IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TXN Ensembl ENSG00000136810 Chromosome 9 Start 112046121 End 112058608
Description Thioredoxin (Trx)(ATL-derived factor)(ADF)(Surface-associated sulphydryl protein)(SASP) [Source:UniProtKB/Swiss-Prot;Acc:P10599]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 12435
     Entrez Gene : 7295
     UCSC : uc004bep.1
     GeneCards : 12435
     RefSeq : NM_003329
     CCDS : CCDS35103.1
     Uniprot : P10599
     Interpro : P10599
     OMIM : 187700
     GeneTests : TXN
     CGAP : TXN

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36992_at  0.35  1.19e-2  2.72e-2  0.98  1.80e-6  1.07e-5
 HG_U133A  208864_s_at  0.62  2.25e-14  1.16e-13  -3.04  7.92e-123  1.05e-121
 HG_U133A  216609_at  -0.16  8.80e-2  1.16e-1  -2.48  4.28e-47  9.29e-47
 HG_U133_Plus2  208864_s_at  0.27  2.37e-3  5.64e-3  0.71  1.42e-8  5.26e-8
 HG_U133_Plus2  216609_at  -0.51  3.45e-4  9.86e-4  0.33  2.92e-2  4.37e-2
 Stanford  1746  -0.99  1.27e-3  1.70e-2  -1.42  5.82e-4  9.58e-3
 Agilent_HS_21.6K  10753  0.34  7.30e-4  5.94e-3  0.65  1.01e-6  1.57e-5

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208864_s_at  -0.06  8.21e-1  9.84e-1  0.20  4.86e-1  1.00e+0
 HG_U133A  216609_at  -0.09  7.09e-1  9.69e-1  0.04  8.71e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36992_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208864_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216609_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208864_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216609_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1746    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10753    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
trx human t-cell leukemia We analyzed effects of a newly developed anti-rheumatic drug, KE-298 (2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid) and it is active metabolite; KE-758 (2-mercaptomethyl-4-(4-methylphenyl)-4-oxobutanoic acid) on the secretion of TRX and the le 11841839 NA
trx human neuroblastoma Using models of serum deprivation and 1-methyl-4-phenylpyridinium (MPP(+)), we investigated the mechanism by which thioredoxin (Trx) exerts its antiapoptotic protection in human neuroblastoma cells (SH-SY5Y) and preconditioning-induced neuroprotection. 11751890 Human
thioredoxin human neuroblastoma Using models of serum deprivation and 1-methyl-4-phenylpyridinium (MPP(+)), we investigated the mechanism by which thioredoxin (Trx) exerts its antiapoptotic protection in human neuroblastoma cells (SH-SY5Y) and preconditioning-induced neuroprotection. 11751890 Human
thioredoxin gastrointestinal cancer Surgical stress during operation for gastrointestinal cancer increases plasma thioredoxin levels and decreases mitochondrial membrane potential in peripheral blood lymphocytes. 12189047 Human
trx gastrointestinal cancer In the present study, we examined plasma levels of TRX in cases undergoing operations for gastrointestinal cancer. 12189047 Human
thioredoxin cancer The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. 12189205 Human
trx colon carcinoma The aim of this study was to determine the redox state of cellular GSH/glutathione disulfide (GSH/GSSG) and Trx as a consequence of progression from proliferation to contact inhibition and spontaneous differentiation in colon carcinoma (Caco-2) cells. 12433666 Human
thioredoxin breast carcinoma Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma. 15056229 Human
thioredoxin in-situ carcinomas We investigated the expression of thioredoxin and thioredoxin reductase in a large set of breast invasive and in situ carcinomas by immunohistochemistry. 15056229 Human
thioredoxin ductal carcinomas Ductal carcinomas showed stronger cytoplasmic thioredoxin immunoreactivity than lobular ones. 15056229 Human
thioredoxin lobular carcinomas Nuclear thioredoxin positivity was more often found in in situ lesions, and lobular carcinomas were more often negative than ductal ones. 15056229 Human
thioredoxin tumours Whilst thioredoxin or thioredoxin reductase was not associated with patient survival, cases showing both cytoplasmic and nuclear thioredoxin reductase-positive tumours had a shorter disease-free interval than those with negative immunostaining. 15056229 Human
thioredoxin neuroblastoma Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion. 11168376 Human
trx hepatocellular carcinoma HepG2 hepatocellular carcinoma cells induced to secrete Trx inhibited TIMP activity in the presence of TrxR. 11168376 Human
trx neuroblastoma SK-N-SH neuroblastoma cells secreted TrxR, which inhibited TIMP and MMP-2 activity in the presence of Trx. 11168376 Human
thioredoxin tumor This study therefore identifies a novel extracellular role for the thioredoxin/thioredoxin reductase redox system in the differential inhibition of TIMP and MMP activity and provides a novel mechanism for altering the TIMP/MMP balance that is of potential 11168376 NA
thioredoxin cancer A 40644 possessing a sesquiterpene-substituted p-benzoquinone structure with cis-fused B/C ring stereochemistry that inhibits the human thioredoxin system as the well as the growth of several cancer cell lines. 11272823 Human
thioredoxin cancers Ape1/ref-1 has also been shown to be closely linked to apoptosis associated with thioredoxin, and altered levels of Ape1/ref-1 have been found in some cancers. 11280790 Human
trx fibrosarcoma Human TRX-transfected L929 murine fibrosarcoma cells were more resistant to BLM-induced cytotoxicity than the parental and the control transfected cells, indicating that TRX plays the protective role in BLM-induced cytotoxicity. 11292065 Mouse
thioredoxin malignant pleural mesothelioma Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma. 11307155 Human
trx malignant pleural mesothelioma We assessed the Trx system in malignant pleural mesothelioma cell lines, in nonmalignant pleural mesothelium and in biopsies of malignant pleural mesothelioma. 11307155 Human
trx mesothelioma The mRNA and immunoreactive proteins of Trx and cytosolic and mitochondrial TrxR were positive in all four human mesothelioma cell lines investigated. 11307155 Human
trx malignant pleural mesothelioma Six cases of nonmalignant, histologically healthy pleural mesothelium showed no Trx or TrxR immunoreactivity, whereas immunohistochemistry on 26 biopsies of human malignant pleural mesothelioma showed positive Trx in all cases and positive TrxR in 23 (88% 11307155 Human
trx mesothelioma Moderate or strong immunoreactivity for Trx or TrxR was detected in 85% (22 cases) and 61% (14 cases) of the mesothelioma cases, respectively. 11307155 Human
trx mesothelioma Both Trx and TrxR staining patterns were mainly diffuse and cytoplasmic, but in 39% of the mesothelioma cases prominent nuclear staining could also be detected. 11307155 Human
trx mesothelioma Although staining for Trx and TrxR was seen in tumor cells, no significant association could be demonstrated between Trx or TrxR expression and tumor cell proliferation or apoptosis in the biopsies of mesothelioma. 11307155 Human
trx tumor Although staining for Trx and TrxR was seen in tumor cells, no significant association could be demonstrated between Trx or TrxR expression and tumor cell proliferation or apoptosis in the biopsies of mesothelioma. 11307155 Human
trx malignant mesothelioma Although the Trx system may have an important role in the drug resistance of malignant mesothelioma, these studies also suggest that multiple factors contribute to the promotion, cell proliferation and apoptosis of malignant mesothelioma cells in vivo. 11307155 Human
thioredoxin non-small cell lung carcinoma Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. 11410516 Human
trx non-small cell lung carcinomas We investigated the expression of thioredoxin (Trx) and thioredoxin reductase (TrxR) in 89 non-small cell lung carcinomas. 11410516 Human
thioredoxin non-small cell lung carcinomas We investigated the expression of thioredoxin (Trx) and thioredoxin reductase (TrxR) in 89 non-small cell lung carcinomas. 11410516 Human
trx human lung carcinoma Additionally, immortalized human bronchial epithelial cells (BEAS 2B) and four human lung carcinoma cells lines (A549, SK-MES-1, CALU-6, and A427) were studied by Western blot and reverse transcription-PCR for the synthesis of Trx and TrxR protein and mRN 11410516 Human
trx non-small cell lung carcinomas In non-small cell lung carcinomas, there was a widespread expression of Trx and TrxR with only three and eight cases negative, respectively. 11410516 Human
trx tumors Grade I-II tumors showed stronger cytoplasmic and nuclear Trx and TrxR immunoreactivity than grade III tumors. 11410516 Human
trx carcinoma In the cell lines studied, both non-neoplastic BEAS 2B cells and all of the carcinoma cell lines expressed Trx and TrxR proteins and mRNA. 11410516 Human
trx tumors In high-grade tumors, Trx and TrxR expression is diminished, suggesting loss of redox regulation in tumors with low differentiation. 11410516 Human
trx cancer Cancer cells have high levels of thioredoxin (Trx) and of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). 14730345 Human
thioredoxin cancer Cancer cells have high levels of thioredoxin (Trx) and of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). 14730345 Human
