IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IKZF1 Ensembl ENSG00000185811 Chromosome 7 Start 50314924 End 50440293
Description DNA-binding protein Ikaros (Ikaros family zinc finger protein 1)(Lymphoid transcription factor LyF-1) [Source:UniProtKB/Swiss-Prot;Acc:Q13422]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 13176
     Entrez Gene : 10320
     UCSC : uc003tow.3
     GeneCards : 13176
     RefSeq : NM_006060
     Uniprot : Q13422
     Interpro : Q13422
     OMIM : 603023
     GeneTests : IKZF1
     CGAP : IKZF1
     PMID : 1439790

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40007_at  -0.05  6.60e-1  7.44e-1  -0.17  2.09e-1  3.01e-1
 HG_U95  834_at  -0.23  5.16e-2  9.47e-2  -0.39  6.32e-3  1.54e-2
 HG_U133A  205038_at  -0.18  1.33e-1  1.69e-1  1.31  6.63e-34  1.17e-33
 HG_U133A  205039_s_at  -0.14  6.19e-2  8.45e-2  -3.70  1.08e-69  3.48e-69
 HG_U133A  216901_s_at  0.15  2.89e-1  3.42e-1  0.63  1.28e-4  1.46e-4
 HG_U133A  220704_at  0.01  9.16e-1  9.30e-1  -0.30  3.60e-2  3.85e-2
 HG_U133_Plus2  1565816_at  -0.10  3.88e-1  4.79e-1  0.16  2.45e-1  3.00e-1
 HG_U133_Plus2  1565817_at  0.45  3.46e-2  6.11e-2  0.36  1.30e-1  1.70e-1
 HG_U133_Plus2  1565818_s_at  0.06  7.77e-1  8.29e-1  0.04  8.63e-1  8.87e-1
 HG_U133_Plus2  205038_at  -0.75  1.29e-6  5.71e-6  -1.55  1.64e-12  9.75e-12
 HG_U133_Plus2  205039_s_at  -0.07  5.83e-1  6.64e-1  -0.69  6.39e-5  1.47e-4
 HG_U133_Plus2  216901_s_at  0.37  8.58e-2  1.34e-1  -0.36  1.01e-1  1.36e-1
 HG_U133_Plus2  220704_at  -1.29  6.31e-11  5.15e-10  -1.95  2.39e-13  1.56e-12
 HG_U133_Plus2  227344_at  -0.61  1.08e-7  5.72e-7  -1.03  2.16e-11  1.12e-10
 HG_U133_Plus2  227346_at  -0.84  2.56e-9  1.69e-8  -1.68  8.72e-12  4.74e-11

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205038_at  0.92  2.55e-2  6.98e-1  -0.15  7.16e-1  1.00e+0
 HG_U133A  205039_s_at  0.14  5.72e-1  9.47e-1  -0.09  5.83e-1  1.00e+0
 HG_U133A  216901_s_at  -0.11  8.14e-1  9.84e-1  0.35  3.34e-1  1.00e+0
 HG_U133A  220704_at  -1.10  6.40e-2  7.27e-1  0.08  8.45e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40007_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 834_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205038_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205039_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216901_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 220704_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1565816_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1565817_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1565818_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205038_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205039_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216901_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220704_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227344_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227346_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ikaros malignancy Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. 16870249 Mouse
ikaros tumorigenesis Thus, combined Notch1 and Ikaros dysfunction can be a significant early event in T-cell proliferation and tumorigenesis. 16870249 Human
ikaros t-cell lymphoma An Ikaros (Plastic) point mutation inhibits activity of normal Ikaros and Ikaros family members, and leads to T-cell lymphoma in heterozygotes (Plstc/+). 16870249 Human
ikaros lymphomagenesis In these seven cases, partner regions identified by FISH contained genes known to be involved in lymphomagenesis, namely BCL6, BCL11A, PAX5 and IKAROS. 17230227 Human
znfn1a1 t-cell lymphomas Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice. 11839096 Human
ikaros t-cell lymphomas Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice. 11839096 Human
znfn1a1 t-cell lymphoma We have previously reported a high frequency of LOH (approximately 50%) at the Znfn1a1 locus in radiation-induced T-cell lymphoma in susceptible B6C3F1 mice. 11839096 Mouse
