IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene UPP1 Ensembl ENSG00000183696 Chromosome 7 Start 48094766 End 48114855
Description Uridine phosphorylase 1 (UrdPase 1)(UPase 1)(EC 2.4.2.3) [Source:UniProtKB/Swiss-Prot;Acc:Q16831]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12576
     Entrez Gene : 7378
     UCSC : uc003toj.2
     GeneCards : 12576
     RefSeq : NM_003364
     CCDS : CCDS5507.1
     Uniprot : Q16831
     Interpro : Q16831
     OMIM : 191730
     GeneTests : UPP1
     CGAP : UPP1
     PMID : 752472

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37351_at  0.17  2.55e-1  3.55e-1  -0.49  1.46e-2  3.20e-2
 HG_U133A  203234_at  0.22  7.39e-2  9.92e-2  0.67  4.39e-11  5.59e-11
 HG_U133_Plus2  203234_at  -0.14  2.82e-1  3.68e-1  -0.52  4.50e-4  9.15e-4
 Agilent_HS_21.6K  2950  -0.08  1.19e-1  2.66e-1  -0.08  1.96e-1  3.39e-1
 Agilent_HS_21.6K  12282  -0.06  5.41e-1  7.07e-1  -0.07  5.32e-1  6.75e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203234_at  -0.68  9.19e-2  7.65e-1  -0.75  5.99e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37351_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203234_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203234_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2950    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12282    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
uridine phosphorylase tumor RESULTS: OPRT, thymidylate synthase, RNR, thymidine phosphorylase, uridine phosphorylase and thymidine kinase activities were significantly higher in tumor areas than in nontumor areas. 17192711 Human
uridine phosphorylase human gastric tumors Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis. 17214321 Human
uridine phosphorylase solid tumors Thymidine phosphorylase (TP) and uridine phosphorylase (UP) are often upregulated in solid tumors and catalyze the phosphorolysis of natural (deoxy)nucleosides and a wide variety of fluorinated pyrimidine nucleosides. 17098463 Human
uridine phosphorylase colorectal cancers METHODS: Activities of seven enzymes involved in nucleic acid metabolism--orotate phosphoribosyltransferase (OPRT), ribonucleotide reductase (RNR), thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, uridine phosphorylase and t 17192711 Human
uridine phosphorylase tumor METHODS: Activities of seven enzymes involved in nucleic acid metabolism--orotate phosphoribosyltransferase (OPRT), ribonucleotide reductase (RNR), thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, uridine phosphorylase and t 17192711 Human
the up gene gastric cancer These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU. 17214321 Human
upase breast carcinomas The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in normal tissues. 11807789 Human
upase breast carcinomas To clarify the correlation between the expression levels of UPase and dThdPase genes and the clinicopathological factors, mRNA levels of these enzymes were examined by RT-PCR in 43 breast carcinomas. 11807789 Human
upase tumors The UPase gene expression levels in tumors of patients who relapsed were significantly higher than in those from patients who did not (p = 0.039). 11807789 Human
upase human breast carcinoma Our findings suggest that the expression level of UPase gene may be an independent prognostic marker in human breast carcinoma. 11807789 Human
uridine phosphorylase colorectal cancer PURPOSE: Expression of thymidylate synthase (TS) and the 5-fluorouracil (5-FU) metabolic enzymes, including dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), and uridine phosphorylase (UP), has 15060742 Human
uridine phosphorylase breast cancer We have reported the elevation of uridine phosphorylase (UPase) in many solid tumors and the presence of a variant phosphorolytic activity in breast cancer tissues (M. 11956089 Human
upase breast cancer We have reported the elevation of uridine phosphorylase (UPase) in many solid tumors and the presence of a variant phosphorolytic activity in breast cancer tissues (M. 11956089 Human
upase cancer Considering the role of UPase in 5-FU metabolism and the elevated expression of this protein in cancer cells compared with paired normal tissues, additional investigation should be warranted to firmly establish the clinical role of UPase in the tumor sele 11956089 Human
