IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ABCA1 Ensembl ENSG00000165029 Chromosome 9 Start 106583104 End 106730257
Description ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1)(ATP-binding cassette 1)(ABC-1)(Cholesterol efflux regulatory protein) [Source:UniProtKB/Swiss-Prot;Acc:O95477]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 29
     Entrez Gene : 19
     UCSC : uc004bcl.2
     GeneCards : 29
     RefSeq : NM_005502
     CCDS : CCDS6762.1
     Uniprot : Q9UN09
     Interpro : Q9UN09
     OMIM : 600046
     GeneTests : ABCA1
     CGAP : ABCA1
     PMID : 8088782

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31998_at  -0.00  9.92e-1  9.95e-1  0.07  8.39e-1  8.86e-1
 HG_U95  31999_at  0.30  4.99e-2  9.20e-2  0.74  7.52e-4  2.41e-3
 HG_U95  32000_g_at  0.46  2.32e-7  1.76e-6  0.63  2.35e-7  1.66e-6
 HG_U133A  203504_s_at  -0.39  3.85e-7  1.04e-6  -1.48  1.12e-45  2.37e-45
 HG_U133A  203505_at  -0.85  1.12e-23  1.15e-22  -1.03  5.40e-32  9.32e-32
 HG_U133A  216066_at  0.18  1.46e-1  1.85e-1  1.91  3.28e-42  6.58e-42
 HG_U133_Plus2  1570279_at  -0.42  3.32e-2  5.88e-2  0.01  9.57e-1  9.66e-1
 HG_U133_Plus2  203504_s_at  -0.29  1.75e-2  3.36e-2  0.02  8.56e-1  8.81e-1
 HG_U133_Plus2  203505_at  -0.23  1.48e-2  2.89e-2  -0.00  9.76e-1  9.81e-1
 HG_U133_Plus2  216066_at  0.01  9.56e-1  9.69e-1  0.12  5.51e-1  6.08e-1
 Agilent_HS_21.6K  16323  -0.03  2.20e-1  3.98e-1  -0.03  4.20e-1  5.79e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203504_s_at  0.42  9.05e-2  7.65e-1  -0.38  2.80e-2  1.00e+0
 HG_U133A  203505_at  0.33  2.07e-1  8.33e-1  -0.23  2.31e-1  1.00e+0
 HG_U133A  216066_at  0.11  8.30e-1  9.86e-1  -0.00  9.95e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31998_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 31999_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 32000_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203504_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203505_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216066_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1570279_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203504_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203505_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216066_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16323    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
abca1 hepatoma To evaluate whether this effect is the result of reduction of ABCA1-dependent or -independent pathways of cholesterol efflux, in this study we examined the efflux of cholesterol to preparations of chymase-treated HDL(3) in two types of cell: 1) in J774 mu 14701812 Rat
abca1 human hepatoma Recombinant expression of a dominant negative form of FADD or the C terminus of ABCA1 in the human hepatoma cell line HepG2 markedly reduced the transfer of phospholipids to apoA-I. 12235128 Human
tangier disease werner's syndrome In addition, less common genetically determined associations like homocystinuria, Tangier disease, Hutchinson-Gilford syndrome (progeria), Werner's syndrome, radiation induced atherosclerosis and the implications of Chlamydia pneumoniae on the arteri 11228092 Human
abca1 lung adenocarcinoma RT-PCR revealed mRNA and Western blotting demonstrated protein for the ATP binding cassette A1 (ABCA1) transporter in mouse FS, TtT/GF, and A549 lung adenocarcinoma cells from which glucocorticoids also induce externalization of ANXA1. 12586783 Mouse
tangier disease xanthomas Specific entities falling within this category include Tangier disease, familial HDL deficiency with planar xanthomas, familial apolipoprotein A-I and C-III deficiency (formerly known as apolipoprotein A-I absence), familial deficiency of apolipoprotein A 6431953 Human
tangier disease xanthoma The fundamental ultrastructure of lipid storage in the xanthoma cells of various xanthomatous diseases, including familial hyperlipoproteinemia type IIa, III, and V, cerebrotendinous xanthomatosis, Wolman's disease, Tangier disease, Hand-Schüller-Ch 6650173 Human
