IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RNF20 Ensembl ENSG00000155827 Chromosome 9 Start 103335954 End 103365447
Description E3 ubiquitin-protein ligase BRE1A (BRE1-A)(hBRE1)(EC 6.3.2.-)(RING finger protein 20) [Source:UniProtKB/Swiss-Prot;Acc:Q5VTR2]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10062
     Entrez Gene : 56254
     UCSC : uc004bbn.2
     GeneCards : 10062
     RefSeq : NM_019592
     CCDS : CCDS35084.1
     Uniprot : Q9HA51
     Interpro : Q9HA51
     OMIM : 607699
     GeneTests : RNF20
     CGAP : RNF20
     PMID : 16337599

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  222683_at  -0.06  2.02e-1  2.79e-1  0.30  2.34e-7  7.45e-7
 Agilent_HS_21.6K  954  -0.11  6.12e-3  3.17e-2  -0.06  1.96e-1  3.39e-1

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 222683_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 954    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rnf20 oncogenes In contrast, RNF20 suppresses the expression of several proto-oncogenes, which reside preferentially in closed chromatin and are modestly transcribed despite bearing marks usually associated with high transcription rates. 18832071 Human
rnf20 tumorigenesis Remarkably, RNF20 depletion augmented the transcriptional effects of epidermal growth factor (EGF), increased cell migration, and elicited transformation and tumorigenesis. 18832071 Human
rnf20 tumors Furthermore, frequent RNF20 promoter hypermethylation was observed in tumors. 18832071 Human

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