upase tumor Considering the role of UPase in 5-FU metabolism and the elevated expression of this protein in cancer cells compared with paired normal tissues, additional investigation should be warranted to firmly establish the clinical role of UPase in the tumor sele 11956089 Human
upase tumor The evaluation of human surgical specimens has shown elevated UPase activity in tumor tissue compared to paired normal tissue. 12084455 Human
uridine phosphorylase oral squamous-cell carcinoma Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma. 12115385 Human
upase oral squamous-cell carcinoma METHODS: The authors prepared the antibody against UPase, examined the staining of UPase in 72 cases of oral squamous cell carcinoma (SCC) with immunohistochemical analysis using the antibody, and analyzed its relation to clinical and pathologic factors. 12115385 Human
upase tumors RESULTS: UPase stained mainly within the invasive edges of tumors and macrophages. 12115385 Human
upase tumor High staining of UPase (defined as > 50% of cells in a tumor biopsy that are positive for UPase) in primary tumors frequently was associated with the presence of metastasis to lymph nodes (P = 0.007 by the Fischer exact test) and with lower overall surviv 12115385 Human
upase metastasis to lymph nodes High staining of UPase (defined as > 50% of cells in a tumor biopsy that are positive for UPase) in primary tumors frequently was associated with the presence of metastasis to lymph nodes (P = 0.007 by the Fischer exact test) and with lower overall surviv 12115385 Human
uridine phosphorylase tumors The activities of uridine phosphorylase in all tumors used showed no changes in response to IFNalpha or Paclitaxel. 12359357 Human
uridine phosphorylase human mcf-7 breast cancer Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase. 11401323 Human
uridine phosphorylase cancer The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. 11401323 Human
uridine phosphorylase tumour The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. 11401323 Human
the up gene cancer A recombinant adenovirus encoding the UP gene (AxCA.UP) has been applied in gastric cancer gene therapy to sensitize cancer cells to lower concentrations of 5-FU. 11498773 Human
the up gene gastric cancer A recombinant adenovirus encoding the UP gene (AxCA.UP) has been applied in gastric cancer gene therapy to sensitize cancer cells to lower concentrations of 5-FU. 11498773 Human
uridine phosphorylase colon tumor Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10. 10927027 Mouse
uridine phosphorylase tumor The effect of co-administration of 5-(phenylselenenyl)acyclouridine (PSAU), a new uridine phosphorylase (UrdPase, EC 2.4.2.3) inhibitor, on the efficacy of 5-fluoro-2'-deoxyuridine (FdUrd) was tested against murine colon C26-10 tumor xenografts. 10927027 Human
uridine phosphorylase tumors Coadministration of uridine phosphorylase inhibitor with FdUrd caused selective toxicity against tumors with low or no thymidine phosphorylase, but not against the host tissues which have thymidine phosphorylase, and thus retain the capacity to cleave FdU 2697111 Human
uridine phosphorylase tumor Daily oral administration of CPA up-regulated human dThdPase levels in the tumor tissue of mice bearing a human mammary tumor xenograft, MX-1, whereas in the small intestine and liver, it did not affect levels of pyrimidine nucleoside phosphorylases (PyNP 10449619 Human
uridine phosphorylase mammary tumor Daily oral administration of CPA up-regulated human dThdPase levels in the tumor tissue of mice bearing a human mammary tumor xenograft, MX-1, whereas in the small intestine and liver, it did not affect levels of pyrimidine nucleoside phosphorylases (PyNP 10449619 Human
uridine phosphorylase tumor 5'-Deoxy-5-fluorouridine (5'-dFUrd) is a prodrug of 5-fluorouracil (5-FUra) activated by pyrimidine nucleoside phosphorylase (PyN Pase), mainly by uridine phosphorylase (Urd Pase) in rodents and by thymidine phosphorylase (TdR Pase) in humans, w 10530779 Mouse
uridine phosphorylase human prostate cancer At a nontoxic growth inhibitory concentration benzyloxyacyclouridine (BAU), a potent and specific inhibitor of uridine phosphorylase (UrdPase), enhanced 5-fluorouracil (5-FU) cytotoxic activity against human prostate cancer PC-3 and DU-145 cell lines. 9494066 Human
uridine phosphorylase human tumors Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. 9850074 Human