tangier disease hand-schuller-christian disease The fundamental ultrastructure of lipid storage in the xanthoma cells of various xanthomatous diseases, including familial hyperlipoproteinemia type IIa, III, and V, cerebrotendinous xanthomatosis, Wolman's disease, Tangier disease, Hand-Schüller-Ch 6650173 Human
tangier disease juvenile xanthogranuloma The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy. 629544 Human
tangier disease dermatofibroma The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy. 629544 Human
tangier disease reticulohistiocytoma The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy. 629544 Human
tangier disease xanthoma The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy. 629544 Human
tangier disease xanthomas The role of HDL in reverse cholesterol transport and its disturbances in Tangier disease and HDL deficiency with xanthomas. 2226526 Human
abc-1 glioma Expression of ABC-1 transporter is elevated in human glioma cells under irradiation and temozolomide treatment. 15723240 Human
abc-1 glioma This study investigates an effect of both temozolomide (TMZ) treatment and/or irradiation on the expression of the ABC-1 transporter in human U87-MG glioma cells. 15723240 Human
abc-1 malignant gliomas Strong up-regulation of ABC-1 expression under both irradiation and chemo-treatment might be a clue to multidrug and irradiation cross-resistance mechanisms of malignant glioma cells converting the ABC-1 transporter into an attractive pharmacological targ 15723240 Human
abc-1 malignant glioma Strong up-regulation of ABC-1 expression under both irradiation and chemo-treatment might be a clue to multidrug and irradiation cross-resistance mechanisms of malignant glioma cells converting the ABC-1 transporter into an attractive pharmacological targ 15723240 Human
abca1 hepatocellular carcinoma We measured ABCA1, A2, B1-B4, C1 degrees C5, G1 and G2 gene expression levels in PBL, and cancerous and non-cancerous portions of liver from patients with hepatocellular carcinoma by means of real time reverse-transcription (RT)-PCR. 15182435 Human
abca1 hcc Compared with the non-tumor part, HCC tissue expressed lower levels of ABCA1, B4 and G2. 15182435 Human
abca1 hcc Administration of chemotherapeutic agents which are substrates of ABCA1, B4 and G2 should be effective for the treatment of HCC. 15182435 Human
abca1 hepatoma In this work we investigated the ability of pitavastatin to modulate ABCA1-mediated efflux from Fu5AH rat hepatoma cells, that here we demonstrate to express functional ABCA1 upon treatment with 22OH/cRA. 15358158 Rat
abca1 lncap human prostate cancer We have found that the expression of the cholesterol transporter, ATP-binding cassette transporter A1 (ABCA1), was 15- to 20-fold higher in androgen-dependent than in androgen-independent LNCaP human prostate cancer cells, indicating a possible relationsh 15520169 Human
abca1 prostate cancer We have found that the expression of the cholesterol transporter, ATP-binding cassette transporter A1 (ABCA1), was 15- to 20-fold higher in androgen-dependent than in androgen-independent LNCaP human prostate cancer cells, indicating a possible relationsh 15520169 Human
abca1 androgen-independent prostate cancer Using an ABCA1 promoter-reporter gene assay, androgenic suppression was observed at the transcriptional level in androgen-dependent but not in androgen-independent prostate cancer cells. 15520169 Human
abca1 prostate cancer Therefore, a suppressive effect of androgen on ABCA1 expression may be one of the mechanisms by which androgens regulate proliferation in prostate cancer cells. 15520169 Human
abca1 prostate cancer Attenuated ABCA1 expression in androgen-independent cells thus may contribute, in part, to prostate cancer progression. 15520169 Human
abca1 hepatoma In Fu5AH hepatoma cells that contain scavenger receptor class B, type I, but not functional ABCA1, we observed no effect of probucol on cholesterol efflux. 15514211 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.