with the immediate goal of assessing the role of PP12 in the blood coagulation system and of studying the expression of both proteins in various forms of cancer. 6322659 Human
pp12 cystic glandular hyperplasia No PP12 was found in the endometrium under the following conditions: (1) during the proliferative phase, (2) in cystic glandular hyperplasia, (3) during the first 3 postovulatory days in ovulatory cycles, (4) in atrophic postmenopausal endometrium, and (5 6370734 Human
pp12 primary liver cancer Placental protein 12 (PP12) in primary liver cancer and cirrhosis. 6209778 Human
pp12 primary liver cancer Serum concentrations of the placental protein 12 (PP12), measured by radioimmunoassay, were found to be elevated in 15 out of 16 (94%) patients with primary liver cancer, 10 out of 68 (15%) patients with other gastrointestinal malignancies, 5 out of 10 (5 6209778 Human
pp12 primary liver cancer No correlation was observed between the serum levels of alphafetoprotein (AFP) and PP12 in patients with primary liver cancer. 6209778 Human
pp12 gastrointestinal cancers Using immunoperoxidase staining, PP12 was localised in malignant hepatocytes and hyperactive nodules of cirrhosis, but rarely in malignant cells of other gastrointestinal cancers. 6209778 Human
pp12 cancer These data show that PP12 is a somatomedin-binding protein and extend through previous literature on PP12 the existing knowledge on the physiology and pathophysiology of somatomedin-binding protein(s) in human reproduction and cancer. 2419121 Human
pp12 lung cancer [Levels of tumor markers (orosomucoid, pregnancy-associated alpha 2-glycoprotein, pregnancy protein-1, placental specific-tissue protein 10, placental specific-tissue protein 12, alpha 1-fetoprotein) in the serum of patients with bronchial carcinoma] Conc 2421681 Human
pp12 cancer Orosomucoid, PP12 and AFP serum concentrations of the cancer group compared with those of the control group, were increased significantly. 2421681 Human
pp12 tumour Orosomucoid (control group: means = 0.828 g/l; s = 0.301; tumour group: mean = 2.16 g/l; s = 0.862); PP12 (control group: mean = 54.08 micrograms/l; s = 61.70; tumour group: mean = 122.52 micrograms/l; s = 131.16); AFP (control group: mean = 3.05 microgra 2421681 Human
pp12 ovarian cancer Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer. 2428459 Human
pp12 ovarian tumors The circulating levels of placental protein 12 (PP12), a somatomedin-binding protein, were measured by radioimmunoassay in 37 postmenopausal women with ovarian tumors. 2428459 Human
pp12 rous sarcoma We have studied the interactions of single-stranded polyribonucleotides with murine leukemia virus structural proteins p10, p10' (a p10 variant), and Pr65gag, as well as Rous sarcoma virus (RSV) pp12 (a p10 analog). 2435721 NA
pp12 murine leukemia We have studied the interactions of single-stranded polyribonucleotides with murine leukemia virus structural proteins p10, p10' (a p10 variant), and Pr65gag, as well as Rous sarcoma virus (RSV) pp12 (a p10 analog). 2435721 NA
pp12 tumors SP1 was occasionally demonstrated and PP5 was faintly stained only in the heterotransplanted tumors, although PP10 and PP12 were not demonstrable. 3611867 Human
pp12 hydatidiform moles The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
pp12 tumour The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
pp12 cancer The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). 2444151 Human
pp12 ovarian cyst Insulin-like growth factor-binding protein PP12 in ovarian cyst fluid. 2445309 Human
pp12 choriocarcinoma The production of human chorionic gonadotropin (hCG), pregnancy-specific beta-1 glycoprotein (SP1), and the various placental tissue proteins (PP4, PP5, PP10, PP11, PP12, MP1) was examined in human choriocarcinoma cell lines using radioimmunoassay (RIA) a 2446567 Human
pp12 tumors Positive staining for PP4 and MP1, and weakly positive staining for PP5, PP10, and PP12 was found in the xenograft tumors by immunoperoxidase (PAP) stain, but the staining for PP11 was negative. 2446567 Human
pp12 tumor PP12 has been found in several forms of cancer, although not with sufficient frequency to make it a useful tumor marker. 2469425 Human
pp12 cancer PP12 has been found in several forms of cancer, although not with sufficient frequency to make it a useful tumor marker. 2469425 Human
pp12 endometrial adenocarcinoma PP12 mRNA was expressed in cytotrophoblast-derived normal placental tissue or endometrium-derived normal cells, but was not expressed in syncytiotrophoblast-derived normal placental tissue, choriocarcinoma or endometrial adenocarcinoma, suggesting that th 8543850 Human