uridine phosphorylase tumors The BAU-insensitive phosphorolytic activity in selected tumors, coupled with the potent inhibitory activity of BAU against the "classical" uridine phosphorylase in normal human tissues, provides the rationale for combining BAU with 5-fluorouraci 9850074 Human
uridine phosphorylase tumor 19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine. 9402191 Human
uridine phosphorylase tumor A uridine phosphorylase inhibitor, 5-benzylacyclouridine (BAU), has been utilized as biochemical modulator of 5-fluorouracil (5-FU) anti-tumor activity in a murine tumor model. 9402191 Mouse
uridine phosphorylase tumours In the majority of colonic tumours, the activity of uridine phosphorylase and thymidine phosphorylase may have prognostic relevance for the cytotoxicity of 5-FU in vitro. 9416974 Human
uridine phosphorylase tumors 5-(Benzyloxybenzyl)barbituric acid acyclonucleoside (BBBA) was recently synthesized as a potent and specific inhibitor of uridine phosphorylase (EC 2.4.2.3), the enzyme responsible for the catabolism of 5-fluoro-2'-deoxyuridine (FdUrd) in many types 7866994 Human
uridine phosphorylase tumors Uridine phosphorylase was purified 10,300-fold from tumors of the murine colorectal adenocarcinoma cell line, Colon-26. 7744869 Mouse
uridine phosphorylase colorectal adenocarcinoma Uridine phosphorylase was purified 10,300-fold from tumors of the murine colorectal adenocarcinoma cell line, Colon-26. 7744869 Mouse
uridine phosphorylase cancer The underlying mechanism(s) have varied in different cancer cell lines, and include increased fluorouracil anabolism to fluorodeoxyuridine monophosphate, further inhibition of thymidylate synthase, stimulation of thymidine and uridine phosphorylase activi 7577043 Human
uridine phosphorylase tumour The underlying mechanism(s) have varied in different cancer cell lines, and include increased fluorouracil anabolism to fluorodeoxyuridine monophosphate, further inhibition of thymidylate synthase, stimulation of thymidine and uridine phosphorylase activi 7577043 Human
uridine phosphorylase human colorectal tumor Using a mouse cDNA probe we have identified a human uridine phosphorylase cDNA clone from the cDNA library of a human colorectal tumor cell line, HCT116. 7488099 Human
uridine phosphorylase hepatoma Uridine phosphorylase from Novikoff rat hepatoma cells: purification, kinetic properties, and its role in uracil anabolism. 2981897 Rat
uridine phosphorylase hepatoma Uridine phosphorylase was purified 5,330-fold from Novikoff rat hepatoma cells by ammonium sulfate precipitation, DEAE-Sephadex chromatography, hydroxyapatite chromatography, and Sephadex G-200 fractionation. 2981897 Rat
uridine phosphorylase sarcoma 180 Compounds 1 and 2 were found to be very potent inhibitors of uridine phosphorylase isolated from Sarcoma 180 cells, with a Ki value of 0.098 and 0.020 microM, respectively, and exhibited no apparent cytotoxicity against Sarcoma 180 host cells. 4009620 Human
uridine phosphorylase tumor The activities of enzymes responsible for activating 5-fluorouracil (FUra) to 5-fluorouridine-5'-monophosphate (FUMP) were compared in normal and tumor tissues of rodents to assess the potential capacity of uridine phosphorylase to anabolize FUra to 2996553 Human
uridine phosphorylase colon tumor Uridine phosphorylase [measured as the formation of 5-fluorouridine (FUrd) from FUra and R-1-P] was 35-230 nmoles/mg/hr in bone marrow and in two FUra-sensitive solid tumors, colon tumor No. 38 in mice and RPMI colon tumor in rats; the activity of uridine 2996553 Mouse
uridine phosphorylase tumor Uridine phosphorylase was partially purified from rat liver, RPMI rat tumor and colon tumor No. 38; the apparent Km of FUra averaged 50 microM, almost 9-fold lower than that of uracil, and the apparent Km of R-1-P for condensation with FUra was 33 microM. 2996553 Rat
uridine phosphorylase colon tumor Uridine phosphorylase was partially purified from rat liver, RPMI rat tumor and colon tumor No. 38; the apparent Km of FUra averaged 50 microM, almost 9-fold lower than that of uracil, and the apparent Km of R-1-P for condensation with FUra was 33 microM. 2996553 Rat
uridine phosphorylase tumors The high levels of uridine phosphorylase and uridine kinase activities in normal tissues and even higher levels in tissues from FUra-sensitive tumors, as well as the sufficient concentration of R-1-P relative to its kinetic constant, suggest that FUra met 2996553 Human