thioredoxin lung carcinoma Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin. 15003321 Human
thioredoxin breast cancer The most potent compound in this series inhibited thioredoxin with an IC(50) of 350 nM, and many derivatives showed low micromolar activities for growth inhibition against two breast cancer cell lines. 11551767 Human
thioredoxin cancer Our results demonstrate pronounced selective selenium-mediated apoptosis in therapy-resistant cells and suggest that redox regulation through the thioredoxin system is an important target for cancer therapy. 15037203 Human
trx human t-cell leukemia Human T cell leukemia virus type I-transformed T lymphocytes constitutively release a large amount of TRX. 14688353 Human
thioredoxin tumor This study focuses on the presence of and subcellular localisation of thioredoxin reductase in a tumor model where neoplastic lesions are selected by their resistance to the toxic effects of the promotor. 11580149 NA
thioredoxin tumor CONCLUSIONS: These findings indicate that the thioredoxin system makes an important contribution to the resistant phenotype of the neoplastic liver cell, which conveys a growth advantage of significance for tumor progression. 11580149 Human
thioredoxin t-cell acute lymphoblastic leukemia Thioredoxin expression in primary T-cell acute lymphoblastic leukemia and its therapeutic implication. 11585774 Human
thioredoxin t-cell acute lymphoblastic leukemia In the present studies, we analyzed expression of thioredoxin in samples from 28 children with T-cell acute lymphoblastic leukemia and analyzed their sensitivity toward inhibition of thioredoxin expression. 11585774 Human
thioredoxin t-cell acute lymphoblastic leukemia Exogenously added thioredoxin stimulated proliferation of clonogenic cells among the T-cell acute lymphoblastic leukemia samples expressing relatively lower levels of intracellular thioredoxin, whereas there was no effect on the clonogenic cells expressin 11585774 Human
thioredoxin leukemia In addition, there was differential sensitivity of the leukemia clonogenic cells toward 1-methylpropyl 2-imidazolyl disulfide, an inhibitor of thioredoxin expression, as compared with normal hematopoietic progenitors. 11585774 Human
thioredoxin leukemia Because overexpression of thioredoxin is associated with resistance to many anticancer drugs, the inhibition of thioredoxin expression may overcome this drug resistance and probably sensitize leukemia cells to other chemotherapeutic agents. 11585774 Human
thioredoxin non-small cell lung cancer Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer. 11595699 Human
trx lung carcinomas High TRX mRNA levels have been found in lung carcinomas, a trait associated with a growth and survival advantage. 11595699 Human
trx non-small cell lung carcinomas EXPERIMENTAL DESIGN: In this study, we examined the immunohistochemical expression of human TRX in normal lung and in 102 primary non-small cell lung carcinomas. 11595699 Human
trx lung carcinomas In lung carcinomas, the pattern of expression for TRX was predominantly cytoplasmic and only occasionally nuclear. 11595699 Human
trx tumor CONCLUSIONS: We conclude that overexpression of TRX in non-small cell lung carcinomas is indicative of a more aggressive tumor phenotype and is associated with bad prognostic features and possibly with a poorer outcome. 11595699 Human
thioredoxin breast cancer Inverse correlation of thioredoxin expression with estrogen receptor- and p53-dependent tumor growth in breast cancer tissues. 11705859 Human
thioredoxin tumor Inverse correlation of thioredoxin expression with estrogen receptor- and p53-dependent tumor growth in breast cancer tissues. 11705859 Human
trx breast cancer To clarify the regulation mechanism of tumor growth in breast cancer, here we investigated the expression of TRX, ER, pS-2, and p53 and the mitotic index (MI) in 147 breast cancer tissues using immunohistochemical analysis. 11705859 Human
trx tumor To clarify the regulation mechanism of tumor growth in breast cancer, here we investigated the expression of TRX, ER, pS-2, and p53 and the mitotic index (MI) in 147 breast cancer tissues using immunohistochemical analysis. 11705859 Human
trx breast cancer These findings suggest that TRX expression is linked to the ER- and p53-dependent regulation of tumor growth in breast cancer. 11705859 Human
trx tumor These findings suggest that TRX expression is linked to the ER- and p53-dependent regulation of tumor growth in breast cancer. 11705859 Human
thioredoxin b-type chronic lymphocytic leukemia Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells. 10666220 Human
trx b-type chronic lymphocytic leukemia (b-cll) Previously, we showed that Trx, in synergy with interleukin 1 (IL-1), IL-2, IL-4, tumor necrosis factor alpha (TNF-alpha), and CD40-ligation induced S-phase entry and mitosis in normal B cells and B-type chronic lymphocytic leukemia (B-CLL) cells. 10666220 Human
trx adult t-cell leukemias All B-CLL cells expressed constitutive Trx at varying but low levels, in contrast to adult T-cell leukemias, which overexpress Trx, as previously reported. 10666220 Human
thioredoxin pancreatic cancer Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer. 10757123 Human
trx pancreatic ductal carcinoma Pancreatic ductal carcinoma tissues were immunohistochemically more positive for TRX (24/32 cases) and GRX (29/32 cases) than pancreatic cystadenocarcinoma or normal pancreas tissues. 10757123 Human
trx pancreatic cystadenocarcinoma Pancreatic ductal carcinoma tissues were immunohistochemically more positive for TRX (24/32 cases) and GRX (29/32 cases) than pancreatic cystadenocarcinoma or normal pancreas tissues. 10757123 Human
trx pancreatic ductal carcinoma Plasma levels of TRX (mean +/- SD) measured by ELISA were significantly higher in patients with pancreatic ductal carcinoma (54.8 +/- 37.6 ng/ml, n = 60) than in healthy controls (24.4 +/- 12.9 ng/ml, n = 81). 10757123 Human
trx pancreatic ductal carcinoma These results indicate the possible association of TRX and GRX with malignant potential of pancreatic ductal carcinoma. 10757123 Human
thioredoxin prostate cancer METHODS: Three cell lines of human hormone-independent prostate cancer (PC-3, PC-3 MA2, and HPC36M) were examined for activities of superoxide dismutase, catalase, and glutathione peroxidase, and for levels of protein and nonprotein thiols such as metallo 10754530 NA
trx cancers Studies on overexpression of Trx and TrxR in human cancers have indicated a role of these proteins in tumor development. 10786696 Human
trx tumor Studies on overexpression of Trx and TrxR in human cancers have indicated a role of these proteins in tumor development. 10786696 Human
trx tumor These results highlight the role of extracellular Trx and TrxR during inflammation and tumor progression. 10786696 Human
thioredoxin gastric carcinoma Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival. 10821495 Human
thioredoxin tumor Human thioredoxin is a putative oncogene that may confer both a growth and survival advantage to tumor cells. 10821495 Human
thioredoxin colorectal cancers Overexpressed thioredoxin mRNA has been found in both primary human lung and colorectal cancers. 10821495 Human
thioredoxin primary carcinomas To determine the intratumor distribution and amount of thioredoxin protein in human primary carcinomas, we developed an immunohistochemical assay for thioredoxin in paraffin-embedded tissue. 10821495 Human
thioredoxin gastric carcinomas In this survey, we found that thioredoxin was localized to tumor cells and overexpressed compared with normal gastric mucosa in 8 of 10 gastric carcinomas. 10821495 Human
thioredoxin tumor In this survey, we found that thioredoxin was localized to tumor cells and overexpressed compared with normal gastric mucosa in 8 of 10 gastric carcinomas. 10821495 Human
thioredoxin carcinomas The thioredoxin was found at high levels in 5 of the 8 overexpressing carcinomas. 10821495 Human
thioredoxin tumors Thus, human primary gastric tumors that are highly expressive of thioredoxin have both a higher proliferative rate and a higher survival rate than tumors that do not express thioredoxin. 10821495 Human
thioredoxin cancer Cancer cell lines transfected with thioredoxin show increased anchorage-independent growth and decreased sensitivity to induction of apoptosis by a number of anticancer drugs. 10903908 Human
thioredoxin lymphocytic leukemia A redox-inactive mutant thioredoxin was stably transfected into WEHI7.2 mouse lymphocytic leukemia cells and two clones were examined for growth characteristics and the induction of apoptosis by dexamethasone, etoposide, doxorubicin, and staurosporine. 10903908 Mouse
thioredoxin invasive cervical carcinomas Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis. 14742261 Human
thioredoxin cervical carcinoma Because elevated thioredoxin or APE/ref-1 is also associated with resistance to certain forms of cancer treatment, we examined their tissue distribution in a series of 110 cervical carcinoma biopsies. 14742261 Human
thioredoxin cancer Because elevated thioredoxin or APE/ref-1 is also associated with resistance to certain forms of cancer treatment, we examined their tissue distribution in a series of 110 cervical carcinoma biopsies. 14742261 Human
