IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ALDOB Ensembl ENSG00000136872 Chromosome 9 Start 103222681 End 103237926
Description Fructose-bisphosphate aldolase B (EC 4.1.2.13)(Liver-type aldolase) [Source:UniProtKB/Swiss-Prot;Acc:P05062]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 417
     Entrez Gene : 229
     UCSC : uc004bbk.2
     GeneCards : 417
     RefSeq : NM_000035
     CCDS : CCDS6756.1
     Uniprot : P05062
     Interpro : P05062
     OMIM : 612724
     GeneTests : ALDOB
     CGAP : ALDOB

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33455_at  -0.02  9.18e-1  9.40e-1  -0.35  1.51e-1  2.31e-1
 HG_U133A  204704_s_at  -0.32  1.03e-1  1.34e-1  5.63  1.74e-78  6.79e-78
 HG_U133A  204705_x_at  0.29  8.61e-3  1.36e-2  3.89  7.52e-90  3.90e-89
 HG_U133A  211357_s_at  0.53  4.24e-3  7.04e-3  3.43  4.33e-55  1.07e-54
 HG_U133A  214423_x_at  -0.16  6.37e-3  1.03e-2  -0.69  3.56e-22  5.33e-22
 HG_U133A  214424_s_at  -0.35  2.39e-4  4.73e-4  2.99  5.13e-82  2.18e-81
 HG_U133A  216600_x_at  -0.08  1.78e-1  2.21e-1  -0.37  1.45e-8  1.77e-8
 HG_U133A  217238_s_at  0.87  3.72e-7  1.00e-6  0.14  3.65e-1  3.75e-1
 HG_U133_Plus2  204704_s_at  -0.05  8.54e-1  8.91e-1  -0.18  5.24e-1  5.82e-1
 HG_U133_Plus2  204705_x_at  0.49  1.13e-2  2.27e-2  0.43  5.01e-3  8.60e-3
 HG_U133_Plus2  211357_s_at  0.95  8.22e-5  2.65e-4  -0.07  6.84e-1  7.31e-1
 HG_U133_Plus2  214423_x_at  0.44  1.24e-3  3.14e-3  1.05  2.68e-15  2.18e-14
 HG_U133_Plus2  214424_s_at  -0.41  2.56e-2  4.69e-2  -0.37  8.75e-2  1.19e-1
 HG_U133_Plus2  216600_x_at  0.77  3.96e-6  1.62e-5  1.68  3.31e-19  4.21e-18
 HG_U133_Plus2  217238_s_at  0.61  1.10e-2  2.22e-2  -0.17  4.40e-1  5.02e-1
 HG_U133_Plus2  241280_at  0.56  2.66e-4  7.80e-4  0.85  1.74e-6  4.96e-6
 HG_U133_Plus2  243901_at  -1.55  4.15e-12  3.94e-11  -2.26  1.35e-15  1.14e-14
 Stanford  4316  0.85  2.01e-2  1.01e-1  1.21  9.08e-4  1.31e-2
 Agilent_HS_21.6K  297  0.01  7.51e-1  8.55e-1  0.01  5.71e-1  7.07e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204704_s_at  0.34  5.06e-1  9.30e-1  -0.08  8.30e-1  1.00e+0
 HG_U133A  204705_x_at  0.07  7.55e-1  9.75e-1  0.09  6.17e-1  1.00e+0
 HG_U133A  211357_s_at  -0.31  5.26e-1  9.34e-1  -0.19  6.04e-1  1.00e+0
 HG_U133A  214423_x_at  -0.07  7.15e-1  9.71e-1  -0.04  7.55e-1  1.00e+0
 HG_U133A  214424_s_at  0.13  7.43e-1  9.74e-1  -0.10  7.07e-1  1.00e+0
 HG_U133A  216600_x_at  0.42  8.77e-2  7.61e-1  0.07  6.28e-1  1.00e+0
 HG_U133A  217238_s_at  -0.43  4.67e-1  9.21e-1  0.15  6.73e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33455_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204704_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204705_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211357_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214423_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214424_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216600_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217238_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204704_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204705_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211357_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214423_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214424_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216600_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217238_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241280_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243901_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4316    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 297    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
aldolase b primary hepatocellular carcinoma Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. 14966907 Human
aldolase b liver tumor We identified 4 genes, the expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues. 14966907 Human
aldolase b human hepatoma We report here that the degradation of recombinant aldolase B was enhanced two-fold when rat and human hepatoma cells were starved for amino acid and serum. 11241348 Human
aldolase b malignant tumors Decreased serum aldolase B levels in patients with malignant tumors. 3191454 Human
aldolase b malignant tumors Serum aldolase B levels were determined in patients with malignant tumors using a radioimmunoassay method. 3191454 Human
aldolase b malignant tumors Thirty-one of 52 patients with malignant tumors had decreased serum aldolase B levels of less than 20 ng/ml, whereas almost all of the normal subjects and the patients with liver diseases and other benign diseases showed serum aldolase B levels of more th 3191454 Human
