IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TAL2 Ensembl ENSG00000186051 Chromosome 9 Start 107464559 End 107464947
Description T-cell acute lymphocytic leukemia protein 2 (TAL-2) [Source:UniProtKB/Swiss-Prot;Acc:Q16559]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11557
     Entrez Gene : 6887
     UCSC : uc004bct.2
     GeneCards : 11557
     RefSeq : NM_005421
     CCDS : CCDS6767.1
     Uniprot : Q16559
     Interpro : Q16559
     OMIM : 186855
     GeneTests : TAL2
     CGAP : TAL2
     PMID : 1763056

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  1553593_a_at  -0.02  9.25e-1  9.45e-1  -0.26  2.34e-1  2.88e-1
 HG_U133_Plus2  231759_at  0.18  1.10e-1  1.66e-1  0.18  1.32e-1  1.73e-1
 Agilent_HS_21.6K  4079  0.05  1.63e-2  6.58e-2  0.03  1.52e-1  2.81e-1

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 1553593_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 231759_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4079    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tal2 t-cell acute lymphoblastic leukaemia We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors--TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2--in 52 adults with T-cell acute lymphoblastic leukaemia. 14975618 Human
tal2 t cell acute lymphoblastic leukemia (t-all) Our data support the involvement of 2 distinct mechanisms: translocations involving LMO2, TAL2, and TAL1 in T cell acute lymphoblastic leukemia (T-ALL), are compatible with illegitimate V(D)J recombination between a TCR locus and a proto-oncogene locus be 11781368 Human
tal2 non-hodgkin's lymphomas Our data support the involvement of 2 distinct mechanisms: translocations involving LMO2, TAL2, and TAL1 in T cell acute lymphoblastic leukemia (T-ALL), are compatible with illegitimate V(D)J recombination between a TCR locus and a proto-oncogene locus be 11781368 Human
tal-2 t-cell acute lymphoblastic leukemia Four related genes have been described in mammals (LYL-1, TAL-2, NSCL1, and NSCL2), all of which exhibit a high degree of sequence similarity to SCL/TAL-1 in the bHLH domain and two of which (LYL-1 and TAL-2) have also been implicated in the pathogenesis 9503016 Human
tal2 t-cell acute lymphoblastic leukemia (t-all) The TAL2 gene is activated as a result of the (7;9) (q34;q32) translocation, a chromosome defect found in the malignant cells of some patients with T-cell acute lymphoblastic leukemia (T-ALL). 8152805 Human
tal2 t-cell acute leukaemia TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. 8142619 Human
tal-2 lymphoid tumors Five members of this family (MYC, SCL, TAL-2, LYL-1 and E2A) are implicated in oncogenic events in human lymphoid tumors because of their consistent involvement in chromosomal translocations. 1453013 Human
tal2 human t-cell leukemia TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. 1763056 Human
tal-2 t-all The cDNA sequence of SCL/tal encodes a basic helix-loop-helix (bHLH) protein with regions of marked homology to lyl-1 and tal-2, two other bHLH proteins involved in T-ALL chromosomal translocations. 1450410 Human
tal2 t-all The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. 1763056 Human
tal2 t-all TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). 1763056 Human
tal2 t-all Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL. 1763056 Human
tal2 t-all The bHLH domain of TAL1 is especially homologous to those encoded by TAL2 and LYL1, distinct genes that were also identified on the basis of chromosomal rearrangement in T-ALL. 8142619 Human
tal2 t-all TAL2 potentially encodes a basic helix-loop-helix motif that is highly related to those specified by TAL1 and LYL1, distinct genes that have also been implicated in T-ALL. 8152805 Human
tal2 t-all Taken together, the properties of TAL2 evaluated here broadly resemble those described previously for TAL1, and therefore support the idea that both proteins promote T-ALL by a common mechanism. 8152805 Human
tal2 acute leukaemia TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. 8142619 Human
tal2 t-cell acute lymphoblastic leukemia (t-all) Activation of Hox-11, Tal2/SCL-2, and Rbtn1/Ttg1 expression, which are highly associated with human T-cell acute lymphoblastic leukemia (T-ALL), was observed in three of three T-cell lymphomas with E2 expression but not E6/E7 expression, showing that path 9727621 Human
tal2 t-cell lymphomas Activation of Hox-11, Tal2/SCL-2, and Rbtn1/Ttg1 expression, which are highly associated with human T-cell acute lymphoblastic leukemia (T-ALL), was observed in three of three T-cell lymphomas with E2 expression but not E6/E7 expression, showing that path 9727621 Mouse
tal2 tumor Activation of Hox-11, Tal2/SCL-2, and Rbtn1/Ttg1 expression, which are highly associated with human T-cell acute lymphoblastic leukemia (T-ALL), was observed in three of three T-cell lymphomas with E2 expression but not E6/E7 expression, showing that path 9727621 Mouse
tal-2 malignant lymphoma In malignant lymphoma, the rearrangements of immunoglobulin and T-cell receptor genes, and new genes such as Bcl-1, Bcl-2, Bcl-5, Tal-1, and Tal-2 were also reported and rearrangements of the Bcl-5 gene were found in this study using Bcl-5 specific probe 7914242 Human
tal-2 human t-cell leukemia The leukemic oncogene tal-2 is expressed in the developing mouse brain. tal-1 (T-cell acute leukemia-1; also known as SCL) and tal-2 genes belong to a family of basic helix-loop-helix transcription factors and were originally isolated from the breakpoints 9931488 Human
tal2 oncogene Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. 8152805 Human
tal2 oncoprotein The kinetic properties of activated wild-type ERK2 and K52 mutants were examined using the oncoprotein TAL2, myelin basic protein, and a designed synthetic peptide as substrates. 8639522 Human
tal-2 oncoproteins Because this domain is shared by lyl-1 and tal-2, these latter putative T-cell oncoproteins probably use a nuclear localization mechanism identical to that of SCL/tal. 1450410 Human
tal-2 oncogenic Five members of this family (MYC, SCL, TAL-2, LYL-1 and E2A) are implicated in oncogenic events in human lymphoid tumors because of their consistent involvement in chromosomal translocations. 1453013 Human
tal2 oncogene The T cell oncogene Tal2 is necessary for normal development of the mouse brain. 11071772 Human
tal2 leukemogenesis TAL2 is a member of a basic helix-loop-helix gene family specifically involved in T cell leukemogenesis. 11071772 Human
tal2 oncogenic We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors--TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2--in 52 adults with T-cell acute lymphoblastic leukaemia. 14975618 Human
tal-2 oncogene The leukemic oncogene tal-2 is expressed in the developing mouse brain. tal-1 (T-cell acute leukemia-1; also known as SCL) and tal-2 genes belong to a family of basic helix-loop-helix transcription factors and were originally isolated from the breakpoints 9931488 Mouse

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