IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene EPB41L4B Ensembl ENSG00000095203 Chromosome 9 Start 110974075 End 111122842
Description Band 4.1-like protein 4B (Protein EHM2)(FERM-containing protein CG1) [Source:UniProtKB/Swiss-Prot;Acc:Q9H329]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 19818
     Entrez Gene : 54566
     UCSC : uc004bdz.1
     GeneCards : 19818
     RefSeq : NM_018424
     CCDS : CCDS43859.1
     Uniprot : Q9H329
     Interpro : Q9H329
     OMIM : 610340
     GeneTests : EPB41L4B
     CGAP : EPB41L4B
     PMID : 10783258

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220161_s_at  0.02  7.86e-1  8.17e-1  -4.91  5.95e-99  3.91e-98
 HG_U133A  220524_at  0.07  3.86e-1  4.41e-1  -0.35  4.61e-2  4.91e-2
 HG_U133_Plus2  220161_s_at  0.31  1.09e-2  2.21e-2  0.21  8.64e-2  1.18e-1
 HG_U133_Plus2  220524_at  0.59  1.25e-3  3.18e-3  0.84  1.17e-4  2.59e-4
 HG_U133_Plus2  223426_s_at  -0.38  3.17e-3  7.35e-3  -0.19  9.87e-2  1.33e-1
 HG_U133_Plus2  223427_s_at  0.41  8.33e-4  2.20e-3  0.63  1.00e-6  2.94e-6
 HG_U133_Plus2  223859_at  -0.20  2.78e-1  3.63e-1  0.46  2.71e-2  4.09e-2
 HG_U133_Plus2  233098_s_at  -0.21  3.25e-1  4.14e-1  -0.25  3.25e-1  3.85e-1
 Agilent_HS_21.6K  13469  0.08  3.50e-2  1.13e-1  0.07  6.58e-2  1.52e-1
 Agilent_HS_21.6K  16387  0.06  4.16e-2  1.28e-1  0.07  7.17e-2  1.62e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  220161_s_at  -0.40  1.84e-1  8.22e-1  0.16  4.83e-1  1.00e+0
 HG_U133A  220524_at  0.38  1.96e-1  8.27e-1  0.11  5.58e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 220161_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 220524_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220161_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 220524_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223426_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223427_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 223859_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233098_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13469    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16387    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ehm2 melanoma Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. 10783258 Mouse
ehm2 melanoma We have cloned a novel gene, Ehm2, that is expressed in high-metastatic but not in low-metastatic K-1735 murine melanoma cells. 10783258 Mouse
epb41l4b prostate cancer Real-time RT-PCR revealed GADD45A, MX1, EPB41L3/DAL1, and FBLN1 as generally downregulated in prostate cancer, whereas HOXB13 and EPB41L4B were upregulated. 17280610 Human
ehm2 prostate cancer Increased expression of the metastasis-associated gene Ehm2 in prostate cancer. 16927306 Human
ehm2 metastasis Ehm2 is an androgen-regulated gene that has been associated with metastasis in other systems, so we sought to determine if it is expressed in prostate cancer and if the FGFR-4 Arg(388) variant can increase its expression. 16927306 Human
ehm2 prostate cancer Ehm2 is an androgen-regulated gene that has been associated with metastasis in other systems, so we sought to determine if it is expressed in prostate cancer and if the FGFR-4 Arg(388) variant can increase its expression. 16927306 Human
ehm2 prostate cancer RESULTS: Ehm2 expression is upregulated in prostate cancer cell lines and prostate cancer tissues. 16927306 Human
ehm2 metastasis Increased expression of Ehm2 leads to decreased adhesion to collagen IV, which has been associated with metastasis in cancers. 16927306 Human
ehm2 cancers Increased expression of Ehm2 leads to decreased adhesion to collagen IV, which has been associated with metastasis in cancers. 16927306 Human
ehm2 metastasis CONCLUSIONS: Ehm2 is overexpressed in prostate cancer and may enhance disease progression and metastasis. 16927306 Human
ehm2 prostate cancer CONCLUSIONS: Ehm2 is overexpressed in prostate cancer and may enhance disease progression and metastasis. 16927306 Human

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