aldolase b cancer The decreased aldolase B levels observed in cancer patients were unrelated to the clinical stage of their disease. 3191454 Human
aldolase b cancer The decrease of aldolase B correlated well with the decrease of fructose-1-phosphate (F1P)-aldolase activity, but not with fructose-1,6-diphosphate (FDP)-aldolase activity in the sera of cancer patients. 3191454 Human
aldolase b cancer Mixing experiments did not identify an inhibitor of aldolase B in sera of cancer patients. 3191454 Human
aldolase b cancer Furthermore, recovery of serum aldolase B levels after successful surgical resection in cancer patients suggested that the low levels of aldolase B in sera of cancer patients was not of genetic origin. 3191454 Human
aldolase b cancer The mechanism responsible for the decrease of aldolase B in sera of cancer patients is unclear. 3191454 Human
aldolase b hepatoma Transcription promoter of the aldolase B gene was previously shown to be centered on an initiation region of DNA replication in rat hepatoma cells in vivo. 9299431 Rat
aldolase b hepatoma Since transcription of the aldolase B gene is repressed in the hepatoma cells, the cell cycle-regulated protein-binding is considered to be involved in regulation of replication initiation. 9299431 Rat
aldolase b tumour Twenty-four hamster-sheep hybrid cell lines representing eleven ovine synteny groups were used to make syntenic assignments for seven loci ALDOB (aldolase B, fructose biophosphate); AMH (anti-Müllerian hormone); CYP19 [cytochrome P450 aromatase, subfamil 7486251 Human
aldolase b malignant hepatoma At the terminal stage of hepatocarcinogenesis, i.e. in malignant hepatoma cells, expression and inducibility of aldolase B and L-type pyruvate kinase mRNAs were similar to those in normal adult rats while mRNAs specific for undifferentiated or foetal stag 2410270 Rat
aldolase b primary liver cell carcinoma In cancer patients, serum aldolase B was slightly elevated in 15 of 26 (58%) patients with cancer metastatic to the liver or primary liver cell carcinoma, whereas no elevation of serum aldolase B was observed in 16 cancer patients without liver metastasis 6724519 Human
aldolase b cancer In cancer patients, serum aldolase B was slightly elevated in 15 of 26 (58%) patients with cancer metastatic to the liver or primary liver cell carcinoma, whereas no elevation of serum aldolase B was observed in 16 cancer patients without liver metastasis 6724519 Human
aldolase b liver metastasis In cancer patients, serum aldolase B was slightly elevated in 15 of 26 (58%) patients with cancer metastatic to the liver or primary liver cell carcinoma, whereas no elevation of serum aldolase B was observed in 16 cancer patients without liver metastasis 6724519 Human
aldolase b metastatic liver cancer In cancer patients, serum aldolase B was slightly elevated in patients with metastatic liver cancer and primary lever cell carcinoma, whereas no elevation of serum aldolase B was shown in patients without liver metastasis. 6828389 Human
aldolase b cancer In cancer patients, serum aldolase B was slightly elevated in patients with metastatic liver cancer and primary lever cell carcinoma, whereas no elevation of serum aldolase B was shown in patients without liver metastasis. 6828389 Human
aldolase b liver metastasis In cancer patients, serum aldolase B was slightly elevated in patients with metastatic liver cancer and primary lever cell carcinoma, whereas no elevation of serum aldolase B was shown in patients without liver metastasis. 6828389 Human
aldolase-b hepatoma Faza 967 cell line--a clonal descendant of the Reuber H35 hepatoma--is characterized by the activity of tyrosine aminotransferase (TAT) and gluconeogenetic enzymes; secretion of serum albumin; and the presence of liver isozymes of alcohol dehydrogenase (A 6132453 Rat
aldolase b hepatoma Aldolase A was elevated in hepatoma tissue and hepatoma cell lines, where aldolase B was distinctly low. 6322658 Human
aldolase-b tumor These histological enzyme analyses suggest that most, if not all, hypernephroid carcinomas are derived from kidney proximal tubule cells and that the tumor cells then progressively lose aldolase-B, and subsequently the brush border enzymes, but at the sam 1016198 Human
