IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GRB10 Ensembl ENSG00000106070 Chromosome 7 Start 50625259 End 50828652
Description Growth factor receptor-bound protein 10 (GRB10 adapter protein)(Insulin receptor-binding protein Grb-IR) [Source:UniProtKB/Swiss-Prot;Acc:Q13322]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 4564
     Entrez Gene : 2887
     UCSC : uc003tpi.2
     GeneCards : 4564
     RefSeq : NM_001001549
     CCDS : CCDS43582.1
     Uniprot : Q92907
     Interpro : Q92907
     OMIM : 601523
     GeneTests : GRB10
     CGAP : GRB10

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37615_at  -0.06  6.38e-1  7.25e-1  0.10  5.04e-1  6.05e-1
 HG_U133A  209409_at  -0.27  2.26e-3  3.91e-3  -0.54  1.69e-13  2.24e-13
 HG_U133A  209410_s_at  0.30  3.60e-6  8.77e-6  -0.35  4.09e-5  4.70e-5
 HG_U133A  210999_s_at  0.47  4.25e-6  1.03e-5  2.39  6.53e-80  2.64e-79
 HG_U133A  215248_at  0.03  8.49e-1  8.72e-1  1.25  5.51e-23  8.35e-23
 HG_U133_Plus2  209409_at  0.10  3.69e-1  4.59e-1  0.09  3.91e-1  4.53e-1
 HG_U133_Plus2  209410_s_at  0.24  2.12e-2  3.97e-2  0.61  3.69e-7  1.15e-6
 HG_U133_Plus2  210999_s_at  0.12  3.29e-1  4.18e-1  0.26  7.01e-2  9.73e-2
 HG_U133_Plus2  215248_at  -0.71  7.68e-5  2.49e-4  -0.85  6.24e-8  2.13e-7
 Stanford  23495  0.34  3.99e-1  5.95e-1  0.27  4.16e-1  6.48e-1
 Agilent_HS_21.6K  10625  0.17  2.07e-5  3.21e-4  0.16  3.34e-4  2.18e-3
 Agilent_HS_21.6K  15629  -0.06  6.52e-1  7.90e-1  0.03  8.64e-1  9.18e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209409_at  0.11  7.34e-1  9.73e-1  -0.04  8.53e-1  1.00e+0
 HG_U133A  209410_s_at  -0.10  7.12e-1  9.69e-1  0.19  1.72e-1  1.00e+0
 HG_U133A  210999_s_at  -0.15  6.56e-1  9.61e-1  0.09  7.13e-1  1.00e+0
 HG_U133A  215248_at  -0.77  1.73e-1  8.17e-1  0.48  2.14e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37615_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209409_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209410_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210999_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215248_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209409_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209410_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210999_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215248_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23495    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10625    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15629    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
grb10 retinoblastoma These included the following: Grb10, a growth factor receptor binding protein; eps15, a growth factor receptor substrate; nuc2+, a retinoblastoma protein binding protein; cdc25B, a cell cycle tyrosine phosphatase; the peroxisome proliferator-activated rec 11121581 Rat
grb10 hepatoma We show in Huh-7 hepatoma cells that Grb10 and GHR associate under GH stimulation. 9632636 Human
grb10 tumor Tumor suppressor genes TP53 and CDKN2A were downregulated and protooncogenes JUN and GRB10 were upregulated. 14553942 Human
irbp retinal tumors METHODS: The 661W cells were cloned from retinal tumors of a transgenic mouse line that expresses the simian virus (SV) 40 T antigen under control of the human interphotoreceptor retinol-binding protein (IRBP) promoter. 14985288 NA
rss plasma cell dyscrasia We have studied 30 patients with plasma cell dyscrasia (PCD) by both methods and concluded that RSS is clearly superior to RIBS in PCD. 6219530 NA

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