thioredoxin tumor Thioredoxin and APE/ref-1 levels were expressed as the average pixel brightness in tumor tissue, subdivided based on CAIX and 4',6-diamidino-2-phenylindole staining. 14742261 Human
thioredoxin cancer Elevated expression of thioredoxin and APE/ref-1 might promote cancer cell survival in hypoxic microenvironments of cervical carcinomas. 14742261 Human
thioredoxin cervical carcinomas Elevated expression of thioredoxin and APE/ref-1 might promote cancer cell survival in hypoxic microenvironments of cervical carcinomas. 14742261 Human
thioredoxin tumors The redox-active, asymmetrical 1-methylpropyl-2-imidazolyl disulfide (IV-2) has previously been shown to react with and inhibit thioredoxin activity in vitro, the proliferation of human tumor cells in culture, and the growth of tumors in mice. 10945861 Human
thioredoxin human tumor The redox-active, asymmetrical 1-methylpropyl-2-imidazolyl disulfide (IV-2) has previously been shown to react with and inhibit thioredoxin activity in vitro, the proliferation of human tumor cells in culture, and the growth of tumors in mice. 10945861 Human
thioredoxin granulomas Expression of thioredoxin in granulomas of sarcoidosis: possible role in the development of T lymphocyte activation. 10950894 Human
trx granulomas The expression of TRX and IL-2R in granulomas of patients with sarcoidosis has been studied to clarify a possible role for TRX in the induction of IL-2R expression. 10950894 Human
trx granulomas METHODS: Granulomas in specimens of lung tissue and lymph nodes from five patients with sarcoidosis were immunohistochemically stained with anti-TRX antibody and anti-IL-2Ralpha chain antibody and the concentration of TRX in the bronchoalveolar lavage (BA 10950894 NA
trx granulomas CONCLUSIONS: TRX is highly expressed and is locally produced by granulomas in patients with sarcoidosis. 10950894 Human
trx granulomas The coexistence of immunoreactive TRX and IL-2R in the same granulomas suggests that TRX might act as a local inducing factor for IL-2R expression on T cells. 10950894 Human
thioredoxin melanoma Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack. 10985667 Human
trx tumour These mechanisms are not fully understood, but cytokines and redox-active antioxidant proteins such as catalase, superoxide dismutase, thioredoxin (Trx) and Trx reductase (TrxR) present in the tumour cells constitute part of this protection. 10985667 Human
thioredoxin tumour These mechanisms are not fully understood, but cytokines and redox-active antioxidant proteins such as catalase, superoxide dismutase, thioredoxin (Trx) and Trx reductase (TrxR) present in the tumour cells constitute part of this protection. 10985667 Human
trx metastatic malignant melanoma In this study firstly we investigated the constitutive intracellular expression of Trx, TrxR, the cytokines interleukin (IL)-1alpha, IL1beta, IL2, IL4, IL6, IL8, IL10, tumour necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) in normal melan 10985667 NA
trx melanoma All the cultured cells showed intracellular overexpression of Trx and TrxR, which was not always the case for melanoma cells in vivo (tissue sections). 10985667 Human
trx melanoma All the melanoma cell lines were relatively resistant against exogenous TNFalpha, and there was a significant correlation (P < 0.01) between intracellular Trx/TrxR expression and TNFalpha resistance (IC50). 10985667 Human
trx malignant melanoma In conclusion, Trx and TrxR, as well as TNFalpha, IL1alpha and IL1beta, were highly expressed in cultured normal skin melanocytes and malignant melanoma cell lines. 10985667 Human
thioredoxin tumour diseases Reduced thioredoxin acts as an autocrine growth factor in various tumour diseases, as a chemoattractant, and it synergises with interleukins 1 and 2. 11012663 Human
thioredoxin cancer The role of the redox protein thioredoxin in cell growth and cancer. 11035260 Human
thioredoxin cancer An increase in thioredoxin levels seen in many human primary cancers compared to normal tissue appears to contribute to increased cancer cell growth and resistance to chemotherapy. 11035260 Human
thioredoxin primary cancers An increase in thioredoxin levels seen in many human primary cancers compared to normal tissue appears to contribute to increased cancer cell growth and resistance to chemotherapy. 11035260 Human
thioredoxin cancer Because of its role in stimulating cancer cell growth and as an inhibitor of apoptosis, thioredoxin offers a target for the development of drugs to treat and prevent cancer. 11035260 Human
trx hepatocellular carcinoma METHODS: Serum TRX levels were determined with a sandwich enzyme-linked immunosorbent assay kit in 174 serum HCV-RNA positive patients, including 6 asymptomatic carriers, 124 chronic hepatitis, 20 liver cirrhosis, and 24 hepatocellular carcinoma, and in 1 11059866 NA
trx hepatocellular carcinoma RESULTS: The serum TRX levels (medians and [ranges], ng/ml) were significantly elevated in the HCV-infected patients; 30.9 [20.7-37.7] in asymptomatic carriers, 34.5 [8.6-135.6]* in chronic hepatitis, 42.5 [21.4-97.2]* in liver cirrhosis, and 43.9 [11.7-1 11059866 Human
thioredoxin breast cancer Possible association of thioredoxin and p53 in breast cancer. 11163861 Human
trx cancer Expression of thioredoxin (TRX), a dithiol-reducing enzyme, and mutations of p53 have been detected in various cancer tissues. 11163861 Human
thioredoxin cancer Expression of thioredoxin (TRX), a dithiol-reducing enzyme, and mutations of p53 have been detected in various cancer tissues. 11163861 Human
trx breast cancer In this study, we investigated the possibility of functional association between TRX and p53 in breast cancer. 11163861 NA
trx primary breast cancer First, we examined the expression of TRX and mutated p53 in 100 primary breast cancer tissues by immunohistochemistry. 11163861 Human
trx breast cancer Next, we examined the expression of TRX and p53 in breast cancer cell line MCF-7 cells after CDDP treatment or irradiation. 11163861 Human
trx breast cancer These results suggest the possible association of TRX with p53-dependent function including DNA repair in breast cancer. 11163861 Human
trx cancer These findings suggest that secreted TRX may play an important role in the acquisition of cellular CDDP resistance through enhancement of the L-cystine uptake activity, and that the L-cystine transport system, as well as the TRX system, may be a novel the 11213475 Human
trx t-cell leukemia TRX secretion was investigated in several cell lines including the T-helper cell hybridoma MP6, the Jurkat T-cell leukemia, the U-937 myelomonocytic leukemia, and the 3B6, EBV-transformed, lymphoblastoid B-cell line. 11213477 Human
trx myelomonocytic leukemia TRX secretion was investigated in several cell lines including the T-helper cell hybridoma MP6, the Jurkat T-cell leukemia, the U-937 myelomonocytic leukemia, and the 3B6, EBV-transformed, lymphoblastoid B-cell line. 11213477 Human
thioredoxin gastric cancer Detection of thioredoxin in gastric cancer: association with histological type. 11229365 Human
trx tumors Recently, augmentation of the expression and transcription level of TRX has been reported in tumors of various organs. 11229365 Human
trx gastric cancer In this study, we examined the expression of TRX in gastric cancer with respect to its histological type and depth of invasion. 11229365 NA
trx gastric cancer Results of histochemical analysis of surgical specimens as well as cytochemical analysis and Northern blot analysis of gastric cancer cell lines indicated that TRX is predominantly expressed in undifferentiated type gastric cancer rather than in the diffe 11229365 Human
trx tumor Neither the depth of tumor invasion nor cell proliferation significantly determined the staining intensity for TRX. 11229365 Human
trx adult t-cell leukemia We originally cloned human TRX as adult T cell leukemia derived factor (ADF) produced by HTLV-I transformed cells. 11237106 Human
thioredoxin mesothelioma Upregulation of 9 genes, including that for thioredoxin, during epithelial differentiation of mesothelioma cells. 11269944 Human
thioredoxin cancer The thioredoxin system (NADPH, thioredoxin reductase/ thioredoxin) is important for cancer cell growth and inhibition of apoptosis and presents an attractive target for anticancer drug development. 11354308 Human
trx mcf-7 human breast cancer One of the analogues discovered through the combinatorial syntheses/screening for Trx inhibition, 1-phenylethyl 2-imidazolyl disulfide, N1 (ProlX agent PX-C5), has demonstrated excellent in vivo activity against the MCF-7 human breast cancer and the HL-60 10766297 Human
trx human leukemia One of the analogues discovered through the combinatorial syntheses/screening for Trx inhibition, 1-phenylethyl 2-imidazolyl disulfide, N1 (ProlX agent PX-C5), has demonstrated excellent in vivo activity against the MCF-7 human breast cancer and the HL-60 10766297 Human
thioredoxin cancers Thioredoxin stimulates cell growth, is found in dividing normal cells, and is over-expressed in a number of human cancers. 9890567 Human
thioredoxin rous sarcoma Thioredoxin mRNA is differentially expressed in normal and Rous sarcoma virus-transformed chicken embryo fibroblasts. 2838473 others
