IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HUS1 Ensembl ENSG00000136273 Chromosome 7 Start 47970308 End 47985771
Description Checkpoint protein HUS1 (hHUS1) [Source:UniProtKB/Swiss-Prot;Acc:O60921]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5309
     Entrez Gene : 3364
     UCSC : uc003toe.1
     GeneCards : 5309
     RefSeq : NM_004507
     CCDS : CCDS34635.1
     Uniprot : O60921
     Interpro : O60921
     OMIM : 603760
     GeneTests : HUS1
     CGAP : HUS1
     PMID : 9878245

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38153_at  0.25  1.68e-1  2.53e-1  0.20  4.53e-1  5.58e-1
 HG_U133A  204883_s_at  1.95  1.44e-48  6.53e-47  1.83  3.62e-21  5.34e-21
 HG_U133A  204884_s_at  0.17  9.17e-2  1.21e-1  1.76  4.04e-20  5.87e-20
 HG_U133A  217618_x_at  0.11  1.36e-1  1.74e-1  -3.07  7.20e-103  5.29e-102
 HG_U133_Plus2  204883_s_at  0.14  1.95e-1  2.70e-1  0.04  7.50e-1  7.89e-1
 HG_U133_Plus2  204884_s_at  0.34  2.70e-2  4.92e-2  0.45  1.40e-3  2.63e-3
 HG_U133_Plus2  217618_x_at  0.52  1.65e-9  1.12e-8  0.58  2.79e-9  1.13e-8
 Agilent_HS_21.6K  12440  0.03  2.44e-2  8.77e-2  0.05  1.90e-2  5.93e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204883_s_at  0.10  8.33e-1  9.86e-1  -0.22  5.08e-1  1.00e+0
 HG_U133A  204884_s_at  0.45  3.82e-1  8.96e-1  0.16  5.90e-1  1.00e+0
 HG_U133A  217618_x_at  -0.44  3.57e-1  8.92e-1  -0.23  2.25e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38153_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204883_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204884_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217618_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204883_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204884_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217618_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12440    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hus1 human lung carcinoma Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin. 11920544 Human
hus1 lung carcinoma METHODS: Transfection of 2'-O-methoxyethyl-modified Hus1 antisense oligoribonucleotides into human H1299 nonsmall lung carcinoma cells was performed using Lipofectin as the carrier. 11920544 NA
hus1 tumorigenesis A significant increase in micronucleus formation was observed in peripheral blood cells from Hus1(neo/Delta1) mice, but reduced Hus1 expression did not cause an elevated predisposition to spontaneous tumor development or accelerate tumorigenesis in p53-de 17220276 Mouse
hus1 tumor A significant increase in micronucleus formation was observed in peripheral blood cells from Hus1(neo/Delta1) mice, but reduced Hus1 expression did not cause an elevated predisposition to spontaneous tumor development or accelerate tumorigenesis in p53-de 17220276 Mouse
hus1 hyperplasia Genes overexpressed only in hyperplasia were: MDM2, MCL1, BCL2A1, BLK, RIPK2, CD40LG, TRAF5, HUS1, BNIP3. 16888677 Human
hus1 tumor The novel tools described here hold promise for elucidating how the Hus1-dependent checkpoint mechanism contributes to chromosomal stability, DNA damage responses, and tumor suppression in adult mice. 15919177 Mouse
hus1 esophageal cancer Introduction of exogenous Fhit into cells in vitro led to modulation of expression of checkpoint proteins Hus1 and Chk1 at mid-S checkpoint, a modulation that led to induction of apoptosis in esophageal cancer cells but not in noncancerous primary culture 17145874 Human

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