aldolase-b hypernephroid carcinomas These histological enzyme analyses suggest that most, if not all, hypernephroid carcinomas are derived from kidney proximal tubule cells and that the tumor cells then progressively lose aldolase-B, and subsequently the brush border enzymes, but at the sam 1016198 Human
aldolase b tumor In the hypernephroid carcinoma cells only aldolase A could be found, but the capillaries within the tumor tissue did contain some aldolase B. 766744 Human
aldolase b hypernephroid carcinoma In the hypernephroid carcinoma cells only aldolase A could be found, but the capillaries within the tumor tissue did contain some aldolase B. 766744 Human
aldolase b hepatoma Although it contains binding sites for HNF1, NFY and C/EBP/DBP, the proximal promoter of the aldolase B gene is surprisingly weak when tested by transient transfection in differentiated hepatoma cells. 8165139 Human
aldolase b hepatoma In contrast, aldolase A was the predominant isozyme found in hepatoma and gastric cancer tissues, whereas aldolase B was distinctly low in hepatoma tissues, and extremely low in gastric cancer tissues. 8046542 Human
aldolase b gastric cancer In contrast, aldolase A was the predominant isozyme found in hepatoma and gastric cancer tissues, whereas aldolase B was distinctly low in hepatoma tissues, and extremely low in gastric cancer tissues. 8046542 Human
aldolase b cancer Serum aldolase B levels showed a trend to decrease in cancer patients with normal GPT levels. 8046542 Human
aldolase b human hepatoma Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. 8383844 Human
aldolase b tumor Immunohistochemically, aldolases A and C were found localized in all RCC tissues (n = 10); aldolase B was faintly stained in only a few tumor cells of two cases (20%). 1856954 Human
aldolase b renal-cell carcinoma These findings indicate that aldolase C was first expressed in renal cell carcinoma, which is derived from proximal renal tubules, because proximal renal tubules had aldolase B but not aldolase C. 2183586 Human
aldolase b hepatocellular carcinomas In hepatocellular carcinomas, both foetal proteins (aldolase isozymes and AFP) and adult aldolase B were present in malignant cells. 6171577 Human
aldob wilms' tumour Twenty-four hamster-sheep hybrid cell lines representing eleven ovine synteny groups were used to make syntenic assignments for seven loci ALDOB (aldolase B, fructose biophosphate); AMH (anti-Müllerian hormone); CYP19 [cytochrome P450 aromatase, subfamil 7486251 Human
aldob hcc We found 8 mRNAs underexpressed in primary HCC tissues in 20 patients in higher percentages than found in previous studies, including 18 cases (90%) for aldolase B (ALDOB), 15 cases (75%) for carbamyl phosphate synthetase 1 (CPS1), albumin (ALB), plasmino 12143053 Human
aldolase b necrosis Measurements of aldolase B serum levels by radioimmunoassay appear to be a useful measure of liver cell necrosis from benign or malignant liver diseases. 6724519 Human
aldolase b cancer Aldolase A was increased in cancer tissues of 3'-Me-DAB induced hepatoma, whereas aldolase B was decreased in the same tissues according to both RIA and the immunohistochemical technique. 2511129 Human
aldolase b hepatoma Aldolase A was increased in cancer tissues of 3'-Me-DAB induced hepatoma, whereas aldolase B was decreased in the same tissues according to both RIA and the immunohistochemical technique. 2511129 Human
aldolase b hepatoma Aldolase A was predominantly found in human hepatoma tissues, whereas aldolase B was distinctly low in the same hepatoma tissues. 7868061 Human
aldolase b human hepatoma Aldolase A was predominantly found in human hepatoma tissues, whereas aldolase B was distinctly low in the same hepatoma tissues. 7868061 Human
aldolase b human hepatoma With regard to human hepatoma cell lines, aldolase A was also predominantly found in HepG2 and PLC/PRF/5 cell lines, whereas aldolase B levels were extremely low. 7868061 Human
aldolase b hepatoma Substitution of aldolase B by aldolase AC apparantly ossurred in hepatoma 22a. 494546 Mouse
aldolase b hcc We found 8 mRNAs underexpressed in primary HCC tissues in 20 patients in higher percentages than found in previous studies, including 18 cases (90%) for aldolase B (ALDOB), 15 cases (75%) for carbamyl phosphate synthetase 1 (CPS1), albumin (ALB), plasmino 12143053 Human
aldolase b hcc The authors performed proteomic analysis of cancerous and noncancerous tissues from HCC patients with HCV infection, and determined that, in the cancerous tissues, HSP70 family proteins such as GRP78, HSC70, GRP75 and HSP70.1, glutaine synthetase isoforms 16097891 Human

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