znfn1a1 t-cell lymphomas The aim of the present study was to delineate the types of Znfn1a1 inactivation, with special reference to the LOH status, and to determine the relative contribution of each type of Znfn1a1 inactivation in radiation-induced T-cell lymphomas in B6C3F1 mice 11839096 Human
znfn1a1 t-cell lymphomas We demonstrated that Znfn1a1 was frequently altered (in approximately 50% of T-cell lymphomas), and that its inactivation was caused by a variety of mechanisms, which came under one of the following four categories: (1) null expression (14%); (2) expressi 11839096 Human
znfn1a1 t-cell lymphomas On the other hand, T-cell lymphomas expressing dominant-negative Znfn1a1 isoforms retained both alleles. 11839096 Human
znfn1a1 t-cell lymphomas These results indicate that Znfn1a1 inactivation takes place by a variety of mechanisms in radiation-induced murine T-cell lymphomas and is frequently associated with LOH, this association depending on the type of inactivation. 11839096 Mouse
ikaros leukemia Ikaros gene expression and leukemia. 11908734 Human
ikaros leukemias Indeed, several groups including ours have underlined evidences that expression of different Ikaros isoforms vary among different types of leukemias. 11908734 Human
ikaros human leukemias Here, additional observations reinforced the hypothesis that Ikaros expression may be deregulated in human leukemias. 11908734 Human
ikaros chronic myelogenous leukemia OBJECTIVE: In previous studies, we demonstrated overexpression of the dominant-negative isoform of the transcription factor Ikaros, Ik-6, in patients with blast crisis of chronic myelogenous leukemia and B-cell acute lymphoblastic leukemia. 11937265 Human
ikaros blast crisis OBJECTIVE: In previous studies, we demonstrated overexpression of the dominant-negative isoform of the transcription factor Ikaros, Ik-6, in patients with blast crisis of chronic myelogenous leukemia and B-cell acute lymphoblastic leukemia. 11937265 Human
ikaros b-cell acute lymphoblastic leukemia OBJECTIVE: In previous studies, we demonstrated overexpression of the dominant-negative isoform of the transcription factor Ikaros, Ik-6, in patients with blast crisis of chronic myelogenous leukemia and B-cell acute lymphoblastic leukemia. 11937265 Human
ikaros lymphoma In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-cell acute lymphoblastic leukemia. 11937265 Human
ikaros human t-cell leukemia In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-cell acute lymphoblastic leukemia. 11937265 Human
ikaros t-cell acute lymphoblastic leukemia In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-cell acute lymphoblastic leukemia. 11937265 Human
znfn1a1 lymphomas Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas. 11980663 Human
ikaros lymphomas Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas. 11980663 Human
znfn1a1 lymphomas In this study, exons 3-5 and exon 7 of the Znfn1a1 gene that encode the functional domains of Ikaros were analyzed for point mutations and deletions in murine lymphomas induced by 1,3-butadiene, 2',3'-dideoxycytidine, or phenolphthalein. 11980663 Human
ikaros lymphomas In this study, exons 3-5 and exon 7 of the Znfn1a1 gene that encode the functional domains of Ikaros were analyzed for point mutations and deletions in murine lymphomas induced by 1,3-butadiene, 2',3'-dideoxycytidine, or phenolphthalein. 11980663 Human
znfn1a1 tumors Allelic losses on markers surrounding the Znfn1a1 gene were detected in 27% (12 of 45) of the tumors analyzed. 11980663 Human
znfn1a1 tumors However, only 2 tumors with allelic losses also showed mutations in the Znfn1a1 gene, indicating that other tumor suppressor genes located on this region might be involved as well. 11980663 Human
znfn1a1 thymic lymphomas Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. 10956435 Human
ikaros thymic lymphomas Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. 10956435 Human