uridine phosphorylase human lung carcinoma At a nontoxic dose (50 microM), the two potent uridine phosphorylase inhibitors, benzylacyclouridine and benzyloxybenzylacyclouridine (BBAU), potentiated 5-fluoro-2'-deoxyuridine (FdUrd) growth inhibition of human pancreatic carcinoma (DAN) and, to a 6231986 Human
uridine phosphorylase human pancreatic carcinoma At a nontoxic dose (50 microM), the two potent uridine phosphorylase inhibitors, benzylacyclouridine and benzyloxybenzylacyclouridine (BBAU), potentiated 5-fluoro-2'-deoxyuridine (FdUrd) growth inhibition of human pancreatic carcinoma (DAN) and, to a 6231986 Human
uridine phosphorylase melanoma tumor High uridine phosphorylase activity in human melanoma tumor. 6881921 Human
uridine phosphorylase sarcoma 180 5-Ethyl-2,2'-anhydrouridine (ANEUR) proved to be a potent inhibitor of uridine phosphorylase isolated from sarcoma 180 cells with an apparent Ki (Ki(app) value of 99 nM. 3428126 Human
uridine phosphorylase carcinoma Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine. 8486533 Mouse
uridine phosphorylase mammary adenocarcinoma 2,2'-Anhydro-5-ethyluridine (ANEUR), a potent inhibitor of uridine phosphorylase, markedly potentiated the antitumor activity of fluorouridine (FUR) against murine mammary adenocarcinoma 755 in BDF1 mice and human colon adenocarcinoma LS174T in athym 2138895 Mouse
uridine phosphorylase human colon adenocarcinoma 2,2'-Anhydro-5-ethyluridine (ANEUR), a potent inhibitor of uridine phosphorylase, markedly potentiated the antitumor activity of fluorouridine (FUR) against murine mammary adenocarcinoma 755 in BDF1 mice and human colon adenocarcinoma LS174T in athym 2138895 Human
uridine phosphorylase tumors 5'-Deoxy-5-fluorouridine (5'-dFUrd, 1) possesses a significantly higher chemotherapeutic index than other fluoropyrimidines as a result of its being selectivity cleaved in tumors to 5-fluorouracil (FUra) by uridine phosphorylase. 7120290 Human
uridine phosphorylase tumor In addition, the uridine phosphorylase was found to be abundant in sarcoma-180 solid tumor, leading to a significantly higher concentration of converted 5-fluorouracil in this tumor than in other normal tissues. 6445847 Human
upase tumor UPase activity is usually elevated in various tumor tissues, and this induction appears to confer 5-FU therapeutic advantage to cancer patients. 15319798 Human
upase cancer UPase activity is usually elevated in various tumor tissues, and this induction appears to confer 5-FU therapeutic advantage to cancer patients. 15319798 Human
upase tumor To address its potential in cancer treatment, we will also discuss the regulatory mechanisms of UPase gene expression and its induction in tumor tissues. 15319798 Human
upase cancer To address its potential in cancer treatment, we will also discuss the regulatory mechanisms of UPase gene expression and its induction in tumor tissues. 15319798 Human
uridine phosphorylase tumors [5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues] It has been reported that 5'-DFUR is converted to 5-FU by uridine phosphorylase in experimental animal tumors. 6237613 others
uridine phosphorylase human tumors We found that this conversion in human tumors was catalyzed not by uridine phosphorylase but by thymidine phosphorylase. 6237613 Human
uridine phosphorylase cancer [Mode of action of fluoropyrimidines, in relation to their clinical application] From results which we obtained in experiments on 5-fluoropyrimidine analogs, it was demonstrated that the mode of action of these compounds was as follows: In human cancer, i 6497396 Human
uridine phosphorylase tumors [Mode of action of fluoropyrimidines, in relation to their clinical application] From results which we obtained in experiments on 5-fluoropyrimidine analogs, it was demonstrated that the mode of action of these compounds was as follows: In human cancer, i 6497396 others
uridine phosphorylase solid tumors Uridine phosphorylase [measured as the formation of 5-fluorouridine (FUrd) from FUra and R-1-P] was 35-230 nmoles/mg/hr in bone marrow and in two FUra-sensitive solid tumors, colon tumor No. 38 in mice and RPMI colon tumor in rats; the activity of uridine 2996553 Mouse
uridine phosphorylase acute leukemia [Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues] The activities of five enzymes, orotate phosphoribosyltransferase ( 2167917 Human
