IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ZNF189 Ensembl ENSG00000136870 Chromosome 9 Start 103200976 End 103212763
Description Zinc finger protein 189 [Source:UniProtKB/Swiss-Prot;Acc:O75820]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12980
     Entrez Gene : 7743
     UCSC : uc004bbh.1
     GeneCards : 12980
     RefSeq : NM_003452
     CCDS : CCDS6754.1
     Uniprot : O75820
     Interpro : O75820
     OMIM : 603132
     GeneTests : ZNF189
     CGAP : ZNF189
     PMID : 9653648

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36072_at  -0.15  7.00e-2  1.22e-1  -0.45  1.97e-3  5.61e-3
 HG_U133A  207513_s_at  -0.38  2.10e-8  6.40e-8  -0.44  8.64e-14  1.15e-13
 HG_U133_Plus2  207513_s_at  -0.24  8.50e-4  2.24e-3  -0.35  5.55e-5  1.28e-4
 Stanford  10350  -0.06  7.84e-1  8.80e-1  0.15  6.31e-1  8.06e-1
 Agilent_HS_21.6K  795  0.02  4.01e-1  5.88e-1  0.02  5.27e-1  6.71e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207513_s_at  -0.02  9.38e-1  9.97e-1  0.20  3.20e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36072_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207513_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207513_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10350    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 795    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
znf189 bladder cancer The chromosome 9q genes TGFBR1, TSC1, and ZNF189 are rarely mutated in bladder cancer. 11329144 Human
znf189 bladder cancer Mutation analysis of the ZNF189 gene in bladder cancer cell lines identified one amino acid substitution (lysine-->isoleucine) at position 323 in exon 4. 11329144 Human
znf189 basal cell cancer In that study we found no mutations in the coding sequence when using ZNF189 as a candidate gene for sporadic basal cell cancer and squamous cell cancer. 10415338 Human
znf189 squamous-cell cancer In that study we found no mutations in the coding sequence when using ZNF189 as a candidate gene for sporadic basal cell cancer and squamous cell cancer. 10415338 Human
znf189 tumour Here, by direct sequencing of the proximal promotor of ZNF189, mutations were found to appear in a small hot-spot region in over 50% of analysed tumour samples, the majority being G to A substitutions. 10415338 Human
znf189 sporadic basal cell carcinoma Direct sequencing of the ZNF189 gene in microdissected tumor biopsies of sporadic basal cell carcinoma and squamous cell carcinoma reveals no mutations in the coding sequence or at exon/intron boundaries. 9653648 Human
znf189 tumor Direct sequencing of the ZNF189 gene in microdissected tumor biopsies of sporadic basal cell carcinoma and squamous cell carcinoma reveals no mutations in the coding sequence or at exon/intron boundaries. 9653648 Human
znf189 squamous-cell carcinoma Direct sequencing of the ZNF189 gene in microdissected tumor biopsies of sporadic basal cell carcinoma and squamous cell carcinoma reveals no mutations in the coding sequence or at exon/intron boundaries. 9653648 Human
znf189 bladder tumour This study assessed a series of bladder tumours and bladder tumour cell lines for sequence variation in the Krüppel-like zinc finger gene ZNF189, the tuberous sclerosis complex gene 1 (TSC1), and the TGF beta receptor type I (TGFBR1). 11329144 Human
znf189 bladder tumours This study assessed a series of bladder tumours and bladder tumour cell lines for sequence variation in the Krüppel-like zinc finger gene ZNF189, the tuberous sclerosis complex gene 1 (TSC1), and the TGF beta receptor type I (TGFBR1). 11329144 Human

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