ikaros acute lymphoblastic leukemia (all) PURPOSE: We sought to determine if molecular abnormalities involving the Ikaros gene could contribute to the development of acute lymphoblastic leukemia (ALL) in children. 10577847 Human
ik1 adenomas Ik1 expression was detected in human pituitary tumors and we also identified a truncated isoform consistent with the non-DNA-binding Ik6 isoform in a subset of adenomas by reverse transcriptase-polymerase chain reaction, sequencing, and Western immunoblot 12937159 Human
ik1 pituitary tumors Ik1 expression was detected in human pituitary tumors and we also identified a truncated isoform consistent with the non-DNA-binding Ik6 isoform in a subset of adenomas by reverse transcriptase-polymerase chain reaction, sequencing, and Western immunoblot 12937159 Human
ik1 pituitary tumors We conclude that dominant-negative Ik6 isoforms with their distinct localization and effects on Ik1 action may contribute to the altered expression of FGFR4 and possibly other target genes in human pituitary tumors. 12937159 Human
ikaros childhood all CONCLUSION: Our findings link specific molecular defects involving the Ikaros gene to childhood ALL. 10577847 Human
ikaros lymphomas (2) A sex difference in the latency was found. 15658891 Human
znfn1a1 other tumor However, only 2 tumors with allelic losses also showed mutations in the Znfn1a1 gene, indicating that other tumor suppressor genes located on this region might be involved as well. 11980663 Human
znfn1a1 tumours Additional analyses revealed that c-Myc over-expression and partial inactivation of Znfn1a1/Ikaros appear to be relevant events some how coupled to alterations in Notch genes inducing these kinds of tumours. 14976135 Human
znfn1a1 acute lymphoblastic leukemia Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes. 15390181 Human
znfn1a1 childhood leukemia The zinc finger protein, subfamily 1, member 1 gene (ZNFN1A1; OMIM 603023), on 7p12, codes for a lymphoid-restricted zinc finger transcription factor, ZNFN1A1, also called IKAROS, that regulates lymphocyte differentiation and has been associated with the 15390181 Human
ik1 all The ratio (Ik1 + Ik2)/(Ik1 + Ik2 + Ik4 + Ik7 + Ik8) ranged from 13.5% to 85% and was lower (P < 0. 05) in samples from patients with m-bcr-abl ALL. 11054064 Human
ikaros all In leukemic cells from each of the 12 infants with ALL, we found high level expression of dominant-negative isoforms of Ikaros with abnormal subcellular compartmentalization patterns. 9892693 Human
ikaros all These results implicate the expression of dominant-negative Ikaros isoforms and the disruption of normal Ikaros function in the leukemogenesis of ALL in infants. 9892693 Human
ikaros all Additional genetic changes, especially Ikaros alterations, are found in infant ALL. 10394590 Human
ikaros human leukemia Reverse transcription-PCR was used to determine the relative expression levels of Ikaros isoforms in a panel of human leukemia/lymphoma cell lines and human bone marrow samples from patients with hematological malignancies. 10463586 Human
ikaros cml In 9 of 17 samples of patients in blast crisis of CML, Ikaros activity had been reduced either by drastically reducing mRNA expression (4 of 17) or by overexpressing the dominant-negative isoform Ik-6 (5 of 17). 10463586 Human
ikaros cml In summary, these findings suggest that a reduction of Ikaros activity may be an important step in the development of blast crisis in CML and provide further evidence that mutations that alter Ikaros expression may contribute to human hematological malign 10463586 Human
ikaros all PATIENTS AND METHODS: We studied Ikaros gene expression in normal human bone marrow, normal thymocytes, normal fetal liver-derived immature lymphocyte precursor cell lines, eight different ALL cell lines, and leukemic cells from 69 children with ALL (T-li 10577847 Human
ikaros all RESULTS: In each of the ALL cases, we found high-level expression of a non-DNA-binding or aberrant DNA-binding isoform of Ikaros with abnormal subcellular compartmentalization patterns. 10577847 Human