uridine phosphorylase solid tumor [Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues] The activities of five enzymes, orotate phosphoribosyltransferase ( 2167917 Human
uridine phosphorylase colonic tumours In the majority of colonic tumours, the activity of uridine phosphorylase and thymidine phosphorylase may have prognostic relevance for the cytotoxicity of 5-FU in vitro. 9416974 Human
uridine phosphorylase solid tumor In addition, the uridine phosphorylase was found to be abundant in sarcoma-180 solid tumor, leading to a significantly higher concentration of converted 5-fluorouracil in this tumor than in other normal tissues. 6445847 Human
uridine phosphorylase colon cancer [Analysis of the salvage synthesis within biosynthesis of nucleic acid route in colon cancer] Orotate phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), uridine phosphorylase (UP), dihydropyrimidine dehydrogenase (DPD), and thymidylate synth 10969598 Human
uridine phosphorylase solid tumors We have reported the elevation of uridine phosphorylase (UPase) in many solid tumors and the presence of a variant phosphorolytic activity in breast cancer tissues (M. 11956089 Human
uridine phosphorylase tumors Although IFN-alpha, given as 100,000 units/mouse/3 times/week subcutaneously x 6, and 5-FU, given as 0.5 mg/mouse/3 times/week intraperitoneally, showed addititive antitumor effect against HuH7 and PLC/PLF/5, the activities of thymidylate synthase (TS), d 15508442 Mouse
uridine phosphorylase cancers Fluorine-18 labeled Xeloda may serve as a novel radiotracer for positron emission tomography (PET) to image enzymes such as thymidine phosphorylase and uridine phosphorylase in cancers. 15607485 Human
uridine phosphorylase breast cancer [Significance of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) activity in breast cancer tissue] TS, DPD, uridine phosphorylase and thymidine phosphorylase are enzymes involved in the metabolism of the anticancer drug pyrimidine fluo 10925685 Human
uridine phosphorylase cancer To predict the sensitivity of colorectal cancer to 5-FU, mRNA is extracted from surgically obtained cancer specimens and expression of thymidylate synthetase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), uridine phosphorylase 15911984 Human
uridine phosphorylase colorectal cancer To predict the sensitivity of colorectal cancer to 5-FU, mRNA is extracted from surgically obtained cancer specimens and expression of thymidylate synthetase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), uridine phosphorylase 15911984 Human
uridine phosphorylase human colon tumors Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor. 16528530 Human
upase murine breast cancer Through transient expression analysis of the 5'-flanking region of UPase gene, we have evaluated the promoter activity for a series of fragments with 5'- to 3'-deletion in murine breast cancer EMT-6 cells and immortalized murine fibroblast 11559567 Mouse
upase oral squamous cell carcinoma METHODS: The authors prepared the antibody against UPase, examined the staining of UPase in 72 cases of oral squamous cell carcinoma (SCC) with immunohistochemical analysis using the antibody, and analyzed its relation to clinical and pathologic factors. 12115385 Human
uridine phosphorylase oral squamous cell carcinoma Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma. 12115385 Human
upase breast cancer UPase activity is usually elevated in various tumor tissues, including breast cancer, compared to matched normal tissues and this induction appears to contribute to the therapeutic efficacy of fluoropyrimidines in cancer patients. 16720348 Human
upase cancer UPase activity is usually elevated in various tumor tissues, including breast cancer, compared to matched normal tissues and this induction appears to contribute to the therapeutic efficacy of fluoropyrimidines in cancer patients. 16720348 Human
upase tumor UPase activity is usually elevated in various tumor tissues, including breast cancer, compared to matched normal tissues and this induction appears to contribute to the therapeutic efficacy of fluoropyrimidines in cancer patients. 16720348 Human
upase breast cancer In this review, we will discuss in detail the role of UPase in the activation of fluoropyrimidines and its effect on the prognosis of breast cancer patients. 16720348 Human
uridine phosphorylase breast cancer Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells. 16397116 Human
