IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NR4A3 Ensembl ENSG00000119508 Chromosome 9 Start 101623958 End 101668994
Description Nuclear receptor subfamily 4 group A member 3 (Nuclear hormone receptor NOR-1)(Neuron-derived orphan receptor 1)(Mitogen-induced nuclear orphan receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q92570]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7982
     Entrez Gene : 8013
     UCSC : uc004bai.2
     GeneCards : 7982
     RefSeq : NM_006981
     CCDS : CCDS6742.1
     Uniprot : Q9UEK3
     Interpro : Q9UEK3
     OMIM : 600542
     GeneTests : NR4A3
     CGAP : NR4A3
     PMID : 8614405

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  190_at  -1.35  8.70e-8  7.24e-7  -1.83  3.90e-6  2.16e-5
 HG_U95  40659_at  -1.11  6.98e-7  4.77e-6  -1.45  4.29e-6  2.35e-5
 HG_U95  40660_at  0.46  6.03e-2  1.08e-1  0.31  3.89e-1  4.95e-1
 HG_U95  40661_at  -0.88  5.96e-5  2.58e-4  -1.39  6.90e-5  2.85e-4
 HG_U95  40662_g_at  -1.03  6.48e-5  2.77e-4  -1.60  5.82e-4  1.92e-3
 HG_U133A  207978_s_at  -0.84  1.57e-12  6.98e-12  -2.31  1.77e-46  3.80e-46
 HG_U133A  209959_at  -2.42  2.17e-29  3.23e-28  -2.38  1.49e-29  2.48e-29
 HG_U133A  216979_at  -0.04  6.26e-1  6.71e-1  6.52  1.27e-175  1.31e-173
 HG_U133_Plus2  207978_s_at  -1.66  5.40e-13  5.74e-12  -1.92  3.47e-14  2.48e-13
 HG_U133_Plus2  209959_at  -3.08  8.06e-30  5.51e-28  -3.69  2.64e-31  1.42e-29
 HG_U133_Plus2  216979_at  0.30  5.71e-2  9.45e-2  0.20  2.04e-1  2.56e-1
 Stanford  1533  1.00  1.04e-3  1.50e-2  0.47  4.01e-1  6.36e-1
 Agilent_HS_21.6K  13783  -0.08  2.35e-2  8.55e-2  -0.08  7.81e-2  1.72e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207978_s_at  0.76  6.44e-2  7.28e-1  0.17  6.44e-1  1.00e+0
 HG_U133A  209959_at  0.57  3.45e-1  8.87e-1  0.34  3.57e-1  1.00e+0
 HG_U133A  216979_at  -0.01  9.71e-1  9.99e-1  -0.07  7.35e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 190_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40659_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40660_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40661_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 40662_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207978_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209959_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216979_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207978_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209959_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216979_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1533    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13783    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tec tumors The EWS/TEC fusion protein encoded by the t(9:22) chromosomal translocation in human extraskeletal myxoid chondrosarcoma tumors is thought to participate in the tumoral process at least in part by deregulating the expression of specific target genes invol 12049818 Human
tec extraskeletal myxoid chondrosarcoma The EWS/TEC fusion protein encoded by the t(9:22) chromosomal translocation in human extraskeletal myxoid chondrosarcoma tumors is thought to participate in the tumoral process at least in part by deregulating the expression of specific target genes invol 12049818 Human
tec chondrosarcoma These results suggest that EWS/TEC interacts at least in part with the same transcriptional coactivators as the native TEC receptor, and that these coactivators may be involved in the tumoral process leading to human chondrosarcoma tumors. 12049818 Human
tec tumors These results suggest that EWS/TEC interacts at least in part with the same transcriptional coactivators as the native TEC receptor, and that these coactivators may be involved in the tumoral process leading to human chondrosarcoma tumors. 12049818 Human
chn extraskeletal myxoid chondrosarcoma Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. 12378528 Human
chn neoplasm Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion genes, respectively. 12378528 Human
chn extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion genes, respectively. 12378528 Human