ikaros all Posttranscriptional regulation of alternative splicing of Ikaros RNA seems to be defective in leukemic lymphocyte precursors from most children with ALL. 10577847 Human
ikaros all Consequently, leukemic cells from ALL patients, in contrast to normal lymphocyte precursors, express high levels of non-DNA-binding Ikaros isoforms that are reminiscent of the non-DNA-binding Ikaros isoforms that lead to lymphoblastic leukemia in mice. 10577847 Human
ikaros all We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos, in human bone marrow samples from patients with adult acute lymphoblastic leukemia [ALL (n = 46; B-cell ALL = 41; T-cell ALL = 5)]. 10945610 Human
ikaros all Overexpression of the dominant negative isoform of Ikaros gene Ik-6 was observed in 14 of 41 B-cell ALL patients by reverse transcription-PCR, and the results were confirmed by sequencing analysis and immunoblotting. 10945610 Human
ikaros leukemia In this report, we investigated Ikaros isoforms in human non-lymphoid leukemia cell lines and normal granulocyte/macrophage (CFU-GM) and erythroid (BFU-E)-derived colonies.We evaluated Ikaros gene expression by RT-PCR, Southern blotting, sequencing analys 11063871 Human
ikaros all We examined the expression of Ikaros isoforms in 11 leukemic cell lines and adult acute lymphoblastic leukemia cells from 36 patients with B-precursor acute lymphoblastic leukemia (pre-B ALL) and nine with T-precursor acute lymphoblastic leukemia (pre-T A 12094252 Human
ikaros all When INC and primary pre-B ALL cells that express Ik-6 alone were irradiated and cultured in the absence of serum, these cells produced functional Ikaros isoforms, Ik-1 and Ik-2. 12094252 Human
ikaros all In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). 12648068 Human
ikaros all Overexpression of DN Ikaros isoforms has been reported in some forms of leukaemia, such as childhood acute myelomonocytic and monocytic leukaemias, adult B-cell acute lymphoblastic leukaemias (B ALL) and in childhood and adult pre-B ALL. 15015965 Human
ikaros all The present study analyzed the expression of the following 13 TFs: AML1, CEBPA, E2A, ETS1, GATA1, GATA2, GATA3, IKAROS, IRF1, PAX5, PU1, TBET and TCF1 in 7 malignant NK-cell lines together with 5 malignant NKT-cell lines, 5 T-cell acute lymphoblastic leuk 15369140 Human
ik-1 leukemia In this report, we investigated Ikaros isoforms in human non-lymphoid leukemia cell lines and normal granulocyte/macrophage (CFU-GM) and erythroid (BFU-E)-derived colonies.We evaluated Ikaros gene expression by RT-PCR, Southern blotting, sequencing analys 11063871 Human
ik-1 all When INC and primary pre-B ALL cells that express Ik-6 alone were irradiated and cultured in the absence of serum, these cells produced functional Ikaros isoforms, Ik-1 and Ik-2. 12094252 Human
ikaros lymphoblastic leukemia BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. 16205638 Human
ikaros lymphoblastic leukemia Consistent with this, BCR-ABL1+ pre-B lymphoblastic leukemia cells exhibit defective expression of IKAROS, a transcription factor needed for early lymphoid lineage commitment. 16205638 Human
ikaros lymphoblastic leukemia Therefore, we propose that BCR-ABL1 induces aberrant splicing of IKAROS, which interferes with lineage identity and differentiation of pre-B lymphoblastic leukemia cells. 16205638 Human
ikaros tumor Recent studies raise the possibility that Ctip may itself be a tumor susceptibility gene and suggest that it might be important for the activities of tumor suppressors BRCA1, pRb family proteins and Ikaros family members. 16249056 Human
ikaros tumor The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. 16354692 Human
ikaros thymic lymphomas Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. 16354692 Mouse
ikaros tumor Strikingly, restoration of Ikaros activity in tumor cells leads to a rapid and specific downregulation of Notch target gene expression and proliferation arrest. 16354692 Mouse