thioredoxin rous sarcoma Transformation of chicken embryo fibroblasts by Rous sarcoma virus elevates the level of thioredoxin mRNA whereas the level of thioredoxin mRNA in a nonproliferative tissue (brain) is much lower than in chicken embryo fibroblasts. 2838473 others
trx monocytic leukemia We therefore investigated the expression of redox-regulating proteins such as glutaredoxin (GRX) and thioredoxin (TRX) during the differentiation of murine monocytic leukemia cell line M1 cells and human monocytic leukemia cell line U937 cells. 10424449 Human
thioredoxin monocytic leukemia We therefore investigated the expression of redox-regulating proteins such as glutaredoxin (GRX) and thioredoxin (TRX) during the differentiation of murine monocytic leukemia cell line M1 cells and human monocytic leukemia cell line U937 cells. 10424449 Human
thioredoxin breast cancer Nuclear factor kappaB transactivation is increased but is not involved in the proliferative effects of thioredoxin overexpression in MCF-7 breast cancer cells. 10463612 Human
thioredoxin tumor We have measured the levels of thioredoxin, thioredoxin reductase and glutaredoxin enzyme activity in mouse skin following topical application of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator and tumor pr 10469622 Human
thioredoxin tumor Multiple applications of TPA to tumor initiated (7,12-dimethyl[a]benzanthracene-treated) skin resulted in elevated levels of both the thioredoxin and glutaredoxin systems when examined 6 days after the last phorbol ester treatment. 10469622 Human
thioredoxin tumor Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms. 10469622 Human
trx adult t-cell leukemia Adult T cell leukemia derived factor (ADF)/thioredoxin (Trx) is known to be an important intracellular antioxidant involved in a number of redox reactions such as ribonucleotide reductase (RNR) as well as of tyrosinase. 9475178 Human
trx tumor These data highlight a novel deregulatory effect of extracellular Trx upon morphological capillary differentiation that appears to depend upon the reduction of laminin and destabilisation of its interaction with galectin-3, possibly leading to galectin-3 14644168 Human
thioredoxin human tumors Thioredoxin is a redox protein found over-expressed in some human tumors. 9679540 Human
thioredoxin cancer Thioredoxin is secreted by tumor cells and stimulates cancer cell growth. 9679540 Human
thioredoxin tumor Thioredoxin is secreted by tumor cells and stimulates cancer cell growth. 9679540 Human
thioredoxin tumor Cells transfected with thioredoxin cDNA show increased tumor growth and decreased apoptosis in vivo and decreased sensitivity to apoptosis induced by a variety of agents both in vitro and in vivo. 9679540 Human
thioredoxin tumor Cells transfected with a redox-inactive mutant thioredoxin show inhibited tumor growth in vivo. 9679540 Human
thioredoxin human stomach cancer Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. 9870185 Human
thioredoxin hepatocellular carcinoma Elevated serum level of thioredoxin in patients with hepatocellular carcinoma. 9950104 Human
trx hepatocellular carcinoma (hcc) The objective of the present study was to investigate whether circulating TRX levels are elevated in patients with chronic hepatitis (CH) or liver cirrhosis (LC) and hepatocellular carcinoma (HCC). 9950104 Human
trx tumor In four patients with HCC, the initially high level of serum TRX (>150 ng/ml) decreased below 150 ng/ml after surgical removal of the tumor. 9950104 Human
thioredoxin adult t-cell leukemia Possible roles of an adult T-cell leukemia (ATL)-derived factor/thioredoxin in the drug resistance of ATL to adriamycin. 9116292 Human
thioredoxin t-cell acute lymphocytic leukemia (t-all) Immunoblot analysis demonstrated that ATL cell lines expressed ADF/thioredoxin at levels 2.8 to 12 times those of other T-cell acute lymphocytic leukemia (T-ALL) cell lines, and that ATL cell lines were 2 to 15 times more resistant to ADM than other T-ALL 9116292 Human
thioredoxin adult t-cell leukemia In this study, we analyzed the effect of L-cystine and GSH depletion on lymphocyte survival and investigated the regulatory roles of adult T cell leukemia (ATL)-derived factor (ADF)/human thioredoxin (hTRX) in relation to these low m.w. thiols. 9120263 NA
thioredoxin colon cancer Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines. 9137526 Human
trx colon cancer METHODS: We developed cell lines stably expressing high levels of TRX by transfection of human ovarian cancer A2780 and colon cancer HT-29, and examined their sensitivity to cDDP. 9137526 NA
trx human ovarian cancer METHODS: We developed cell lines stably expressing high levels of TRX by transfection of human ovarian cancer A2780 and colon cancer HT-29, and examined their sensitivity to cDDP. 9137526 NA
trx b cell-type chronic lymphocytic leukaemia (b-cll) This paper reports on differences between B cell-type chronic lymphocytic leukaemia (B-CLL) and normal B cells in their response to IL-2+thioredoxin (Trx), Staphylococcus aureus Cowan strain 1 (SAC)+IL-2+Trx, and to CD40 ligation of IL-2+Trx and SAC+IL-2+ 9201312 Human
thioredoxin b-chronic lymphocytic leukemia Interleukin-15 + thioredoxin induce DNA synthesis in B-chronic lymphocytic leukemia cells but not in normal B cells. 9264384 Human
trx b-chronic lymphocytic leukemia (b-cll) We have previously shown that Staphylococcus aureus Cowan strain 1 particles (SAC) + thioredoxin (Trx) + IL-2 may induce B-chronic lymphocytic leukemia (B-CLL) cells to proliferate. 9264384 Human
thioredoxin b-chronic lymphocytic leukemia (b-cll) We have previously shown that Staphylococcus aureus Cowan strain 1 particles (SAC) + thioredoxin (Trx) + IL-2 may induce B-chronic lymphocytic leukemia (B-CLL) cells to proliferate. 9264384 Human
trx melanoma One exception was the melanoma cell line FM28.4, which did not show any Trx expression. 9344598 Human
trx cancer Trx is overexpressed by a number of human tumors, and experimental studies have shown that Trx contributes to the growth and to the transformed phenotype of some human cancer cells. 9354464 Human
trx human tumors Trx is overexpressed by a number of human tumors, and experimental studies have shown that Trx contributes to the growth and to the transformed phenotype of some human cancer cells. 9354464 Human
trx cancer Thus, TR, by reducing Trx, could play a role in regulating the growth of normal and cancer cells. 9354464 Human
thioredoxin cancer Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. 9371519 Human
thioredoxin cancer The redox protein thioredoxin plays an important role in controlling cancer cell growth through regulation of DNA synthesis and transcription factor activity. 9371519 Human
thioredoxin primary cancers Thioredoxin is overexpressed by a number of human primary cancers and its expression is decreased during dexamethasone-induced apoptosis of mouse WEHI7.2 thymoma cells. 9371519 Human
thioredoxin cancers This study suggests that increased thioredoxin expression in human cancers may result in an increased tumor growth through inhibition of spontaneous apoptosis and a decrease in the sensitivity of the tumor to drug-induced apoptosis. 9371519 Human
thioredoxin tumor This study suggests that increased thioredoxin expression in human cancers may result in an increased tumor growth through inhibition of spontaneous apoptosis and a decrease in the sensitivity of the tumor to drug-induced apoptosis. 9371519 Human
thioredoxin human tumors Thioredoxin is a redox protein found overexpressed in some human tumors. 9406236 Human
thioredoxin cancer Thioredoxin is secreted by tumor cells and enhances the sensitivity of the cancer cells to other growth factors. 9406236 Human
thioredoxin tumor Thioredoxin is secreted by tumor cells and enhances the sensitivity of the cancer cells to other growth factors. 9406236 Human
thioredoxin tumor Cells transfected with thioredoxin cDNA show increased tumor growth and decreased apoptosis in vivo and decreased sensitivity to apoptosis induced by a variety of agents both in vitro and in vivo. 9406236 Human
thioredoxin tumor Cells transfected with a redox-inactive mutant thioredoxin show inhibited tumor growth in vivo. 9406236 Human
thioredoxin cancer Thioredoxin, and particularly extracellular thioredoxin, presents an attractive target for developing novel agents to treat cancer. 9406241 Human
thioredoxin tumors One of the analogues that binds to thioredoxin, 1-methylpropyl 2-imidazolyl disulfide (IV-2), selectively inhibits the thioredoxin-dependent growth of tumor cells in culture and has antitumor activity against MCF-7 and HL-60 tumors in vivo. 9406241 Human
thioredoxin tumor One of the analogues that binds to thioredoxin, 1-methylpropyl 2-imidazolyl disulfide (IV-2), selectively inhibits the thioredoxin-dependent growth of tumor cells in culture and has antitumor activity against MCF-7 and HL-60 tumors in vivo. 9406241 Human
thioredoxin cancers This rapid method of evaluating biological activity is a means to identify agents with specificity for inhibition of the thioredoxin system, and may provide novel antitumor agents with activity against solid tumor cancers. 9406241 Human
trx adenocarcinoma However, when TRX reductase and nicotinamide adenine dinucleotide (NADPH) were added to the extracellular medium with TRX, more than 80% of E. coli TRX was found to be in a fully reduced state in human adenocarcinoma (A549) cells. 9409558 Human