chn tumors The most frequent EWS/CHN transcript (type 1; 10 tumors), involved fusion of EWS exon 12 with CHN exon 3, and the second most common (type 5; two cases) was fusion of EWS exon 13 with CHN exon 3. 12378528 Human
chn tumors In all tumors with RBP56/CHN fusion, exon 6 of RBP56 was fused to exon 3 of CHN. 12378528 Human
tec extraskeletal myxoid chondrosarcoma Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). 11156374 Human
tec extraskeletal myxoid chondrosarcoma Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. 10537274 Human
chn extraskeletal myxoid chondrosarcoma Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. 10602520 Human
tec cancers In many human cancers, the N-terminal portion of hTAF(II)68, EWS, or TLS is fused to the DNA binding domain of one of several transcription factors including Fli-1, ERG, ETV1, E1AF, WT1, ATF-1, CHOP, or TEC. 15094065 Human
nor1 extraskeletal myxoid chondrosarcoma In extraskeletal myxoid chondrosarcoma, chromosomal translocation creates a gene fusion between EWS and the orphan nuclear receptor NOR1. 11673470 Human
chn skeletal myxoid chondrosarcoma Skeletal myxoid chondrosarcoma is a histologic variant of conventional skeletal myxoid chondrosarcoma, whereas extraskeletal myxoid chondrosarcoma is a distinct entity characterized by a reciprocal t(9;22) translocation resulting in fusion of the EWS and 10410173 Human
chn extraskeletal myxoid chondrosarcoma Skeletal myxoid chondrosarcoma is a histologic variant of conventional skeletal myxoid chondrosarcoma, whereas extraskeletal myxoid chondrosarcoma is a distinct entity characterized by a reciprocal t(9;22) translocation resulting in fusion of the EWS and 10410173 Human
chn low-grade sarcoma It was initially thought to be a low grade sarcoma of cartilage derivation and was recently found, in most cases, to contain a reciprocal t(9;22), resulting in a fusion of the EWS and CHN genes. 9781944 Human
nor1 nasopharyngeal carcinoma Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line. 12819961 Human
chn myxoid chondrosarcoma Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. 8570200 Human
chn skeletal myxoid chondrosarcoma In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-31, in a skeletal myxoid chondrosarcoma. 8570200 Human
chn myxoid chondrosarcomas Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). 10602519 Human
chn myxoid chondrosarcomas A proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. 10602520 Human
chn extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is characterized by recurrent chromosomal translocations resulting in fusions of the nuclear receptor gene NOR1 (also known as CHN or TEC) to various N-terminal partners, including EWS and TAF2N (or RBP56). 15188455 Human
nor-1 human neuroblastoma Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines. 7553599 Human
nor-1 human neuroblastoma In the present study, we examined the gene expression of NOR-1 as well as NGFI-B and NURR1 in human neuroblastoma cell lines by reverse transcription-polymerase chain reaction and nucleotide sequencing. 7553599 Human
nor-1 tumor This is the first demonstration of NOR-1 gene expression in tumor cell lines. 7553599 Human
nor-1 breast cancer Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7. 9070291 Human
nor-1 human breast cancer Early induction of the orphan nuclear receptor NOR-1 during cell death of the human breast cancer cell line MCF-7. 10854708 Human
nor-1 human breast cancer Here, we examined the regulation and expression of the NOR-1 gene during cell death induced by a calcium ionophore A23187 in the human breast cancer cell line MCF-7. 10854708 Human
nor-1 neuroblastoma Nurr1, NGFI-B and NOR-1 mRNA were coexpressed in all human neural and nonneural cell lines under the serum-containing culture condition, except for SK-N-SH neuroblastoma, in which Nurr1 mRNA was undetectable. 12564761 Human
nor-1 myxoid chondrosarcomas The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. 12543801 Human
nor-1 tumors NOR-1 is normally involved in the balance between cell proliferation and cell death, and is implicated in oncogenesis as part of the EWS/NOR-1 fusion protein found in human extraskeletal myxoid chondrosarcoma (EMC) tumors. 12543801 Human