ikaros choriocarcinoma In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, 16364975 Human
ikaros all EXPERIMENTAL DESIGN: RNAs from 18 ALL lymphoblast specimens and 10 nonobese diabetic/severe combined immunodeficient ALL xenografts were assayed by real-time reverse transcription-PCR for hRFC-A1/A2 and hRFC-B transcripts and for transcripts encoding USF1 16428507 Human
ikaros leukemogenesis These results implicate the expression of dominant-negative Ikaros isoforms and the disruption of normal Ikaros function in the leukemogenesis of ALL in infants. 9892693 Human
ikaros lymphoma Reverse transcription-PCR was used to determine the relative expression levels of Ikaros isoforms in a panel of human leukemia/lymphoma cell lines and human bone marrow samples from patients with hematological malignancies. 10463586 Human
ikaros leukemogenesis The Ikaros gene (symbol ZNFN1A1) encodes the hematopoietic zinc finger DNA binding protein, which is now recognized as a central regulator of lymphoid differentiation and has been implicated in leukemogenesis. 10552935 Human
ikaros oncogenic Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia. 10577847 Human
ikaros oncogenic Interestingly, to this region the mouse Ikaros gene was mapped which was postulated to participate in oncogenic process from the study of Ikaros knockout mice. 10597273 Mouse
ikaros lymphoid leukemia In this report, we investigated Ikaros isoforms in human non-lymphoid leukemia cell lines and normal granulocyte/macrophage (CFU-GM) and erythroid (BFU-E)-derived colonies.We evaluated Ikaros gene expression by RT-PCR, Southern blotting, sequencing analys 11063871 Human
ikaros lymphomagenesis Here we test whether Helios and Aiolos, two other members of the Ikaros gene family, are also involved in lymphomagenesis. 11173542 Human
ikaros tumor Our results suggest inactivation of Ikaros in a subset of chemically induced lymphomas and additionally support the contention of tumor-suppressor activity for Ikaros. 11980663 Human
ikaros leukemogenesis Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. 12842084 Mouse
ikaros t-cell lymphomas Altered expression of Tfg and Dap3 in Ikaros-defective T-cell lymphomas induced by X-irradiation in B6C3F1 mice. 14687027 Human
ikaros lymphomagenesis These results suggest that Tfg and Dap3 function downstream of Ikaros and may be involved in radiation-induced lymphomagenesis. 14687027 Mouse
ikaros lymphomagenesis (3) A marked difference was noted in the frequency of allelic loss at the Ikaros gene on chromosome 11, encoding a transcription factor required for normal lymphocyte development and differentiation; 2% in the lymphomas of Trp53-/- mice and 78% in the rad 15658891 Mouse
ikaros human leukemia To investigate the roles of TFs in human B-cell precursors (BCPs), the present study analyzed the expression of the following 16 hematopoietic TFs: AML1, C/EBPalpha, C/EBPbeta, C/EBPgamma, C/EBPepsilon, E2A, Ets-1, GATA-1, GATA-2, GATA-3, Ikaros, IRF-1, P 15927679 Human
ikaros leukemogenesis Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. 16354692 Mouse
ikaros tumor Thus, Ikaros-mediated repression of Notch target gene expression may play a critical role in defining the tumor suppressor function of this factor. 16354692 Human
ikaros lymphoma In particular, the expression levels of the Pten, Top3b, and Ikaros genes were downregulated in both lymphoma groups, but the expression level of Ercc4 was downregulated only in the MNU group. 16616109 Human
ikaros leukemogenesis [Notch activation during T-cell leukemogenesis in Ikaros-deficient mice] 16962043 Mouse
ik-1 lymphoid leukemia In this report, we investigated Ikaros isoforms in human non-lymphoid leukemia cell lines and normal granulocyte/macrophage (CFU-GM) and erythroid (BFU-E)-derived colonies.We evaluated Ikaros gene expression by RT-PCR, Southern blotting, sequencing analys 11063871 Human