thioredoxin myeloma It was investigated whether such disulfides are cleaved in human polyclonal IgG and IgG subclass myeloma proteins by both the human and the Escherichia coli thioredoxin systems. 9430198 Human
thioredoxin human tumors We have used a cell line-directed screening approach (CDSA) to identify novel inhibitors of the thioredoxin reductase signaling pathway which contributes to the transformed phenotype of some human tumors. 9448705 Human
thioredoxin cancer Thus, the CDSA using data from the NCI cancer cell panel and known inhibitors of the selected target as seed compounds can greatly increase hit rates, compared with random screening, for identifying novel inhibitors of a target, in this case thioredoxin s 9448705 Human
thioredoxin human tumors Thioredoxin is over-expressed by a number of human tumors. 9494575 Human
thioredoxin cancer Experimental studies have shown that thioredoxin is responsible for the growth and transformed phenotype of some human cancer cells. 9494575 Human
thioredoxin fibrosarcoma In this and other cell lines, such as fibrosarcoma and endothelial cells, thioredoxin also dose-dependently increased the synthesis of IL-6. 8543831 Human
trx tumors Tumors in SCID mice reconstituted with mononuclear cells of salivary glands from SS patients, which were composed of human B cells carrying EBV DNA, were positive for TRX/ADF. 8639174 Mouse
thioredoxin tumor Thioredoxin can also act as a growth factor, and is overexpressed and secreted in certain tumor cells. 8805557 Human
trx metaplasia We investigated immunohistochemical expression of manganese superoxide dismutase (MnSOD) and three hydrogen peroxide (H(2)O(2)) scavenging pathways, i.e. catalase (CAT), gamma-glutamyl cysteine synthetase (gammaGCS) and thioredoxin (Trx) system in normal 12499089 Human
thioredoxin metaplasia We investigated immunohistochemical expression of manganese superoxide dismutase (MnSOD) and three hydrogen peroxide (H(2)O(2)) scavenging pathways, i.e. catalase (CAT), gamma-glutamyl cysteine synthetase (gammaGCS) and thioredoxin (Trx) system in normal 12499089 Human
thioredoxin adult t-cell leukemia Adult T-cell leukemia-derived factor (ADF), identified in the supernatant of adult T-cell leukemia (ATL) cell culture, is a human homologue of thioredoxin and consists of 104 amino acids; it has two redox-active half-cysteine residues in an exposed active 8859944 Human
trx human neuroblastoma Human neuroblastoma cells, SH-SY5Y, contain relatively low levels of thioredoxin (Trx); thus, they serve favorably as a model for studying oxidative stress-induced apoptosis (Andoh, T., Chock, P. B., and Chiueh, C. C. 12414792 Human
thioredoxin human neuroblastoma Human neuroblastoma cells, SH-SY5Y, contain relatively low levels of thioredoxin (Trx); thus, they serve favorably as a model for studying oxidative stress-induced apoptosis (Andoh, T., Chock, P. B., and Chiueh, C. C. 12414792 Human
thioredoxin human hepatocellular carcinoma Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin. 8968078 Human
trx human hepatocellular carcinoma In this study, we asked whether expression of TRX, glutathione-thiol transferase pi, and high mobility group protein 1 (HMG-1) genes is enhanced in human hepatocellular carcinoma and whether expression of these genes is associated with sensitivity to cisp 8968078 NA
trx hepatocellular carcinomas Both TRX and HMG-1 were co-overexpressed in almost all cancerous lesions in comparison to normal tissue in surgically resected hepatocellular carcinomas of 20 patients. 8968078 Human
trx cancer Tumor sensitivity to cisplatin [cis-diamminedichloroplatinum (II)], but not to mitomycin C or doxorubicin, correlated with mRNA levels of TRX in cancer tissue. 8968078 Human
trx tumor Tumor sensitivity to cisplatin [cis-diamminedichloroplatinum (II)], but not to mitomycin C or doxorubicin, correlated with mRNA levels of TRX in cancer tissue. 8968078 Human
trx human hepatocellular carcinomas TRX and HMG-1 may be useful tumor markers, and TRX might be also a useful marker for sensitivity to cisplatin in human hepatocellular carcinomas. 8968078 Human
trx tumor TRX and HMG-1 may be useful tumor markers, and TRX might be also a useful marker for sensitivity to cisplatin in human hepatocellular carcinomas. 8968078 Human
thioredoxin human breast cancer Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells. 8971189 Human
thioredoxin primary cancers Thioredoxin, a redox protein with growth factor activity that modulates the activity of several proteins important for cell growth, has been reported to be overexpressed in a number of human primary cancers. 8971189 Human
thioredoxin mcf-7 human breast cancer In the present study, the effects of stably transfecting mouse NIH 3T3 cells and MCF-7 human breast cancer cells with cDNA for wild-type human thioredoxin or a redox-inactive mutant thioredoxin, Cys32-->Ser32/Cys35-->Ser35 (C32S/C35S), on cell proliferati 8971189 Human
thioredoxin tumor NIH 3T3 cells transfected with thioredoxin achieved increased saturation densities compared with vector alone-transfected cells, but were not transformed as assessed by tumor formation in immunodeficient mice. 8971189 Mouse
thioredoxin cancers The results of the study suggest that thioredoxin plays an important role in the growth and transformed phenotype of some human cancers. 8971189 Human
thioredoxin cancer The inhibition of tumor cell growth by the dominant-negative redox-inactive mutant thioredoxin suggests that thioredoxin could be a novel target for the development of drugs to treat human cancer. 8971189 Human
thioredoxin tumor The inhibition of tumor cell growth by the dominant-negative redox-inactive mutant thioredoxin suggests that thioredoxin could be a novel target for the development of drugs to treat human cancer. 8971189 Human
trx tumor Thioredoxin (Trx) is a widely distributed redox protein that regulates several intracellular redox-dependent processes and stimulates the proliferation of both normal and tumor cells. 8986137 Human
thioredoxin tumor Thioredoxin (Trx) is a widely distributed redox protein that regulates several intracellular redox-dependent processes and stimulates the proliferation of both normal and tumor cells. 8986137 Human
thioredoxin colorectal carcinomas Half of human primary colorectal carcinomas (5/10) examined had increased thioredoxin mRNA, of 3- to over 100-fold, compared to adjacent normal colonic mucosa from the same subject. 9042207 Human
thioredoxin breast cancer We found that serum stimulation of growth arrested MCF-7 breast cancer cells caused a 59% increase in thioredoxin mRNA and a 62% increase in thioredoxin reductase mRNA by 24 hours. 9042207 Human
thioredoxin colon cancer Exposure of HT-20 colon cancer cells to hypoxia resulted in a 14-fold increase in thioredoxin mRNA by 16 hours, and a transient 4-fold increase in thioredoxin reductase mRNA at 1 hour that had returned to control levels by 8 hours. 9042207 Human
thioredoxin cancer Cancer cells were found to release thioredoxin into the medium at rates between 1 to 2 pmole/10(6) cells/3 hours. 9042207 Human
thioredoxin solid tumors The results of the study show that the expression of thioredoxin and thioredoxin reductase are increased several fold in some human solid tumors compared to normal tissue. 9042207 Human
thioredoxin cancer Secretion of thioredoxin, which is known to have a direct growth stimulating activity, by human tumor cells might lead to the stimulation of cancer cell growth. 9042207 Human
thioredoxin human tumor Secretion of thioredoxin, which is known to have a direct growth stimulating activity, by human tumor cells might lead to the stimulation of cancer cell growth. 9042207 Human
trx adult t-cell leukemia Adult T-cell leukemia derived factor (ADF)/human thioredoxin (TRX), which has thiol reducing and radical scavenging activities, plays an essential role on cellular protection against oxidative stress and cell death. 9052856 Human
thioredoxin adult t-cell leukemia Adult T-cell leukemia derived factor (ADF)/human thioredoxin (TRX), which has thiol reducing and radical scavenging activities, plays an essential role on cellular protection against oxidative stress and cell death. 9052856 Human
thioredoxin cancer Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. 9816187 Human
trx colon cancer Therefore, we examined the involvement of TRX in cDDP resistance using two cell lines designated St/DDP and HT/DDP, which were established from the human gastric cancer cell line St-4 and the colon cancer cell line HT-29. 9816187 Human
trx human gastric cancer Therefore, we examined the involvement of TRX in cDDP resistance using two cell lines designated St/DDP and HT/DDP, which were established from the human gastric cancer cell line St-4 and the colon cancer cell line HT-29. 9816187 Human
trx human ovarian cancer Because cDDP is the first-line drug against ovarian cancer, we examined the expression of TRX in 11 human ovarian cancer cell lines not treated with cDDP in vitro. 9816187 Human
trx ovarian cancer Because cDDP is the first-line drug against ovarian cancer, we examined the expression of TRX in 11 human ovarian cancer cell lines not treated with cDDP in vitro. 9816187 Human
thioredoxin hepatoma High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells. 7834639 Human
