IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RAD23B Ensembl ENSG00000119318 Chromosome 9 Start 109085365 End 109134291
Description UV excision repair protein RAD23 homolog B (hHR23B)(XP-C repair-complementing complex 58 kDa protein)(p58) [Source:UniProtKB/Swiss-Prot;Acc:P54727]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9813
     Entrez Gene : 5887
     UCSC : uc004bde.2
     GeneCards : 9813
     RefSeq : NM_002874
     CCDS : CCDS6769.1
     Uniprot : P54727
     Interpro : P54727
     OMIM : 600062
     GeneTests : RAD23B
     CGAP : RAD23B
     PMID : 7851894

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1874_at  0.03  7.35e-1  8.07e-1  -0.08  3.36e-1  4.41e-1
 HG_U133A  201222_s_at  1.36  1.26e-39  3.38e-38  2.39  1.11e-52  2.63e-52
 HG_U133A  201223_s_at  0.25  1.37e-4  2.80e-4  1.95  3.74e-76  1.39e-75
 HG_U133A  214422_at  0.07  6.32e-1  6.77e-1  7.91  1.01e-148  3.26e-147
 HG_U133_Plus2  201222_s_at  0.23  1.73e-2  3.32e-2  0.19  7.99e-2  1.10e-1
 HG_U133_Plus2  201223_s_at  -0.15  6.58e-2  1.07e-1  -0.05  6.53e-1  7.03e-1
 HG_U133_Plus2  214422_at  -0.04  8.30e-1  8.73e-1  -0.69  1.75e-3  3.24e-3
 HG_U133_Plus2  223598_at  -0.51  4.71e-14  5.70e-13  -0.53  5.16e-11  2.56e-10
 Stanford  4511  -0.08  8.34e-1  9.09e-1  -0.17  6.66e-1  8.28e-1
 Stanford  6022  -1.50  1.63e-1  3.42e-1  -3.83  2.10e-3  2.32e-2
 Stanford  16033  0.11  7.60e-1  8.65e-1  -0.13  6.33e-1  8.08e-1
 Stanford  23490  0.45  1.41e-1  3.12e-1  0.60  4.64e-2  1.62e-1
 Agilent_HS_21.6K  20680  0.07  2.90e-1  4.77e-1  0.14  1.59e-2  5.14e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201222_s_at  -0.22  3.31e-1  8.87e-1  0.01  9.48e-1  1.00e+0
 HG_U133A  201223_s_at  -0.24  3.09e-1  8.78e-1  0.01  9.51e-1  1.00e+0
 HG_U133A  214422_at  -0.72  2.08e-1  8.34e-1  0.64  5.48e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1874_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201222_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201223_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214422_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201222_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201223_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214422_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223598_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4511    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6022    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16033    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23490    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20680    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rad23b hepatoma We found that the gene expression of BNIP3 was up-regulated while ZK1, RAD23B, and HSPD1 were down-regulated during early apoptosis of the hepatoma cell mediated by PRE. 12215374 Human
hhr23b xeroderma pigmentosum group c Cells from humans with xeroderma pigmentosum group C do not perform NER in the bulk of the genome and are corrected by XPC protein, which forms a complex with hHR23B protein. 10873465 Human
hhr23b xeroderma pigmentosum group c The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome. hHR23B is one of two human homologs of the Saccharomyces cerevisiae nucleotide excision repair (NER) gene product RAD23 and a component of a protein complex that 10488153 Human
hhr23b xeroderma pigmentosum group c Identification and characterization of XPC-binding domain of hHR23B. hHR23B was originally isolated as a component of a protein complex that specifically complements nucleotide excision repair (NER) defects of xeroderma pigmentosum group C cell extracts i 9372923 Human
hhr23b xeroderma pigmentosum group c Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a. hHR23B is the human homologue of the yeast protein RAD23 and is known to participate in DNA repair by stabilizing xeroderma pi 12832454 Human
hhr23b xeroderma pigmentosum The HHR23B protein is complexed with the protein defective in the cancer-prone repair syndrome xeroderma pigmentosum, complementation group C, and is specifically involved in the global genome NER subpathway. 8808275 Human
hhr23b multiple myeloma Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. 15550378 Human
hhr23b myeloma Here we report epigenetic hypermethylation of the hHR23B gene, a key component of the nucleotide excision repair in response to DNA damage, in interleukin-6 (IL-6)-responsive myeloma KAS-6/1 cells. 15550378 Human
hhr23b myeloma The inclination of DNA to be remethylated, at least within the hHR23B gene promoter region, reflects an epigenetic driving force by the cytogenetic/tumorigenic status of KAS-6/1 myeloma. 15550378 Human
hhr23b hcc METHODS: Expression of CSA, CSB, XPC, hHR23B, XPA, XPB, ERCC1 and p53 genes was analyzed by quantitative RT-PCR and immunoblotting in 26 HCC and 9 normal livers. 15922480 Human
hhr23b hcc XPA, XPC, hHR23B and ERCC1 mRNA levels were significantly increased (p<0.05) in HCC arising in cirrhotic livers compared to non fibrotic tissue. 15922480 Human
rad23b lung cancer We studied single nucleotide polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer in Xuan Wei. 15849729 Human
rad23b lung cancer In addition, subjects with one or 2 copies of the Val allele at codon 249 of RAD23B had a 2-fold increased risk of lung cancer (OR = 1.91, 95% CI 1.12-3.24). 15849729 Human

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