znfn1a1 leukemogenesis The Ikaros gene (symbol ZNFN1A1) encodes the hematopoietic zinc finger DNA binding protein, which is now recognized as a central regulator of lymphoid differentiation and has been implicated in leukemogenesis. 10552935 Human
znfn1a1 lymphoid malignancy We hypothesize that constitutional deletion of the ZNFN1A1 gene in this patient may have resulted in an increased risk of lymphoid malignancy. 15390181 Human
ikaros lymphomagenesis Ikaros is a mutational target for lymphomagenesis in Mlh1-deficient mice. 17086208 Mouse
ikaros t-cell lymphomas Here we identified Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation, as a mutational target in spontaneous and radiation-induced T-cell lymphomas in Mlh1-deficient mice. 17086208 Mouse
ikaros lymphomas Three quarters of lymphomas lacked Ikaros protein expression, which resulted from a frameshift mutation that created a stop codon. 17086208 Mouse
ikaros lymphomas In total, 85% of the lymphomas showed aberrations in Ikaros. 17086208 Mouse
ikaros lymphomagenesis This is the first report of Ikaros mutations coupled with Mlh1 deficiency in lymphomagenesis. 17086208 Mouse
ikaros thymic lymphomas Thus, clonal growth and DNA changes at Bcl11b, Ikaros, Pten, Notch1 and Myc were examined in not only thymic lymphomas but also in atrophic thymuses at various times after irradiation. 17325664 Mouse
ikaros lymphomas Loss of heterozygosity (LOH) at Bcl11b and trisomy of Myc were found at high frequencies in both lymphomas and atrophic thymuses, and in contrast, LOH at Ikaros and Pten were rare in atrophic thymuses but prevalent in lymphomas. 17325664 Mouse
ikaros lymphomagenesis These results suggest the order of genetic changes during lymphomagenesis, Bcl11b and Myc being at the early stage; whereas Ikaros, Pten and Notch1 at the late stage. 17325664 Mouse
ikaros leukemogenesis Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre-TC 17332745 Human
ikaros leukemogenesis Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis. 17357110 Human
ikaros leukemogenesis We also show that deregulation of Ikaros activity does not rapidly result in B cell leukemogenesis as it does with 100% penetrance within the T cell lineage. 17357110 Mouse
ikaros acute lymphoblastic leukemia Recent studies have demonstrated that mouse thymic lymphomas (TL), a suitable model for the mechanistic study of human acute lymphoblastic leukemia, show frequent LOH on chromosomes 4 (p15/p16), 11 (Ikaros), 12 (Bcl11b), 19 (Pten), and X. 17981208 Human
ikaros thymic lymphomas Recent studies have demonstrated that mouse thymic lymphomas (TL), a suitable model for the mechanistic study of human acute lymphoblastic leukemia, show frequent LOH on chromosomes 4 (p15/p16), 11 (Ikaros), 12 (Bcl11b), 19 (Pten), and X. 17981208 Mouse
ikaros cell leukemia Notch and Ikaros: not only converging players in T cell leukemia. 18032925 Human
ikaros leukemogenesis It has been suggested that increased expression of non DNA-binding Ikaros isoforms and constitutively activated Notch play a cooperative role in leukemogenesis, converging on the transcriptional regulation of one or more key genes. 18032925 Human
ikaros leukemogenesis We recently suggested that pre-TCR is the missing link between Notch and Ikaros in T cell leukemogenesis. 18032925 Human
ikaros leukemogenesis Our findings may help in clarifying the regulatory mechanism of Ikaros alternative splicing and suggest a crosstalk among Notch3, pre-TCR signalling and spliced Ikaros variants in T cell leukemogenesis, mediated by HuD. 18032925 Human
ikaros leukemia Interestingly, Ikaros is required for normal development of lymphocytes, and aberrant expression of Ikaros has been found in leukemia. 18037964 Human
ikaros leukemias In a murine model, the expression of a dominant negative isoform of Ikaros causes leukemias and lymphomas. 18037964 Mouse
ikaros lymphomas In a murine model, the expression of a dominant negative isoform of Ikaros causes leukemias and lymphomas. 18037964 Mouse
ikaros leukemias These results suggest that CALM/AF10 might interfere with normal Ikaros function, and thereby block lymphoid differentiation in CALM/AF10 positive leukemias. 18037964 Human
