IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTPN3 Ensembl ENSG00000070159 Chromosome 9 Start 111177800 End 111300407
Description Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48)(Protein-tyrosine phosphatase H1)(PTP-H1) [Source:UniProtKB/Swiss-Prot;Acc:P26045]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9655
     Entrez Gene : 5774
     UCSC : uc004bed.2
     GeneCards : 9655
     RefSeq : NM_001145368
     CCDS : CCDS6776.1
     Uniprot : P26045
     Interpro : P26045
     OMIM : 176877
     GeneTests : PTPN3
     CGAP : PTPN3
     PMID : 1648725

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1458_at  0.53  2.17e-5  1.04e-4  0.73  2.16e-8  1.87e-7
 HG_U95  31885_at  0.33  7.44e-2  1.29e-1  0.58  1.07e-2  2.45e-2
 HG_U133A  203997_at  0.74  1.29e-20  1.06e-19  -1.02  6.04e-31  1.03e-30
 HG_U133_Plus2  203997_at  0.43  8.10e-5  2.62e-4  0.76  2.49e-12  1.45e-11
 HG_U133_Plus2  227944_at  -0.61  2.67e-8  1.54e-7  -0.64  1.36e-7  4.45e-7
 Stanford  6301  0.84  1.91e-2  9.78e-2  0.57  2.83e-2  1.16e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203997_at  -0.40  1.75e-1  8.19e-1  0.09  6.75e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1458_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 31885_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203997_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203997_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227944_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6301    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ptph1 cancer In contrast, the expression of PTPH1 mRNA was significantly increased in cancer lesions compared with that in normal mucosa. 10816386 Human
ptph1 ascites hepatoma Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells. mRNA levels for ten protein tyrosine phosphatases (PTPs), PTP-S, PTPH1, PTP-1, GLEPP1, LRP, PTP1D, PTPG1, PTP gamma, PTP delta, and LAR, were deter 7591957 Human
cytoskeletal-associated protein tyrosine phosphatase human hepatocellular carcinoma Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. 7874267 Human
ptph1 human hepatocellular carcinoma Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. 7874267 Human
ptph1 human hepatocellular carcinomas We investigated the mRNA expression of cytosolic protein tyrosine phosphatase (PTPH1), which has a homologous domain to cytoskeletal-associated proteins, in human hepatocellular carcinomas (HCCs) by using reverse transcriptase-polymerase chain reaction (R 7874267 Human
ptph1 colorectal cancer PTPH1 mRNA was not detected only in Colo 320 cells over-expressing c-myc mRNA, among the colorectal cancer cell lines examined. 8253532 Human
ptpn3 cancers A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and g 15155950 Human
ptpn3 colorectal cancers A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and g 15155950 Human
ptpn3 gastric cancers A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and g 15155950 Human
ptph1 gorlin syndrome Interestingly, PTPH1 gene was mapped to 9q31 where the gene for Gorlin syndrome, a putative tumor suppressor gene, exists. 8253532 Human
ptph1 hcc PTPH1 mRNA was detected in all HCC cell lines (n = 6), and HCC and adjacent noncancerous tissues (n = 8) examined, indicating that PTPH1 was expressed in HCCs and hepatocytes. 7874267 Human
ptph1 hcc There was no remarkable difference in the level expression of PTPH1 mRNA between HCC and adjacent noncancerous tissues. 7874267 Human
ptph1 hcc We also performed RT-PCR single-strand conformation polymorphism (SSCP) analysis in HCC cell lines and tissues in the C-terminal region of the catalytic domain of PTPH1. 7874267 Human
ptph1 hcc These results suggest that another mutation leading to the development of HCC could occur in some region of PTPH1 other than that investigated in this study. 7874267 Human

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