nor-1 extraskeletal myxoid chondrosarcoma NOR-1 is normally involved in the balance between cell proliferation and cell death, and is implicated in oncogenesis as part of the EWS/NOR-1 fusion protein found in human extraskeletal myxoid chondrosarcoma (EMC) tumors. 12543801 Human
nor-1 tumors Reverse transcription-PCR analyses indicate that EMC tumors expressing the EWS/NOR-1 mRNA also express mRNAs encoding NOR-1 and Six3. 12543801 Human
nor-1 chondrosarcomas The NOR-1 subfamily (NR4), composed also of Nurr1 and Nurr77, has been implicated in cell proliferation, differentiation, apoptosis, chondrosarcomas, inflammation, and atherogenesis. 15358368 Human
nor-1 cancer The NR4A1-3 (Nur77, NURR1 and NOR-1) subfamily of nuclear hormone receptors (NRs) has been implicated in Parkinson's disease, schizophrenia, manic depression, atherogenesis, Alzheimer's disease, rheumatoid arthritis, cancer and apoptosis. 15956351 Human
nor1 extraskeletal myxoid chondrosarcoma TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. 15188455 Human
nor1 extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is characterized by recurrent chromosomal translocations resulting in fusions of the nuclear receptor gene NOR1 (also known as CHN or TEC) to various N-terminal partners, including EWS and TAF2N (or RBP56). 15188455 Human
nor1 myxoid chondrosarcomas Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes. 15262426 Human
nor1 extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
nor1 mesenchymal tumor Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
nor1 tumors Fourteen tumors with detectable NR4A3 fusion genes (EWSR1-NR4A3; TAF15-NR4A3) expressed neither native NOR1 nor SIX3. 15262426 Human
nor1 tumors In approximately 70% of human extraskeletal myxoid chondrosarcoma (EMC) tumors, a t(9;22) chromosome translocation gives rise to a fusion protein, named EWS/NOR1, containing the amino-terminal domain of EWS fused to the complete amino acid sequence of the 16112421 Human
nor1 extraskeletal myxoid chondrosarcoma In approximately 70% of human extraskeletal myxoid chondrosarcoma (EMC) tumors, a t(9;22) chromosome translocation gives rise to a fusion protein, named EWS/NOR1, containing the amino-terminal domain of EWS fused to the complete amino acid sequence of the 16112421 Human
nor1 extraskeletal myxoid chondrosarcoma Modulation of NOR1 function would be therapeutic potential for diseases related to dysfunction of NOR1, including extraskeletal myxoid chondrosarcoma and autoimmune diseases. 16141523 Human
nr4a3 myxoid chondrosarcomas Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes. 15262426 Human
nr4a3 extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
nr4a3 mesenchymal tumor Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
nr4a3 tumors Fourteen tumors with detectable NR4A3 fusion genes (EWSR1-NR4A3; TAF15-NR4A3) expressed neither native NOR1 nor SIX3. 15262426 Human
tec myxoid chondrosarcomas Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent t(9;22) or t(9;17) translocations resulting in fusions of the NH2-terminal transactivation domains of EWS or TAF2N to the entire TEC protein. 11156374 Human
tec chondrosarcomas The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. 10359536 Human
tec myxoid chondrosarcomas The EWS/TEC gene fusion generated by the t(9;22) chromosomal translocation found in extraskeletal myxoid chondrosarcomas encodes a fusion protein containing the amino-terminal domain of the EWS protein fused to the whole coding sequence of the orphan nucl 10359536 Human
tec myxoid chondrosarcomas Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent chromosome translocations resulting in fusions of the nuclear receptor TEC to various NH(2)-terminal partners. 12598313 Human
tec extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is characterized by recurrent chromosomal translocations resulting in fusions of the nuclear receptor gene NOR1 (also known as CHN or TEC) to various N-terminal partners, including EWS and TAF2N (or RBP56). 15188455 Human
the tec gene myxoid chondrosarcomas Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by a recurrent t(9;22)(q22;q12) translocation, resulting in the fusion of the EWS gene in 22q12 and the TEC gene in 9q22. 10537274 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.