trx b-cell lymphoma In contrast, exogenous thiols and TRX stimulate proliferation of a B-cell lymphoma line, indicating that different cell types respond differently to variations in the extracellular redox potential. 7834639 Human
trx cancer Thioredoxin (Trx) expression is increased in several human primary cancers and the Trx/Trx reductase (TrxR) system therefore provides an attractive target for cancer drug development. 12569302 Human
thioredoxin cancer Thioredoxin (Trx) expression is increased in several human primary cancers and the Trx/Trx reductase (TrxR) system therefore provides an attractive target for cancer drug development. 12569302 Human
trx primary cancers Thioredoxin (Trx) expression is increased in several human primary cancers and the Trx/Trx reductase (TrxR) system therefore provides an attractive target for cancer drug development. 12569302 Human
thioredoxin primary cancers Thioredoxin (Trx) expression is increased in several human primary cancers and the Trx/Trx reductase (TrxR) system therefore provides an attractive target for cancer drug development. 12569302 Human
thioredoxin plasmacytoma A total of 61 mutated forms of hIL-11 were produced in E. coli as thioredoxin fusion proteins and tested in a murine T10 plasmacytoma proliferation assay. 7668526 others
thioredoxin prostatic cancer We first determined cellular levels of thioredoxin in several human bladder and prostatic cancer cell lines resistant to cis-diamminedichloroplatinum(II) (cisplatin). 7671238 Human
thioredoxin bladder cancer We then, by introducing thioredoxin antisense expression plasmids into human bladder cancer T24 cells, established two bladder cancer cell lines that had decreased levels of thioredoxin. 7671238 Human
thioredoxin human bladder cancer We then, by introducing thioredoxin antisense expression plasmids into human bladder cancer T24 cells, established two bladder cancer cell lines that had decreased levels of thioredoxin. 7671238 Human
thioredoxin cancer Cellular levels of thioredoxin thus appear to limit sensitivity to various superoxide-generating anticancer drugs in cancer cells. 7671238 Human
thioredoxin tumor A NADP+-dependent thioredoxin (17 muM)-thioredoxin reductase system from Novikoff ascites rat tumor was found to be the most powerful reducing agent tested. 1125184 Human
thioredoxin metastatic amelanotic melanoma In addition, it has been shown that reduced thioredoxin displaces the nitrosourea-inhibitor complex from the active site of thioredoxin reductase to fully reactivate enzyme purified from human metastatic amelanotic melanoma. 2200526 Human
trx colorectal carcinoma In this report immunocytochemical approaches have been used to simultaneously determine the expression and localisation of both TRX and TR in primary human cancers, including breast cancer, thyroid, prostate and colorectal carcinoma, and malignant melanom 12894524 Human
trx breast cancer In this report immunocytochemical approaches have been used to simultaneously determine the expression and localisation of both TRX and TR in primary human cancers, including breast cancer, thyroid, prostate and colorectal carcinoma, and malignant melanom 12894524 Human
trx malignant melanoma In this report immunocytochemical approaches have been used to simultaneously determine the expression and localisation of both TRX and TR in primary human cancers, including breast cancer, thyroid, prostate and colorectal carcinoma, and malignant melanom 12894524 Human
trx cancers In this report immunocytochemical approaches have been used to simultaneously determine the expression and localisation of both TRX and TR in primary human cancers, including breast cancer, thyroid, prostate and colorectal carcinoma, and malignant melanom 12894524 Human
thioredoxin invasive mammary carcinomas In aggressive invasive mammary carcinomas and advanced malignant melanomas, thioredoxin was highly over-expressed compared to tumours of lesser aggressive nature. 12894524 Human
thioredoxin malignant melanomas In aggressive invasive mammary carcinomas and advanced malignant melanomas, thioredoxin was highly over-expressed compared to tumours of lesser aggressive nature. 12894524 Human
thioredoxin tumours In aggressive invasive mammary carcinomas and advanced malignant melanomas, thioredoxin was highly over-expressed compared to tumours of lesser aggressive nature. 12894524 Human
trx colorectal carcinomas These results, which are the first immunocytochemical studies on the in vivo expression and localisation of TRX and TR in melanomas, thyroid, prostate and colorectal carcinomas and the first reports of TR expression in breast carcinomas, significantly ext 12894524 Human
trx breast carcinomas These results, which are the first immunocytochemical studies on the in vivo expression and localisation of TRX and TR in melanomas, thyroid, prostate and colorectal carcinomas and the first reports of TR expression in breast carcinomas, significantly ext 12894524 Human
trx cancers These results, which are the first immunocytochemical studies on the in vivo expression and localisation of TRX and TR in melanomas, thyroid, prostate and colorectal carcinomas and the first reports of TR expression in breast carcinomas, significantly ext 12894524 Human
trx melanomas These results, which are the first immunocytochemical studies on the in vivo expression and localisation of TRX and TR in melanomas, thyroid, prostate and colorectal carcinomas and the first reports of TR expression in breast carcinomas, significantly ext 12894524 Human
trx tumours Overall the results support the conclusion that aggressive tumours greatly over-express both TRX and TR. 12894524 Human
trx tumours Such tumours have a high proliferation capacity, a low apoptosis rate and an elevated metastatic potential strongly implicating the involvement of the TRX system in the processes of oncogenesis and tumourogenesis and confirming its potential as a target f 12894524 Human
thioredoxin human tumors In some human tumors, the thioredoxin system is found over-expressed. 12963029 Human
trx cancer Because of its role in stimulating cancer cell growth and as an inhibitor of apoptosis, the Trx system offers a target for the development of drugs to treat and prevent cancer. 12963029 Human
txn non-small cell lung cancer Protein analysis of six genes (ETS2, Cyclin D3, CDH2, DAPK1, TXN, and CTSL) showed that the changes induced by RASSF1A at the RNA level correlated with changes in protein expression in both non-small cell lung cancer and neuroblastoma cell lines. 14500366 Human
txn neuroblastoma Protein analysis of six genes (ETS2, Cyclin D3, CDH2, DAPK1, TXN, and CTSL) showed that the changes induced by RASSF1A at the RNA level correlated with changes in protein expression in both non-small cell lung cancer and neuroblastoma cell lines. 14500366 Human
trx nad These mutants included ubi, nad, cys, nar, trx, grx, gsh and sod. 8574407 Human
thioredoxin solid tumor We now report that recombinant human thioredoxin added to minimal culture medium in the absence of serum stimulates the proliferation of a number of human solid tumor cell lines measured over several days. 9019170 Human
thioredoxin breast cancer The concentration of thioredoxin producing half-maximal stimulation of MCF-7 breast cancer cell proliferation was 350 nM, and the maximum stimulation occurred at 5 microM. 9019170 Human
thioredoxin cancer The human redox protein thioredoxin is an autocrine growth factor for some cancer cells. 8163023 Human
thioredoxin adult t-cell leukemia PURPOSE. Adult T cell leukemia derived factor (ADF) is a human homologue of thioredoxin (hTx), which exhibits scavenging activity with reactive oxygen intermediates. 8206709 NA
thioredoxin human tumors The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors. 8049254 Human
thioredoxin human colon cancer The cDNA sequences of thioredoxin obtained by PCR cloning from human colon cancer cells, human lymphoblastoid cells, and human liver have been found to be identical with the cDNA sequence reported for the autocrine growth factor, human adult T-cell leukem 8049254 Human
thioredoxin primary lung tumors Human non-small cell primary lung tumors from subjects who were not cigarette smokers at the time of surgery showed significantly increased levels of thioredoxin mRNA compared to thioredoxin mRNA in paired normal human lung tissue. 8049254 Human
thioredoxin tumor Subjects who were smokers did not show a significant increase in lung tumor thioredoxin mRNA. 8049254 Human
thioredoxin cancers The results of the study show that human thioredoxin and ADF are identical species and suggest that there may be increased production of thioredoxin (ADF) by some human cancers. 8049254 Human
trx astrocytoma We showed that ADF/TRX was actively released from U251 astrocytoma cells upon exposure to a low concentration of H2O2. 7953744 Human
thioredoxin c6 glioma Furthermore, SASP purified from rat C6 glioma cells had an identical N-terminal amino acid sequence to that deduced for rat liver thioredoxin, showing that they were both members of the same family of proteins. 7818492 Rat
thioredoxin cancer Recombinant human thioredoxin stimulates the proliferation of Swiss murine 3T3 fibroblasts with an EC50 of 100 nM and the proliferation of a number of human cancer cells. 7620223 Human