pp12 choriocarcinoma PP12 mRNA was expressed in cytotrophoblast-derived normal placental tissue or endometrium-derived normal cells, but was not expressed in syncytiotrophoblast-derived normal placental tissue, choriocarcinoma or endometrial adenocarcinoma, suggesting that th 8543850 Human
pp12 malignant tumours Ectopic synthesis of pregnancy specific beta 1-glycoprotein (SP1) and placental specific tissue proteins (PP5, PP10, PP11, PP12) in nontrophoblastic malignant tumours. 6160287 Human
pp12 malignant tumours By using an enzyme-bridge immunoperoxidase (PAP) technique, localization of so-called pregnancy-specific beta 1-glycoprotein (SP1) and placental-specific tissue proteins (PP5, PP10, PP11, PP12) was investigated in 19 cases of breast cancer, 24 cases of te 6160287 Human
pp12 gastric cancer By using an enzyme-bridge immunoperoxidase (PAP) technique, localization of so-called pregnancy-specific beta 1-glycoprotein (SP1) and placental-specific tissue proteins (PP5, PP10, PP11, PP12) was investigated in 19 cases of breast cancer, 24 cases of te 6160287 Human
pp12 breast cancer By using an enzyme-bridge immunoperoxidase (PAP) technique, localization of so-called pregnancy-specific beta 1-glycoprotein (SP1) and placental-specific tissue proteins (PP5, PP10, PP11, PP12) was investigated in 19 cases of breast cancer, 24 cases of te 6160287 Human
pp12 breast cancer But to a certain percentage these proteins could also be detected in the cytoplasma of malignant cells: In breast cancer, SP1 was present in 52.6% of cases, PP5 in 63.2%, PP10 in 68.4%, PP11 in 55.6% and PP12 in 31.6%. 6160287 Human
pp12 gastric metaplasia In addition, it was found that mononuclear histiocytes showed a strong cytoplasmic staining for PP10 and PP12 and that a few other non-cancerous cells (i.e. striated cells in gastric metaplasia, gastric polyps etc.) stained for PP5, PP10, PP11 and/or PP12 6160287 Human
pp12 gastric polyps In addition, it was found that mononuclear histiocytes showed a strong cytoplasmic staining for PP10 and PP12 and that a few other non-cancerous cells (i.e. striated cells in gastric metaplasia, gastric polyps etc.) stained for PP5, PP10, PP11 and/or PP12 6160287 Human
pp12 malignant neoplasms The results suggest that SP1, PP10 and PP12 may be synthesized by polymorphonuclear neutrophils and/or mononuclear phagocytes and could represent markers not only for trophoblasts and some kinds of malignant neoplasms but also for normal neutrophils and/o 6794297 Human
pp12 breast cancer Thus PP5 and PP11 may be markers for breast cancer and the detection of these proteins in sera from breast cancer patients may be more reliable and useful in the detection and monitoring of breast cancer patients than the determination of SP1, PP10, or PP 7036917 Human
pp12 ovarian adenocarcinomas Immunohistochemical detection of pregnancy-specific protein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11 and PP12) in ovarian adenocarcinomas. 6755403 Human
pp12 serous cystadenocarcinoma By using an immunoglobulin-enzyme bridge method, pregnancy-specific beta 1-glycoprotein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11, PP12) were investigated in 15 cases of mucinous cystadenocarcinoma and 20 cases of serous cystadenocarcin 6755403 Human
pp12 mucinous cystadenocarcinoma By using an immunoglobulin-enzyme bridge method, pregnancy-specific beta 1-glycoprotein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11, PP12) were investigated in 15 cases of mucinous cystadenocarcinoma and 20 cases of serous cystadenocarcin 6755403 Human
pp12 mucinous cystadenocarcinomas In mucinous cystadenocarcinomas, SP1, was present in 53.3% of cases, PP5 in 80.0%, PP10 in 20.0%, PP11 in 66.7% and PP12 in 46.7%. 6755403 Human
pp12 serous cystadenocarcinomas In serous cystadenocarcinomas, SP1 was present in 35.0% of cases, PP5 in 76.2%, PP10 in 9.5%, PP11 in 57.1% and PP12 in 23.8%. 6755403 Human
pp12 bronchial carcinoma The concentrations of pregnancy protein 1 (SP1), placental-specific tissue protein 10 (PP10), placental-specific tissue protein 12 (PP12) and alpha1-Fetoprotein (AFP) were analyzed in serum samples of 83 patients with bronchial carcinoma at stages II-IV P 16033079 Human
pp12 cancer PP12 and AFP serum concentrations were significantly increased in the cancer group compared with the control group. 16033079 Human
pp12 tumor PP12 (control group: x=54.08 microg/l; s=61. 70; tumor group: x = 122.52 microg/l; s = 131.16); AFP (control group: x=3.05 microg/l; s=3. 76; tumor group: x = 8.29 microg/l; s = 17.75). 16033079 Human

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