uridine phosphorylase colorectal cancer In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), 16525674 Human
uridine phosphorylase liver metastases In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), 16525674 Human
uridine phosphorylase primary colorectal cancer In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), 16525674 Human
uridine phosphorylase breast cancer Uridine phosphorylase in breast cancer: a new prognostic factor? 16720348 Human
upase murine breast cancer Our data indicate that TNF-alpha significantly induced UPase mRNA expression and its enzymatic activity in EMT6 murine breast cancer cells, leading to an enhanced cytotoxicity of 5'-DFUR. 16397116 Mouse
uridine phosphorylase leukemia Furthermore, a subline of L1210 leukemia resistant to 5'-DFUR but not to 5-fluorouracil was found to lack the uridine phosphorylase. 6445847 Human
uridine phosphorylase novikoff hepatoma On the basis of this definition and studies with GPT in nonfocused cytosol preparations, we conclude that FdUrd is cleaved to 5-fluorouracil by uridine-deoxyuridine phosphorylase activity in Ehrlich ascites cells and in Novikoff hepatoma cells, and by dTh 6451286 Rat
uridine phosphorylase lymphoma Inhibition of nucleoside transport in murine lymphoma L5178Y cells and human erythrocytes by the uridine phosphorylase inhibitors 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine. 6744292 Mouse
upase solid tumors The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in normal tissues. 11807789 Human
upase solid tumors We have reported the elevation of uridine phosphorylase (UPase) in many solid tumors and the presence of a variant phosphorolytic activity in breast cancer tissues (M. 11956089 Human
upase solid tumors The expression levels and the enzymatic activity of UPase are reported to be higher in human solid tumors than in adjacent normal tissues. 12115385 Human
upase tumors UPase-positive staining was observed in 56 of the 72 tumors (77.8%). 12115385 Human
upase primary tumors High staining of UPase (defined as > 50% of cells in a tumor biopsy that are positive for UPase) in primary tumors frequently was associated with the presence of metastasis to lymph nodes (P = 0.007 by the Fischer exact test) and with lower overall surviv 12115385 Human
upp tumorigenesis However, there is an increasing body of evidence showing that UPP dysregulation plays an important role in mammary tumorigenesis. 16556079 Human
uridine phosphorylase oncogenic Ectopic expression of uridine phosphorylase was able to support anchorage-independent cell growth, indicating that it plays an active role in the oncogenic process. 12874036 Human
uridine phosphorylase oral cancer 5'-deoxy-5-fluorouridine (5'-DFUR) and capecitabine are oral anti-cancer agents, which are enzymatically converted to 5-fluorouracil (5-FU) by thymidine phosphorylase in humans and uridine phosphorylase in mice. 16077977 Mouse
uridine phosphorylase lung cancer Altered expression of genes for glutathione-S-transferase-pi, uridine phosphorylase, O-6-methylguanine-DNA methyltransferase, and multidrug resistance 1 was identified in lung cancer cell lines. 17625370 Human
uridine phosphorylase cancer In this study, the preliminary analyses were conducted of enzymatic activities of uridine phosphorylase (UP) and thymidine phosphorylase (TP) in normal tissues and cancer tissues of the uterine cervix. 17949350 Human
uridine phosphorylase liver metastases METHODS: RNA was extracted from microdissected tumor cells of fixed and embedded specimens of resected liver metastases (94 cases) and analyzed by quantitative reverse-transcription polymerase chain reaction (RT-PCR) for thymidine phosphorylase, dihydropy 18054556 Human
uridine phosphorylase human gastric carcinoma METHODS: Experimental chemotherapy was performed using human gastric carcinoma xenografts, MKN-45 and TMK-1, to examine anticancer effects and gene expressions of fluoropyrimidine metabolism-related enzymes including thymidine phosphorylase (TP), thymidyl 18506536 Human
uridine phosphorylase tumor METHODS: RNA was extracted from microdissected tumor cells of fixed and embedded specimens of resected liver metastases (94 cases) and analyzed by quantitative reverse-transcription polymerase chain reaction (RT-PCR) for thymidine phosphorylase, dihydropy 18054556 Human

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