thioredoxin hepatocellular carcinoma A human thioredoxin homologue in hepatocellular carcinoma. 1311982 Human
trx tumors Necrotic tumors were more often immunopositive for Trx (p = 0.001) and TrxR (p = 0.02) and AOE expression was generally higher in mitotically active tumors. 12744469 Human
trx tumors The results show that MnSOD and Trx may influence the biological behaviour of astrocytomas, possibly by modulating cell proliferation and necrosis in these tumors. 12744469 Human
thioredoxin cancer In this study, we evaluated the effects of thioredoxin, which is a powerful protein disulfide reductase, on mouse (Institute of Cancer Research, ICR) preimplantation embryo development. 1628853 NA
trx b-type chronic lymphocytic leukemia (b-cll) We show in this paper that exposure of B lymphocytes from normal, healthy donors and B cells from B-type chronic lymphocytic leukemia (B-CLL) to Staphylococcus aureus Cowan I (SAC) induced expression of Trx mRNA. 1334710 Human
thioredoxin metastatic melanoma In human metastatic melanoma cells and tissues the thioredoxin reductase/thioredoxin system is located both in the cell cytosol and on plasma membranes and is under allosteric regulation by calcium. 1841712 Human
thioredoxin lung tumor Subjects who were smokers did not show a significant increase in lung tumor thioredoxin mRNA. 8049254 Human
thioredoxin solid tumor A number of human hematologic and solid tumor cell lines were studied and showed a 10-fold range of thioredoxin mRNA and a 23-fold range of thioredoxin reductase mRNA. 9042207 Human
thioredoxin t-all Immunoblot analysis demonstrated that ATL cell lines expressed ADF/thioredoxin at levels 2.8 to 12 times those of other T-cell acute lymphocytic leukemia (T-ALL) cell lines, and that ATL cell lines were 2 to 15 times more resistant to ADM than other T-ALL 9116292 Human
thioredoxin necrosis Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. 9274857 Human
thioredoxin solid tumor This rapid method of evaluating biological activity is a means to identify agents with specificity for inhibition of the thioredoxin system, and may provide novel antitumor agents with activity against solid tumor cancers. 9406241 Human
thioredoxin fibroid Thioredoxin mRNA concentrations were determined in myometrial and fibroid tissues obtained from women during the menstrual cycle, during treatment with an analogue of gonadotrophin releasing hormone (GnRH agonist), in the postmenopausal period (PMP) and d 10611262 Human
thioredoxin gastric tumors Thus, human primary gastric tumors that are highly expressive of thioredoxin have both a higher proliferative rate and a higher survival rate than tumors that do not express thioredoxin. 10821495 Human
thioredoxin mesotheliomas Overexpression of thioredoxin might be a factor behind the poor prognosis and reduced responsiveness to therapy of mesotheliomas. 11269944 Human
thioredoxin astrocytomas We studied the expression of antioxidant enzymes (AOEs) and related proteins manganese superoxide dismutase (MnSOD), thioredoxin (Trx), thioredoxin reductase (TrxR), and the catalytic (GLCL-c) and regulatory (GLCL-r) subunits of glutamate cysteine ligase 12744469 NA
thioredoxin necrosis Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis. 12878175 Human
thioredoxin squamous-cell cancer Thioredoxin expression is increased in several human primary cancers including lung, colon, cervix, liver, pancreatic, colorectal and squamous cell cancer. 14604673 Human
thioredoxin primary cancers Thioredoxin expression is increased in several human primary cancers including lung, colon, cervix, liver, pancreatic, colorectal and squamous cell cancer. 14604673 Human
thioredoxin pancreatic cancer Thioredoxin is downstream of Smad7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer. 15150118 Human
thioredoxin tumor Thioredoxin-binding protein-2 (TBP-2)/vitamin D(3) up-regulated protein 1 is an endogenous molecule interacting with thioredoxin (TRX), negatively regulating TRX function, and being implicated in the suppression of tumor development and metastasis. 15234975 Human
thioredoxin metastasis Thioredoxin-binding protein-2 (TBP-2)/vitamin D(3) up-regulated protein 1 is an endogenous molecule interacting with thioredoxin (TRX), negatively regulating TRX function, and being implicated in the suppression of tumor development and metastasis. 15234975 Human
thioredoxin melanoma We tested the hypothesis that reactive oxygen species (ROS), regulated by thioredoxin interacting protein (Txnip) through the action of thioredoxin (Trx), influence human SK-MEL-28 melanoma cell reverse (basolateral-to-apical) transendothelial migration ( 15474995 Human
thioredoxin melanoma These data suggest that TEM of melanoma cells during intravasation is in part mediated by ROS-sensitive cellular signaling cascades, may be controlled by Txnip and its interaction with thioredoxin that in turn modulates cellular levels of oxidative stress 15474995 Human
thioredoxin ewing sarcoma NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing sarcoma cells. 15581626 Human
thioredoxin tumors Thioredoxin (Trx), a small redox protein, is overexpressed in a number of tumors, however, its roles in tumor cells were not defined well. 15754001 Human
thioredoxin tumor Thioredoxin (Trx), a small redox protein, is overexpressed in a number of tumors, however, its roles in tumor cells were not defined well. 15754001 Human
thioredoxin hyperplastic The aim of this report was to evaluate the expression of insulinlike growth factor I (IGF-I), estrogen receptor alpha, estrogen receptor beta, growth hormone receptor, and thioredoxin in a rat model of hypoplastic, hyperplastic, and normal fetal lungs to 15793718 Human
thioredoxin neuroblastoma Antisense bcl-2 transfection up-regulates anti-apoptotic and anti-oxidant thioredoxin in neuroblastoma cells. 15803370 Human
thioredoxin neuroblastoma The up-regulation of thioredoxin may be a compensating mechanism for cell survival in neuroblastoma when Bcl-2 expression is suppressed, and it may to some extent attenuate the effectiveness of antisense bcl-2 therapy. 15803370 Human
thioredoxin cancer The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy. 15684606 Human
thioredoxin cancers We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor-induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors prefer 15738652 Human
thioredoxin cancer We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor-induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors prefer 15738652 Human
thioredoxin nasal polyp Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp. 16158536 Human
trx tumors In various tumors including EBV-related malignancies, an elevated expression of TRX is reported, but the role of TRX in such tumors has not yet been clarified. 9046841 Human
trx neoplasms This review presents recent progress concerning the relation between TRX and neoplasms. 9046841 Human
trx necrosis Collectively, these data suggest that: (a) ADF/TRX is induced and translocated to nuclei by oxidative damage mediated by Fe-NTA in the renal proximal tubules; (b) induction of ADF/TRX is independent of tubular necrosis or sulfhydryl depletion; and (c) ADF 9274857 Human
trx hcc The serum level of TRX in LC/CH patients without HCC was 80.87 ng/ml (69.66-93.88 ng/ml). 9950104 Human
trx hcc In contrast, the serum level of TRX in patients with HCC was 147.35 ng/ml (125.53-172.96 ng/ml), which was significantly higher when compared with the level in serum of normal volunteers (p<0.001) and in serum of LC/CH patients without HCC (p<0.001). 9950104 Human
trx hcc In four patients with HCC, the initially high level of serum TRX (>150 ng/ml) decreased below 150 ng/ml after surgical removal of the tumor. 9950104 Human
trx hcc The data reported herein revealed that patients with HCC had a significantly elevated serum level of TRX, suggesting that measurement of serum of TRX might be a useful clinical parameter when HCC is suspected. 9950104 Human
trx necrosis As ROS are inducers of cell death, this raises the question as to whether Trx is able to protect cells from apoptosis and/or necrosis induced by UVA. 11522443 Human
trx necrosis Mitochondria-specific thioredoxin (Trx-2) and Trx peroxidases (peroxiredoxins) are suggested to regulate cytochrome c release from mitochondria, which is a critical early step in the apoptotis-signaling pathway. dATP/ATP and reducing factors including Trx 12215208 Human
trx astrocytomas We studied the expression of antioxidant enzymes (AOEs) and related proteins manganese superoxide dismutase (MnSOD), thioredoxin (Trx), thioredoxin reductase (TrxR), and the catalytic (GLCL-c) and regulatory (GLCL-r) subunits of glutamate cysteine ligase 12744469 NA
trx pilocytic astrocytomas Diffuse astrocytomas showed more intense staining for Trx (p = 0.002), TrxR (p = 0.004), GLCL-c (p = 0.001), GLCL-r (p = 0.04) and MnSOD (p = 0.01) than pilocytic astrocytomas. 12744469 Human
trx diffuse astrocytomas Diffuse astrocytomas showed more intense staining for Trx (p = 0.002), TrxR (p = 0.004), GLCL-c (p = 0.001), GLCL-r (p = 0.04) and MnSOD (p = 0.01) than pilocytic astrocytomas. 12744469 Human
trx diffuse astrocytomas Within diffuse astrocytomas only Trx (p = 0.0001) and TrxR (p= 0.04) significantly associated with increased malignancy grade. 12744469 Human