ikaros leukemia Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation. 18287091 Human
ikaros leukemogenesis Deregulation of Ikaros and Notch activities cooperate to promote T cell leukemogenesis, providing evidence that they function in converging pathways in developing T cells. 18287091 Human
ikaros leukemia In this report, a mechanism for Ikaros:Notch cooperativity is described, revealing a non-redundant role for Ikaros in regulating expression of the Notch target gene Hes1 in a leukemia T cell line. 18287091 Human
ikaros non-hodgkin lymphoma Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. 18332232 Human
ikaros tumors Furthermore, the loss of heterozygosity analyses of tumors in F(1) mice indicated that allelic losses at Ikaros and Bcl11b were caused primarily by multilocus deletions, whereas those at the Cdkn2a/Cdkn2b and Pten loci were due mainly to uniparental disom 18363431 Mouse
ikaros lymphoblastic leukaemia BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. 18408710 Human
ikaros all IKZF1 (encoding the transcription factor Ikaros) was deleted in 83.7% of BCR-ABL1 ALL, but not in chronic-phase CML. 18408710 Human
ikaros cml IKZF1 (encoding the transcription factor Ikaros) was deleted in 83.7% of BCR-ABL1 ALL, but not in chronic-phase CML. 18408710 Human
ikaros all These findings suggest that genetic lesions resulting in the loss of Ikaros function are an important event in the development of BCR-ABL1 ALL. 18408710 Human
ikaros acute leukemia Ikaros and acute leukemia. 18464105 Human
ikaros lymphoid malignancies Mice transgenic for the Ikaros dominant negative (DN) mutation rapidly develop lymphoid malignancies. 18464116 Mouse
ikaros leukemogenesis Various human leukemias have also been reported to express Ikaros DN isoforms, but its role in leukemogenesis is yet to be defined. 18464116 Human
ikaros human leukemias Various human leukemias have also been reported to express Ikaros DN isoforms, but its role in leukemogenesis is yet to be defined. 18464116 Human
ikaros cancers These findings expand the repertoire of Ikaros actions to include regulation of the cholesterol uptake metabolic pathway with therapeutic implications for lipid-modifying drugs in Ikaros-associated cancers. 18483254 Human
ikaros myeloid leukemias Deletions of the CDKN2A/B tumor suppressor locus and of the IKAROS and PAX5 genes that promote B-lineage development occur frequently in lymphoid, but not myeloid leukemias initiated by the BCR-ABL tyrosine kinase. 18519632 Human
ikaros leukaemias Overexpression of the dominant negative Ikaros splice isoform, Ik6, is found in many human cancers particularly leukaemias. 18623087 Human
ikaros cancers Overexpression of the dominant negative Ikaros splice isoform, Ik6, is found in many human cancers particularly leukaemias. 18623087 Human
ikaros tumor We also discuss the interactions between Notch and the tumor suppressors Ikaros and p53. 18758476 Human
ikaros neoplasm Loss of Ikaros, a direct repressor of Notch target genes, and suppression of p53-mediated apoptosis are essential for development of this neoplasm. 18758476 Human
ikzf1 all IKZF1 (encoding the transcription factor Ikaros) was deleted in 83.7% of BCR-ABL1 ALL, but not in chronic-phase CML. 18408710 Human
ikzf1 cml IKZF1 (encoding the transcription factor Ikaros) was deleted in 83.7% of BCR-ABL1 ALL, but not in chronic-phase CML. 18408710 Human
ikzf1 all Deletion of IKZF1 was also identified as an acquired lesion at the time of transformation of CML to ALL (lymphoid blast crisis). 18408710 Human
ikzf1 cml Deletion of IKZF1 was also identified as an acquired lesion at the time of transformation of CML to ALL (lymphoid blast crisis). 18408710 Human
ikzf1 blast crisis Deletion of IKZF1 was also identified as an acquired lesion at the time of transformation of CML to ALL (lymphoid blast crisis). 18408710 Human

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