trx malignancy Within diffuse astrocytomas only Trx (p = 0.0001) and TrxR (p= 0.04) significantly associated with increased malignancy grade. 12744469 Human
trx diffuse astrocytomas Expression of Trx and lack of MnSOD expression was associated with a worse prognosis in diffuse astrocytomas. 12744469 Human
trx necrosis The results show that MnSOD and Trx may influence the biological behaviour of astrocytomas, possibly by modulating cell proliferation and necrosis in these tumors. 12744469 Human
trx astrocytomas The results show that MnSOD and Trx may influence the biological behaviour of astrocytomas, possibly by modulating cell proliferation and necrosis in these tumors. 12744469 Human
trx necrosis Moreover, TRX expression did not affect hepatocyte spheroid formation and it extensively suppressed necrosis in the internal cells. 12878175 Human
trx human tumours Such tumours have a high proliferation capacity, a low apoptosis rate and an elevated metastatic potential strongly implicating the involvement of the TRX system in the processes of oncogenesis and tumourogenesis and confirming its potential as a target f 12894524 Human
trx cancer Some of the newly prepared classes of tellurium-based inhibitors (lipid-like compounds 3b and 3e, amino acid derivative 5b, nucleic base derivative 8b, and polyamine derivatives 14a and 14b) inhibited TrxR/Trx and cancer cell growth in culture with IC(50) 14604673 Human
trx human lung cancer Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues. 14703116 Human
trx lung cancer Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues. 14703116 Human
trx lung cancer Here we show a dynamic change of glutathione homeostasis in lung cancer A549 cells and an up-regulation of Prx I and Trx following hypoxia. 14703116 Human
trx human lung cancer Western blot analysis of 10 human lung cancer and paired normal lung tissues also revealed an elevated expression of Prx I and Trx proteins in lung cancer tissues. 14703116 Human
trx lung cancer Western blot analysis of 10 human lung cancer and paired normal lung tissues also revealed an elevated expression of Prx I and Trx proteins in lung cancer tissues. 14703116 Human
trx cancer Immunohistochemical analysis of the lung cancer tissues confirmed an augmented Prx I and Trx expression in cancer cells with respect to the parenchymal cells in adjacent normal lung tissue. 14703116 Human
trx lung cancer Immunohistochemical analysis of the lung cancer tissues confirmed an augmented Prx I and Trx expression in cancer cells with respect to the parenchymal cells in adjacent normal lung tissue. 14703116 Human
trx lung tumor Based on these results, we suggest that the redox changes in lung tumor microenvironment could have acted as a trigger for the up-regulation of Prx I and Trx in lung cancer cells. 14703116 Human
trx lung cancer Based on these results, we suggest that the redox changes in lung tumor microenvironment could have acted as a trigger for the up-regulation of Prx I and Trx in lung cancer cells. 14703116 Human
trx tumor Although the clinical significance of our finding awaits more rigorous future study, preferential augmentation of the Prx I and Trx in lung cancer cells may well represent an attempt of cancer cells to manipulate a dynamic redox change in tumor microenvir 14703116 Human
trx cancer Although the clinical significance of our finding awaits more rigorous future study, preferential augmentation of the Prx I and Trx in lung cancer cells may well represent an attempt of cancer cells to manipulate a dynamic redox change in tumor microenvir 14703116 Human
trx lung cancer Although the clinical significance of our finding awaits more rigorous future study, preferential augmentation of the Prx I and Trx in lung cancer cells may well represent an attempt of cancer cells to manipulate a dynamic redox change in tumor microenvir 14703116 Human
trx pancreatic cancer Analysis by differential display identified thioredoxin-1 (TRX) as a gene whose basal expression is increased in COLO-357 pancreatic cancer cells engineered to overexpress Smad7. 15150118 Human
trx pancreatic cancer Moreover, analysis of laser-captured pancreatic cancer cells revealed parallel increases in Smad7 and TRX mRNA levels. 15150118 Human
trx pancreatic cancer These findings suggest that TRX is downstream of Smad7 in a pathway that confers a growth advantage to pancreatic cancer cells and that increases their resistance to CDDP-mediated apoptosis, implying novel regulatory functions for Smad7. 15150118 Human
trx tumor Thioredoxin-binding protein-2 (TBP-2)/vitamin D(3) up-regulated protein 1 is an endogenous molecule interacting with thioredoxin (TRX), negatively regulating TRX function, and being implicated in the suppression of tumor development and metastasis. 15234975 Human
trx metastasis Thioredoxin-binding protein-2 (TBP-2)/vitamin D(3) up-regulated protein 1 is an endogenous molecule interacting with thioredoxin (TRX), negatively regulating TRX function, and being implicated in the suppression of tumor development and metastasis. 15234975 Human
trx melanoma We tested the hypothesis that reactive oxygen species (ROS), regulated by thioredoxin interacting protein (Txnip) through the action of thioredoxin (Trx), influence human SK-MEL-28 melanoma cell reverse (basolateral-to-apical) transendothelial migration ( 15474995 Human
trx tumor Taken together, our results suggest that Trx may regulate cell cycle and growth through a novel modulation of Jab1-mediated proliferation signals, further indicating that Trx may have the ability to control tumor progression. 15480426 Human
trx tumors Thioredoxin (Trx), a small redox protein, is overexpressed in a number of tumors, however, its roles in tumor cells were not defined well. 15754001 Human
trx tumor Thioredoxin (Trx), a small redox protein, is overexpressed in a number of tumors, however, its roles in tumor cells were not defined well. 15754001 Human
trx tumor angiogenesis Taken together, we suggest that Trx plays an important role in angiogenesis and, therefore, antisense-Trx might be applicable to the inhibition of tumor angiogenesis through the induction of pVHL-mediated HIF-1alpha degradation. 15754001 Human
trx cancer These findings suggest that the TRX/TX system may represent an attractive target for development of new cancer therapeutics. 15684606 Human
trx cancers We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor-induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors prefer 15738652 Human
trx cancer We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor-induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors prefer 15738652 Human
trx primary cancers An increment of thioredoxin-1 (TRX) is observed in many human primary cancers and appears to contribute to an increase of cell growth and a resistance to chemotherapy. 16024017 Human
trx fibrosarcoma On the contrary, when TRX was overexpressed in the HT-1080 fibrosarcoma cells, the cell growth was retarded and chromosomal polyploidy and cellular senescence were induced. 16024017 Human
trx cancer Not surprisingly, the role of Trx in a wide range of human diseases and conditions, including cancer, viral disease, ischaemia-reperfusion injury, cardiac conditions, aging, premature birth and newborn physiology, is subject to intense investigation. 15990177 Human
trx nasal polyp Based on the fact that normal nasal mucosa is continuously exposed to inhaled toxicants and contains a considerable number of inflammatory cells, Trx and TrxR may be upregulated even in normal nasal mucosa and perhaps the difference in their expression le 16158536 Human
trx nasal polyp Further studies will be needed to clarify the roles of Trx and TrxR in the pathogenesis of nasal polyp. 16158536 Human
trx nasal polyp This study was undertaken to investigate the expression and distribution of Trx and TrxR in normal human nasal mucosa and nasal polyp, and to improve understanding of the significance of the Trx system in these conditions. 16158536 NA
trx nasal polyp MATERIAL AND METHODS: The expression and distribution of Trx and TrxR in normal human inferior turbinate mucosa and nasal polyp were investigated using reverse transcriptase polymerase chain reaction (RT-PCR), semiquantitative RT-PCR, Western blotting and 16158536 NA
trx nasal polyp RESULTS: mRNAs and protein for both Trx and TrxR were detected in normal human inferior turbinate mucosa and nasal polyp. 16158536 Human
trx nasal polyp Semiquantitative RT-PCR and Western blotting revealed that there was no significant difference in the expression levels of Trx and TrxR between inferior turbinate mucosa and nasal polyp. 16158536 Human
trx nasal polyp Immunoreactivity for both Trx and TrxR was seen in nasal epithelial cells, glands and vascular endothelium of inferior turbinate mucosa and nasal polyp. 16158536 Human
trx nasal polyp Trx and TrxR immunoreactivity was also found in inflammatory infiltrating cells in inferior turbinate mucosa and nasal polyp. 16158536 Human
txn mesothelioma Among them, the expression levels of eight genes, namely BF, FTL, IGFBP7, RARRES1, RARRES2, RBP1, SAT, and TXN according to HUGO nomenclature, were increased, whereas six: ALOX5AP, CLNS1A, EIF4A2, ELK3, REQ and SYPL, were found to be underexpressed in mes 14987796 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.